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Kelly Sarah-Louise - - 2012
OBJECTIVES: To review clinical indications and demographics of transfusion and the patterns of blood component ordering, transfusion, wastage and traceability, before (2007) and after (2011) implementation of simple improvement strategies. METHODS: Retrospective case note review of all patients presenting to the Royal Infirmary of Edinburgh (RIE) Emergency Department (ED) for ...
Emmerich Nathan - - 2012
This essay comments on the British Medical Association's recent suggestion that protocols for Elective Ventilation (EV) might be revived in order to increase the number of viable organs available for transplant. I suggest that the proposed revival results, at least in part, from developments in the contemporary political landscape, notably ...
van de Beek Diederik - - 2012
Bacterial meningitis kills or maims about a fifth of people with the disease. Early antibiotic treatment improves outcomes, but the effectiveness of widely available antibiotics is threatened by global emergence of multidrug-resistant bacteria. New antibiotics, such as fluoroquinolones, could have a role in these circumstances, but clinical data to support ...
Pelletier Amandine - - 2012
The effects of radiofrequency electromagnetic fields (RF-EMF) on the control of body energy balance in developing organisms have not been studied, despite the involvement of energy status in vital physiological functions. We examined the effects of chronic RF-EMF exposure (900 MHz, 1 V m(-1)) on the main functions involved in body energy homeostasis ...
Goyal Deepak - - 2012
PURPOSE: There is an increasing use of various synthetic and biological products in orthopaedics. The use of a biological product can be a major area of concern for patients of various cultures/religions. The purpose of this work is to study various restrictions in different faiths and their compatibility with available ...
Gradmann Sabine - - 2012
We present a computational environment for Fast Analysis of multidimensional NMR DAta Sets (FANDAS) that allows assembling multidimensional data sets from a variety of input parameters and facilitates comparing and modifying such "in silico" data sets during the various stages of the NMR data analysis. The input parameters can vary ...
Oddstig Jenny - - 2012
BACKGROUND: For a 1-day myocardial perfusion SPECT (MPS) the recommendations for administered activity stated in the EANM guidelines results in an effective dose of up to 16 mSv per patient. Recently, a gamma camera system, based on cadmium zinc telluride (CZT) technology, was introduced. This technique has the potential to reduce ...
Sun Chun-Yi - - 2013
Metal-organic frameworks (MOFs) are a unique class of hybrid porous solids based on metals and organic linkers. Compared to traditional porous materials, they possess predominance of large surface areas, tunable pore size and shape, adjustable composition and functionalized pore surface, which enable them unique advantages and promises for applications in ...
Vaquero Javier - - 2012
PURPOSE: The purpose of this study was to perform a cross-cultural adaptation of the Knee Injury and Osteoarthritis Outcome Score (KOOS) into Spanish and to evaluate the psychometric properties of this version in patients with chondral lesion of the knee, as expressed by its validity, reliability and responsiveness. METHODS: The ...
Veses Oscar - - 2012
This study was carried out in order to assess potential toxicity of hazardous pollutants (8 trace elements and 8 polycyclic aromatic hydrocarbons) in 20 sediment samples of the Ebro River basin (Spain) sampled in 2009. Mean-probable effect concentration quotient (m-PECQ) was found to range from 0.03 to 0.79. Two sites ...
Hofmann Meike - - 2012
We demonstrate an integrated optofluidic system for monitoring the particle mass concentration and the Sauter mean diameter of polydisperse flowing suspensions of water and standardized test dust. For optimum integration, a planar emitter-receiver unit is developed and fabricated on Si technology. A vertical cavity surface emitting laser at 850 nm serves ...
Grenvald Julie Cornelius - - 2012
Oil exploration is expected to increase in the near future in Western Greenland. At present, effects of exposure to oil compounds on early life-stages of the ecologically important Calanus spp. are unknown. We investigated the effects of the oil compound pyrene, on egg hatching and naupliar development of the calanoid ...
Monini Simonetta - - 2012
This retrospective study aimed to evaluate the efficacy of the Esteem(®) middle ear implant in sensorineural hearing loss (SNHL) of different degree as well as to compare it with that obtained with conventional hearing aids. Fifteen out of 30 adults patients who received an Esteem(®) middle ear device for rehabilitation ...
Sole C V - - 2012
PURPOSE: To investigate the outcomes and risk factors of patients treated with stereotactic ablative radiotherapy (SABR) delivered by image-guided helical tomotherapy (HT) for extracranial oligometastases. METHODS: From August 2006 through July 2011, 42 consecutive patients (median age 69 years [range 16-87]) with oligometastases (≤3) received HT to all known cancer sites ...
