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Bodde Amy E - - 2012
Adults with intellectual disabilities (ID) have low levels of physical activity and higher than average rates of related chronic health conditions. Understanding correlates of their physical activity participation may improve health promoting interventions. Forty-two adults with ID participated in a physical activity study. Physical activity knowledge and skills, awareness of ...
Danoun Grégory - - 2012
No activation needed: The first efficient method for direct α-arylation of non-activated or non-protected family of enolizable ketones with simple aryl iodides employs a catalytic copper system. The method shows potential for the easy and step-economical synthesis of tamoxifen, the most commonly administrated drug for management of breast cancer. R, ...
Rius Cristina - - 2012
BACKGROUND: Cigarette smoking is an important risk factor for the development of cardiovascular disease, yet the pathways through which this may operate are poorly understood. Therefore, the mechanism underlying cigarette smoke (CS)-induced arterial endothelial dysfunction and the potential link with fractalkine/CX(3)CL1 upregulation were investigated. METHODS AND RESULTS: Stimulation of human ...
Louis J - - 2012
The aim of this study was to investigate the physiological demands of Supercross BMX in elite athletes. Firstly athletes underwent an incremental cycling test to determine maximal oxygen uptake (VO2max) and power at ventilatory thresholds. In a second phase, athletes performed alone a simulated competition, consisting of 6 cycling races ...
Li Wenjun - - 2013
Blastomyces dermatitidis is a dimorphic fungal pathogen that primarily causes blastomycosis in the midwestern and northern United States and Canada. While the genes controlling sexual development have been known for a long time, the genes controlling sexual reproduction of B. dermatitidis (teleomorph, Ajellomyces dermatitidis) are unknown. We identified the mating-type ...
Andre Philipp P Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, - - 2012
The Wnt signaling pathways control many critical developmental and adult physiological processes. In vertebrates, one fundamentally important function of Wnts is to provide directional information by regulating the evolutionarily conserved planar cell polarity (PCP) pathway during embryonic morphogenesis. However, despite the critical roles of Wnts and PCP in vertebrate development ...
Bacon Douglas R - - 2012
If one person can be credited with the creation of the infrastructure of modern anesthesiology, that individual would be Francis Hoeffer McMechan. He has been largely forgotten since his death in 1939 despite his remarkable and enduring accomplishments. McMechan edited the first national journal devoted to anesthesiology, created and managed ...
Schouw M L J ML Department of Radiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. - - 2013
Dopamine (DA) is involved in systems governing motor actions, motivational processes and cognitive functions. Preclinical studies have shown that even relatively low doses of d-amphetamine (dAMPH) (equivalent to doses used in clinical Practice) can lead to DA neurotoxicity in rodents and non-human primates (Ricaurte et al., 2005). Therefore, we investigated ...
Lahousse Lies - - 2012
RATIONALE: Chronic obstructive pulmonary disease (COPD) is an independent risk factor for ischemic stroke and the risk increases with severity of airflow limitation. Even though vulnerable carotid artery plaque components, such as intraplaque hemorrhage and lipid core, place persons at high risk for ischemic events, the plaque composition in COPD ...
Al-Holou Wajd N - - 2012
Object Arachnoid cysts are a frequent finding on intracranial imaging. The prevalence and natural history of these cysts in adults are not well defined. Methods We retrospectively reviewed the electronic medical records of a consecutive series of adults who underwent brain MRI over a 12-year interval to identify those with ...
Syvänen Stina - - 2012
The aim of the present study was to investigate if flumazenil blood-brain barrier transport and binding to the benzodiazepine site on the γ-aminobutyric acid A (GABA(A)) receptor complex is altered in an experimental model of epilepsy and subsequently to study if changes in P-glycoprotein (P-gp)-mediated efflux of flumazenil at the ...
Grant Christoffer - - 2012
Abstract Objectives: Ninety-seven (97) undergraduates with a family history of hypertension participated in a study that evaluated the effects of a brief mindfulness-induction on cardiovascular reactivity and recovery to two stressors. Materials and methods: Participants were randomized to either a mindfulness-induction or control condition and were then exposed to the ...
Güttinger J - - 2012
We review transport experiments on graphene quantum dots and narrow graphene constrictions. In a quantum dot, electrons are confined in all lateral dimensions, offering the possibility for detailed investigation and controlled manipulation of individual quantum systems. The recently isolated two-dimensional carbon allotrope graphene is an interesting host to study quantum ...
