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Zlotina Anna - - 2012
Chicken (Gallus gallus domesticus, GGA) and Japanese quail (Coturnix coturnix japonica, CCO) karyotypes are very similar. They have identical chromosome number (2n = 78) and show a high degree of synteny. Centromere positions on the majority of orthologous chromosomes are different in these two species. To explore the nature of this divergence, ...
Prabowo Satria A - - 2012
Tuberculosis (TB) has scourged humankind for millennia, and latent infection affects nearly one-third of today's world population. The emergence of multidrug-resistant (MDR)-TB is a major global threat and reflects treatment failure of drug-sensitive disease. MDR-TB management is a burden for patients and society; success rates are unacceptably low with prolonged ...
Papaharilaou Yannis - - 2012
Head and neck postures may cause morphology changes to the geometry of the carotid bifurcation (CB) that alter the low and oscillating wall shear stress (WSS) regions previously reported as important in the development of atherosclerosis. Here the right and left CB were imaged by MRI in two healthy subjects ...
Winter Anke C AC Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA. - - 2013
Previous studies have suggested that migraineurs are at decreased risk for developing breast cancer. Further prospective studies are warranted to confirm these results. In addition, studies evaluating migraine characteristics (e.g., migraine subtypes and frequency) are lacking. We conducted a prospective cohort study among 39,696 participants in the Women's Health Study ...
Jurt Simon - - 2012
(15)N relaxation rates of amide moieties provide insight both into global as well as local backbone dynamics of peptides and proteins. As the differences in the relaxation rates in general are small, their accurate determination is of prime importance. One potential source of error is fast amide exchange. It is ...
Xu Peng - - 2012
This paper proposes an integral method to achieve a more accurate weighting matrix that makes very positive contributions to the image reconstruction in inertial confinement fusion research. Standard algebraic reconstruction techniques with a positivity constraint included are utilized. The final normalized mean-square error between the simulated and reconstructed projection images ...
Pilliar Robert M - - 2012
Porous calcium polyphosphate (CPP) is being investigated for fabrication of novel biodegradable bone substitutes. In this study, porous CPP implants formed by conventional CPP powder packing and using a two-step sinter/anneal process was used to form 20 and 30 vol % porous samples displaying relatively high strength. These were implanted ...
Mangold Stefanie - - 2012
Zinc can occur in extremely high concentrations in acidic, heavy metal polluted environments inhabited by acidophilic prokaryotes. Although these organisms are able to thrive in such severely contaminated ecosystems their resistance mechanisms have not been well studied. Bioinformatic analysis of a range of acidophilic bacterial and archaeal genomes identified homologues ...
Liu Xin - - 2012
PURPOSE: The aim was to assess the effects of a Tai Chi-based program on health-related quality of life (HR-QOL) in people with elevated blood glucose or diabetes who were not on medication for glucose control. METHOD: 41 participants were randomly allocated to either a Tai Chi intervention group (N = 20) or ...
Roy Soumyajit - - 2012
Giant cell tumour (GCT) constitutes about 5 % of all skeletal tumors. They rarely occur in the skull. When involved, they preferentially involve the sphenoid or temporal bones. Skull-base GCTs generally present with multiple cranial nerves involvement, most commonly sixth followed by the third cranial nerve. We describe a case of ...
Jetschke Sylvia - - 2012
We investigated the photodarkening (PD) kinetics of two fiber series with variation of the Yb content for constant Al concentration or constant ratio of Al/Yb, respectively. The results show the outstanding importance of the absolute value of Al concentration also in the case of fibers with strongly reduced Yb content. ...
Martini Paolo - - 2012
Despite a clear ability to detect temporal modulations of visual stimuli in excess of 50 Hz, temporal individuation and serial order judgment tasks can be performed only when stimuli alternate at much slower rates, and the nature of such sluggishness remains unclear. One example of a task with a slow temporal ...
Lee Jan Hau - - 2012
BACKGROUND: High flow nasal cannula (HFNC) systems utilize higher gas flow rates than standard nasal cannulae. The use of HFNC as a respiratory support modality is increasing in the infant, pediatric, and adult populations as an alternative to non-invasive positive pressure ventilation. OBJECTIVES: This critical review aims to: (1) appraise ...
Hewitt Gillian - - 2012
Participatory approaches are a popular and entrenched strategy in community development, yet a number of unresolved issues and tensions persist regarding the definition, rationales, outcomes and ethics of participation. Despite its popularity there are relatively few examples of participatory projects with older people or in institutional settings so their potential ...
