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Stava Eric - - 2012
We outline the fabrication of piezoelectric through-pores in crystalline quartz using a rapid micromachining process, and demonstrate piezoelectric deformation of the pore. The single-step fabrication technique combines ultraviolet (UV) laser irradiation with a thin layer of absorbing liquid in contact with the UV-transparent quartz chip. The effects of different liquid ...
Chiba Junya J Graduate School of Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930-0194, Japan. - - 2012
APOBEC3G catalyzes deamination of cytosines in HIV-1 genome, and restricts the HIV-1 infection. Here, we propose a picomole-scale assay for the detection of DNA deamination catalyzed by APOBEC3G. Our results show the suitability of the developed method for a time course analysis of enzyme-catalyzed DNA modifications.
Du Gaixia - - 2012
Bis(imino)diphenylamido rare-earth metal dialkyl complexes [o-(2,6-(i)Pr(2)-C(6)H(3)-N[double bond, length as m-dash]C-C(6)H(4))(2)-N]Ln(CH(2)SiMe(3))(2) (: Ln = Sc; : Ln = Lu; : Ln = Y) have been synthesized in good yields and structurally characterized by elemental analysis, NMR spectroscopy, and single-crystal X-ray diffraction studies. They serve as highly efficient single-component catalysts both for ...
Miragoli Michele - - 2012
Aim: To investigate the effect of surface charge of therapeutic nanoparticles on sarcolemmal ionic homeostasis and the initiation of arrhythmias. Materials & methods: Cultured neonatal rat myocytes were exposed to 50 nm-charged polystyrene latex nanoparticles and examined using a combination of hopping probe scanning ion conductance microscopy, optical recording of ...
Sheng Zijing - - 2012
8-Oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species, is associated with carcinogenesis and neurodegeneration. Although the mechanism by which 8-oxoG causes carcinogenesis is well understood, the mechanism by which it causes neurodegeneration is unknown. Here, we report that neurodegeneration is triggered by MUTYH-mediated excision repair of 8-oxoG-paired ...
Das Shaoli - - 2012
Investigations have revealed that silencing unwanted transcripts or off-targeting can induce false positive phenotype during RNA interference (RNAi)-based gene function study. But still the standard computational approaches towards small interfering RNA (siRNA) off-target minimization fall short in terms of addressing this false positive phenotype issue. Some of these off-targets may ...
Wong Josephine Pui-Hing - - 2012
Homophobia and heterosexism are ubiquitous in Canadian society. They contribute to significant health and mental health disparities for lesbian, gay and bisexual youth and their families. Anti-homophobia efforts tend to focus on students and teachers at school. While these efforts are important, they do not reach parents, who play an ...
Cui Lin - - 2012
To investigate the conformation of cyclopentanetetracarboxylic acid, four new "brick-wall"-like metal-organic frameworks have been synthesized from hydrothermal reactions with different metal salts, (S,S,R,R)-1,2,3,4-cyclopentanetetracarboxylic acid (H(4)cptc) and auxiliary N-donor ligands, namely, Cu(2)(S,S,R,R-cptc)(bpe)(H(2)O)(2)·2H(2)O (), Co(2)(S,S,R,R-cptc)(bpe)(0.5)(H(2)O)(2)·2H(2)O (), Cd(4)(S,S,R,R-cptc)(2)(bpa)(2)(H(2)O)(5)·2H(2)O () and Co(2)(S,S,R,R-cptc)(bpy)(0.5)(H(2)O)(2)·2(H(2)O) () (bpe = 4-(2-(pyridine-4-yl)vinyl)pyridine, bpa = 4-(2-(pyridine-4-yl)ethyl)pyridine, bpy = 4-(pyridine-4-yl)pyridine). The complexes ...
Lee Won-Kyu - - 2012
We demonstrate self-aligned and high-performance liquid crystal (LC) systems doped with 1-dimensional (1D) chain-like clusters of CuInS(2) (CIS)-ZnS core-shell quantum dots (QDs). By changing the cell fabrication method of the LC-QD composites, we can selectively control the orientation of the LC molecules between the homogeneous and homeotropic states without conventional ...
Li Feng - - 2012
A new strategy for determining the RNA endonuclease activity of mammalian argonaute2 (Ago2) protein has been developed, which combines the unique cleavage function of Ago2 protein with an RNA molecular beacon (RMB). Through the fluorescence restoration of the RMB, simple and sensitive detection of Ago2 is achieved.
Guo Qiang - - 2012
A fabrication methodology for 120 nm-diameter, <111>-oriented single crystalline Cu nanopillars which are uniformly implanted with helium is described. Uniaxial compression experiments reveal that their yield strength is 30% higher than that of their unimplanted counterparts. This study sheds light on the fundamental understanding of the deformation mechanism of irradiated ...
