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Defazio Giovanni G Department of Neuroscience and Sensory Organs, 'Aldo Moro' University of Bari, Piazza Giulio Cesare, Bari 2-70124, Italy. - - 2013
To investigate the frequency and the main clinical features of tremor in primary adult-onset dystonia (PAOD). This cross-sectional study was conducted on 429 patients with PAOD from eight Italian movement disorder centres. Of the 429 dystonic patients, 72 (16.7%) had tremor. Although sex and age at dystonia onset were similar ...
Vidal Josep J Exercise and Sports Science Research Group, University of Balearic Islands, Ctra. Valldemossa km.7'5, Edifici Guillem Cifre de Colonya, Palma of Majorca 07122, Spain. - - 2013
Population based studies have demonstrated that children and adolescents often complain of low back pain. A group-randomized controlled trial was carried out to investigate the effects of a postural education program on school backpack habits related to low back pain in children aged 10-12 year. The study sample included 137 ...
Li Shuping S Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Box 5069, Boston, MA 02111, - - 2013
Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS). Missense mutations in a number of genes involved in RNA function and metabolisms are associated with ALS. Among these genes is angiogenin (ANG), the fifth member of the vertebrate-specific, secreted ribonuclease superfamily. ANG is an angiogenic ribonuclease, and ...
Mueller Monika M Bioprocessing Technology Institute A*STAR (Agency for Science Technology and Research), 20 Biopolis Way, #03-01, Centros, 138668, Singapore, Singapore. - - 2013
To develop a liquid formulation for IgMs to survive physical stress and storage. Stabilizing formulations for 8 monoclonal immunoglobulin (IgMs) were found using differential scanning calorimetry (DSC). In these formulations, the IgMs were subjected to stress and storage and analyzed by size exclusion chromatography and fluorescence activated cell sorting. Structure ...
Chhablani Jay J Shiley Eye Center, University of California, San Diego, 9415 Campus Point Drive, Rm 217B, La Jolla, CA 92093, - - 2013
To evaluate the impact of scanning density on macular choroidal volume measurement using spectral-domain optical coherence tomography (SD-OCT). Thirty eyes of normal subjects underwent consecutive raster choroidal scanning protocols using SD-OCT in enhanced-depth imaging mode. Manual choroidal segmentation was performed using the built-in automated retinal segmentation software to obtain five ...
Bailly Xavier X UPMC-CNRS, FR2424, Station Biologique de Roscoff, France. - - 2013
Flatworms are classically considered to represent the simplest organizational form of all living bilaterians with a true central nervous system. Based on their simple body plans, all flatworms have been traditionally grouped together in a single phylum at the base of the bilaterians. Current molecular phylogenomic studies now split the ...
Costedoat-Chalumeau Nathalie N UPMC, Université Paris 6, , Paris, - - 2013
Hydroxychloroquine (HCQ) is an important medication for treating systemic lupus erythematosus (SLE). Its blood concentration ([HCQ]) varies widely between patients and is a marker and predictor of SLE flares. This prospective randomised, double-blind, placebo-controlled, multicentre study sought to compare standard and adjusted HCQ dosing schedules that target [HCQ] ≥1000 ng/ml ...
Kroenke Candyce H CH Division of Research, Kaiser Permanente, 2101 Webster, 20th Floor, Oakland, CA 94612, USA. - - 2013
Larger social networks have been associated with lower breast cancer mortality. The authors evaluated how levels of social support and burden influenced this association. We included 2,264 women from the Life After Cancer Epidemiology study who were diagnosed with early-stage, invasive breast cancer between 1997 and 2000, and provided data ...
Schoels Monika M MM Correspondence to Dr Monika M Schoels, 2nd Department of Internal Medicine, Center for Rheumatic Diseases, Hietzing Hospital, Wolkersbergenstrasse 1, Vienna 1130, Austria. - - 2013
Suppression of the immunoinflammatory cascade by targeting interleukin 6 (IL-6) mediated effects constitutes a therapeutic option for chronic inflammatory diseases. Tocilizumab is the only IL-6 inhibitor (IL-6i) licensed for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), but also other agents targeting either IL-6 or its receptor are investigated in ...
