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Hahnfeldt Philip - - 2013
An increasingly appreciated focus of carcinogenesis research is on mechanisms governing tumor growth after the fact of cancer cell creation. Of particular interest are dynamical interactions between tumor and host cell populations that can themselves strongly impact the fate of established cancer lesions. Regardless of tumor type, all cancers face ...
Wang Min - - 2013
Although many gene transfer methods have been employed for successfully obtaining transgenic cotton, the major constraint in cotton improvement is the limitation of genotype because the majority of transgenic methods require plant regeneration from a single transformed cell which is limited by cotton tissue culture. Comparing with other plant species, ...
Wang Min - - 2013
Recovery of transgenic cotton plants from tissue culture condition to greenhouse condition is a critical step for improving cotton through genetic engineering. Traditional methods always cause low survival rate of transplanted plants. In 1998, we developed an efficient grafting technique for recovery of transgenic cotton plants, which significantly increased the ...
Hubmacher Dirk - - 2013
Extracellular matrix (ECM) has both structural and regulatory roles. This update reviews the representative recent developments in diverse aspects of ECM biology relevant to inflammation, tissue destruction, fibrosis, and regeneration. Biological regulation by ECM is emerging as a major research area, driven by several new directions. Sensing of mechanical cues ...
Sosa Maria Soledad - - 2013
The development of metastasis is the major cause of death in cancer patients. In certain instances, this occurs shortly after primary tumor detection and treatment, indicating these lesions were already expanding at the moment of diagnosis or initiated exponential growth shortly after. However, in many types of cancer, patients succumb ...
Cattoir V - - 2013
Adaptation of bacterial pathogens to a host can lead to the selection and accumulation of specific mutations in their genomes with profound effects on the overall physiology and virulence of the organisms. The opportunistic pathogen Pseudomonas aeruginosa is capable of colonizing the respiratory tract of individuals with cystic fibrosis (CF), ...
Paulander Wilhelm - - 2013
Staphylococcus aureus is a human commensal that at times turns into a serious bacterial pathogen causing life-threatening infections. For the delicate control of virulence, S. aureus employs the agr quorum-sensing system that, via the intracellular effector molecule RNAIII, regulates virulence gene expression. We demonstrate that the presence of the agr ...
Bellovin David I - - 2013
Cancers are frequently addicted to initiating oncogenes that elicit aberrant cellular proliferation, self-renewal, and apoptosis. Restoration of oncogenes to normal physiologic regulation can elicit dramatic reversal of the neoplastic phenotype, including reduced proliferation and increased apoptosis of tumor cells (Science 297(5578):63-64, 2002). In some cases, oncogene inactivation is associated with ...
MacDonell Karen K Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA. - - 2013
The study explored barriers to antiretroviral medication adherence in perinatally and behaviorally HIV infected adolescents and young adults in a cross-sectional, multisite sample. The study included a subset of a convenience sample from a cross-sectional analysis. Participants were youth with HIV ages 12-24 who were prescribed HIV medication and reported ...
Kuncewitch Michael M Department of Surgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY 11030, - - 2013
The Wnt/β-catenin signaling pathway is well characterized in stem cell biology and plays a critical role in liver development, regeneration, and homeostasis. We hypothesized that pharmacologic activation of Wnt signaling protects against hepatic ischemia/reperfusion (I/R) injury through its known proliferative and antiapoptotic properties. Sprague-Dawley rats underwent 70% hepatic ischemia by ...
Jones Deborah D Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1400 NW 10th Avenue, Miami, FL 33136, USA. - - 2013
HIV knowledge may impact patient access, understanding, and utilization of HIV medical information. This study explored the relationship between personal HIV knowledge, appointment adherence and treatment outcomes. HIV-infected individuals (n = 210) were assessed on factors related to HIV knowledge and appointment adherence. Adherence data and laboratory values were extracted ...
Rendon Juan L JL Alcohol Research Program, Loyola University Health Sciences Division, Maywood, IL, - - 2013
Interleukin-22 (IL-22) maintains gut epithelial integrity and expression of antimicrobial peptides Reg3β and Reg3γ. Our laboratory has shown that acute alcohol/ethanol (EtOH) exposure before burn injury results in increased gut permeability, intestinal T-cell suppression, and enhanced bacterial translocation. Herein, we determined the effect of combined EtOH intoxication and burn injury ...
