Search Results
Results 701 - 750 of 4626
< 10 11 12 13 14 15 16 17 18 19 20 >
Li Shuping S Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Box 5069, Boston, MA 02111, - - 2013
Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS). Missense mutations in a number of genes involved in RNA function and metabolisms are associated with ALS. Among these genes is angiogenin (ANG), the fifth member of the vertebrate-specific, secreted ribonuclease superfamily. ANG is an angiogenic ribonuclease, and ...
Rottschy C - - 2012
In a previous meta-analysis across almost 200 neuroimaging experiments, working memory for object location showed significantly stronger convergence on the posterior superior frontal gyrus, whereas working memory for identity showed stronger convergence on the posterior inferior frontal gyrus (dorsal to, but overlapping with Brodmann's area BA 44). As similar locations ...
van Breda Shane V - - 2012
The anatomical localization of caffeine within young Camellia sinensis leaves was investigated using immunohistochemical methods and confocal scanning laser microscopy. Preliminary fixation experiments were conducted with young C. sinensis leaves to determine which fixation procedure retained caffeine the best as determined by high-performance liquid chromatography analysis. High pressure freezing, freeze ...
Choi B-O - - 2012
The objective of the study was to investigate the disease-causing mutation in an autosomal dominant Charcot-Marie-Tooth disease type 2 family and examine the clinical and histopathological evaluation. We enrolled a family of Korean origin with axonal Charcot-Marie-Tooth disease neuropathy (FC305; 13 males, six females) and applied genome-wide linkage analysis. Whole ...
He Wenqi - - 2012
We propose a method to achieve the purpose of hierarchical authentication on the basis of two beams' interference and the one-way hash function. For this security protection system, only if the "phase key" and the password-controlled "phase lock" of a user are verified simultaneously can one obtain a permission to ...
Zhang Lihua - - 2012
The objective of the study is to investigate the mechanisms of cyclophosphamide sequential therapy for patient with primary Sjögren's syndrome-associated interstitial lung disease (PSS-ILD). This was a retrospective review of 15 patients (2005-2008) with PSS-ILD who underwent cyclophosphamide sequential therapy. Peripheral blood and bronchoalveolar lavage (BALF) were obtained before and ...
Nam Hae-Sung HS Department of Preventive Medicine and Public Health, Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon, South - - 2013
The epidemiologic information regarding international differences in bone mineral density (BMD) in women is currently insufficient. We compared BMD in older women across five racial/ethnic groups in four countries. The femoral neck, total hip, and lumbar spine BMD were measured in women (aged 65-74 years) from the Study of Osteoporotic Fractures ...
Korkmaz T - - 2012
PURPOSE: Small cell lung cancer (SCLC) has a high relapse rate despite being very chemosensitive. The efficacy of second-line treatment is dismal. Our aim was to evaluate the outcome of second-line treatment. METHODS: We retrospectively assessed data of 120 SCLC patients who failed first-line treatment and received second-line treatment at ...
Alatise Olusegun Isaac - - 2012
PURPOSE: The aim of this study was to determine the length of the sigmoid colon and sigmoid mesocolon in living subjects and fresh cadavers. METHODS: The subjects for the study were consecutive 50 living subjects undergoing abdominal surgeries via midline incision and 50 fresh cadavers undergoing a medicolegal postmortem at ...
Liu Chuan - - 2012
Published data regarding the association between the apurinic/apyrimidinic endonuclease 1 (APE1) Asp148Glu polymorphism and bladder cancer risk showed inconclusive results. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, Elsevier and Springer for relevant articles with a time limit ...
Delort Estelle - - 2012
Oyster leaf (Mertensia maritima), also called vegetarian oyster, has a surprising oyster-like aroma. Its volatile composition was investigated here for the first time. In total, 109 compounds were identified by gas chromatography/mass spectrometry (GC/MS) and quantified by GC-FID. The use of GC-olfactometry on both polar and non-polar columns allowed us ...
Mueller Monika M Bioprocessing Technology Institute A*STAR (Agency for Science Technology and Research), 20 Biopolis Way, #03-01, Centros, 138668, Singapore, Singapore. - - 2013
To develop a liquid formulation for IgMs to survive physical stress and storage. Stabilizing formulations for 8 monoclonal immunoglobulin (IgMs) were found using differential scanning calorimetry (DSC). In these formulations, the IgMs were subjected to stress and storage and analyzed by size exclusion chromatography and fluorescence activated cell sorting. Structure ...