Hart Lori S - - 2012
The proto-oncogene c-Myc paradoxically activates both proliferation and apoptosis. In the pathogenic state, c-Myc-induced apoptosis is bypassed via a critical, yet poorly understood escape mechanism that promotes cellular transformation and tumorigenesis. The accumulation of unfolded proteins in the ER initiates a cellular stress program termed the unfolded protein response (UPR) ...
Plant Katherine L - - 2012
Schema Theory is intuitively appealing although it has not always received positive press; critics of the approach argue that the concept is too ambiguous and vague and there are inherent difficulties associated with measuring schemata. As such, the term schema can be met with scepticism and wariness. The purpose of ...
Kluft C - - 2012
In a recent manuscript Raps et al (1) used the correlation between sex hormone-binding globulin (SHBG) and the normalised APC sensitivity ratio (nAPCsr) as an argument for using SHBG as a useful marker to estimate thrombotic risk of a hormonal contraceptive preparation. They present a log-normal association of SHBG with ...
Boyda H N - - 2012
It is now accepted that several pharmacological drug treatments trigger clinical manifestations of glucose dysregulation such as hyperglycemia, glucose intolerance and insulin resistance, in part through poorly understood mechanisms. Persistent sympathoadrenal activation is linked to glucose dysregulation and insulin resistance, both of which significantly increase the risk of emergent endocrinological ...
Nguyen John D - - 2012
Herein we report a one-pot deoxygenation protocol for primary and secondary alcohols developed via the combination of the Garegg-Samuelsson reaction, visible light-photoredox catalysis, and flow chemistry. This procedure is characterized by mild reaction conditions, easy-to-handle reactants and reagents, excellent functional group tolerance, and good yields.
Durugbo Christopher - - 2012
The aim of this study was to assess and improve how recyclers (individuals carrying out the task of recycling) make use of visual cues to carryout recycling tasks in relation to 'recycling chimneys' (repositories for recycled waste). An initial task analysis was conducted through an activity sampling study and an ...
Zhou Haiqing - - 2012
Using Raman spectroscopic studies, we firstly report that Pd film deposition can induce a tensile strain at the interface between Pd and n-layer graphenes, which results in the splitting of the G peak and a red Raman shift of the 2D peak in monolayer graphene, and red Raman shifts of ...
Chung Aram J - - 2012
A novel inertial focusing platform creates a single-stream microparticle train in a single-focal plane without sheath fluids and external forces, all in a high-throughput manner. The proposed design consists of a low-aspect-ratio straight channel interspersed with a series of constrictions in height arranged orthogonally, making use of inertial focusing and ...
Hope Jennifer M JM Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, - - 2013
A platinum(II) complex of a monoanionic, tetradentate β-diketiminate (BDI) ligand with pendant quinoline arms, BDI(QQ)H, is reported. The complex, [Pt(BDI(QQ))]Cl, is emissive in DMSO, but non-emissive in aqueous buffer. Upon binding DNA in buffer, however, a 150-fold turn-on in emission intensity occurs. Dynamic light scattering and (1)H NMR spectroscopy indicate ...
Chen Mu-Hong MH Department of Psychiatry, Taipei Veterans General Hospital, Taipei, - - 2013
Attention deficit hyperactivity disorder (ADHD) and tic disorder usually co-occur in the same individuals, but the underlying mechanisms remain unclear. Previous evidence has shown that a frequent coexistence of allergic diseases was noted in patients with ADHD or tic disorder. We attempted to investigate the possible link among ADHD, tic ...
Jia Lei - - 2012
Janus Au-Ni particles are modified asymmetrically with polymer brushes. The asymmetric chemistry affect their binding onto catecholic attapulgite nanorods either through the Au domains or through the Ni domains.
Smith Charlene A - - 2012
The trimetallic complex [{CpMn(μ-OSiPh(3))(2)}(2)Mn] () and the heterocubane [CpMn(μ(3)-SSiPh(3))](4) () are formed by deprotonation of Ph(3)SiQH (Q = O, S) by manganocene, or by transmetallation of manganocene by Ph(3)SiQLi. The Mn(ii) centres in and are antiferromagnetically coupled, with J = -4.4 and -3.0 cm(-1) in and , respectively (-2J formalism).
Johansen Mark K - - 2012
A class of dual-system theories of categorization assumes a categorization system based on actively formed prototypes in addition to a separate instance memory system. It has been suggested that, because they have used poorly differentiated category structures (such as the influential "5-4" structure), studies supporting the alternative exemplar theory reveal ...
