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Results 251 - 300 of 4626
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Lee Dong Yun - - 2012
Nanoparticle (NP) ribbons and fabrics are fabricated using a facile, evaporation-driven approach that directs NP assembly at a liquid meniscus, which is constrained using principles of elastocapillarity with uniform molecular dimensions over large lateral distances. This results in the creation of uniform NP ribbons of nanoscale height and sub-micrometer width, ...
Manzano-Román Raul - - 2012
Protein interactions play a critical role in the regulation of many biological events and their study in a high-throughput format has become a key area of proteomic research. Nucleid Acid Programable Protein Arrays (NAPPA) technology allows the construction of protein arrays from cDNA expression libraries in high-throughput cell-free systems to ...
Gitto Rosaria - - 2012
In the course of the identification of new indole derivatives targeting GluN2B-subunit-containing N-methyl-D-Aspartate (NMDA) receptor, the (N-1H-indol-6-methanesulfonamide-3-yl)-2-(4-benzylpiperidin-1-yl)ethanone (10b) was identified as a potent ligand for this NMDA receptor subunit. It displays very high binding affinity (IC50 value of 8.9 nmol) for displacement of [3H]-ifenprodil thus showing improved potency with respect ...
Rahmanpour Arezoo - - 2012
Plasma membrane of each micro-organism has a unique set of lipid composition as a consequence of the environmental adaptation or a response to exposure to antimicrobial peptides (AMPs) as antibiotic agents. Understanding the relationship between lipid composition and action of antimicrobial peptides or considering how different lipid bilayers respond to ...
Zhang Ting-Xing - - 2013
To investigate the effects of a single dose of metformin (MF) on endothelium-dependent vasodilatation and serum antioxidant and free fatty acid levels in patients with primary hypertension (PH) after an acute glucose load. Patients with untreated PH were randomized to a no-metformin group (PH, n = 34) and a metformin ...
Thrailkill Elizabeth A - - 2012
A sulky is a single-wheeled platform attachment on which the operator of a commercial walk-behind lawn mower rides while standing. The effects of sulky vibration on operator comfort and health have not been investigated. In this study, tri-axial accelerometers measured sulky vibration during mower use by two commercial mowers on ...
Jiang Zhilong - - 2012
ABSTRACT: BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been implicated in the pathogenesis of cardiovascular disease. A therapeutic targeting of this enzyme was however challenged by the concern that increased circulating platelet activating factor (PAF) may predispose to or increase the severity of the allergic airway response. The ...
Wroblewska A - - 2012
Only a fraction of hemophilia A patients develops a neutralizing antibody (inhibitor) response to therapeutic infusions of factor VIII (FVIII). Our present understanding of the underlying causes of the immunogenicity of this protein is limited. In the past few years, insights into the uptake and processing of FVIII by antigen ...
Chieffi Paolo - - 2012
Testicular germ cell tumors (TGCTs), are the most frequent solid malignant tumors in men 20-4o years of age, and the most frequent cause of death from solid tumors in this age group. TGCTs can be subdivided into seminoma and non-seminoma germ cell tumors (NSGCTs), including embryonal cell carcinoma, choriocarcinoma, yolk ...
Brede Christian - - 2012
Understanding the spatiotemporal changes of cellular and molecular events within an organism is crucial to elucidate the complex immune processes involved in infections, autoimmune disorders, transplantation, and neoplastic transformation and metastasis. Here we introduce a novel multicolor light sheet fluorescence microscopy (LSFM) approach for deciphering immune processes in large tissue ...
Sobolevsky Y - - 2012
The conserved protein sequence motifs present in all prokaryotic proteomes, "omnipresent motifs," presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the ...
Li Yifei - - 2012
A novel and efficient route for the synthesis of 7-aza-tetrahydroindoles from N-aryl/alkyl-alkenoylacetamides and ethyl isocyanoacetate is described. A mechanism, involving a stepwise [3+2] cycloaddition-intramolecular aza-Michael addition cascade, is proposed that explains the origin of the double nucleophilic attack on the isocyanide carbon atom.
