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Hunn Martin K - - 2012
PURPOSE: The prognosis for patients with glioblastoma multiforme (GBM) remains extremely poor despite recent treatment advances. There is an urgent need to develop novel therapies for this disease.EXPERIMENTAL DESIGN: We used the implantable GL261 murine glioma model to investigate the therapeutic potential of a vaccine consisting of intravenous injection of ...
Miles Mathew C - - 2012
Chronic obstructive pulmonary disease (COPD) is a serious global health burden. Comprehensive management of COPD includes both pharmacologic and non-pharmacologic interventions aimed at improving disease-related functional capacity, health-related quality of life, and survival. The primary medications used for treatment of COPD are inhaled bronchodilator drugs which are delivered directly to ...
Mahmud Salaheddin M - - 2012
Please cite this paper as: Mahmud et al. (2012) Outbreaks of influenza-like illness in long-term care facilities in Winnipeg, Canada. Influenza and Other Respiratory Viruses 10.1111/irv.12052 Background  Outbreaks of influenza-like illness (ILI) are common in long-term care facilities (LTCFs) and result in significant morbidity and mortality among residents. Objectives  We describe ...
Wilcken Rainer - - 2012
Halogen bonding has been known in material science for decades, but until recently, halogen bonds in protein-ligand interactions were largely the result of serendipitous discovery rather than rational design. In this perspective, we provide insights into the phenomenon of halogen bonding, with special focus on its role in drug discovery. ...
Saglam Mehmet - - 2012
Abstract Abstract: Modification of sinus floor and providing adequate space for implant surgery by orthodontic tooth movement might be a predictable treatment procedure. In this case, implant therapy was performed by providing adequate space with orthodontic tooth movement in a patient has inadequate alveol height at posterior maxilla.Method: A 54 ...
Solomon Keith R - - 2012
The article "The ecological risk assessment of atrazine in North American surface waters" [1] is one of the few among the 100 most cited articles in Environmental Toxicology and Chemistry to specifically address risk and/or assessment of risk, and it was the first to use probabilistic approaches for a pesticide. ...
Altmann S - - 2012
Background: The implantation of endoprostheses is an established procedure in orthopaedic and trauma surgery. However, the techniques are often associated with a high risk of postinterventional infections and wound healing disorders that can result in loss of the prosthesis or the limb - most likely based on an insufficient debridement ...
Nasu Mamiko - - 2012
Most pharmaceutical drug substances and excipients in formulations exist in a crystalline or amorphous form, and an understanding of their state during manufacture and storage is critically important, particularly in formulated products. Carbon 13 solid-state nuclear magnetic resonance (NMR) spectroscopy is useful for studying the chemical and physical state of ...
Wang Zhe-Ming - - 2012
Aggravating aggregation: An N-terminal domain that is in close proximity to the polyQ domain in the huntingtin protein, htt105-138 is shown to be highly aggregation prone. Potential cross-talk between this domain and the polyQ region may play a central role in regulating the aggregation and toxicity of Htt-N-terminal fragments.
Cauchy F - - 2012
BACKGROUND: The incidence of metabolic syndrome-associated hepatocellular carcinoma (MS-HCC) is increasing. However, the results following liver resection in this context have not been described in detail. METHODS: Data for all patients with metabolic syndrome as a unique risk factor for HCC who underwent liver resection between 2000 and 2011 were ...
Knudsen C S - - 2012
OBJECTIVES: To report on a series of dogs and cats with long bone fractures that occurred as a direct consequence of linear external skeletal fixation (ESF) application. METHODS: Retrospective study. Data from the medical records and radiographs of canine (n = 4) and feline (n = 7) cases were collected from three referral and ...
Di Minno M N D - - 2012
Peripheral arterial disease (PAD) predicts cardiovascular and cerebrovascular ischemic events. PAD treatment is aimed at reducing clinical symptoms, local tissue loss and at preventing complications. Aims:To evaluated the effect of peridural analgesia on peripheral perfusion and pain control.In 280 diabetic subjects with severe limb ischemia (65.7% males and 34.3% females, ...
Hites Maya - - 2012
Severe sepsis and septic shock can alter the pharmacokinetics of broad-spectrum β-lactams (meropenem, ceftazidime/cefepime, and piperacillin-tazobactam), resulting in inappropriate serum concentrations. Obesity may further modify the pharmacokinetics of these agents. We reviewed our data on critically ill obese patients, (body mass index ≥30 kg/m(2)), treated with a broad-spectrum β-lactam in ...
