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Storr Sarah J - - 2012
ABSTRACT: BACKGROUND: Pancreatic cancer, including cancer of the ampulla of Vater and bile duct, is very aggressive and has a poor five year survival rate; improved methods of patient stratification are required. METHODS: We assessed the expression of calpain-1, calpain-2 and calpastatin in two patient cohorts using immunohistochemistry on tissue ...
Johannsen Adam M - - 2012
BACKGROUND:Consistent radiographic guidelines for tunnel placement in single- or double-bundle posterior cruciate ligament (PCL) reconstructions are not well defined. Quantitative guidelines reporting the location of the individual PCL bundle attachments would aid in intraoperative tunnel placement and postoperative assessment of a PCL reconstruction. HYPOTHESIS:Consistent and reproducible measurements in relation to ...
Ma Yingzhong - - 2012
We report synthesis and detailed spectroscopic study of three water-soluble polythiophene derivatives with distinct homologous oligo(ethylene oxide) side-chain lengths and lower critical solution temperatures (LCSTs). The linear absorption spectra exhibit reversible shifts and broadening with the variation of their aqueous solution temperature, whereas the corresponding steady state fluorescence emission spectra ...
Movsessian Yeraz - - 2012
Objective: This paper offers a reflection on temporal routines that underscore daily work life and work transitions. Participants: This reflection includes personal experience and examination of a worker's transition into the Chilean working life. Method: A narrative reflection on lived experience is used to examine 9 to 5 work transitions. ...
Romeo Andrew - - 2012
Object Endoscopic third ventriculostomy (ETV) is an alternative to shunt placement in children with hydrocephalus due to tectal plate gliomas (TPGs). However, controversy remains regarding the amount of ventricular size reduction that should be expected after ETV. This study investigates ventricular size change after ETV for TPGs. Methods Twenty-two children ...
Sood Neeraj - - 2012
Achievement of the health-related Millennium Development Goals is dependent on increasing take-up of preventive public health services (PHSs) in developing countries. Poor country governments often lack the resources to provide optimal access to preventive services and a great deal of attention is being directed towards the private sector to fill ...
McLaughlin Nancy - - 2012
The supraorbital keyhole approach offers a limited access for aneurysms located at the middle cerebral artery (MCA) bifurcation with long M(1) segments or proximal M(2) aneurysms. Alternative minimally invasive routes centered on the pterion have been developed to address these aneurysms. Appropriate dissection and reconstruction of the temporal muscle are ...
Srorniak Piotr - - 2012
The intact thymidine homodimer anion (dT2-) was generated in the gas phase using an infrared desorption/photoemission source and recorded by a pulsed photoelectron spectrometer. The photoelectron spectrum (PES) revealed a broad signal with the maximum at electron binding energy ~2.0 eV and the threshold value at 1.1 eV. The relative ...
Nakanishi Kazuyoshi - - 2012
Object The pathophysiology of occult tethered cord syndrome (OTCS) with no anatomical evidence of a caudally shifted conus and a normal terminal filum is hard to understand. Therefore, the diagnosis of OTCS is often difficult. The authors hypothesized that the posterior displacement of the terminal filum may become prominent in ...
Reihmane Dace - - 2012
Data on interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) release during acute exercise are not conclusive and lack information about the impact of physical inactivity. Some studies have shown an increase, but others report no changes in IL-6 and TNF-α release during exercise. We have now studied the temporal relationship ...
Hayashi Yukiko - - 2012
The first comprehensive study of the synthesis and structure-property relationships of 2,2'-bis(benzo[b]phosphole)s and 2,2'-benzo[b]phosphole-benzo[b]heterole hybrid π systems is reported. 2-Bromobenzo[b]phosphole P-oxide underwent copper-assisted homocoupling (Ullmann coupling) and palladium-catalyzed cross-coupling (Stille coupling) to give new classes of benzo[b]phosphole derivatives. The benzo[b]phosphole-benzo[b]thiophene and -indole derivatives were further converted to P,X-bridged terphenylenes (X=S, ...
Liu Jing - - 2012
Same selectivity hides different pathways: The same apparent 4-electron process for the oxygen-reduction-reaction hides different pathways over carbon-supported cobalt oxide catalysts depending on the potential. At low overpotentials, the ORR intermediate HO(2) (-) preferably disproportionates to oxygen, whereas at high overpotentials the disproportionation and reduction reaction occur in parallel.