Prongidi-Fix Lydia - - 2012
Detailed knowledge of the structure of the ribosomal particles during their assembly on mRNA is a prerequisite for understanding the intricate translation initiation process. In vitro preparation of eukaryotic translation initiation complexes is limited by the rather tricky assembly from individually purified ribosomal subunits, initiation factors and initiator tRNA. In ...
Thétiot-Laurent Sophie - - 2012
Original αγα tripeptides containing one β,γ-diamino acid have been synthesized and their conformation determined by extensive NMR and molecular dynamic studies. These studies revealed the presence of a C(9) hydrogen bonded turn around the β,γ-diamino acid which was stabilized by bulky side chains of the preceding residue. This turn can ...
Grubor-Lajšić Gordana - - 2012
The Arctic springtail, Megaphorura arctica, survives sub-zero temperatures in a dehydrated state via trehalose-dependent cryoprotective dehydration. Regulation of trehalose biosynthesis is complex; based in part on studies in yeast and fungi, its connection with oxidative stress caused by exposure of cells to oxidants, such as hydrogen peroxide (H(2) O(2) ), ...
Mygind Naja Dam - - 2012
OBJECTIVE: YKL-40 is an inflammatory biomarker associated with disease activity and mortality in patients with diseases characterized by inflammation and tissue remodelling. The aim of this study was to describe the prognostic value of YKL-40 in an unselected patient population. DESIGN: In consecutive patients admitted to hospital during a 1-year ...
Ikbal Mohammed - - 2012
We have introduced a series of non-ionic photoacid generators (PAGs) for carboxylic and sulfonic acids based on N-hydroxy anthracene-1,9-dicarboxyimide (HADI). The newly synthesized PAGs exhibited positive solvachromatic emission (λmax (hexane) = 461 nm, λmax (ethanol) = 505 nm) as a function of solvent polarity. Irradiation of PAGs in acetonitrile (ACN) ...
Krishnamurty Ratika - - 2013
Protein kinases, key regulators of intracellular signal transduction, have emerged as an important class of drug targets. Chemical proteomic tools that facilitate the functional interrogation of protein kinase active sites are powerful reagents for studying the regulation of this large enzyme family and performing inhibitor selectivity screens. Here we describe ...
Al-Biltagi Mohammed - - 2012
Thrombocytopenia can be a real challenge during cardiac surgery in children with cyanotic congenital heart disease. This report describes a 7-year-old girl with d-transposition of the great arteries, ventricular septal defect, pulmonary hypertension, chronic thrombocytopenia, polycythemia, and chronic renal impairment. The thrombocytopenia improved several days after splenectomy. The child then ...
Friedmacher Florian - - 2012
PURPOSE: The high morbidity of newborn infants with congenital diaphragmatic hernia (CDH) is attributed to pulmonary hypoplasia (PH), which is characterized by a failure of alveolar development. The nitrofen-induced CDH model has been widely used to investigate the pathogenesis of PH in CDH. It has previously been shown that the ...
Wang Chun-Guang - - 2012
The cerebrospinal fluid-contacting nucleus (CSF-CN) may influence actual composition of the CSF for non-synaptic signal transmission via releasing or absorbing bioactive substances, which distributes and localizes in the ventral periaqueductal central gray of the brainstem. Previous studies demonstrated that CSF-CN was involved in neuropathic pain and morphine dependence. Thus, to ...
Wang Zhitao - - 2012
Bone marrow stromal cells (MSCs) were used as cell therapy for various diseases in recent years. Some reports showed that transplanted MSCs promote functional recovery in animal models of brain trauma. But other studies indicate that tissue replacement by this method may not be the main source of therapeutic benefit. ...
Hoblyn J C - - 2012
Predictive characteristics of subjects agreeing to be randomized into clinical trials for the treatment of schizophrenia and schizoaffective disorder have been little studied. In this study, we used data from the recruitment phase of a randomized trial that compared long acting injectable (LAI) risperidone to oral antipsychotic medications. Basic socio-demographic ...
Kaylor Joanna J JJ Jules Stein Eye Institute, University of California, Los Angeles School of Medicine, Los Angeles, California, - - 2013
Absorption of a light particle by an opsin-pigment causes photoisomerization of its retinaldehyde chromophore. Restoration of light sensitivity to the resulting apo-opsin requires chemical re-isomerization of the photobleached chromophore. This is carried out by a multistep enzyme pathway called the visual cycle. Accumulating evidence suggests the existence of an alternative ...
Lu Da-Wen - - 2012
BACKGROUND: To assess the efficacy and safety of anterior chamber paracentesis (ACP) and the changes in pH values in eyes with acute primary angle closure (APAC). METHODS: This retrospective case-control study involved 22 patients with APAC who underwent ACP (study group) and 21 patients with APAC who did not undergo ...