Bauer Patricia J - - 2012
Memory is of fundamental importance for cognitive, social, and educational function, making it a target for neuropsychological assessment. The subject of this review is one particular type of memory, namely, episodic memory of unique events and experiences. Episodic memory allows for rapid, even one-trial learning of new information and retention ...
Chen J - - 2012
OBJECTIVE: von Hippel-Lindau (VHL) disease is a hereditary tumor syndrome predisposed to the development of tumors in a variety of body organs. The major etiopathogenesis of VHL is a mutation of the VHL tumor-suppressor gene on the short arm of chromosome 3 (3p25-26). We report on the clinical and molecular ...
Pasquier Eddy - - 2012
The anti-angiogenic activity of chemotherapy is both dose- and schedule-dependent. While conventional maximum tolerated dose (MTD) chemotherapy exerts only mild and reversible anti-angiogenic effects, low-dose metronomic (LDM) chemotherapy was developed to specifically target tumour angiogenesis. However, the long-term effects of either MTD or LDM chemotherapy on vascular endothelial cells have ...
Tseng Chia-Chen - - 2012
This study utilized audiometry, and cervical vestibular-evoked myogenic potential (cVEMP), ocular VEMP (oVEMP) and caloric tests to investigate the sequence of vestibular deficits in patients with noise-induced hearing loss (NIHL). Thirty patients with NIHL underwent an inner ear test battery. Another 30 normal controls with age- and sex-matched were included ...
Kupchik Yonatan M YM Department of Neurosciences, Medical University of South Carolina, Charleston, SC, 29425, USA, - - 2013
The ventral pallidum (VP) is a part of the ventral striatopallidal system and is involved in reward-related behaviors. The VP is composed of a ventromedial (VPvm) and a dorsolateral (VPdl) subregion, and some rostral-caudal differences are reported. Study of the VP often focuses on the subcommissural VP, typically considered homogenous ...
Blanc D S - - 2012
The performance of the Xpert MRSA polymerase chain reaction (PCR) assay on pooled nose, groin, and throat swabs (three nylon flocked eSwabs into one tube) was compared to culture by analyzing 5,546 samples. The sensitivity [0.78, 95 % confidence interval (CI) 0.73-0.82] and specificity (0.99, 95 % CI 0.98-0.99) were similar to ...
Wang Hongyuan - - 2012
A modeling and validation method of photometric characteristics of the space target was presented in order to track and identify different satellites effectively. The background radiation characteristics models of the target were built based on blackbody radiation theory. The geometry characteristics of the target were illustrated by the surface equations ...
Skafida Valeria - - 2012
OBJECTIVES: To examine how transnational tobacco companies (TTCs) tried to penetrate the Bulgarian cigarette market and influence tobacco excise tax policy after the fall of communism and during Bulgaria's accession to the European Union (EU). DESIGN: Analysis of internal tobacco industry documents supplemented by analysis of press coverage, tobacco industry ...
Uddin Fatema S - - 2012
BACKGROUND: Obesity is a risk factor for colorectal cancer, and colonoscopy can be technically challenging in obese patients. It has been proposed (with little supporting data) that prone positioning of obese patients might facilitate a difficult colonoscopy. AIM: The aim of this study was to determine if starting colonoscopy in ...
Bonomo Silvia - - 2012
Dihydroorotate dehydrogenase (DHODH) is an important drug target due to its prominent role in pyrimidine biosynthesis. Leflunomide and brequinar are two well-known DHODH inhibitors, which bind to the enzyme in the same pocket with different binding modes. We have recently realized a series of new inhibitors based on the 4-hydroxy-1,2,5-oxadiazole ...
Millan N M - - 2012
It is well established that chromosomes occupy distinct positions within the interphase nuclei, conferring a potential functional implication to the genome. In addition, alterations in the nuclear organisation patterns have been associated with disease phenotypes (e.g. cancer or laminopathies). The human sperm is the smallest cell in the body with ...
Tang Nelson L S - - 2012
BACKGROUND: Breast cancer patients regularly undergo adjuvant chemotherapies following surgery. However, these treatments are largely associated with chemotherapeutic toxicities ranging from nausea to severe myelosuppression. In this investigation, we examined the effects of four SNPs in NR1I2, CYP3A4 and CYP3A5 genes on chemotherapy-induced severe neutropenia in 311 female Chinese breast ...
Paterson R Russell M - - 2012
Many fungi have significant industrial applications or biosafety concerns and maintaining the original characteristics is essential. The preserved fungi have to represent the situation in nature for posterity, biodiversity estimations, and taxonomic research. However, spontaneous fungal mutations and secondary metabolites affecting producing fungi are well known. There is increasing interest ...