Hill Amy L - - 2012
The emerald ash borer (Agrilus planipennis Fairmaire, EAB) is an alien, invasive wood-boring insect that is responsible for killing millions of ash trees since its discovery in North America in 2002. All North American ash species (Fraxinus spp.) that EAB has encountered have shown various degrees of susceptibility, while Manchurian ...
Watanabe Memi - - 2012
Purpose:To measure the mean diffusional age-related changes of the brain over the full human life span by using diffusion-weighted spin-echo single-shot echo-planar magnetic resonance (MR) imaging and sequential whole-brain apparent diffusion coefficient (ADC) histogram analysis and, secondarily, to build mathematical models of these normal age-related changes throughout human life.Materials and ...
Stepanovic-Petrovic Radica M - - 2012
BACKGROUND:We have recently shown that levetiracetam, administered systemically, exerts an antihyperalgesic effect in a rat inflammatory pain model. In this study, we examined whether levetiracetam has local peripheral antihyperalgesic/antiedematous effects in the same model of localized inflammation and whether opioidergic, adrenergic, purinergic, 5-HTergic, and GABAergic receptors are involved in its ...
Alkasir Rashad - - 2012
Staphylococcus aureus is a major pathogen associated to bovine mastitis and has the ability to form a slow-growing population termed the small colony variants (SCVs). From 20 samples of 5 chronic S. aureus cases, 1 SCV isolate (SCV102) was recovered simultaneously with 1 of 8 S. aureus isolates. SCV102 showed ...
Cronin Shawna - - 2012
Objective: To explore the work transitions of Chilean women. Participants: Observations and dialogue of Chilean women and their experiences in work current and past. Method: A personal and historical reflection to understand the experiences of work for Chilean women. Results: Exploring work transitions requires an understanding of the macro level ...
Scornaiencki Jennifer M - - 2012
Objective: This personal reflection on occupational transitions is based on the life stories of two of the interesting people I met while in Chile, one in Santiago and the other in my travels to San Pedro de Atacama and how their stories have aided in strengthening my knowledge of occupational ...
Nishikuni Koshiro - - 2012
Object The surface of the developing fetal brain undergoes significant morphological changes during fetal growth. The purpose of this study was to evaluate the morphological development of the brain sulci from the fetal to the early postnatal period. Methods Two hundred fourteen brain hemispheres from 107 human brain specimens were ...
Schmitt William R - - 2012
Object The goal of vestibular schwannoma surgery is tumor removal and preservation of neural function. Intraoperative facial nerve (FN) monitoring has emerged as the standard of care, but its role in predicting long-term facial function remains a matter of debate. The present report seeks to describe and critically assess the ...
Kumbhani Dharam J - - 2012
AimsThe effect of resistant hypertension on outcomes in patients with atherothrombotic disease is currently unknown. Accordingly, we sought to determine the prevalence and outcomes of resistant hypertension in stable hypertensive outpatients with subclinical or established atherothombotic disease enrolled in the international Reduction of Atherothrombosis for Continued Health (REACH) registry.Methods and ...
Zhao Baozhong - - 2012
PEGged! A series of mono-PEGylated zinc(II) phthalocyanines for photodynamic therapy with singlet oxygen have been prepared and formulated in aqueous media with different methods. The system based on silica nanoparticles exhibits remarkably high stability and in vitro photocytotoxicity.
Vrubel Heron - - 2012
Getting the hydrogen out: Molybdenum boride (MoB) and carbide (Mo(2) C) are excellent catalysts for electrochemical hydrogen evolution at both pH 0 and pH 14.
Worth Paul F - - 2012
BACKGROUND: The major clinical feature of ataxia telangiectasia (A-T) is severe progressive neurodegeneration with onset in infancy. This classical A-T phenotype is caused by biallelic null mutations in the ATM gene, leading to the absence of ATM protein and increased cellular radiosensitivity. We report an unusual case of A-T in ...
Danoun Grégory - - 2012
No activation needed: The first efficient method for direct α-arylation of non-activated or non-protected family of enolizable ketones with simple aryl iodides employs a catalytic copper system. The method shows potential for the easy and step-economical synthesis of tamoxifen, the most commonly administrated drug for management of breast cancer. R, ...