Zhang Baochun B Department of Surgery and Price Institute of Surgical Research, University of Louisville, Louisville, KY, USA. - - 2013
Adenosine 3',5'-cyclic adenosine monophosphate (cAMP) activates intracellular signaling by regulating protein kinase A, calcium influx, and cAMP-binging guanine nucleotide exchange factors (Epac [exchange protein directly activated by cAMP] or cAMP-GEF). Cyclic adenosine monophosphate inhibits cytokine-induced expression of inducible nitric oxide synthase (iNOS) in hepatocytes by a protein kinase A-independent mechanism. ...
Mitchell Teresa V TV Eunice Kennedy Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452, USA. - - 2013
This study examined the effects of deafness and sign language use on the distribution of attention across the top and bottom halves of faces. In a composite face task, congenitally deaf signers and typically hearing controls made same/different judgments of the top or bottom halves of faces presented with the ...
Picciotto Marina R MR Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA. - - 2013
Tobacco smoking results in more than 5 million deaths each year and accounts for almost 90% of all deaths from lung cancer. Nicotine, the major reinforcing component of tobacco smoke, acts in the brain through the neuronal nicotinic acetylcholine receptors (nAChRs). The nAChRs are allosterically regulated, ligand-gated ion channels consisting ...
Betts Corinne A CA Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, - - 2013
Duchenne muscular dystrophy is a severe, X-linked muscle wasting disorder caused by the absence of an integral structural protein called dystrophin. This is caused by mutations or deletions in the dystrophin gene which disrupt the reading frame, thereby halting the production of a functional protein. A number of potential therapies ...
Kim Suhee S Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, Missouri 65211, - - 2013
The aim of the present study was to evaluate the effects of various physical interventions on the function of epididymal rat spermatozoa and determine whether there are correlations among these functional parameters. Epididymal rat spermatozoa were subjected to various mechanical (pipetting, centrifugation and Percoll gradient separation) and anisotonic conditions, and ...
Small Mary Rose MR School of Occupational Therapy, The University of Western Ontario, London, ON, N6A 5B9, Canada. - - 2013
This paper is a reflection on work transitions in an international context. Seasonal employees and employer of the winery Emiliana. The following is a personal reflection by a Canadian occupational therapy student after a recent trip to Chile. The commitment to social responsibility by the winery Emiliana guided the reflection ...
Bill O O Department of Clinical Neurosciences, Neurology Service, University of Lausanne, Lausanne, Switzerland. - - 2013
Severe stroke carries high rates of mortality and morbidity. The aims of this study were to determine the characteristics of patients who initially presented with severe ischemic stroke, and to identify acute and subacute predictors of favorable clinical outcome in these patients. An observational cohort study, Acute Stroke Registry and ...
Cronin Shawna S Faculty of Health Sciences, School of Occupational Therapy, Western University, Elborn College, 1201 Western Rd, London, ON, N6G 1H1, Canada. - - 2013
To explore the work transitions of Chilean women. Observations and dialogue of Chilean women and their experiences in current and past work. A personal and historical reflection to understand the experiences of work for Chilean women. Exploring work transitions requires an understanding of the macro level historical impact on the ...
Choi Jae-Hoon - - 2012
KR-31543, (2S, 3R, 4S)-6-amino-4-[N-(4-chlorophenyl)- N-(2-methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro- 2-dimethyoxymethyl-3-hydroxy-2-methyl-2H-1-benz opyran is a new neuroprotective agent for ischemiareperfusion damage. It has also been reported that KR-31543 has protective effects on lipid peroxidation and H₂O₂-induced reactive oxygen species production. In this study, we investigated the anti-inflammatory and anti-atherogenic properties of KR-31543. We observed that ...
He Yu-qi - - 2012
Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. Estrogen receptor (ER) expression is associated with microRNA (miRNA) expression in ER-positive tumors. However, studies of direct link between estrogen (especially estradiol E2), miRNA expression, and MMR in colorectal cancer (CRC) have not ...
Kang Sang Sun - - 2012
The transient receptor potential vanilloid 4 (TRPV4) cation channel, a member of the TRP vanilloid subfamily, is expressed in a broad range of tissues where it participates in the generation of Ca²⁺ signals and/or depolarization of the membrane potential. Regulation of TRPV4 abundance at the cell surface is critical for ...