Ostertag Maya - - 2012
Membrane trafficking is vital to plant development and adaptation to the environment. It is suggested that post-Golgi vesicles and multivesicular bodies are essential for plant defence against directly penetrating fungal parasites at the cell wall. However, the actual plant proteins involved in membrane transport for defence are largely unidentified. We ...
Nakano Shu-Ichi - - 2012
Incorporation of modified nucleotides into nucleic acid strands often produces conformational constraints and steric hindrances that may change the property of base pairing. In this study, we investigated a 2'-deoxycytidine derivative that tethers a phenyl moiety to the exocyclic amino group of cytosine linked through a ureido group. This derivative ...
Peters S O - - 2012
Brangus heifers (i.e., 3/8 Brahman-Bos indicus x 5/8 Angus- Bos Taurus; n ≈ 800) heifers from 67 sires were used to estimate heritability and conduct a genome-wide association study (GWAS) for 2 binary fertility traits, first service conception (FSC) and heifer pregnancy (HPG). Genotypes were from 53,692 loci on the ...
Bottje W - - 2012
Understanding the cellular basis of feed efficiency (FE) is instrumental to helping poultry and livestock industries continue to provide high quality protein for an increasingly crowded world. To understand relationships of FE and gene expression, global RNA transcription was investigated in breast muscle obtained from a male broiler line fed ...
Mukai Chisato - - 2012
The unprecedented Csp3-Csp3 bond cleavage of the unactivated cyclopentane has been achieved. The RhI-catalyzed cycloaddition of allenylcyclopentane-alkynes produced in situ the 9-cyclopentyl-8-rhodabicyclo[4.3.0]nona-1,6-diene intermediates, which were subsequently susceptible to the [7+2] cycloaddition via β-carbon elimination affording the bicyclo[7.4.0]tridecatriene derivatives in good yields. Changing the RhI catalyst effected the Cγ-H bond activation ...
Zhang Bingbo - - 2012
Quantum dots (QDs) have been widely used as fluorescent probes in cell-targeted imaging. However, nonspecific binding to cellular membranes has been a major challenge. In this study, a new approach is developed for effective reduction of nonspecific binding by bovine serum albumin (BSA)-coated QDs in cell targeting. The experimental results ...
Ackerman Ilana N - - 2012
Objective. To improve understanding of barriers to participation in community-based arthritis self-management programmes and patient preferences for self-management education.Methods. Individuals with hip or knee OA referred to orthopaedic surgeons or rheumatologists at six public and private hospitals in Victoria, Australia, were recruited for a randomized controlled trial (RCT) of the ...
Fishman Randy S - - 2012
The diruthenium compound [Ru(2)(O(2)CMe)(4)](3)[Cr(CN)(6)] contains two weakly coupled, ferrimagnetically ordered sublattices occupying the same volume. Due to the weak, antiferromagnetic dipolar interaction K(c) ≈ 5 × 10(-3) meV between sublattices, a small magnetic field H(c) ∼ K(c)/μ(B) ≈ 800 Oe aligns the sublattice moments. Powder neutron-diffraction measurements on a deuterated sample confirm an earlier prediction that the sublattice moments are ...
Euser Anja S - - 2012
One of the core features of individuals with a substance-use disorder (SUD) is the reduced ability to successfully process errors and monitor performance, as reflected by diminished error-related negativities (ERN). However, whether these error-related brain abnormalities are caused by chronic substance use or rather predates it remains unclear. The present ...
Mayrovitz Harvey N - - 2012
Abstract Background: Skin changes in diabetes mellitus (DM) include possible increases in foot skin water content as interpreted from altered echogenicity in high-frequency ultrasound images. The present goal was to investigate the possibility of undetected increased local skin water in persons with DM using a handheld portable rapid measuring device ...
Zou Duohong - - 2012
Abstract ABSTRACTThe aim of this study was to evaluate oral function rehabilitation in patients with hypohidrotic ectodermal dysplasia (HED) using implant-supported prostheses base on bone augmentation. From September 2005 and March 2009, twenty-five HED patients were chose to analyze clinical data in this study. The criteria for patient selection was ...