Galvan Antonella - - 2012
ABSTRACT: BACKGROUND: Risk factors for lung cancer, such as cigarette smoking, environmental pollution, asbestos, and genetic determinants, are well-known, whereas involvement of the human papillomavirus (HPV) is still unclear. METHODS: We examined a series of 100 lung cancer patients from Italy and the UK for the presence of HPV DNA ...
Da Costa Grégory - - 2012
Neurotensin (NT) is a tridecapeptide hormone in the periphery and neurotransmitter in the brain that principally activates three receptor subtypes, named NTS1, NTS2, and NTS3. Since little is known about its structure in the presence of its principal receptor NTS1, we determined it using the key domain of the receptor, ...
Jacques Simon D M - - 2012
X-ray tomography is a ubiquitous tool used, for example, in medical diagnosis, explosives detection or to check structural integrity of complex engineered components. Conventional tomographic images are formed by measuring many transmitted X-rays and later mathematically reconstructing the object, however the structural and chemical information carried by scattered X-rays of ...
Wu Dong - - 2012
A simple strategy to realize new controllable 3D microstructures and a novel method to reversibly trapping and releasing microparticles are reported. This technique controls the height, shape, width, and arrangement of pillar arrays and realizes a series of special microstructures from 2-pillar-cell to 12 cell arrays, S-shape, chain-shape and triangle ...
Harvey Catherine - - 2012
Analytic models can enable predictions about important aspects of the usability of in-vehicle information systems (IVIS) to be made at an early stage of the product development process. Task times provide a quantitative measure of user performance and are therefore important in the evaluation of IVIS usability. In this study, ...
Carbajal Agustín - - 2012
Tubulin can be acetylated/deacetylated on Lys40 of the α-subunit. Studies of the post-translational acetylation/deacetylation of tubulin using biochemical techniques require tubulin preparations that are enriched in acetylated tubulin (AcTubulin) and (for comparison) preparations lacking AcTubulin. Assembly/disassembly cycling of microtubules gives tubulin preparations that contain little or no AcTubulin. We demonstrated ...
Müller Romy - - 2012
Establishing common ground in remote cooperation is challenging because nonverbal means of ambiguity resolution are limited. In such settings, information about a partner's gaze can support cooperative performance, but it is not yet clear whether and to what extent the abundance of information reflected in gaze comes at a cost. ...
Riday Thorfinn T - - 2012
Angelman syndrome (AS) is a neurodevelopmental disorder caused by maternal deletions or mutations of the ubiquitin ligase E3A (UBE3A) allele and characterized by minimal verbal communication, seizures, and disorders of voluntary movement. Previous studies have suggested that abnormal dopamine neurotransmission may underlie some of these deficits, but no effective treatment ...
Hamza Adel - - 2012
In this work, we extend our previous ligand shape-based virtual screening approach by using the scoring function Hamza-Wei-Zhan (HWZ) score and an enhanced molecular shape-density model for the ligands. The performance of the method has been tested against the 40 targets in the Database of Useful Decoys and compared with ...
Tkachenko Halyna - - 2012
This paper aimed to illustrate the most reliable biomarkers to detect pollution-related oxidative stress in white stork nestlings in polluted (from copper manufacture), suburban and Odra meadows (as a control area) areas . Lipid peroxidation (thiobarbituric acid reactive substances content, TBARS) and oxidative modified protein levels (stable 2,4-dinitrophenyl hydrazine derivates ...
Paschali Myrella - - 2012
The biochemical diagnosis of hypercortisolism is challenging during treatment with oral contraceptives (OC). In previous studies, it has been shown that serum cortisol levels are often elevated on OC and that the dexamethasone suppression test (DST) may give false positive results(1,2) . However, most studies were performed in the 1980s, ...
Holmes M W R - - 2012
Police officers spend large amounts of time performing duties within a police cruiser and report a high prevalence of musculoskeletal problems. This study evaluated the effects of driver seat and duty belt design on posture, pressure and discomfort. Ten male and 10 female university students attended two sessions involving simulated ...
Lehtonen Esko - - 2012
Two functionally distinct types of fixation, guiding fixations and look-ahead fixations, have been identified in naturalistic tasks based on their temporal relationship to the task execution. In car driving, steering through a curve is guided by fixations toward a region located 1-2 s in the future, but drivers also make fixations ...