Pae Chi-Un - - 2012
A number of different antidepressants, each with unique pharmacological profiles, are used for treatment of major depressive disorder (MDD); however, these drugs have been found in placebo-controlled, large practical clinical trials to have limited efficacy for achieving full recovery in MDD patients. In particular, when depressed patients have pain symptoms, ...
Li Dawei - - 2012
Working memory (WM) capacity limit has been extensively studied in the domains of visual and verbal stimuli. Previous studies have suggested a fixed WM capacity of typically about three or four items, on the basis of the number of items in working memory reaching a plateau after several items as ...
Wilshire Candice L - - 2012
BACKGROUND: Current diagnostic techniques establishing gastroesophageal reflux disease as the underlying cause in patients with respiratory symptoms are poor. Our aim was to provide additional support to our prior studies suggesting that the association between reflux events and oxygen desaturations may be a useful discriminatory test in patients presenting with ...
Jamison Andrew C - - 2012
Self-assembled monolayers (SAMs) were prepared from a novel two-tailed partially-fluorinated thiol (F8C11:C16), possessing one hydrocarbon chain and one chain with an extended fluorinated segment, and from mixtures of F8C11:C16 and hexadecanethiol (C16) on gold, with the expectation that the internal chemical dissimilarity and wedge-like shape of F8C11:C16 would lead to ...
Mizia-Stec Katarzyna - - 2012
Copeptin is a new biomarker of cardiovascular diseases. Its diagnostic value in degenerative aortic valve stenosis (AS) with preserved left ventricle systolic function is unknown. We aimed to assess the association of serum copeptin levels with AS severity and coexistence of coronary artery disease (CAD). Sixty-four patients with AS and ...
Xu Lin - - 2012
During a study of the diversity and phylogeny of rhizobia isolated from root nodules of Oxytropis ochrocephala grown in the northwest of China, four strains were classified in the genus Rhizobium on the basis of their 16S rRNA gene sequences. These strains have identical 16S rRNA gene sequences, which showed ...
Yovcheva Temenuzhka - - 2012
The refractive index (RI) of polymer nanocomposite of poly(vinyl alcohol) films with TiO<sub>2</sub> nanoparticle inclusions with low concentration up to 1.2 wt. % was investigated. Accurate refractometric measurements, by a specially designed laser microrefractometer, were performed at wavelengths 532 and 632.8 nm. The influence of TiO<sub>2</sub> concentration on the RI dispersion curves ...
Son Jun Sik - - 2012
The goal of this study was to develop a functional titanium (Ti) implant loaded with bioactive molecules using biodegradable polymeric particles as drug delivery carrier for dental applications. In this study, dexamethasone (DEX)-loaded poly(lactic-co-glycolic acid) (PLGA) particles were electrostatically immobilized on a Ti disc surface coated with hydroxyapatite (HA) nanocrystals ...
Yilmaz Neslihan - - 2012
Takayasu arteritis (TA) and Crohn's disease (CD) are chronic inflammatory diseases with granulomatous nature. Here, we report a case of TA with a silent course of CD who was refractory to corticosteroid and immunosuppressive treatments and improved with adalimumab therapy.
Nishizawa Yoshiki - - 2012
Recently the clinical application of bone metabolic markers has achieved significant progress and the measurements of these indices give us a better understanding of the pathogenesis of osteoporosis. Bone metabolic markers were adapted to select drug treatment for osteoporosis and to evaluate drug efficacy. Therefore, the proper application and assessment ...
Paban Véronique - - 2012
Inbred LOU/C/Jall rats are currently described as a model of successful aging. These rats have a longer healthy median lifespan than many other strains, do not develop obesity, diabetes, or tumor and more importantly they do not show cognitive decline with aging. This is the first study to examine gene ...
van der Linden Carolien M J - - 2012
BACKGROUND: Earlier studies have shown poor documentation of the reasons for medication discontinuation during hospitalization. Communication of reasons for discontinuation, e.g. adverse drug reactions (ADRs), to general practitioners and pharmacists was also found to be insufficient, leading to a rate of represcription after an ADR of 27 % during the first ...
Uesugi Kazuhiro - - 2012
BACKGROUND: The Wilms' tumor 1 (WT1) gene is known to be overexpressed in hepatocellular carcinoma (HCC) and to upregulate tumor growth and oncogenic potential, although the detailed mechanisms remain to be elucidated. METHODS: We identified host genes involved in WT1 gene modulation of human liver cancer cell lines in vitro, ...