Packer Dominic J - - 2012
Not every situation affords the appropriate setting to articulate group problems, and I predicted that strongly identified members would be particularly sensitive to the intergroup context in which ingroup criticism is expressed. In Study 1, strongly but not weakly identified members reduced criticism of their ingroup when communicating with an ...
Kotsakis Georgios - - 2012
Abstract It has been documented that after every extraction of one or more teeth, the alveolar bone of the respective region undergoes resorption and atrophy. Therefore, ridge preservation techniques are often employed after tooth extraction to limit this phenomenon. The benefits of a flapless procedure include maintenance of the buccal ...
Sakamoto Tomoaki - - 2012
The phytohormones auxin and brassinosteroid are both essential regulators of physiological and developmental processes, and it has been suggested that they act interdependently and synergistically. In rice (Oryza sativa), auxin co-application improves the brassinosteroid response in the rice lamina inclination bioassay. Here, we showed that auxin stimulates brassinosteroid perception by ...
Bohrer B M - - 2012
The objective was to summarize previous literature, using a meta-analysis approach, on the effects of ractopamine hydrochloride (RAC) when fed at doses of 5 to 10 mg/kg for up to 35 days prior to harvest on carcass cutability and belly quality of finishing pigs. The meta-analysis provided an opportunity to ...
Xiong Yun - - 2012
The novel chlorogermyliumylidene complex [ClGe:](+) ( = 1,8-bis(tri-n-butylphosphanzenyl)naphthalene) with a 'naked' Cl(-) as a counter anion was synthesized through reaction of with Cl(2)Ge: and fully characterized. Its reaction with elemental sulfur afforded the first germathionium [ClGe[double bond, length as m-dash]S](+) cation containing species. The latter has also been fully characterized, ...
Wang Yufei - - 2012
The solution-based manufacture of chemically converted graphene (CCG) provides a cost-effective and facile approach to construct graphene-based materials. However, uncontrollable wrinkles and aggregates are usually seen when transferring graphene sheets from solution to solid-state, significantly altering their optical, electrical and electrochemical properties. A number of strategies have been devoted to ...
Sun Lin - - 2012
Ketamine, a non-competitive N-methyl-D-aspartic acid receptor antagonist, has emerged as an increasingly popular drug among young drug abusers worldwide. Available evidence suggests that ketamine produces acute impairments of working, episodic and semantic memory along with psychotogenic and dissociative effects when a single dose is given to healthy volunteers. However, understanding ...
Harrison Sandy P - - 2012
Approximately 1-2% of net primary production by land plants is re-emitted to the atmosphere as isoprene and monoterpenes. These emissions play major roles in atmospheric chemistry and air pollution-climate interactions. Phenomenological models have been developed to predict their emission rates, but limited understanding of the function and regulation of these ...
Navarro-Compán Victoria - - 2012
Objective. To investigate the relationship between oxidative stress and smoking and development of RA.Methods. A case-control study was conducted in treatment-naïve early-onset RA patients and healthy controls, matched by age, gender and current smoking habit. Plasma lipid hydroperoxides (LOOH), carbonyl protein (CP) and malonyldialdehyde (MDA) levels were measured to estimate ...
McKenzie Blair M - - 2012
To penetrate soil, a root requires pressure both to expand the cavity it is to occupy, σ(n) and to overcome root-soil friction, σ(f) . Difficulties in estimating these two pressures independently has limited our ability to estimate the coefficient of soil-root friction, µ(sr) . We used a rotated penetrometer probe, ...
McKeown Joseph T - - 2012
Using pump-probe electron microscopy techniques, the dewetting of thin nickel films exposed to a pulsed nanosecond laser was monitored at tens of nanometers spatially and nanosecond timescales to provide insight into the liquid-phase assembly dynamics. Thickness-dependent and correlated time and length scales indicate that a spinodal instability drives the assembly ...
Koyano Kosuke - - 2012
BACKGROUND: Anemia of prematurity commonly occurs in infants with very low birth weight; blood transfusion is an important treatment. However, there is no clear evidence to support the criteria currently widely used, based on blood hemoglobin (bHb) and hematocrit indices. Previous studies showed that overtransfusion or a low threshold for ...
Singha Roy Atanu - - 2012
Green tea is rich in several polyphenols, such as (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC), and (-)-epigallocatechin-3-gallate (EGCG). The biological importance of these polyphenols led us to study the major polyphenol EGCG with human serum albumin (HSA) in an earlier study. In this report, we have compared the binding of ECG, EGC, ...