Smith Sean M SM Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, - - 2012
Directed catalytic asymmetric hydroborations of 1,1-disubstituted alkenes afford γ-dioxaborato amides and esters in high enantiomeric purity (90-95% ee).
De Bishnu P BP Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, - - 2013
Adenovirus (Ad) vaccine vectors have been used for many applications due to the capacity of the Ad capsid proteins to evoke potent immune responses, but these vectors are often ineffective in the context of pre-existing anti-Ad immunity. Leveraging the knowledge that E1(-)E3(-) Ad gene transfer vectors are potent immunogens, we ...
Mahabir Vishwanath K VK Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, - - 2013
The role of bone marrow examinations in patients with primary immune thrombocytopenia (ITP) is uncertain. The objectives of this study were to determine the inter-rater reliability of bone marrow examinations and to identify distinguishing morphological features of ITP bone marrows under controlled conditions. Histological slides of bone marrow biopsy specimens ...
Pelascini Laetitia P L LP Department of Molecular Cell Biology, Leiden University Medical Center, 2333 ZC Leiden, The - - 2013
Integration-defective lentiviral vectors (IDLVs) are being increasingly deployed in both basic and preclinical gene transfer settings. Often, however, the IDLV transgene expression profile is muted when compared to that of their integration-proficient counterparts. We hypothesized that the episomal nature of IDLVs turns them into preferential targets for epigenetic silencing involving ...
Wang K - - 2012
This study proposes a method for measuring the refractive index of articular cartilage within a thin and small specimen slice. The cartilage specimen, with a thickness of about 50 μm, was put next to a thin film of immersion oil of similar thickness. Both the articular cartilage and immersion oil ...
Padró-Martínez Luz T - - 2012
Accurate quantification of exposures to traffic-related air pollution in near-highway neighborhoods is challenging due to the high degree of spatial and temporal variation of pollutant levels. The objective of this study was to measure air pollutant levels in a near-highway urban area over a wide range of traffic and meteorological ...
Nathanael Dimitris - - 2012
The present paper is a commentary on the recently published IEA strategy for human factors/ergonomics (Dul, J., et al. (2012), A strategy for human factors/ergonomics: developing the discipline and profession. Ergonomics, 55(4), 377-395). Two main issues that demand attention are: (i) the way others understand our profession and discipline, and ...
Wieczorek Karina - - 2012
The present study provides new data related to the morphology of the male genitalia of Aphididae. The structure of the male genitalia of 39 species from 23 genera of Aphididae was studied using light and scanning electron microscopy. In the species studied, the genitalia of males consist of a phallus ...
Bonilla R - - 2012
The spatial distribution of electrical charges along the longitudinal axes of a polypropylene electret fiber was determined using Electrostatic Force Microscopy (EFM). EFM mapping on highly curved surfaces, such as those of polymeric fibers, is a challenging endeavour and most work reported in the scientific literature has been limited to ...
Gold Daniel Ross - - 2012
Aberrant regeneration of a third nerve palsy (oculomotor synkinesis) excludes an ischaemic cause and in the absence of relevant trauma strongly suggests a compressive aetiology. A scan is mandatory in such cases. We describe the case of a 52-year-old woman who presented with complete pupil-involving third nerve palsy from a ...
Smits Bronwyn - - 2012
Background -  Canine leproid granuloma (CLG) characteristically presents as single to multiple circumscribed dermal to subcutaneous nodules in haired skin. An unidentified mycobacterium is considered be the aetiological agent of this entity. Animals -  Several cases of canine leproid granulomas occurred in dogs in New Zealand during 2010 and 2011. Cases appeared ...
Pirim Harun - - 2012
High throughput biological data need to be processed, analyzed, and interpreted to address problems in life sciences. Bioinformatics, computational biology, and systems biology deal with biological problems using computational methods. Clustering is one of the methods used to gain insight into biological processes, particularly at the genomics level. Clearly, clustering ...
Plant Jon D - - 2012
Background -  The third iteration of the Canine Atopic Dermatitis Extent and Severity Index (CADESI-03) is the only tool rigorously validated for canine atopic dermatitis (CAD) lesion scoring. The CADESI-03 requires 248 evaluations, limiting its widespread use. Hypothesis/Objectives -  The goal of the study was to develop and validate a ...
Eiben A E - - 2012
Evolution is one of the major omnipresent powers in the universe that has been studied for about two centuries. Recent scientific and technical developments make it possible to make the transition from passively understanding to actively using evolutionary processes. Today this is possible in Evolutionary Computing, where human experimenters can ...