Sirci Francesco - - 2012
Virtual Fragment Screening (VFS) is a promising new method that uses computer models to identify small, fragment-like biologically active molecules as useful starting points for Fragment-Based Drug Discovery (FBDD). Training sets of true active and inactive fragment-like molecules to construct and validate target customized VFS methods are however lacking. We ...
Barth J - - 2012
Clinically, subscapularis tendon tears are suggested by the presence of increased passive external rotation compared to the opposite side, resisted internal rotation manoeuvres (Lift-Off test [LOT], Belly-Press test [BPT], Napoleon test and Bear-Hug test [BHT] and positive Internal Rotation Lag Sign and/or Belly-Off Signs). Associated bicipital involvement is frequent with ...
Monga Jitender - - 2012
Objective. The chemopreventive potential of (+)-catechin-rich extract of Acacia catechu (L.f.) Willd. heartwood (AQCE) was evaluated against human breast adenocarcinoma cell line (MCF-7) and 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinoma in Balb/c mice. METHODS: Cell cytotoxicity was investigated using different colorimetric assays. Apoptosis was observed using diphenylamine assay and fluorescent microscopy. AQCE ...
Kezios Katrina L KL Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. - - 2013
Organochlorine pesticides (OCPs) are persistent endocrine disruptors. OCPs cross the placenta; this prenatal exposure has been associated with adverse pregnancy outcomes. We investigated associations between prenatal exposure to OCPs and gestational age and birth weight in 600 infants born between 1960 and 1963. The primary OCP was 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (p,p'-DDT), its ...
Fujii Masataka - - 2012
The meniscus is a fibrocartilaginous tissue that plays an important role in controlling complex biomechanics of the knee. A perimeniscal capillary plexus supplies the outer meniscus, whereas the inner meniscus is composed of avascular tissue. Anti-angiogenic molecules, such as chondromodulin-I (ChM-I) and endostatin, have pivotal roles in preserving the avascularity ...
Lyhs Benjamin - - 2012
Delicate crystals: ClN(3) adopts a polymeric structure in the solid state (see picture; N blue, C green) with short intermolecular Cl⋅⋅⋅Cl distances, as was observed for the elemental halogen.
Oliveira R S - - 2012
The aim of this study was to determine the changes in physical performance and resting heart rate variability (HRV) in professional futsal players during the pre-season and in-season training periods. 11 athletes took part in the study (age=24.3±2.9 years; height=176.3±5.2 cm; weight=76.1±6.3 kg), and performed a repeated-sprint ability (RSA) test [6×40 m (20+20 m ...
Mårtensson Carina - - 2012
Abstract Objective. The aim of this study was to investigate expectations on and satisfaction with treatment among patients referred for comprehensive treatment to specialist clinics in periodontology and to explore factors associated with satisfaction in regression analysis. Materials and methods. Patients referred for comprehensive periodontal treatment were sampled for the ...
Kriegshauser J Scott - - 2012
OBJECTIVES: To determine the prevalence and significance of fat in the urinary bladder wall detectable by computed tomography (CT). METHODS: Retrospective review of 200 consecutive patients with noncontrast CT. Cystectomy specimen CT/pathologic correlation. RESULTS: CT-detectable fat in 30 (15%) patients was significantly more predominant in men (P=.003) and in patients ...
Cho Sung Ki - - 2012
Silicon for solar cells: Relatively pure, polycrystalline, and photoactive silicon was directly obtained from silicon dioxide nanoparticles (NP) by electrodeposition in molten CaCl(2) salt on a silver electrode. This process is based on the formation of liquid droplets of a silver-silicon eutectic alloy and the continuous reduction of SiO(2) to ...
Shi Shujie S Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, - - 2012
The epithelial Na(+) channel (ENaC) is regulated by a variety of external factors that alter channel activity by inducing conformational changes within its large extracellular region that are transmitted to the gate. The wrist domain consists of small linkers connecting the extracellular region to the transmembrane domains, where the channel ...
Küçük Can C Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, - - 2013
HACE1 is an E3 ubiquitin ligase located in 6q21, the genomic region frequently deleted in natural killer (NK) cell malignancies. Here, we report HACE1 as a candidate tumor suppressor gene silenced through a combination of deletion and cytosine phosphate guanine island hypermethylation. We detected deletion of HACE1 in malignant NK ...
McCabe Helen - - 2012
The purpose of this study was to gain an in-depth understanding of autism intervention in China, including history, progress, and current challenges. This qualitative research study included interviews with experienced professionals and observation at autism intervention organizations. Analysis of this empirical data led to three themes regarding this field. First, ...