Koczywas Marianna M Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA, - - 2013
Emerging evidence supports the integration of palliative care concurrently with disease-focused care in patients with serious illnesses, such as lung cancer. This paper describes how longitudinal changes in physical function, symptom burden, and QOL of patients with early-stage non-small cell lung cancer (NSCLC) informed the development of an interdisciplinary, tailored ...
Van Minh Hoang H Department of Health Economics, Center for Health System Research, Institute for Preventive Medicine and Public Health, Hanoi Medical University, No 1 Ton That Tung, Dong Da, Hanoi, Vietnam. - - 2013
The willingness to pay (WTP) for the construction of bathrooms with a flush toilet was assessed in households in a rural community in northern Vietnam. We also examined the effects of socio-economic factors on the WTP. The contingent valuation method, an economic survey technique, was used. We used the iterative ...
Nam Hae-Sung HS Department of Preventive Medicine and Public Health, Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon, South - - 2013
The epidemiologic information regarding international differences in bone mineral density (BMD) in women is currently insufficient. We compared BMD in older women across five racial/ethnic groups in four countries. The femoral neck, total hip, and lumbar spine BMD were measured in women (aged 65-74 years) from the Study of Osteoporotic Fractures ...
Dikken Johan L JL Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, - - 2013
Survival estimates after curative surgery for gastric cancer are based on AJCC staging, or on more accurate multivariable nomograms. However, the risk of dying of gastric cancer is not constant over time, with most deaths occurring in the first 2 years after resection. Therefore, the prognosis for a patient who ...
Francisco Rodríguez Castellanos RC Department of Nephrology, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col Sección XVI, Tlalpan, CP 14080, Mexico City, DF, Mexico, - - 2013
Cardiovascular disease is the leading cause of mortality in patients with chronic kidney disease and has a strong association with hyperphosphatemia. Dialysis is the major treatment tool for attaining serum phosphorus control. Phosphorus removal can be increased with hemodiafiltration. We compared the effect of hemodiafiltration and hemodialysis on serum phosphorus ...
Jin Ke K Jiangsu Province Key Laboratory in Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University; Nanjing, - - 2013
A DNA vaccination approach was used in the current study to screen for the immunogenicity of different fragments of toxin A and toxin B from Clostridium difficile. With this approach, protein antigens do not need to be produced in vitro and the immunogenicity of candidate C. difficile antigens can be ...
Reiter Paul L PL Division of Cancer Prevention and Control; College of Medicine, The Ohio State University, Columbus, OH USA. - - 2013
Appalachia is a geographic region with existing cancer disparities, yet little is known about its burden of HPV-related cancers outside of cervical cancer. We assessed the burden of HPV-related cancers in three Appalachian states and made comparisons to non-Appalachian regions. We examined 1996-2008 cancer registry data for Ohio, Kentucky, West ...
Rowland Rosalind R Jenner Institute; University of Oxford, Oxford, - - 2013
The safety and immunogenicity of a new candidate tuberculosis (TB) vaccine, FP85A was evaluated alone and in heterologous prime-boost regimes with another candidate TB vaccine, MVA85A. This was an open label, non-controlled, non-randomized Phase I clinical trial. Healthy previously BCG-vaccinated adult subjects were enrolled sequentially into three groups and vaccinated ...
Gasparini Roberto R Department of Health Sciences, Genoa University, Genoa, Italy. - - 2013
Annual vaccination is the main mean of preventing influenza in the elderly. In order to evaluate the effectiveness of the adjuvanted seasonal influenza vaccines available in Italy in preventing hospitalization for influenza and pneumonia, a matched case-control study was performed in elderly subjects during the 2010-2011 season in Genoa (Italy). ...