Lin Lan - - 2012
Mouse models for human diseases play an important role in developing therapeutic measures and understanding disease development and mechanisms. Ventricular enlargement is an objective and sensitive biomarker of neuropathological change associated with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Thus, imaging based volumetric measures of mouse brain ventricle can ...
Sastre Natalia - - 2012
Background -  The historical classification of Demodex mites has been based on their hosts and morphological features. Genome sequencing has proved to be a very effective taxonomic tool in phylogenetic studies and has been applied in the classification of Demodex. Mitochondrial 16S rDNA has been demonstrated to be an especially useful ...
Wu Z M - - 2012
In this paper, a bilateral prediction and intersection calculation autofocus method for automated microscopy, which obtains the in-focus position by calculating the intersection of the predicted left and right focus measure curves located respectively in the left and right sides of the peak position of the focus measure curve, is ...
Stahl Jessica - - 2012
Background -  Ceramides are essential stratum corneum (SC) lipids and they play a pivotal role in maintaining effective cutaneous barrier function. Objectives -  The present study aimed at determining the effect of a Dermatophagoides farinae house dust mite (Df-HDM) allergen challenge on SC ceramides of atopic dogs experimentally sensitized to these allergens. ...
Nitzan Dorrit W - - 2012
Temporomandibular joint (TMJ) ankylosis that occurs after TMJ condylar fracture constitutes a treatment challenge. The purpose of the present study is shed light on an alternative treatment approach for certain such cases where the displaced condylar head or part of it can be detected in computed tomography. The leading principle ...
Song Ho-Jun - - 2012
This study examined effects of protein mixing methods into modified simulated body fluid (mSBF) on the crystalline structure and morphology of bone-like mineral (BLM) coated on poly(lactic-co-glycolic acid) PLGA. Using bovine serum albumin (BSA) as a model protein, four sample groups were prepared: the N-BLM group was coated by soaking ...
Dwivedi Amit Nandan Dhar - - 2012
This study evaluated the role of magnetic resonance imaging (MRI) in cases of acute condylar injury and assessed soft tissue damage such as disc displacement, capsular tear, and hemarthrosis within the temporomandibular joint (TMJ). This prospective study was conducted in 15 patients who presented with unilateral or bilateral condylar fracture ...
Hinden Sandro - - 2012
Background -  Recurrent urticaria (RU) is a common skin disease of horses, but little is known about its pathogenesis. Hypothesis/Objective -  The aim of this study was to characterize the inflammatory cell infiltrate and cytokine expression pattern in the skin of horses with RU. Animals -  Biopsies of lesional and ...
Gao Zhanheng - - 2012
Despite its great success in improving the quality of a tetrahedral mesh, the original optimal Delaunay triangulation (ODT) is designed to move only inner vertices and thus cannot handle input meshes containing "bad" triangles on boundaries. In the current work, we present an integrated approach called boundary-optimized Delaunay triangulation (B-ODT) ...
Rami Bou Khalil - - 2012
Alzheimer's disease (AD) is a neurodegenerative disease with no available disease-modifying drugs. However, it has been postulated that neurovascular damage is a primary occurrence in this disease. Neurovascular damage is the result of the presence of cardiovascular risk factor generating hypoxia, oxidative stress, and metabolic changes that activate the endothelial ...
Steffen Ann M - - 2012
This longitudinal study examined the predictors of dementia family caregivers' self-reported attendance at support group meetings over 6 months. First-time attendees were contacted by telephone after their first meeting and assessed for (a) perceptions of similarity between themselves and other members, (b) depressive symptoms, and (c) perceptions of social support ...
Mullin Stephen - - 2012
Acute porphyria, though rare, has well-known neurological sequelae. Vasospasm rarely complicates exacerbations of acute intermittent porphyria, but has not been previously reported in hereditary coproporphyria. We describe a porphyric crisis in a woman with previously undiagnosed hereditary coproporphyria (triggered by rifampicin), leading to vasospasm and stroke.
Bodhak Subhadip - - 2012
Our objective was to establish an in vitro cell culture protocol to improve bone cell attachment and proliferation on Ti substrate using direct current stimulation. For this purpose, a custom made electrical stimulator was developed and a varying range of direct currents, from 5 to 25 µA, were used to ...
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