Phull Manraj K - - 2012
The restoration of body contours as shaped by adipose tissue remains a clinical challenge specifically in patients who have experienced loss of contour due to trauma, surgical removal of tumours or congenital abnormalities. We have developed a novel macro-microporous biomaterial for use in soft tissue re-bulking and augmentation. Alginate beads ...
Nehus Edward J - - 2012
BACKGROUND: Limited data exist on the performance of cystatin C-based glomerular filtration rate (GFR) equations in pediatric transplant recipients and other high-risk patients. The aim of our study was therefore to evaluate the performance of current cystatin C-based equations in this population. METHODS: This was a retrospective, cross-sectional study of ...
Dabaghzadeh Fatemeh F Tehran University of Medical Sciences, Department of Clinical Pharmacy, Faculty of Pharmacy, Enghelab Ave, Tehran, - - 2012
More than 50% of HIV-positive patients experience neuropsychiatric adverse reactions following efavirenz therapy. Discontinuation of efavirenz due to its neuropsychiatric side effects has been reported in 2 - 13% of patients. Dizziness, headache, nightmares, abnormal dreams, mild cognitive difficulty, sleep disturbance (somnolence and insomnia), impaired concentration, depression, hallucination, delusion, paranoia, ...
Spence Scott E - - 2012
Straightforward novel methods for stabilizing, tuning, and controlling a twin Mach-Zehnder interferometer for the purpose of observing a subtle dynamical quantum nonlocality effect in a recent optical experiment are presented and discussed. Weak measurements were required for observing a subtle quantum dynamical nonlocality effect that reveals itself in a change ...
Reiter Paul L PL Division of Cancer Prevention and Control; College of Medicine, The Ohio State University, Columbus, OH USA. - - 2013
Appalachia is a geographic region with existing cancer disparities, yet little is known about its burden of HPV-related cancers outside of cervical cancer. We assessed the burden of HPV-related cancers in three Appalachian states and made comparisons to non-Appalachian regions. We examined 1996-2008 cancer registry data for Ohio, Kentucky, West ...
Otgonsuren Munkhzul - - 2013
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and may be associated with increased mortality. Our aim was to determine whether anthropometric measures are independently associated with mortality in NAFLD. The third National Health and Nutrition Examination Surveys (1988-1994) data was used. Extensive radiologic, serologic and ...
Baghdadi Muhammad - - 2012
Cancer vaccines have been developed to instruct the endogenous immune responses to autologous tumors and to generate durable clinical responses. However, the therapeutic benefits of cancer vaccines remain insufficient due to the multiple immunosuppressive signals delivered by tumors. Thus, to improve the clinical efficacy of cancer immunotherapy, it is important ...
Krasikova Alla - - 2012
Exploration into morphofunctional organisation of centromere DNA sequences is important for understanding the mechanisms of kinetochore specification and assembly. In-depth epigenetic analysis of DNA fragments associated with centromeric nucleosome proteins has demonstrated unique features of centromere organisation in chicken karyotype: there are both mature centromeres, which comprise chromosome-specific homogeneous arrays ...
Lv Xiaomei - - 2012
We constructed a biosynthetic pathway of isoprene production in Escherichia coli by introducing isoprene synthase (ispS) from Populus alba. 1-deoxy-D-xylulose 5-phosphate synthase (dxs), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr) and isopentenyl diphosphate (IPP) isomerase (idi) were overexpressed to enhance the isoprene production. The isoprene production was improved 0.65, 0.16, and 1.22 fold ...
Chen Cui - - 2012
PURPOSE: Platinum-based chemotherapy is the recognized first-line treatment for metastatic nasopharyngeal carcinoma (NPC). However, no standard treatment regimens have been established. This phase II study was designed to evaluate the efficacy and safety of a paclitaxel, cisplatin and 5-FU combination in metastatic and/or recurrent NPC. METHODS: Patients with evaluable metastatic ...
Davis Tessa - - 2012
PURPOSE: It is recognised that paediatric prescribing errors are prevalent, and that most are made by junior doctors; however, detecting errors in order to demonstrate actual error rates can be difficult. There is evidence to suggest that dosing errors are the most common type of prescribing error in practice, but ...