Prasad Anamika A Departments of Bioengineering, Stanford University, Stanford, CA, 94305, - - 2013
Endovascular aneurysm repair (Greenhalgh in N Engl J Med 362(20):1863-1871, 2010) techniques have revolutionized the treatment of thoracic and abdominal aortic aneurysm disease, greatly reducing the perioperative mortality and morbidity associated with open surgical repair techniques. However, EVAR is not free of important complications such as late device migration, endoleak ...
Kupchik Yonatan M YM Department of Neurosciences, Medical University of South Carolina, Charleston, SC, 29425, USA, - - 2013
The ventral pallidum (VP) is a part of the ventral striatopallidal system and is involved in reward-related behaviors. The VP is composed of a ventromedial (VPvm) and a dorsolateral (VPdl) subregion, and some rostral-caudal differences are reported. Study of the VP often focuses on the subcommissural VP, typically considered homogenous ...
Mandal Amit Kumar - - 2012
Femtosecond upconversion, single-molecule fluorescence resonance energy transfer (sm-FRET) and fluorescence correlation spectroscopy (FCS) are applied to study the competition between excited-state proton transfer (ESPT) and FRET [to rhodamine 6G (R6G)] of 8-hydroxypyranine-1,3,6-trisulfonate (HPTS) in cetyltrimethylammonium chloride (CTAC) micelles. Pyranine exhibits dual emission at λ(em) =430 nm for ROH and 520 nm for ...
Uchida Kenji - - 2012
Under control: A stereocontrolled total synthesis of (+)-UCS1025A, a potent telomerase inhibitor, was achieved. The synthesis features an intramolecular Diels-Alder reaction, a tandem Staudinger/aza-Wittig reaction, and stereoselective construction of the hemiaminal moiety facilitated by neighboring-group participation.
Markopoulos Georgios - - 2012
Fusing rings: A new synthesis of the bowl-shaped hydrocarbon tribenzotriquinacene is presented. The synthesis allows easy access to ortho-functionalized and C(3) -chiral derivatives that are attractive for supramolecular chemistry and asymmetric catalysis.
Lunkenbein Thomas - - 2012
Hexagonally ordered mesoporous molybdenum oxycarbide/carbon (MoC/C) nanocomposites were directly accessed by heat treatment of mesostructured poly(butadiene-block-2-vinylpyridine) (PB-b-P2VP) and molybdophosphoric acid. PB-b-P2VP serves as structure-directing agent and as carbon source. The high specific surface area obtained for the nanocomposites renders the materials interesting for potential applications, such as in the catalytic ...
Zhao Xinmei - - 2012
1,2-Diaminobenzene, popularly known as ortho-phenylenediamine (PDA), is found to be a prototype spacer for the deposition of gold nanoparticles on the surfaces of Fe(3) O(4) microspheres. Upon carbonization with PDA, the morphology of the product changes significantly, and the resulting nanocomposites exhibit enhanced magnetism beyond the saturation value of Fe(3) ...
Colson S S - - 2012
The interest in whole-body vibration (WBV) for the enhancement of neuromuscular performance has received considerable attention. However, scientific evidence supporting the optimal prescription of WBV settings is lacking. This study investigated the acute effect of WBV combining high frequency/high peak-to-peak displacement (HH) or low frequency/low peak-to-peak displacement (LL) vs. sham ...
Chang Yi - - 2012
Easy as π: A stable nonaromatic heteroporphyrin bearing a thienopyrrole moiety has been prepared. The nonaromatic nature of this compound is clearly evident based on UV/Vis absorption, (1) H NMR spectroscopy, and theoretical calculations. Single-crystal X-ray analysis demonstrates that the molecule adopts a planar conformation with clear alternation in the ...
Sbiera S - - 2012
Treatment options for adrenocortical carcinoma (ACC) are very limited. In other solid tumors, small vaccination trials targeting the anti-apoptotic molecule survivin suggested immunological and clinical benefit in selected patients. Therefore, we investigated whether survivin might be a suitable target for immunotherapy in ACC. Survivin mRNA and protein expression was assessed ...