- - 2012
This final rule updates and makes revisions to the end-stage renal disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2013. This rule also sets forth requirements for the ESRD quality incentive program (QIP), including for payment year (PY) 2015 and beyond. In addition, this rule implements changes to ...
Kortekaas Kirsten A - - 2012
AIMS: Systemic complications after cardiac surgery are common in heart failure patients. However, the pathophysiological mechanisms, such as a different local inflammatory response of failing hearts, remain in question. This study examines whether failing hearts respond differently to cardioplegic arrest and reperfusion compared with non-failing hearts (controls). METHODS AND RESULTS: ...
Wang H - - 2012
AIM: To compare the diagnostic performance of 320-detector row computed tomographic angiography (CTA) with digital subtraction angiography (DSA) for the detection and characterization of intracranial aneurysms. MATERIALS AND METHODS: Fifty-two consecutive patients with non-traumatic subarachnoid haemorrhage (SAH) and suspected intracranial aneurysms were evaluated from January 2009 to October 2011. All ...
Gower Emily W - - 2012
OBJECTIVE To determine whether a new surgical clamp reduces unfavorable postoperative outcomes. METHODS Patients with trachomatous trichiasis (TT) were randomized to surgery with standard bilamellar tarsal rotation (BLTR) instrumentation or the TT clamp and were followed up for 2 years. MAIN OUTCOME MEASURES Postoperative TT, pyogenic granuloma formation, and eyelid ...
Raman Sudha R - - 2012
OBJECTIVE: The aim of the present work was to assess the short-term effects of stimulant medication use on risk of injury among children diagnosed as having attention deficit hyperactivity disorder (ADHD). METHODS: The study group for this self-controlled case series study was children aged 1-18 years old diagnosed as having ...
de la Puerta R - - 2012
Sideritis perezlarae is a plant widely used in folk medicine in the South of Andalusia (Cádiz, Spain). In this work, a phytochemical analysis has led to the isolation and identification of the flavonoid 7-O- β -glucosyl-luteolin from a methanol extract. The total phenol content estimated by Folin-Ciocalteau assay and expressed ...
Jackling Felicity C - - 2012
White-spotting patterns in mammals can be caused by mutations in the gene KIT, whose protein is necessary for the normal migration and survival of melanocytes from the neural crest. The alpaca (Vicugna pacos) blue-eyed white (BEW) phenotype is characterized by 2 blue eyes and a solid white coat over the ...
Karimova Madina - - 2013
Targeted genome engineering has become an important research area for diverse disciplines, with site-specific recombinases (SSRs) being among the most popular genome engineering tools. Their ability to trigger excision, integration, inversion and translocation has made SSRs an invaluable tool to manipulate DNA in vitro and in vivo. However, sophisticated strategies ...
Ghavanini Amer A - - 2012
BackgroundDecreased level of consciousness is a rare neurological manifestation of spontaneous intracranial hypotension (SIH), which typically presents with orthostatic headache. The optimal management of this uncommon presentation remains uncertain.MethodsWe analyzed the presentation, management and outcome of two patients in our institution and reviewed 22 patients reported in the literature with ...
Bourret A A Service de gynécologie et obstétrique II et médecine de la reproduction, maternité de Port-Royal, groupe hospitalier Cochin - Broca - Hôtel-Dieu, hôpitaux universitaires Paris-Centre, 53, avenue de l'Observatoire, 75679 Paris cedex 14, France. - - 2012
Since the 1993 French consensus conference on uncomplicated pelvic inflammatory diseases (uPID), new antibiotics appeared and bacterial resistances did evoluate. This methodic analysis of the literature updates different aspects of its treatment. Antibiotherapy must be established early (EL3). Inpatient and intravenous treatment is not superior to outpatient and oral treatment ...
Sutton Nora B - - 2013
Microbial community composition and diversity at a diesel-contaminated railway site were investigated by pyrosequencing of bacterial and archaeal 16S rRNA gene fragments to understand the interrelationships among microbial community composition, pollution level, and soil geochemical and physical properties. To this end, 26 soil samples from four matrix types with various ...
Mellbin Linda G - - 2012
AimsHyperglycaemia during hospitalization for acute myocardial infarction (AMI) is a risk predictor, but attempts to improve the prognosis by insulin-based glucose control have not been consistently successful. Increased glycaemic variability, a potential effect of insulin treatment, has been linked to a worse prognosis in critically ill patients. The present aim ...