Nutaratat Pumin - - 2012
A Gram-negative, coccobacilli, non-spore forming and non-motile bacterium, designated PN1(T), was isolated from a banana leaf collected in Mattra island, Thailand. This isolate was observed to grow optimally at 30 °C and pH 7.0, and to grow with 0-3 % NaCl. Comparative 16S rRNA gene sequence analysis showed that strain PN1(T) is ...
Vahabzadeh Yousef - - 2012
In this article we propose a novel mechano-optical switch and dual channel transmitter based on photonic crystal. The device consists of two waveguides and an elliptical cavity in a square lattice structure. Two optical signals at separate wavelengths are inserted in the input waveguide. The elliptical cavity can be rotated ...
Al-Sukhni Eisar - - 2012
PURPOSE: This study was designed to elicit end-user opinions regarding the importance and diagnostic accuracy of MRI for T-category, threatened or involved circumferential margin (CRMi), and lymph node involvement (LNi) for preoperative staging of rectal cancer and to determine completeness of MRI reports for these elements on a population based ...
Sun Yuechi - - 2012
To study the clinical features and associated risk factors of interstitial lung disease (ILD) in clinically amyopathic dermatomyositis (CADM) in Chinese patients. Forty-one Chinese Han patients with a diagnosis of CADM in West China Hospital from August 2008 to 2011 were retrospectively analyzed. The prevalence of ILD in CADM patients ...
Costedoat-Chalumeau Nathalie N UPMC, Université Paris 6, , Paris, - - 2013
Hydroxychloroquine (HCQ) is an important medication for treating systemic lupus erythematosus (SLE). Its blood concentration ([HCQ]) varies widely between patients and is a marker and predictor of SLE flares. This prospective randomised, double-blind, placebo-controlled, multicentre study sought to compare standard and adjusted HCQ dosing schedules that target [HCQ] ≥1000 ng/ml ...
Bai Yan - - 2012
Mesenchymal stem cells (MSCs) were treated with bone morphogenetic protein-2 (BMP-2), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) dose-dependently and time-dependently. Together they caused a strong synergistic effect on the osteogenic differentiation of MSCs, with lower concentrations of each factor being enough to show the synergistic ...
de Moraes Maia Mila Leite - - 2012
This study investigated the effect of low-level laser therapy (LLLT) on the masticatory performance (MP), pressure pain threshold (PPT), and pain intensity in patients with myofascial pain. Twenty-one subjects, with myofascial pain according to Research Diagnostic Criteria/temporomandibular dysfunction, were divided into laser group (n = 12) and placebo group (n = 9) to receive ...
Wang Chenchen - - 2012
We demonstrate the direct coupling of transient capillary isotachophoresis/ capillary zone electrophoresis (CITP/CZE) with a high sensitivity triple quadrupole mass spectrometer operating in selected reaction monitoring (SRM) mode for sample quantitation. The capability of CITP/CZE for in situ sample enrichment and separation has been shown to significantly improve the analytical ...
Han Dongfei - - 2012
A gene encoding p-anisaldehdye dehydrogenase (PAADH), which catalyzes the oxidation of p-anisaldehdye to p-anisic acid, was identified to be clustered with the trans-anethole oxygenase (tao) gene in Pseudomonas putida JYR-1. Heterologously expressed PAADH in E. coli catalyzed the oxidation of vanillin, veratraldehyde and piperonal to the corresponding aromatic acids, vanillic ...
Figueras J - - 2012
PURPOSE: This prospective observational study assessed the efficacy of bevacizumab in combination with chemotherapy as preoperative treatment to downsize tumours for radical resection in patients with unresectable metastatic colorectal cancer (mCRC). PATIENTS/METHODS: Patients with mCRC initially unresectable according to predefined criteria were included. Preoperative treatment consisted of bevacizumab (5 mg/kg) combined ...
Bullingham Roy - - 2012
BACKGROUND: The nonsteroidal anti-inflammatory drug (NSAID) ketorolac tromethamine shows higher plasma concentrations and a longer plasma half-life in adults ≥65 years of age than in subjects aged <65 years, after intramuscular administration. An intranasal formulation of ketorolac tromethamine is approved for short-term treatment of moderate to moderately severe pain requiring analgesia at ...
Wright F L - - 2012
RATIONALE: Previous research suggests that the acute anorectic effect of cannabinoid CB1 receptor antagonist/inverse agonists may be secondary to response competition from the compulsive scratching and grooming syndrome characteristic of these agents. OBJECTIVES: As the pruritic effect of rimonabant can be attenuated by the opioid receptor antagonist naloxone, these studies ...
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