Vermeulen Joan - - 2012
Objective:To investigate the predictive value of self-reported decline in weight, exhaustion, walking difficulty, grip strength and physical activity on development of disabilities in community-dwelling elderly people.Design:A one-year follow-up study.Setting:Participants were recruited via four Dutch general practitioners.Participants:Community-dwelling elderly people aged 70 years or older.Methods:A total of 687 participants received a questionnaire ...
Montoto Silvia - - 2012
Background: Defining the role of high-dose therapy with autologous stem cell rescue in the therapeutic algorithm of follicular lymphoma remains a major challenge. In contrast with the acknowledged poor outcome associated with cyclophosphamide/total body irradiation conditioning in heavily pretreated patients, the prognostic impact of the number of previous therapy lines ...
Stephenson Chris P - - 2012
Objective:This study examined longitudinal trends in the dispensing of psychotropic medications in Australia from January 2000 to December 2011.Method:Dispensing data for the major classes of psychotropic medications (antidepressants, anxiolytics, sedatives, antipsychotics, mood stabilisers and attention-deficit hyperactivity disorder (ADHD) medications) were obtained from the Drug Utilisation Sub-Committee of the Australian Department ...
Izumi Koji - - 2012
Although UDP-glucuronosyltransferase 1A (UGT1A) plays an important role in preventing bladder cancer initiation by detoxifying carcinogenic compounds, its contribution to bladder cancer progression is poorly understood. We immunohistochemically stained for UGT1A in bladder specimens. UGT1A was positive in 130/145 (90%; 28 [19%] weak, 53 [37%] moderate, and 49 [34%] strong) ...
Meng Xianyi - - 2012
Tylophorine and analogs are phenanthroindolizidine alkaloids, several of which have been reported to have anticancer, antiviral, and anti-inflammatory properties. However, their function in the immune system remains widely unknown. Transcription factor Foxp3 is critical for the development and function of Treg, which down-regulates the immune system and maintains tolerance to ...
Lehrer Jocelyn A - - 2012
This paper synthesises and discusses results from the 2005 Survey of Student Well-Being, a closed-ended questionnaire administered to students attending general education courses at a major public university in Santiago (n = 484 women, 466 men). The survey included questions on sexual violence (SV) and dating violence (DV), public health problems that ...
Byun Bo Young - - 2012
  The objective of this study was to analyze overall contents of biogenic amines in Miso and thereby evaluate the safety of the food. Through HPLC analysis of 22 different Miso products, it was found that most samples had low biogenic amine contents. However, some samples contained both histamine and ...
Ho Wanxing Eugene - - 2012
Rationale: Metabolomics refers to the comprehensive analysis of metabolites in biological systems and has been employed to study asthmatic patients based on their metabolite profile. We hypothesize that airway allergic asthma would affect metabolism in the lungs, and could be detected in bronchoalveolar lavage fluid (BALF) using a combined liquid ...
Vianelli Nicola - - 2012
Background. The treatment of choice in steroid-resistant immune thrombocytopenia is still controversial, due to the recent advent of new drugs (anti-CD20 antibodies and thrombopoietin mimetics) which have encouraged a generalized tendency to delay splenectomy. Consequently, the importance to define the efficacy and safety of splenectomy in the long-term is substantial. ...
Laprise Claudie - - 2012
Background. Some studies have shown that tenofovir disoproxil fumarate (TDF), a drug widely used in highly active antiretroviral therapies (HAART), is associated with kidney dysfunction, but the magnitude of the effect and its clinical impact is still being debated. Our objective was to evaluate the association between long-term TDF exposure and ...
- - 2012
This final rule updates and makes revisions to the end-stage renal disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2013. This rule also sets forth requirements for the ESRD quality incentive program (QIP), including for payment year (PY) 2015 and beyond. In addition, this rule implements changes to ...