Wang Kun - - 2012
Recombinant microbial transglutaminase (rMTG) is usually expressed as a soluble zymogen (pro-rMTG) in heterologous expression systems but proteolytic activation of the inactive pro-rMTG is essential. Instead of screening proteases for activating pro-rMTG, we examined an alternative method by introducing a specific cleavage site of enterokinase between the pro-peptide and mature ...
Li Ning - - 2012
Chemical and surface characteristics of sulfite-pretreated royal palm sheath (RPS) fibers and parenchyma cells were investigated in order to study cell-type-dependent biomass hydrolysis by cellulase. Size, chemical composition, cellulose crystallinity and the exposure of cellulose microfibrils in pretreated RPS biomass affected the enzymatic accessibility and digestibility of different cell-type substrates.
Shah Neel A - - 2012
PURPOSE: Elective surgical resection is the curative treatment for colorectal cancer (CRC). Up to 30 % of patients present as surgical emergencies. The objective was to determine the association between presenting with an emergency condition and consequent outcomes of CRC surgery in the Appalachian state of West Virginia (WV) in comparison ...
Rowland Rosalind R Jenner Institute; University of Oxford, Oxford, - - 2013
The safety and immunogenicity of a new candidate tuberculosis (TB) vaccine, FP85A was evaluated alone and in heterologous prime-boost regimes with another candidate TB vaccine, MVA85A. This was an open label, non-controlled, non-randomized Phase I clinical trial. Healthy previously BCG-vaccinated adult subjects were enrolled sequentially into three groups and vaccinated ...
Kong Byung Ho - - 2012
PURPOSE: The existence of cancer stem cells (CSCs) in glioblastoma has been proposed. However, the unknown knowledge that is yet to be revealed is the presence of glioma CSCs (gCSCs) in correlation to each WHO grades of glioma. We approached this study with a hypothesis that specimens from high-grade gliomas ...
Vallejo Narváez Wilmer Esteban - - 2012
The energy-dependent branching ratios of the complementary fragment ions [C5H5O]+ and [HC6H4NH]+ ([M - C5H5O]+) originated from the N-(2-furylmethyl)aniline molecular ion, [HC6H4NH-C5H5O]+•, were obtained from Rice-Ramsperger-Kassel-Marcus (RRKM) rate calculations based on DFT energy profiles. The UB3LYP/6-311G+(3df,2p)//UB3LYP/6-31G(d) level of theory was used to model the competitive reaction mechanisms by which the ...
Senst Christiane - - 2013
Breast cancer tissue is a heterogeneous cellular milieu comprising cancer and host cells. The interaction between breast malignant and non-malignant cells takes place in breast tumor microenvironment (TM), and has a crucial role in breast cancer progression. In addition to cellular component of TM, it mainly consists of cytokines released ...
Craven Stephen - - 2012
A Monod kinetic model, logistic equation model and statistical regression model were developed for a Chinese hamster ovary (CHO) cell bioprocess operated under three different modes of operation (batch, bolus fed-batch and continuous fed-batch) and grown on two different bioreactor scales (3 L bench-top and 15 L pilot-scale). The Monod ...
Hahn M - - 2012
Purpose: Fibroadenoma (FA) of the breast is the most common disorders in young women. The aim of the study was to evaluate cryoablation (CA) under ultrasound guidance in the office setting for patients with FA.Materials and Methods: For this prospective multicenter trial an office-based cryosurgical system was used to treat ...
Montaser Rana R Department of Medicinal Chemistry, University of Florida, Gainesville, 32610, - - 2012
Striking cAMP: certain fatty acid amides from marine cyanobacteria can mimic the endocannabinoids. Serinolamide B, a new analogue identified from a Guamanian sample, and malyngamide B, a representative member of a large class of cyanobacterial metabolites, can decrease forskolin-induced cAMP accumulation through the cannabinoid receptors.
Calvo Manuel G - - 2012
A smile is visually highly salient and grabs attention automatically. We investigated how extrafoveally seen smiles influence the viewers' perception of non-happy eyes in a face. A smiling mouth appeared in composite faces with incongruent non-happy (fearful, neutral, etc.) eyes, thus producing blended expressions, or it appeared in intact faces ...
Fischer Michael A - - 2013
To compare lumbar muscle fat-signal fractions derived from three-dimensional dual gradient-echo magnetic resonance (MR) imaging and multiple gradient-echo MR imaging with fractions from single-voxel MR spectroscopy in patients with low back pain. This prospective study had institutional review board approval, and written informed consent was obtained from all study participants. ...