Rius Cristina - - 2012
BACKGROUND: Cigarette smoking is an important risk factor for the development of cardiovascular disease, yet the pathways through which this may operate are poorly understood. Therefore, the mechanism underlying cigarette smoke (CS)-induced arterial endothelial dysfunction and the potential link with fractalkine/CX(3)CL1 upregulation were investigated. METHODS AND RESULTS: Stimulation of human ...
Louis J - - 2012
The aim of this study was to investigate the physiological demands of Supercross BMX in elite athletes. Firstly athletes underwent an incremental cycling test to determine maximal oxygen uptake (VO2max) and power at ventilatory thresholds. In a second phase, athletes performed alone a simulated competition, consisting of 6 cycling races ...
Bacon Douglas R - - 2012
If one person can be credited with the creation of the infrastructure of modern anesthesiology, that individual would be Francis Hoeffer McMechan. He has been largely forgotten since his death in 1939 despite his remarkable and enduring accomplishments. McMechan edited the first national journal devoted to anesthesiology, created and managed ...
Lahousse Lies - - 2012
RATIONALE: Chronic obstructive pulmonary disease (COPD) is an independent risk factor for ischemic stroke and the risk increases with severity of airflow limitation. Even though vulnerable carotid artery plaque components, such as intraplaque hemorrhage and lipid core, place persons at high risk for ischemic events, the plaque composition in COPD ...
Al-Holou Wajd N - - 2012
Object Arachnoid cysts are a frequent finding on intracranial imaging. The prevalence and natural history of these cysts in adults are not well defined. Methods We retrospectively reviewed the electronic medical records of a consecutive series of adults who underwent brain MRI over a 12-year interval to identify those with ...
Syvänen Stina - - 2012
The aim of the present study was to investigate if flumazenil blood-brain barrier transport and binding to the benzodiazepine site on the γ-aminobutyric acid A (GABA(A)) receptor complex is altered in an experimental model of epilepsy and subsequently to study if changes in P-glycoprotein (P-gp)-mediated efflux of flumazenil at the ...
Grant Christoffer - - 2012
Abstract Objectives: Ninety-seven (97) undergraduates with a family history of hypertension participated in a study that evaluated the effects of a brief mindfulness-induction on cardiovascular reactivity and recovery to two stressors. Materials and methods: Participants were randomized to either a mindfulness-induction or control condition and were then exposed to the ...
Güttinger J - - 2012
We review transport experiments on graphene quantum dots and narrow graphene constrictions. In a quantum dot, electrons are confined in all lateral dimensions, offering the possibility for detailed investigation and controlled manipulation of individual quantum systems. The recently isolated two-dimensional carbon allotrope graphene is an interesting host to study quantum ...
Sirci Francesco - - 2012
Virtual Fragment Screening (VFS) is a promising new method that uses computer models to identify small, fragment-like biologically active molecules as useful starting points for Fragment-Based Drug Discovery (FBDD). Training sets of true active and inactive fragment-like molecules to construct and validate target customized VFS methods are however lacking. We ...
Monga Jitender - - 2012
Objective. The chemopreventive potential of (+)-catechin-rich extract of Acacia catechu (L.f.) Willd. heartwood (AQCE) was evaluated against human breast adenocarcinoma cell line (MCF-7) and 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinoma in Balb/c mice. METHODS: Cell cytotoxicity was investigated using different colorimetric assays. Apoptosis was observed using diphenylamine assay and fluorescent microscopy. AQCE ...
Fu Qiang - - 2012
The widely used hole-transporting host 4,4',4″-tris(N-carbazolyl)-triphenylamine (TCTA) blended with either a hole-transporting or an electron-transporting small-molecule material as a mixed-host was investigated in the phosphorescent organic light-emitting diodes (OLEDs) fabricated by the low-cost solution-process. The performance of the solution-processed OLEDs was found to be very sensitive to the composition of ...
Zhao Tingting - - 2012
  The impact of roasting was observed with regard to certain changes in the chemical components and oxidative stability of oil expelled from the roasted perilla seeds. The roasting times were established differently at each roasting temperature of 180, 200, and 220 °C. Trans fatty acids in perilla oil were ...
