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Sharkey Thomas D - - 2012
Each year, 500 Tg of isoprene is emitted from some plants (Guenther et al. 2006). This exceeds the total amount of hydrocarbon released as a result of human activities; if all the isoprene released from vegetation were collected as a liquid it would fill 300,000 Olympic-sized swimming pools. © 2012 ...
Bertelsen R J RJ Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, N-0403 Oslo, Norway. - - 2013
Exposure to the synthetic antimicrobial chemical, triclosan, used in personal care products, has been hypothesized to lead to allergic disease. We investigated whether triclosan exposure was associated with allergic sensitization and symptoms in 10-year-old Norwegian children. Urinary concentrations of triclosan were measured in one first morning void from 623 children, ...
Turner Alyna - - 2012
Objective: Depression is common following an acute cardiac event and can occur at a time when behaviour change is strongly recommended to reduce the risk of further cardiovascular events. The 'Beating Heart Problems' programme was designed to support cardiac patients in behaviour change and mood management.Methods: The programme was based ...
Ibáñez Elena - - 2012
The essential micronutrient selenium (Se) exerts its biological effects mainly through selenoproteins thereby affecting a number of physiological pathways including intracellular redox control, stress response and cancer cell proliferation. Besides affecting selenoprotein expression, some selenocompounds have been synthesized and analyzed in order to serve as chemotherapeutic substances preferentially targeting cancer ...
Capitanini Alessandro - - 2012
<p>Vascular calcifications usually affect the arteries, while central vein calcifications are rare. <br />A 45-year-old hemodialysis patient underwent a chest CT scan before central vein catheterization required for arteriovenous access thrombosis, in July 2011. He was on hemodialysis since 1995 and from 2005 on warfarin treatment because of repeated thrombosis ...
Allen Charlotte A - - 2013
Fidaxomicin (FDX) is approved to treat Clostridium difficile-associated diarrhea and is superior to vancomycin in providing a sustained clinical response (cure without recurrence in the subsequent 25 days). The mechanism(s) behind the low recurrence rate of FDX-treated patients could be multifactorial. Here, we tested effects of FDX, its metabolite OP-1118, ...
Fry R S - - 2012
Copper (Cu) deficiency is a widespread problem in cattle across the United States and breed differences in Cu metabolism may contribute to this issue. Intracellular Cu is tightly regulated by transport and chaperone proteins, and to date these mechanisms have not been elucidated to address breed differences in Cu metabolism, ...
Lin-Moshier Yaping Y Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, - - 2013
Changes in cytoplasmic Ca(2+) concentration, resulting from activation of intracellular Ca(2+) channels within the endoplasmic reticulum, regulate several aspects of cellular growth and differentiation. Ca(2+) homeostasis endoplasmic reticulum protein (CHERP) is a ubiquitously expressed protein that has been proposed as a regulator of both major families of endoplasmic reticulum Ca(2+) ...
Harding Heather P HP Metabolic Research Laboratories, University of Cambridge, and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom. - - 2012
Loss-of-function mutations in EIF2AK3, encoding the pancreatic endoplasmic reticulum (ER) kinase, PERK, are associated with dysfunction of the endocrine pancreas and diabetes. However, to date it has not been possible to uncouple the long term developmental effects of PERK deficiency from sensitization to physiological levels of ER unfolded protein stress ...
Hii M W - - 2012
BACKGROUND: Oesophageal malignancy is a disease with a poor prognosis. Oesophagectomy is the mainstay of curative treatment but associated with substantial morbidity and mortality. Although mortality rates have improved, the incidence of perioperative morbidity remains high. This study assessed the impact of postoperative morbidity on long-term outcomes. METHODS: A prospective ...
Sontas B H - - 2012
Endometrial adenocarcinoma is described in two young intact female Persian cats presented with haemorrhagic vaginal discharge. The discharge had been present for 3 and 15 days in each case, respectively. On the basis of signalment, history, clinical, laboratory and diagnostic imaging findings a tentative diagnosis of pyometra was made in each ...
Hashizume Naoki - - 2012
Existing standard bioconcentration tests (e.g., the Organization for Economic Cooperation and Development [OECD] test guideline [TG] 305) require large numbers of test animals and resources. The minimized aqueous exposure test is a new approach based on the standard bioconcentration test but allows estimation of bioconcentration factor (BCF) by minimized sampling ...