Mishra Arun K AK School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United - - 2012
Toll-like receptors (TLRs) recognize pathogens by interacting with pathogen-associated molecular patterns, such as the phosphatidylinositol-based lipoglycans, lipomannan (LM) and lipoarabinomannan (LAM). Such structures are present in several pathogens, including Mycobacterium tuberculosis, being important for the initiation of immune responses. It is well established that the interaction of LM and LAM ...
Patel Dinesh S - - 2012
A reliable and sensitive liquid chromatography-tandem mass spectrometry assay has been proposed for the selective determination of diflunisal in the presence of its glucuronide metabolites. The analyte and clofibric acid as internal standard (IS) are extracted from 50 µL of human plasma by solid-phase extraction. Chromatographic separation is conducted on ...
Yuan H K - - 2012
The spin and orbital magnetic moments, as well as the magnetic anisotropy energy (MAE), of small 4d transition metal (TM) clusters are systematically studied by using the spin-orbit coupling (SOC) implementation of the density-functional theory (DFT). The effects of spin-orbit interactions on geometrical structures and spin moments are too weak ...
Yu Xiao-Min - - 2012
Chronic hypoxia induced pulmonary arterial hypertension (HPH) is closely associated with profound vascular remodeling, especially pulmonary arterial medial hypertrophy and muscularization due to hyperplasia of pulmonary artery smooth muscle cells (PASMCs). Aberrant Wnt signaling has been associated with lung diseases, but its role in pulmonary hypertension is unclear. This study ...
Cerda-Maira Francisca A - - 2013
The Vibrio cholerae BreR protein is a transcriptional repressor of the breAB efflux system operon, which encodes proteins involved in bile resistance. In a previous study (F. A. Cerda-Maira, C. S. Ringelberg, and R. K. Taylor, J. Bacteriol. 190:7441-7452, 2008), we used gel mobility shift assays to determine that BreR ...
Frenkel-Morgenstern Milana - - 2013
Chimeric RNAs that comprise two or more different transcripts have been identified in many cancers and among the Expressed Sequence Tags (ESTs) isolated from different organisms; they might represent functional proteins and produce different disease phenotypes. The ChiTaRS database of Chimeric Transcripts and RNA-Sequencing data (http://chitars.bioinfo.cnio.es/) collects more than 16 ...
Coric Domagoj - - 2012
Object The purpose of the study was to evaluate the safety and initial efficacy of NuQu allogeneic juvenile chondrocytes delivered percutaneously for the treatment of lumbar spondylosis with mechanical low-back pain (LBP). NuQu is a cell-based biological therapy for disc repair. The authors report the results at 12 months of ...
Griswold Carol H - - 2012
School absenteeism and poor compliance with prenatal appointments are concerns for pregnant teens. The Prenatal Care at School (PAS) program is a new model of prenatal care involving local health care providers and school personnel to reduce the need for students to leave school for prenatal care. The program combines ...
Pak Julia J Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, - - 2012
The effectiveness of RNA interference (RNAi) in many organisms is potentiated through the signal-amplifying activity of a targeted RNA-directed RNA polymerase (RdRP) system that can convert a small population of exogenously-encountered dsRNA fragments into an abundant internal pool of small interfering RNA (siRNA). As for any biological amplification system, we ...
Xu Jun - - 2012
New couple: The Cu-promoted trifluoromethylation of primary and secondary alkylboronic acids with TMSCF(3) extends the scope of transition-metal-catalyzed trifluoromethylation reactions to sp(3) -hybridized carbon centers. It also represents one of the first examples for Cu-catalyzed CC cross-coupling reactions of alkylboronic acid derivatives.
Dassios Theodore - - 2012
Respiratory muscle function in patients with cystic fibrosis (CF) can be assessed by measurement of maximal inspiratory pressure (Pi(max) ), maximal expiratory pressure (Pe(max) ), and pressure-time index of the respiratory muscles (PTI(mus) ). We investigated the differences in maximal respiratory pressures and PTI(mus) between CF patients with no gross ...
Marolf Angela J - - 2012
Cholangiohepatitis/cholangitis is second only to hepatic lipidosis as the most common liver disease in cats and is often associated with concurrent pancreatitis. Magnetic resonance imaging (MRI) and MR cholangiopancreatography (MRCP) have developed into an accurate, highly sensitive and specific imaging tool for the diagnosis of biliary and pancreatic duct disorders ...
