Search Results
Results 201 - 250 of 4616
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Brockington Alice - - 2012
A consistent clinical feature of amyotrophic lateral sclerosis (ALS) is the sparing of eye movements and the function of external sphincters, with corresponding preservation of motor neurons in the brainstem oculomotor nuclei, and of Onuf's nucleus in the sacral spinal cord. Studying the differences in properties of neurons that are ...
Maniu Alma - - 2012
The aim of this study was to assess the hearing results after unilateral stapes surgery for otosclerosis at Cluj-Napoca University Hospital, and to evaluate surgical trauma to the inner ear in these patients. The medical records of 387 consecutive patients who underwent unilateral stapes surgery were reviewed. Hearing results were ...
Garriboli Massimo - - 2012
PURPOSE: Morgagni diaphragmatic hernia can be repaired laparoscopically. The aim of this study is to evaluate the outcome of this minimally invasive approach. METHODS: A retrospective review was conducted on all consecutive children who underwent repair of Morgagni hernia from January 2002 to December 2011 in our hospital. Data are ...
Zhou Youlang - - 2012
Gekko japonicus undergoes dramatic changes in the caudal spinal cord after tail amputation. The amputation induces cell proliferation in the caudal ependymal tube. We performed hematoxylin and eosin staining at different time points in the regeneration process to investigate the morphological characterization of the regenerated appendages. The central canal extended ...
Moro Maria Luisa - - 2012
Aβ is the main component of amyloid deposits in Alzheimer disease (AD) and its aggregation into oligomers, protofibrils and fibrils is considered a seminal event in the pathogenesis of AD. Aβ with C-terminus at residue 42 is the most abundant species in parenchymal deposits, whereas Aβ with C-terminus at residue ...
Zaldivar Andrew - - 2012
Neuromodulatory systems originate in nuclei localized in the subcortical region of the brain and control fundamental behaviors by interacting with many areas of the central nervous system. An exploratory survey of the cholinergic, dopaminergic, noradrenergic, and serotonergic receptor expression energy in the amygdala, and in the neuromodulatory areas themselves was ...
Fitzpatrick Sarah G SG Department of Oral Pathology, Case Western Reserve University School of Dental Medicine, Cleveland, OH, - - 2013
CD44 is a transmembrane adhesion molecule which has been previously shown to be useful in the differentiation of benign papillary lesions from invasive carcinoma in several different areas including sinonasal mucosa and breast tissue. CD44 expression has previously been shown to be lost in invasive carcinoma and retained in benign ...
Bes Cemal C Department of Rheumatology, Bakirköy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey. - - 2013
Anemia is one of the extra-articular findings of ankylosing spondylitis (AS), and anti-TNF therapy has been shown benefit in patients with anemia associated AS. In this study, we aimed to evaluate and compare the effects of biological and non-biological agents on hemoglobin levels in AS patients. One hundred consecutive patients ...
Lombardi Gaetano - - 2012
The clinical conditions associated with GH excess and GH deficiency are known to be associated with an increased risk for cardiovascular morbidity and mortality, suggesting that either an excess or a deficiency in GH and/or IGF-I is deleterious for cardiovascular system. In patients with acromegaly chronic GH and IGF-I excess ...
de Lima Assis Apio Cláudio - - 2012
This study employed functional and electrophysiological approaches to investigate the mechanisms by which warifteine, a bisbenzylisoquinoline alkaloid isolated from Cissampelos sympodialis Eichl, causes vasorelaxation in the rat thoracic aorta. Warifteine (1 pM-10 μM) induced a concentration-dependent relaxation (pD(2) =9.40±0.06, n=5) in endothelium-intact aortic rings pre-contracted with noradrenaline (10 - 100 ...
Piquemal Jean-Yves - - 2012
Based on selected examples from the literature, this perspective aims to provide a short overview of synthetic methods using hydrogen peroxide and/or peroxidic species for the elaboration of discrete or zero-dimensional species, as well as mono-, bi- and tri-dimensional materials. There are several advantages in using peroxidic species: no foreign ...
Visser Steven - - 2012
Screed floors are bound by sand-cement (SF) or by anhydrite (AF). Sand-cement floors are levelled manually and anhydrite floors are self-levelling and therefore differences in work demands and prevalences of musculoskeletal complaints might occur. The objective was to assess among SF layers and AF layers (1) the prevalence of musculoskeletal ...