Chamney Carissa - - 2012
Spinal cord injury (SCI) results in loss of muscle function due to rapid breakdown of contractile proteins. Glutamine supplementation improves clinical outcomes, but its effects on muscle function after SCI are unknown. Glutamine's benefits in non-skeletal muscle tissues involve elevated heat shock protein (Hsp)70 and Hsp25, but the muscle response ...
Bunn Lisa M - - 2012
Balance impairment is a principal symptom of cerebellar disease, but is poorly understood partly because subjects with heterogenous cerebellar and extracerebellar lesions have often been studied. Spinocerebellar ataxia type 6 (SCA6) provides an opportunity to understand balance dysfunction associated with a relatively homogenous cerebellar lesion. This study investigated stance instability ...
Ellis Elizabeth D - - 2012
BACKGROUND: A cohort of 3,607 workers employed in three DuPont titanium dioxide production facilities was followed from 1935 through 2006. METHODS: Combined and plant-specific cohort mortality was compared with the overall US population and other DuPont employees. The relationships between selected causes of death and annual cumulative exposures to titanium ...
Park Yong-Hee YH Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehakno, Jongnogu, Seoul 110-744, - - 2012
The most common method for determining the hemoglobin concentration is to draw blood from a patient. However, the Radical-7 Pulse CO-Oximeter (Masimo Corporation, Irvine, CA) can noninvasively provide continuous hemoglobin concentration (SpHb). In our study we compared noninvasive measurements of SpHb with simultaneous laboratory measurements of total hemoglobin in arterial ...
de Man Frances S - - 2012
Despite its description some 25 years ago, neurohormonal activation has long been neglected as an important factor in the pathophysiology of pulmonary arterial hypertension (PAH). Neurohormonal activation was interpreted as a necessary compensatory response to maintain cardiac contractility and systemic blood pressure. Therefore, inhibitors of neurohormonal activity (like β-blockers or ...
Chen Wei-Kan - - 2012
The mechanism responsible for the redox reaction of [Co(III)(en)3]Ac3 to Co(II) complex has been determined to be intramolecular electron transfer. It was measured in real time by means of sub-picosecond extended x-ray absorption fine structure spectra, EXAFS, and optical experiments and supported by density functional theory calculations. The proposed mechanism ...
Kalamatianos Theodosis - - 2012
Object A considerable body of evidence indicates that inflammation and angiogenesis play a significant role in the development and progression of chronic subdural hematoma (CSDH). While various experimental and clinical studies have implicated placental growth factor (PlGF) in the processes that underpin pathological angiogenesis, no study has thus far investigated ...
Catana Ciprian - - 2012
PET and MRI provide complementary information in the study of the human brain. Simultaneous PET/MRI data acquisition allows the spatial and temporal correlation of the measured signals, creating opportunities impossible to realize using stand-alone instruments. This paper reviews the methodologic improvements and potential neurologic and psychiatric applications of this novel ...
Dupaul George J - - 2012
Attention-deficit/hyperactivity disorder (ADHD) and learning disability (LD) can co-occur for a significant minority of children with each disorder. A total of 17 studies (2001-2011) examining ADHD-LD comorbidity were reviewed, revealing a higher mean comorbidity rate (45.1%) than has been obtained previously. Higher comorbidity may be the result of including students ...
Fu Qiang - - 2012
The widely used hole-transporting host 4,4',4″-tris(N-carbazolyl)-triphenylamine (TCTA) blended with either a hole-transporting or an electron-transporting small-molecule material as a mixed-host was investigated in the phosphorescent organic light-emitting diodes (OLEDs) fabricated by the low-cost solution-process. The performance of the solution-processed OLEDs was found to be very sensitive to the composition of ...
Sloutsky Vladimir M VM Department of Psychology and Center for Cognitive Science, The Ohio State University, Columbus, OH 43210, United States. - - 2013
Many objects and events can be categorized in different ways, and learning multiple categories in parallel often requires flexibly attending to different stimulus dimensions in different contexts. Although infants and young children often exhibit poor attentional control, several theoretical proposals argue that such flexibility can be achieved without selective attention. ...
Pager Cara T CT Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305-5124, United - - 2013
Components of cytoplasmic processing bodies (P-bodies) and stress granules can be subverted during viral infections to modulate viral gene expression. Because hepatitis C virus (HCV) RNA abundance is regulated by P-body components such as microRNA miR-122, Argonaute 2 and RNA helicase RCK/p54, we examined whether HCV infection modulates P-bodies and ...
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