Muñoz Salvador B SB 3rd Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico 88003, United - - 2012
The synthesis and characterization of new tris(carbene)borate ligand precursors containing substituted benzimidazol-2-ylidene and 1,3,4-triazol-2-ylidene donor groups, as well as a new tris(imidazol-2-ylidene)borate ligand precursor are reported. The relative donor strengths of the tris(carbene)borate ligands have been evaluated by the position of ν(NO) in four-coordinate {NiNO}(10) complexes, and follow the order: ...
Barbieri Cinzia - - 2012
This study analysed particular regulations on the cultivation and collection of medicinal and aromatic plants (MAPs) in the European Union, Italy and several of its regions. Piedmont and Valle d'Aosta (Northwest), Tuscany (Central) and Sicily (South). The analysis should emphasise to private and/or public institutions the information to further develop ...
Chen Tseng-Cheng TC Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, - - 2013
Only a small portion of the patients with locoregionally advanced oral squamous cell carcinoma (OSCC) experience subsequent distant metastasis. This study is to evaluate the occurrence of distant metastasis after curative treatment and to explore the predictive factors for subsequent distant metastasis in patients with locoregionally advanced OSCC. The medical ...
Porsgaard Soeren - - 2012
The stability of Pt nanoparticles (NPs) supported on ultrathin SiO2 films on Si(111) was investigated in situ under H2 and O2 (0.5 Torr) by high pressure x-ray photoelectron spectroscopy (HP-XPS) and ex situ by atomic force microscopy (AFM). No indication of sintering was observed up to 600 °C in both ...
Endo Arata - - 2012
BACKGROUND:Although high-molecular-weight hydroxyethyl starch (HES) has been reported to cause acute kidney injury (AKI), it is not clear whether low-molecular-weight HES (6% HES 70/0.5) can be a risk for AKI or not. We hypothesized that intraoperative 6% HES 70/0.5 administration is not related to postoperative AKI.METHODS:A retrospective chart review was ...
Sullo Nikol - - 2013
Skeletal muscle dysfunction is a significant contributor to exercise limitation in pulmonary emphysema. This study investigated skeletal muscle oxidative metabolism before and after aerosol exposure to a long-acting β-agonist (LABA), such as formoterol, in the pallid mouse (B6.Cg-Pldnpa/J), which has a deficiency in serum α(1)-antitrypsin (α(1)-PI) and develops spontaneous pulmonary ...
Wang Yuzhen Y Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. - - 2013
Invasive aspergillosis is a major cause of infectious morbidity and mortality in immunocompromised patients. The fungus Aspergillus fumigatus (A. fumigatus) is the primary causative agent of invasive aspergillosis. However, A. fumigatus infections remain difficult to diagnose particularly in the early stages due to the lack of a rapid, sensitive and ...
Su Yi Esther - - 2012
Objective: The objective of this study was to assess the psychometric properties of the Chinese ADHD Rating Scale-IV (ADHD RS-IV): Home Version and to explore parent ratings of ADHD symptoms in a large sample of urban schoolchildren in China. Method: Parents of a representative sample of 1,616 schoolchildren (aged 6-17) ...
Barnes Jeffrey - - 2012
Background Diffuse large B cell lymphoma is an aggressive non-Hodgkin lymphoma with out a standard therapy for patients who relapse after or are not eligible for salvage autologous stem cell transplant. In vitro analysis of lymphoma cell lines has shown ability of everolimus to inhibit cell cycle progression in vitro ...
Varney Elizabeth E - - 2013
The objective of this pilot study was to determine the effectiveness of a mixture of essential oils (peppermint, basil, and helichrysum) on mental exhaustion, or moderate burnout (ME/MB) using a personal inhaler. This was a randomized, controlled, double-blind pilot study. Data were collected 3 times a day for 3 weeks ...
Chavez-Dozal Alba A Department of Biology, New Mexico State University, Las Cruces, New Mexico, - - 2013
Vibrio fischeri proliferates in a sessile, stable community known as a biofilm, which is one alternative survival strategy of its life cycle. Although this survival strategy provides adequate protection from abiotic factors, marine biofilms are still susceptible to grazing by bacteria-consuming protozoa. Subsequently, grazing pressure can be controlled by certain ...
López Javier - - 2012
AimPersistent infection is not a scientific evidence-based definition. The guidelines of infective endocarditis (IE) establish a cut-off point of 7-10 days, which is arbitrary and probably too long. Our hypothesis is that persistent positive blood cultures after 48-72 h from the initiation of antibiotic therapy are associated with a worse ...
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