Delelys Michelle E - - 2012
BACKGROUND: Although platelets (PLTs) are known to express ABH antigens, the extent of expression is different on PLTs compared with red blood cells and the relationship between PLT ABH expression and genotype has not been thoroughly investigated. STUDY DESIGN AND METHODS: We measured blood group H and A antigens on ...
Badran Ismail - - 2012
The kinetics and thermochemistry of the decomposition pathways for 1,3-disilacyclobutane (1,3-DSCB) in the gas phase were studied using the second-order Møller-Plesset (MP2) perturbation theory and coupled cluster methods with single, double and perturbative triple excitations (CCSD(T)). The reactions examined include 2+2 cycloreversion to form two silenes by either a concerted ...
Wu Jin - - 2012
Abstract Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been utilized for cancer therapy, but the resistance of cancer cells to TRAIL remains an obstacle. Ether à go-go 1 (Eag1) channel is overexpressed in a variety of cancers and implicated in tumor progression. However, the therapeutic potential of Eag1 in osteosarcoma ...
Song Yantao - - 2012
Silicic acid (H4SiO4) is ubiquitous in natural aquatic systems. Applications of TiO2 in these systems will be influenced by H4SiO4 sorption and oligomerization reactions on the TiO2 surface and this can affect many aspects of TiO2 reactivity. The spatial arrangement of sorption sites on a metal oxide surface can promote ...
Gemes Geza G Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, - - 2013
The T-junction of sensory neurons in the dorsal root ganglion (DRG) is a potential impediment to action potential (AP) propagation towards the CNS. Using intracellular recordings from rat DRG neuronal somata during stimulation of the dorsal root, we determined that the maximal rate at which all of 20 APs in ...
Zong Mei - - 2012
OBJECTIVES: Polymyositis and dermatomyositis are characterised by muscle weakness and fatigue even in patients with normal muscle histology via unresolved pathogenic mechanisms. In this study, we investigated the mechanisms by which high mobility group box protein 1 (HMGB1) acts to accelerate muscle fatigue development. METHODS: Intact single fibres were dissociated ...
Liu Shian - - 2012
K(+) channels exhibit strong selectivity for K(+) ions over Na(+) ions based on electrophysiology experiments that measure ions competing for passage through the channel. During this conduction process, multiple ions interact within the region of the channel called the selectivity filter. Ion selectivity may arise from an equilibrium preference for ...
O'Donnell Martin J - - 2012
We sought to develop and validate a simple clinical prediction rule for death and severe disability after acute ischemic stroke that can be used by general clinicians at the time of hospital admission. We analyzed data from a registry of 9847 patients (4943 in the derivation cohort and 4904 in ...
Selmic Laura E - - 2012
A number of surgical techniques have been reported for dissection and ligation of patent ductus arteriosi (PDAs) in dogs. The objectives of this study were to provide a detailed description of an intrapericardial technique for PDA dissection and ligation and to report the clinical outcome of that technique in dogs. ...
Li Yi-Liang YL Department of Earth Sciences, The University of Hong Kong , Hong Kong. - - 2012
Dissimilatory iron-reducing bacteria are able to enzymatically reduce ferric iron and couple to the oxidation of organic carbon. This mechanism induces the mineralization of fine magnetite crystals characterized by a wide distribution in size and irregular morphologies that are indistinguishable from authigenic magnetite. Thermoanaerobacter are thermophilic iron-reducing bacteria that predominantly ...
Pramanik Rashida - - 2012
BACKGROUND: The UK Biobank (UKB) is a national epidemiological study of the health of 500 000 people, aged 40-69 years, who completed health-related tests and a questionnaire and gave samples of blood and urine. Salivas collected from 120 000 of these subjects were transported at 4°C and were placed in ...
Hubka Vit - - 2012
Two new and phylogenetically closely related species in Aspergillus section Fumigati are described and illustrated. Homothallic A. waksmanii was isolated from New Jersey soil (USA) and is represented by the ex-type isolate NRRL 179T (=CCF 4266T=IBT 31900T). Aspergillus marvanovae was isolated from water with high boracic acid anions content in ...
Banning Adrian P - - 2012
The development of percutaneous valve replacement has broadened the procedural interface between interventional cardiologists and their cardiothoracic surgical colleagues. Our relationship is no longer restricted to the arena of coronary artery disease, and opportunities now exist to share the care of large numbers of high surgical risk patients with severe ...