Hampson A - - 2012
Background: Platelets are highly specialized cells which regulate haemostasis and thrombosis in the vasculature. Upon activation platelets release various granules which impact on platelets, the coagulation system, other blood cells and on the vessel wall, however the mechanisms controlling granule release are only partially known. We have shown previously that ...
Sharma Soma - - 2012
Even though nanostructures of various shapes and sizes can be controlled by microemulsions, there is substantial difficulty in understanding their growth mechanism. The evolution of nanostructures from the time of mixing of reactants to their final stage is a heterogeneous process involving a variety of intermediates. To obtain a deeper ...
Castro-Vázquez Genaro - - 2012
The outcome of interviews with 26 Japanese men is analysed to identify their views concerning male circumcision and their implications in terms of embodiment, gender and sexuality. Data were collected as part of a larger ethnographic investigation of circumcision, masculinity, sexual behaviour and health matters for Japanese men. Participants in ...
Castillo-García Maria Luisa - - 2012
The usefulness of Tb(4)O(7) nanoparticles (NPs) as analytical reagents using sensitized luminescence as detection system is described for the first time and the results obtained are compared with those obtained using Tb(III) ions. Two drugs used in veterinary practice, namely lasalocid (LAS) and salicylate (SAL), have been chosen as model ...
Dalrymple Kirsten A - - 2012
Developmental prosopagnosia (DP) is defined by severe face recognition problems resulting from a failure to develop the necessary visual mechanisms for processing faces. While there is a growing literature on DP in adults, little has been done to study this disorder in children. The profound impact of abnormal face perception ...
Zhang Ming-Zhi - - 2012
Renal tubule epithelia represent the primary site of damage in acute kidney injury (AKI), a process initiated and propagated by the infiltration of macrophages. Here we investigated the role of resident renal macrophages and dendritic cells in recovery from AKI after ischemia/reperfusion (I/R) injury or a novel diphtheria toxin-induced (DT-induced) ...
Chen Quan-Liang - - 2012
Substitutions of trans-Na(Him)[Mo(2)O(4)(ox)(2)(H(2)O)(2)]·H(2)O () and trans-(Him)(2)[Mo(2)O(4)(ox)(2)(H(2)O)(2)] () with imidazole result in the formation of the mixed-ligand molybdenum complexes cis-Na(2)[Mo(2)O(4)(ox)(2)(im)(2)]·4.5H(2)O (), cis-K(2)[Mo(2)O(4)(ox)(2)(im)(2)]·3H(2)O (), respectively (H(2)ox = oxalic acid; im = imidazole). Further reduction of cis-K(2)[Mo(2)O(4)(ox)(2)(im)(2)]·3H(2)O () gives a trinuclear molybdenum(iv) complex K(Him)[Mo(3)O(4)(ox)(3)(im)(3)]·3H(2)O (), which contains an incomplete cubane cluster [Mo(IV)(3)O(4)](4+). Two ...
Correia Vanda - - 2012
Abstract This paper highlights the importance of examining interpersonal interactions in performance analysis of team sports, predicated on the relationship between perception and action, compared to the traditional cataloguing of actions by individual performers. We discuss how ecological dynamics may provide a potential unifying theoretical and empirical framework to achieve ...
Pasceri Raffaele - - 2012
Treating readily available α-diazo-β-ketoesters with HBF(4) results in nucleophilic fluorination by the usually inert and stable tetrafluoroborate anion. The resulting α-fluoro-β-ketoesters are highly versatile synthetic intermediates, for example in the preparation of fluoro-heterocycles, as illustrated by the direct formation of fluoro-pyrimidines, -pyrazoles and -coumarins in a single step.
Duncan Tanya M TM Department of Biology, Duke University, Durham, NC 27708, - - 2013
Folate status and the status of the methionine cycle are typically assessed by measuring folate and metabolites in the plasma. It is assumed that plasma metabolite levels are proportional to their levels in tissues, but there is little information to support this assumption. We developed a mathematical model, based on ...
Greely Precious - - 2012
Increasing evidence suggests that medical male circumcision is associated with a reduced risk of HIV infection for men in sub-Saharan Africa. The aim of this study was to understand the importance of male circumcision as a risk-reducing strategy by exploring perceptions of young men and women. The study draws on ...