Nick Costain - - 2012
KEY POINTS: Cochlear implant device fixation is an important aspect of the surgical procedure to ensure successful long-term outcomes. Inadequate device fixation may lead to constant shear stress, electrode fatigue and device extrusion or migration. Traditional fixation techniques involve bone-anchoring by drilling channels in the skull, which may lead to ...
Deng Hua - - 2012
Unmodified gold nanoparticles (GNPs) can be wrapped with long genomic single- and double-stranded DNA (ssDNA and dsDNA) molecules produced by asymmetric polymerase chain reaction (As-PCR). More importantly, the DNA-Au interaction can be utilized for colorimetric detection of a specific nucleic acid sequence in clinical samples.
Lee Scott A - - 2012
Raman spectroscopy is used to probe the nature of the hydrogen bonds which hold the water of hydration to DNA. The ∼ 3450 cm(-1) molecular O-H stretching mode shows that the first six water molecules per base pair of the primary hydration shell are very strongly bound to the DNA. The ...
Rosendaal Frits R - - 2012
The official journal of the International Society on Thrombosis and Haemostasis (ISTH) has an interesting history. It all began when in 1959 the journal Thrombosis et Diathesis Haemorrhagica, which existed since 1957, became associated with the predecessor of the ISTH (i.e. the International Committee on the Nomenclature of the Blood ...
Huang Xianhong - - 2012
A new selective and sensitive fluorescence turn-on detection of CN(-) is reported by taking advantage of aggregation induced-emission (AIE) behavior of tetraphenylethylene units and the nucleophilic attack of CN(-) on the indolium group in compound .
Grubor-Lajšić Gordana - - 2012
The Arctic springtail, Megaphorura arctica, survives sub-zero temperatures in a dehydrated state via trehalose-dependent cryoprotective dehydration. Regulation of trehalose biosynthesis is complex; based in part on studies in yeast and fungi, its connection with oxidative stress caused by exposure of cells to oxidants, such as hydrogen peroxide (H(2) O(2) ), ...
Mygind Naja Dam - - 2012
OBJECTIVE: YKL-40 is an inflammatory biomarker associated with disease activity and mortality in patients with diseases characterized by inflammation and tissue remodelling. The aim of this study was to describe the prognostic value of YKL-40 in an unselected patient population. DESIGN: In consecutive patients admitted to hospital during a 1-year ...
Kurtikyan Tigran S - - 2012
Reaction of NO with amorphous Mn(TPP) layers gives two Mn(TPP)(NO) isomers with linear and bent Mn-N-O geometries that reversibly interconvert with changes in temperature. DFT computations predict that the linear complex is the singlet ground state while the bent structure is a triplet state.
Strohmeier Oliver - - 2012
Transportation of magnetic beads between different reagents plays a crucial role in many biological assays e.g. for purification of biomolecules or cells where the beads act as a mobile solid support. Therefore, usually a complex set-up either for fluidic processing or for manipulation of magnetic beads is required. To circumvent ...
Jacques Simon D M - - 2012
X-ray tomography is a ubiquitous tool used, for example, in medical diagnosis, explosives detection or to check structural integrity of complex engineered components. Conventional tomographic images are formed by measuring many transmitted X-rays and later mathematically reconstructing the object, however the structural and chemical information carried by scattered X-rays of ...
Wong Josephine Pui-Hing - - 2012
Homophobia and heterosexism are ubiquitous in Canadian society. They contribute to significant health and mental health disparities for lesbian, gay and bisexual youth and their families. Anti-homophobia efforts tend to focus on students and teachers at school. While these efforts are important, they do not reach parents, who play an ...
Byrne Abbey - - 2012
ABSTRACT: BACKGROUND: Unmet need for family planning is responsible for 7.4 million disability-adjusted life years and 30% of the maternity-related disease burden. An estimated 35% of births are unintended and some 200 million couples state a desire to delay pregnancy or cease fertility but are not using contraception. Unmet need ...
Yu Xiao - - 2012
The unique anisotropic wet-etching mechanism of a (111) silicon wafer facilitates the highly controllable top-down fabrication of silicon nanowires (SiNWs) with conventional microfabrication technology. The fabrication process is compatible with the surface manufacturing technique, which is employed to build a nanowire-based field-effect transistor structure on the fabricated SiNW.