Ying Yibo - - 2012
We investigate thermally driven electronic transport through a quantum dot (QD) coupled to two ferromagnetic leads and one normal-metallic lead. The effect of spin accumulation and temperature bias on the tunnel magnetoresistance (TMR) is examined. We obtain a nonlocal negative TMR, which also exhibits a rectification effect as a function ...
Domes G - - 2012
BACKGROUND: The neuropeptide oxytocin (OT) has positive effects on the processing of emotional stimuli such as facial expressions. To date, research has focused primarily on conditions of overt visual attention. Method We investigated whether a single intranasal dose of OT (24 IU) would modulate the allocation of attentional resources towards positive ...
Dube Jonathan W - - 2012
Go for the gold! Incorporating a borate anion into the backbone of a triphosphenium cation produces a unique zwitterionic phosphanide that can coordinate to one or two {AuCl} fragments depending on the steric bulk of the ligand (see picture; Au yellow, P purple, Cl green). Computational investigations show that in ...
Oshrine Kathleen - - 2012
Bilateral lung transplantation remains a treatment for end-stage cystic fibrosis (CF) lung disease when there is no further medical or surgical treatment available. The aim of lung transplantation is to improve patient life expectancy. The consensus view that lung transplantation extends life in children has been challenged. However, challengers have ...
Hayashi Masashi - - 2012
The first highly enantioselective desymmetrization of aziridines with phosphites has been developed. Excellent yields and enantioselectivities were observed for the reaction with various aziridines using a new class of readily accessible chiral catalysts derived from 9-amino-9-deoxy-epi-cinchona alkaloids. In studies probing the reaction mechanism, we observed some complexes for the cinchona ...
Lohman Robert F - - 2012
No universally accepted method of flap monitoring exists, and several techniques are in use. Repeated physical examination is most popular and is often supplemented with a handheld, external Doppler, and/or implantable Doppler probes; near-infrared spectroscopy is less commonly used. We investigated the nursing and resident house staff's experience and confidence ...
Georg Jensen M - - 2012
This review provides a critical update on human and animal studies investigating the effect of alginate supplementation on appetite regulation, glycaemic and insulinemic responses, and lipid metabolism with discussion of the evidence on potential mechanisms, efficacy and tolerability. Dependent on vehicle applied for alginate supplementation, the majority of animal and ...
Mooi Sara M - - 2012
Understanding the role played by external factors on the organization of molecules has the potential to contribute greatly to fundamental research and applications of fields as diverse as nanotechnology, medicine, material chemistry, etc. Countless studies involve the organization of small organic molecules in environments rich in ionic species, yet their ...
Tonnetti Laura - - 2012
BACKGROUND: The increasing frequency of transfusion-transmitted babesiosis represents a concern for the safety of the US blood supply. The agent responsible for the disease, the intraerythrocytic parasite Babesia microti, is naturally transmitted to humans by a tick bite and is endemic in areas of the Northeast and Upper Midwest United ...
Kang Pilgyu - - 2012
Near-field optical techniques have enabled trapping, transport, and handling of nanoscopic materials much smaller than what can be manipulated with traditional optical tweezers. Here we extend the scope of what is possible by demonstrating angular orientation and rotational control of both biological and non-biological nanoscale rods using photonic crystal nanotweezers. ...
Hales K E - - 2012
The use of wet distillers grains with solubles (WDGS) in feedlot diets has increased in the Southern Great Plains as a result of the growing ethanol industry. Nutrient balance and respiration calorimetry research evaluating the use of steam-flaked corn (SFC)-based diets in conjunction with WDGS is limited. Therefore, the effects ...
Döppler Heike H Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, Florida 32224, - - 2013
Neuregulin (NRG; heregulin) is overexpressed in ∼30% of breast cancers and mediates various processes involved in tumor progression, including tumor cell migration and invasion. Here, we show that NRG mediates its effects on tumor cell migration via PKD1. Downstream of RhoA, PKD1 can prevent directed cell migration through phosphorylation of ...
Schäffer Christian - - 2012
Addition of [Mo(2)(V)O(2)(μ-O)(μ-S)(aq)](2+) linker-type units to a solution/dynamic library containing tungstates results via the formation of the complementary pentagonal {(W)W(5)} units logically in the self-assembly of a mixed oxide/sulphide {W(VI)(72)Mo(V)(60)}-type Keplerate, thereby demonstrating the ability to tune the capsule's skeletal softness (the (μ-O)(2) and (μ-S)(2) scenarios are known) and providing ...