Chen Ming - - 2012
Pd(0)-catalyzed cascade reactions of 1,7-diyn-3,6-bis(propargyl carbonate) with organoboronic acids have been developed, which provide one-pot access to functionalized tetracenes or pentacenes.
Naicker Previn - - 2012
The HIV protease plays a major role in the life cycle of the virus and has long been a target in antiviral therapy. Resistance of HIV protease to protease inhibitors (PIs) is problematic for the effective treatment of HIV infection. The South African HIV-1 subtype C protease (C-SA PR), which ...
Blacker Sam D - - 2012
The aim of this study was to quantify the physiological responses of Police Officers wearing chemical, biological, radiological and nuclear personal protective equipment (CBRN PPE) during firearms house entry (FE) unarmed house entry (UE) and crowd control (CC) simulations. Participants volunteered from the UK Police Force [FE (n = 6, age 33 ± 4 ...
Elie Claude-Rosny - - 2012
Herein, we present the first example of a benzimidazolium-based artificial transmembrane chloride transporter and a synthetic calcium ionophore that can regulate intracellular calcium concentrations in bacteria.
Pan Yu - - 2012
Gold nanoparticles (AuNP) show great potential for diagnostic and therapeutic application in humans. A great number of studies have tested the cytotoxicity of AuNP using cell culture. There is, however, an urgent need to test AuNP in vertebrate animal models that interrogate biodistribution and complex biological traits like organ development, ...
Cranford Steven W - - 2012
The mono-atomistic structure and chemical stability of graphene provides a promising platform to design a host of novel graphene-like materials. Using full atomistic first-principles based ReaxFF molecular dynamics, here we perform a systematic comparative study of the stability, structural and mechanical properties of graphynes - a variation of the sp(2) ...
Li Lan-Tao - - 2012
A one-pot dual functionalization of indoles has been developed. The simultaneous C3-formylation and N-aminomethylation of indoles can be achieved using readily available potassium iodide as a catalyst and tert-butyl peroxybenzoate as a co-oxidant.
Yang Fan - - 2012
Lignocellulosic biomass was used for thousands of years as animal feed and is now considered a great sugar source for biofuels production. It is composed mostly of secondary cell walls built with polysaccharide polymers that are embedded in lignin to reinforce the cell wall structure and maintain its integrity. Lignin ...
Laaser Jennifer Elaine - - 2012
We present ways in which pulse sequences and polarizations can be used to extract structural information from one- and two-dimensional vibrational sum frequency generation (2D SFG) spectra. We derive analytic expressions for the polarization dependence of systems containing coupled vibrational modes, and we present simulated spectra to identify the features ...
Rapoport Alexandra E - - 2012
The second parity rule of Chargaff (A≈T and G≈C within one strand) holds all over the living world with minor exceptions. It is maintained with higher accuracy for long sequences. The question addressed in the article is how different sequence types, with different biases from the parity, contribute to the ...
Keum Jung-Won JW Department of Chemical Engineering, University of Massachusetts, Amherst, MA, - - 2012
Non-Watson-Crick base pairing provides an in situ approach for actuation of DNA nanostructures through responses to solution conditions. Here we demonstrate this concept by using physiologically-relevant changes in pH to regulate DNA pyramid assembly/disassembly and to control the release of protein cargo.
Budnik Ursula - - 2012
Near-threshold prime stimuli can facilitate or hinder responses to target stimuli, creating either a positive compatibility effect (PCE) or a negative compatibility effect (NCE). An asymmetry has been reported between primes presented in near periphery, which produced a PCE, and foveal primes, which produced an NCE under comparable conditions. This ...
Maeda Yutaka Y Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, - - 2012
Mucinous adenocarcinoma of the lung is a subtype of highly invasive pulmonary tumors and is associated with decreased or absent expression of the transcription factor NK2 homeobox 1 (NKX2-1; also known as TTF-1). Here, we show that haploinsufficiency of Nkx2-1 in combination with oncogenic Kras(G12D), but not with oncogenic EGFR(L858R), ...
Yusoff Muhamad Saiful Bahri - - 2012
Many studies have shown that the prevalence of psychological distress among medical students during medical training is higher than that in general population. A few studies have shown that the prevalence of psychological distress among medical students before the onset of medical training was similar to general population. This study ...
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