Préau Marie - - 2012
This study aimed to analyze the relationship between spirituality, coping strategies and health-related quality of life (HRQL) among a large representative sample of patients two years after cancer diagnosis. Using a cross-sectional design, medical and self-reported data were collected by physicians and a patient telephone interview, respectively. Among 4270 participants, ...
Hatiboglu Gencay - - 2012
Abstract Objective. The aim of this study was to evaluate the prognostic relevance of melanoma-associated antigen (MAGE) A9 in renal cell carcinoma (RCC). Material and methods. Immunohistochemical staining for MAGE A9 was evaluated in a tissue microarray containing 587 RCC tumour tissue samples. Nuclear MAGE A9 expression was reviewed using ...
Lee Dong Yun - - 2012
Nanoparticle (NP) ribbons and fabrics are fabricated using a facile, evaporation-driven approach that directs NP assembly at a liquid meniscus, which is constrained using principles of elastocapillarity with uniform molecular dimensions over large lateral distances. This results in the creation of uniform NP ribbons of nanoscale height and sub-micrometer width, ...
Castillo-García Maria Luisa - - 2012
The usefulness of Tb(4)O(7) nanoparticles (NPs) as analytical reagents using sensitized luminescence as detection system is described for the first time and the results obtained are compared with those obtained using Tb(III) ions. Two drugs used in veterinary practice, namely lasalocid (LAS) and salicylate (SAL), have been chosen as model ...
Dalrymple Kirsten A - - 2012
Developmental prosopagnosia (DP) is defined by severe face recognition problems resulting from a failure to develop the necessary visual mechanisms for processing faces. While there is a growing literature on DP in adults, little has been done to study this disorder in children. The profound impact of abnormal face perception ...
Jiang Zhilong - - 2012
ABSTRACT: BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been implicated in the pathogenesis of cardiovascular disease. A therapeutic targeting of this enzyme was however challenged by the concern that increased circulating platelet activating factor (PAF) may predispose to or increase the severity of the allergic airway response. The ...
Wroblewska A - - 2012
Only a fraction of hemophilia A patients develops a neutralizing antibody (inhibitor) response to therapeutic infusions of factor VIII (FVIII). Our present understanding of the underlying causes of the immunogenicity of this protein is limited. In the past few years, insights into the uptake and processing of FVIII by antigen ...
Li Yifei - - 2012
A novel and efficient route for the synthesis of 7-aza-tetrahydroindoles from N-aryl/alkyl-alkenoylacetamides and ethyl isocyanoacetate is described. A mechanism, involving a stepwise [3+2] cycloaddition-intramolecular aza-Michael addition cascade, is proposed that explains the origin of the double nucleophilic attack on the isocyanide carbon atom.
Galvan Antonella - - 2012
ABSTRACT: BACKGROUND: Risk factors for lung cancer, such as cigarette smoking, environmental pollution, asbestos, and genetic determinants, are well-known, whereas involvement of the human papillomavirus (HPV) is still unclear. METHODS: We examined a series of 100 lung cancer patients from Italy and the UK for the presence of HPV DNA ...
Da Costa Grégory - - 2012
Neurotensin (NT) is a tridecapeptide hormone in the periphery and neurotransmitter in the brain that principally activates three receptor subtypes, named NTS1, NTS2, and NTS3. Since little is known about its structure in the presence of its principal receptor NTS1, we determined it using the key domain of the receptor, ...
Zhang Mingxi - - 2012
A dispersion-dominated colorimetric approach for the recognition of carbohydrates based on biomolecule-responsive AuNPs is presented. Taking advantage of the unique dual-responsiveness of smart copolymers, the aggregation and dispersion of AuNPs can be modulated by both temperature and different kinds of carbohydrates, giving rise to a novel chromogenic mechanism for the ...
Beard George F - - 2012
Roll compensation during cornering (aligning the feet-to-head axis of the body with the resultant force) reduces lateral acceleration, but how any improvement in comfort depends on the frequency of the acceleration has not previously been investigated. Seated subjects judged the discomfort caused by lateral oscillation, roll oscillation and fully roll-compensated ...