Noda Daisuke - - 2012
Treatment of (η(1)-mesityl)(2)Fe(κ(2)-TMEDA) () with an α,β-unsaturated carbonyl compound results in 1,4-addition of the mesityl group to give an iron enolate quantitatively. The Z-configuration of the enolate suggested the six-centered mechanism for the conjugate addition.
Chen Y C - - 2012
The aims of our meta-analysis were (i) to quantify the predictability of childhood overweight and obesity on the risk of incident asthma; and (ii) to evaluate the gender difference on this relationship. The selection criteria included prospective cohort paediatric studies which use age- and sex-specific body mass index (BMI) as ...
Tzovara Athina - - 2012
Auditory evoked potentials are informative of intact cortical functions of comatose patients. The integrity of auditory functions evaluated using mismatch negativity paradigms has been associated with their chances of survival. However, because auditory discrimination is assessed at various delays after coma onset, it is still unclear whether this impairment depends ...
Vishnuvardhan Reddy S - - 2012
Two helical shaped bacteria (strain JC133T and JC143) which stain Gram-negative were isolated from an alkaline soda lake, Lonar, India. Both strains are obligate anaerobes, mesophilic and require halo-alkaline conditions for growth. Both strains are resistant to rifampicin and kanamycin, but sensitive to gentamycin, tetracycline, ampicillin and chloramphenicol. Both strains ...
Wang Jiaxu - - 2012
Abstract A new species of monorchiid trematode, Leiomonorchis zhanjiangensis n. sp. (Trematoda: Monorchiidae), is described from the intestine of marine fish Secutor ruconius (Hamilton-Buchanan) (Leiognathidae) from Zhanjiang (21°2´N, 110°3´E), Guangdong Province, China. The new species is distinguished from all known species of the genus, mainly by the configuration of vitelline ...
Tsoi Georgiy M - - 2012
High-pressure electrical resistance measurements have been performed on single crystal Ba(0.5)Sr(0.5)Fe(2)As(2) platelets to pressures of 16 GPa and temperatures down to 10 K using designer diamond anvils under quasi-hydrostatic conditions with an insulating steatite pressure medium. The resistance measurements show evidence of pressure-induced superconductivity with an onset transition temperature at ∼31 K and ...
Ye Chu-Yu - - 2012
There are a large number of "non-family" (NF) genes that do not cluster into families with three or more members per genome. While gene families have been extensively studied, a systematic analysis of NF genes has not been reported. We performed comparative studies on NF genes in 14 plant species. ...
Gokmen Zeynel - - 2012
Objective To evaluate the diagnostic potential of resistin in sepsis and to compare results with C-reactive protein (CRP) in infants < 32 weeks of gestation.Study Design A total of 64 infants were prospectively included in the study. Blood samples were collected for basal CRP and resistin within the first hour of life. When sepsis ...
Park Kyung Man - - 2012
Even though matrix-assisted laser desorption ionization (MALDI) is a powerful technique for mass spectrometry of peptides and proteins, it is not quite useful for their quantification that is one of the outstanding problems in quantitative proteomics. The main difficulty lies in the poor reproducibility of MALDI spectra. In this work, ...
Wu Yi-Xin - - 2012
Baicalin and scutellarin are the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz. It has recently been reported that baicalin and scutellarin have antitumor activity. However, the mechanisms of action are unknown. We previously reported that some flavonoids have a specific ...
Emerson M R - - 2012
This study quantified relationships between USDA instrument marbling measurements and LM sensory attributes (tenderness, flavor, juiciness) and shear force. Heifer (n = 390) and steer (n = 328) carcasses (all A-maturity) were selected at 4 beef processing plants in CO, KS, NE, and TX to represent 7 marbling degrees: Traces ...
Talbot N C - - 2012
Totipotent embryonic stem cell lines have not been established from ungulates; however, we have developed a somatic stem cell line from the in vitro culture of pig epiblast cells. The cell line, ARS-PICM-19, was isolated via colony-cloning and was found to spontaneously differentiate into hepatic parenchymal epithelial cell types, namely, ...
Segers Kurt - - 2012
ABSTRACT A patient with a history of Parkinson's disease and severe bilateral peripheral vision loss due to vitreous hemorrhages had complex visual hallucinations that persisted for three days and appeared every morning on awakening. The persistent nature of these hallucinations, the patient's preserved insight, and the presence of severe visual ...
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