Yang Eric H - - 2012
A devastating complication of both native and prosthetic valvular infective endocarditis can involve periannular extension, which is associated with increased perioperative mortality and long-term adverse outcomes. Cardiac imaging, both noninvasive and invasive, is essential to accurately identify the extent and complexity of these infections to perform effective surgical interventional strategies. ...
Tang Yong - - 2012
Many studies using random dot kinematograms have indicated a global motion processing deficit originated from extrastriate cortex, specifically middle temporal area (MT) and media superior temporal area (MST), in patients with amblyopia. However, the nature of this deficit remains unclear. To explore whether the ability of motion integration is impaired ...
Katajavuori P - - 2012
A two-year-old Jack Russell terrier was presented for evaluation of chronic cough and exercise intolerance. Previous treatment with antibiotics and glucocorticoids had only partially ameliorated the clinical signs. During investigation, hypoxaemia, peripheral eosinophilia and an eosinophilic bronchoalveolar lavage fluid were noted. Thoracic radiographs revealed two ovoid clearly delineated soft-tissue opacities, ...
Kisely Steve - - 2013
Among patients with psychiatric disorders, there are 10 times as many preventable deaths from physical disorders as there are from suicide. We investigated whether compulsory community treatment, such as community treatment orders, could reduce all-cause mortality among patients with psychiatric disorders. We conducted a population-based survival analysis of an inception ...
van den Broek Colette B M - - 2012
Background. Use of adjuvant chemotherapy for stage III colon cancer has increased since several trials have shown the beneficial effect on survival. In this population-based study we show time trends in the administration and costs of chemotherapy and relative survival of patients with stage III colon cancer. Methods. All patients ...
García Bocanegra Ignacio - - 2012
Abstract Seroprevalences of Toxoplasma gondii antibodies were assessed using a commercial indirect ELISA in 1501 domestic ruminants in southern Spain. Antibodies against T. gondii were detected in 420 (83.3%) of 504 cattle, 248 (49.3%) of 503 sheep and 124 (25.1%) of 494 goats. The herd seroprevalence was 100% (72/72), 84.7% ...
Xing Na - - 2012
Two new oxomolybdenum(vi) complexes [(TpMoO(2))(2)(μ-O)]·H(2)O () and (Tp(4-I)MoO(2))(2)(μ-O) () were synthesized and characterized by elemental analysis, IR spectra, UV-Vis spectroscopy, powder X-ray diffraction, single-crystal X-ray diffraction and thermogravimetric analyses (TG). In addition, the catalytic performances of complexes and were studied firstly on the oxidation reaction of cyclohexane at room temperature.
Salloum Ramzi G RG Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, USA. - - 2013
On January 1, 2005, Medicare began covering a "Welcome to Medicare" visit (WMV) for new enrollees with fee-for-service (FFS) Medicare (Parts A and B). The new benefit was expected to increase demand for mammography and Pap tests among women transitioning onto Medicare. This study examined whether Medicare's coverage of a ...
Santiago Diana - - 2012
An effort to electrochemically develop smaller and well dispersed catalytic materials on high surface area carbon supports is required for improved fuel cell performance. A high surface area carbon material of interest is carbon nano-onions (CNOs), also known as multilayer fullerenes. The most convenient synthetic method for CNOs is by ...
Hagenbuchner J - - 2012
Gain of chromosome 17q correlates with high-stage disease, an adverse clinical outcome and leads to the overexpression of the antiapoptotic protein BIRC5/Survivin in neuroblastoma (NB). We have shown before that Survivin defines a threshold for the sensitivity of NB cells to DNA-damaging chemotherapeutic agents that require FOXO3 activation for apoptosis ...
Parri Matteo - - 2012
SIGNIFICANCE. We herein review recent advances on the role exerted by protein redox machines engaged in tumor progression, focusing on cell adhesion and migration, regulation of transcriptional response and tumor metabolic reprogramming, all features belonging to the new hallmarks of cancer. RECENT ADVANCES. Several recent insights have reported that oxidative ...
Wang Peng P Hebei Key Laboratory of Molecular Cell Biology, College of Life Science, Hebei Normal University, Shijiazhuang 050024, - - 2012
Calcium ions (Ca(2+)) play a crucial role in many key physiological processes; thus, the maintenance of Ca(2+) homeostasis is of primary importance. Na(+)/Ca(2+) exchangers (NCXs) play an important role in Ca(2+) homeostasis in animal excitable cells. Bioinformatic analysis of the Arabidopsis genome suggested the existence of a putative NCX gene, ...
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