Müller Romy - - 2012
Establishing common ground in remote cooperation is challenging because nonverbal means of ambiguity resolution are limited. In such settings, information about a partner's gaze can support cooperative performance, but it is not yet clear whether and to what extent the abundance of information reflected in gaze comes at a cost. ...
Hamza Adel - - 2012
In this work, we extend our previous ligand shape-based virtual screening approach by using the scoring function Hamza-Wei-Zhan (HWZ) score and an enhanced molecular shape-density model for the ligands. The performance of the method has been tested against the 40 targets in the Database of Useful Decoys and compared with ...
Chieffi Paolo - - 2012
Testicular germ cell tumors (TGCTs), are the most frequent solid malignant tumors in men 20-4o years of age, and the most frequent cause of death from solid tumors in this age group. TGCTs can be subdivided into seminoma and non-seminoma germ cell tumors (NSGCTs), including embryonal cell carcinoma, choriocarcinoma, yolk ...
Sobolevsky Y - - 2012
The conserved protein sequence motifs present in all prokaryotic proteomes, "omnipresent motifs," presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the ...
Manzano-Román Raul - - 2012
Protein interactions play a critical role in the regulation of many biological events and their study in a high-throughput format has become a key area of proteomic research. Nucleid Acid Programable Protein Arrays (NAPPA) technology allows the construction of protein arrays from cDNA expression libraries in high-throughput cell-free systems to ...
Gitto Rosaria - - 2012
In the course of the identification of new indole derivatives targeting GluN2B-subunit-containing N-methyl-D-Aspartate (NMDA) receptor, the (N-1H-indol-6-methanesulfonamide-3-yl)-2-(4-benzylpiperidin-1-yl)ethanone (10b) was identified as a potent ligand for this NMDA receptor subunit. It displays very high binding affinity (IC50 value of 8.9 nmol) for displacement of [3H]-ifenprodil thus showing improved potency with respect ...
Rahmanpour Arezoo - - 2012
Plasma membrane of each micro-organism has a unique set of lipid composition as a consequence of the environmental adaptation or a response to exposure to antimicrobial peptides (AMPs) as antibiotic agents. Understanding the relationship between lipid composition and action of antimicrobial peptides or considering how different lipid bilayers respond to ...
Li Feng - - 2012
A new strategy for determining the RNA endonuclease activity of mammalian argonaute2 (Ago2) protein has been developed, which combines the unique cleavage function of Ago2 protein with an RNA molecular beacon (RMB). Through the fluorescence restoration of the RMB, simple and sensitive detection of Ago2 is achieved.
Guo Qiang - - 2012
A fabrication methodology for 120 nm-diameter, <111>-oriented single crystalline Cu nanopillars which are uniformly implanted with helium is described. Uniaxial compression experiments reveal that their yield strength is 30% higher than that of their unimplanted counterparts. This study sheds light on the fundamental understanding of the deformation mechanism of irradiated ...
Plant Katherine L - - 2012
Schema Theory is intuitively appealing although it has not always received positive press; critics of the approach argue that the concept is too ambiguous and vague and there are inherent difficulties associated with measuring schemata. As such, the term schema can be met with scepticism and wariness. The purpose of ...
Kluft C - - 2012
In a recent manuscript Raps et al (1) used the correlation between sex hormone-binding globulin (SHBG) and the normalised APC sensitivity ratio (nAPCsr) as an argument for using SHBG as a useful marker to estimate thrombotic risk of a hormonal contraceptive preparation. They present a log-normal association of SHBG with ...
Boyda H N - - 2012
It is now accepted that several pharmacological drug treatments trigger clinical manifestations of glucose dysregulation such as hyperglycemia, glucose intolerance and insulin resistance, in part through poorly understood mechanisms. Persistent sympathoadrenal activation is linked to glucose dysregulation and insulin resistance, both of which significantly increase the risk of emergent endocrinological ...
Nguyen John D - - 2012
Herein we report a one-pot deoxygenation protocol for primary and secondary alcohols developed via the combination of the Garegg-Samuelsson reaction, visible light-photoredox catalysis, and flow chemistry. This procedure is characterized by mild reaction conditions, easy-to-handle reactants and reagents, excellent functional group tolerance, and good yields.
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