Persell Stephen D SD Division of General Internal Medicine and Geriatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. - - 2013
Many individuals at higher risk for cardiovascular disease (CVD) do not receive recommended treatments. Prior interventions using personalized risk information to promote prevention did not test clinic-wide effectiveness. To perform a 9-month cluster-randomized trial, comparing a strategy of electronic health record-based identification of patients with increased CVD risk and individualized ...
Wang Guowen - - 2012
Aerobic granule was successfully cultivated in SBR (sequencing batch reactor) by struvite carrier (magnesium ammonium phosphate, MgNH(4)PO(4)), which can increase polysaccharides to 42.2 mg/gMLVSS (mixed liquor volatile suspended solid) versus only 28.4 mg/gMLVSS of the sludge without it. Meanwhile, it was found that struvite play a positive role in initial granulation and ...
Trajkovski Mirko - - 2012
Brown adipose tissue (BAT) uses the chemical energy of lipids and glucose to produce heat, a function that can be induced by cold exposure or diet. A key regulator of BAT is the gene encoding PR domain containing 16 (Prdm16), whose expression can drive differentiation of myogenic and white fat ...
Takata Yuka - - 2012
Bernard-Soulier syndrome (BSS) is an inherited bleeding disorder caused by a defect in the platelet glycoprotein (GP) Ib/IX complex. The GPIX W127X mutation is the most common genetic defect in Japanese patients with BSS, which is often misdiagnosed as immune thrombocytopenic purpura, presumably due to residual expression of GPIbα. Neither ...
Shanechi Maryam M - - 2012
Although brain-machine interfaces (BMIs) have focused largely on performing single-targeted movements, many natural tasks involve planning a complete sequence of such movements before execution. For these tasks, a BMI that can concurrently decode the full planned sequence before its execution may also consider the higher-level goal of the task to ...
Tersi Luca - - 2012
Model-based mono-planar and bi-planar 3D fluoroscopy methods can quantify intact joints kinematics with performance/cost trade-off. The aim of this study was to compare the performances of mono- and bi-planar setups to a marker-based gold-standard, during dynamic phantom knee acquisitions. Absolute pose errors for in-plane parameters were lower than 0.6 mm or ...
Izhaki Ido - - 2012
The phyllosphere is one of the largest habitats for terrestrial microorganisms. To gain a better insight into the factors underlying the composition of bacterial communities inhabiting leaf surfaces we performed culture-dependent and independent (Denaturing Gradient Gel Electrophoresis) analyses on the bacteria associated with the leaves of three plant species: Amygdalus ...
Shahid Shakeel Ahmad - - 2012
Membrane proteins are largely underrepresented among available atomic-resolution structures. The use of detergents in protein purification procedures hinders the formation of well-ordered crystals for X-ray crystallography and leads to slower molecular tumbling, impeding the application of solution-state NMR. Solid-state magic-angle spinning NMR spectroscopy is an emerging method for membrane-protein structural ...
Michalek Matthias - - 2012
Human pathogens often produce soluble protein toxins that generate pores inside membranes, resulting in the death of target cells and tissue damage. In pathogenic amoebae, this has been exemplified with amoebapores of the enteric protozoan parasite Entamoeba histolytica. Here we characterize acanthaporin, to our knowledge the first pore-forming toxin to ...
Thomas S - - 2012
BACKGROUND: There is a paucity of literature regarding the influence of anthropometric features on the hamstring graft obtained in ACL reconstruction. This study was undertaken to assess the influence of anthropometric measurements on the graft diameter obtained at ACL reconstruction surgery within the European population. We hypothesise that anthropometric features ...
Tommasi Stella - - 2013
Progression to malignancy requires that cells overcome senescence and switch to an immortal phenotype. Thus, exploring the genetic and epigenetic changes that occur during senescence/immortalization may help elucidate crucial events that lead to cell transformation. In the present study, we have globally profiled DNA methylation in relation to gene expression ...
Braun Joerg E - - 2012
The removal of the mRNA 5' cap structure by the decapping enzyme DCP2 leads to rapid 5'→3' mRNA degradation by XRN1, suggesting that the two processes are coordinated, but the coupling mechanism is unknown. DCP2 associates with the decapping activators EDC4 and DCP1. Here we show that XRN1 directly interacts ...
Tee Benjamin C-K - - 2012
Pressure sensitivity and mechanical self-healing are two vital functions of the human skin. A flexible and electrically conducting material that can sense mechanical forces and yet be able to self-heal repeatably can be of use in emerging fields such as soft robotics and biomimetic prostheses, but combining all these properties ...
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