Mehdi Ahmed M - - 2012
MOTIVATION: Local motifs are patterns of DNA or protein sequences that occur within a sequence interval relative to a biologically defined anchor or landmark. Current protein motif discovery methods do not adequately consider such constraints to identify biologically significant motifs that are only weakly over-represented but spatially confined. Using negatives, ...
Tóth Ildikó Y - - 2012
Magnetite nanoparticles (MNPs) coated with poly(acrylic acid-co-maleic acid) polyelectrolyte (PAM) have been prepared with the aim of improving colloidal stability of core-shell nanoparticles for biomedical applications and enhancing the durability of the coating shells. FTIR-ATR measurements reveal two types of interaction of PAM with MNPs: hydrogen bonding and inner-sphere metal-carboxylate ...
Ghoseiri Kamiar - - 2012
Background and aim:Sport is associated with risk of injury and re-injury. A rehabilitative sport-related orthosis could protect the injured site and help in the earlier return of athlete to the match. This technical note aims to describe a potential high-prescribed face orthosis to protect/prevent a sport-related injury.Technique:Face-protective orthosis should be ...
Scanlon David - - 2012
The American Psychiatric Association's proposed definition of specific learning disability ("specific learning disorder") for the DSM-5 reflects current thinking and best practice in learning disabilities. It continues the core conceptualization of learning disability (LD) as well as proposes identification criteria to supplant the discredited aptitude-achievement discrepancy formula. Improvements can be ...
Sündermann Simon Harald - - 2012
Tissue replacement is sometimes necessary during surgery for endocarditis. Commonly used materials are Dacron, expanded polytetrafluoroethlyene, or bovine pericardium. Those materials have no potential for bioresorption and cannot restore regional functionality. Extracellular matrices became available lately as patch material. Here we present two cases of patients with endocarditis. CorMatrix ECM ...
Magee C A - - 2012
What is already known about this subject Recent studies have identified distinct trajectories of obesity development in children, but more research is required to further explore these trajectories. Several socio-demographic variables such as parental education and obesity are associated with these trajectories. What this study adds This study further demonstrates ...
Wang Xu-Dong - - 2012
Fiber optics enable direct optical spectroscopy (from the IR to the UV; in absorption, emission and plasmonic resonance) to be performed at inaccessible sites, over large distances, in strong magnetic fields and in harsh environment. If equipped with chemically responsive coatings, they also enable species to be sensed that are ...
Henderson Elisabet - - 2012
Abstract Objective. To compare the efficacy of different chemical solutions when used for chemical debridement of biofilm contaminated titanium surfaces in an in-vitro experimental study. Materials and methods. Commercially pure titanium discs with a diameter of 6.2 mm and height of 2 mm, mirror-polished with a measured surface amplitude value ...
- - 2012
BACKGROUND: The use of non-standard motorcycle helmets has the potential to undermine multinational efforts aimed at reducing the burden of road traffic injuries associated with motorcycle crashes. However, little is known about the prevalence or factors associated with their use. METHODS: Collaborating institutions in nine low- and middle-income countries undertook ...
Adhikari Prakash - - 2012
  Total of 3 different mixtures of rice bran oil (RBO), sheaolein (SO), and palm stearin (PS) (RBO : SO : PS, 40 : 35 : 25; 15 : 40 : 45; 10 : 35 : 55) were modified by enzymatic interesterification (EIE) using TLIM as a bio-catalyst. After interesterification, ...
Du Lianming - - 2012
Microsatellite Search and Building Database (MSDB) is a new Perl program providing a user-friendly interface for identification and building databases of microsatellites from complete genome sequences. The general aims of MSDB are to use the database to store the information of microsatellites and to facilitate the management, classification, and statistics ...
Schuurmans Carol - - 2012
A simple internet search of "maternal stress and pregnancy" turns up hundreds of hits explaining that an adverse intrauterine environment can affect fetal development and potentially lead to various learning, behavioral, and mood disorders in childhood, as well as complex diseases such as obesity and cardiovascular conditions later in life. ...
Rajapandiyan Panneerselvam - - 2012
In this work, a cylindrical-substrate array for surface-enhanced Raman scattering (SERS) measurements was developed to enable analysis of nucleobases in a few microliters of liquid. To eliminate uncertainties associated with SERS detection of aqueous samples, a new type of cylindrical SERS substrate was designed to confine the aqueous sample at ...
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