Kortekaas Kirsten A - - 2012
AIMS: Systemic complications after cardiac surgery are common in heart failure patients. However, the pathophysiological mechanisms, such as a different local inflammatory response of failing hearts, remain in question. This study examines whether failing hearts respond differently to cardioplegic arrest and reperfusion compared with non-failing hearts (controls). METHODS AND RESULTS: ...
Wang H - - 2012
AIM: To compare the diagnostic performance of 320-detector row computed tomographic angiography (CTA) with digital subtraction angiography (DSA) for the detection and characterization of intracranial aneurysms. MATERIALS AND METHODS: Fifty-two consecutive patients with non-traumatic subarachnoid haemorrhage (SAH) and suspected intracranial aneurysms were evaluated from January 2009 to October 2011. All ...
Gower Emily W - - 2012
OBJECTIVE To determine whether a new surgical clamp reduces unfavorable postoperative outcomes. METHODS Patients with trachomatous trichiasis (TT) were randomized to surgery with standard bilamellar tarsal rotation (BLTR) instrumentation or the TT clamp and were followed up for 2 years. MAIN OUTCOME MEASURES Postoperative TT, pyogenic granuloma formation, and eyelid ...
Raman Sudha R - - 2012
OBJECTIVE: The aim of the present work was to assess the short-term effects of stimulant medication use on risk of injury among children diagnosed as having attention deficit hyperactivity disorder (ADHD). METHODS: The study group for this self-controlled case series study was children aged 1-18 years old diagnosed as having ...
de la Puerta R - - 2012
Sideritis perezlarae is a plant widely used in folk medicine in the South of Andalusia (Cádiz, Spain). In this work, a phytochemical analysis has led to the isolation and identification of the flavonoid 7-O- β -glucosyl-luteolin from a methanol extract. The total phenol content estimated by Folin-Ciocalteau assay and expressed ...
Jackling Felicity C - - 2012
White-spotting patterns in mammals can be caused by mutations in the gene KIT, whose protein is necessary for the normal migration and survival of melanocytes from the neural crest. The alpaca (Vicugna pacos) blue-eyed white (BEW) phenotype is characterized by 2 blue eyes and a solid white coat over the ...
Ghavanini Amer A - - 2012
BackgroundDecreased level of consciousness is a rare neurological manifestation of spontaneous intracranial hypotension (SIH), which typically presents with orthostatic headache. The optimal management of this uncommon presentation remains uncertain.MethodsWe analyzed the presentation, management and outcome of two patients in our institution and reviewed 22 patients reported in the literature with ...
Mellbin Linda G - - 2012
AimsHyperglycaemia during hospitalization for acute myocardial infarction (AMI) is a risk predictor, but attempts to improve the prognosis by insulin-based glucose control have not been consistently successful. Increased glycaemic variability, a potential effect of insulin treatment, has been linked to a worse prognosis in critically ill patients. The present aim ...
Chamney Carissa - - 2012
Spinal cord injury (SCI) results in loss of muscle function due to rapid breakdown of contractile proteins. Glutamine supplementation improves clinical outcomes, but its effects on muscle function after SCI are unknown. Glutamine's benefits in non-skeletal muscle tissues involve elevated heat shock protein (Hsp)70 and Hsp25, but the muscle response ...
Bunn Lisa M - - 2012
Balance impairment is a principal symptom of cerebellar disease, but is poorly understood partly because subjects with heterogenous cerebellar and extracerebellar lesions have often been studied. Spinocerebellar ataxia type 6 (SCA6) provides an opportunity to understand balance dysfunction associated with a relatively homogenous cerebellar lesion. This study investigated stance instability ...
Coric Domagoj - - 2012
Object The purpose of this study was to evaluate the long-term results of cervical total disc replacement (TDR) and anterior cervical discectomy and fusion (ACDF) in the treatment of single-level cervical radiculopathy. Methods The results of 2 separate prospective, randomized, US FDA Investigational Device Exemption pivotal trials (Bryan Disc and ...
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