Al-Herz Waleed - - 2012
Major Histocompatibility Complex (MHC) class II deficiency is a combined primary immunodeficiency disease that leads to overwhelming and recurrent infections. It was found to account for 19 % of combined immune deficiency cases in the National Primary Immunodeficiency Disorders Registry in Kuwait, a country with high prevalence of consanguinity. We present ...
Chien A Jo - - 2013
The widespread use of trastuzumab in the past decade has led to a significant and measureable improvement in the survival of patients with human epidermal growth factor receptor-2 (HER2) overexpressing breast cancer, and in many ways has redefined the natural history of this aggressive breast cancer subtype. Historically, survival in ...
Luhmann Andrew - - 2012
Carbon sequestration experiments were conducted on uncemented sediment and lithified rock from the Eau Claire Formation, which consisted primarily of K-feldspar and quartz. Cores were heated to accentuate reactivity between fluid and mineral grains and to force CO2 exsolution. Measured permeability of one sediment core ultimately reduced by four orders ...
Huang Yao-Han - - 2012
In this study, a Fresnel lens with radial and azimuthal liquid crystal (LC) alignments in the odd and even zones was fabricated using the photoalignment technique based on an azo dye doped in LC cells. The lens has approximately 35% focusing efficiency as determined using a linearly polarized probe beam. ...
Gibson Rachel J - - 2012
PURPOSE: The aim of this study was to review the available literature and define clinical practice guidelines for the use of agents for the prevention and treatment of gastrointestinal mucositis. METHODS: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International ...
Shulgina Ludmila L Norwich Medical School, University of East Anglia, Norwich, - - 2013
Idiopathic pulmonary fibrosis (IPF) is a fatal condition with limited treatment options. However, in a previous small study, co-trimoxazole was found to be beneficial. In a double-blind multicentre study, 181 patients with fibrotic idiopathic interstitial pneumonia (89% diagnosed as definite/probable IPF) were randomised to receive co-trimoxazole 960 mg twice daily ...
Tanaka Nobukazu - - 2012
The image quality and potential usefulness for patient skin-dose reduction of a newly developed flat-panel detector (FPD) system employing irradiation side sampling (ISS) were investigated and compared to a conventional computed radiography (CR) system. We used the X-ray beam quality of RQA 9 as noted in the standard evaluation method ...
Hellio le Graverand Marie-Pierre - - 2012
OBJECTIVE: To determine if inhibition of inducible nitric oxide synthase (iNOS) with cindunistat hydrochloride maleate slows progression of osteoarthritis (OA) METHODS: This 2-year, multinational, double-blind, placebo-controlled trial enrolled patients with symptomatic knee OA (Kellgren and Lawrence Grade (KLG) 2 or 3). Standard OA therapies were permitted throughout. Patients were randomly ...
Van Minh Hoang H Department of Health Economics, Center for Health System Research, Institute for Preventive Medicine and Public Health, Hanoi Medical University, No 1 Ton That Tung, Dong Da, Hanoi, Vietnam. - - 2013
The willingness to pay (WTP) for the construction of bathrooms with a flush toilet was assessed in households in a rural community in northern Vietnam. We also examined the effects of socio-economic factors on the WTP. The contingent valuation method, an economic survey technique, was used. We used the iterative ...
Lodde M - - 2012
OBJECTIVE: A second transurethral resection of the bladder (TURB) is recommended for high-grade bladder cancer (BC) yet yields negative results in over half of the cases. Aim of this study was to identify prognostic indicators of a positive second TURB or the need for a subsequent cystectomy. MATERIALS AND METHODS: ...
Jakovljevic Mihajlo B - - 2012
The past 23 years of post-socialist restructuring of health system funding and management patterns has brought many changes to small Balkan markets, putting them under increasing pressure to keep pace with advancing globalization. Socioeconomic inequalities in healthcare access are still growing across the region. This uneven development is marked by the ...
de Paula Eneida - - 2012
One of the most common strategies for pain control during and after surgical procedures is the use of local anesthetics. Prolonged analgesia can be safely achieved with drug delivery systems suitably chosen for each local anesthetic agent. This review considers drug delivery formulations of local anesthetics designed to prolong the ...
Bicho Rita C - - 2012
Pesticide exposure has been related with thyroid disrupting effects in different vertebrate species. However, very little is known about the effects of these compounds in reptiles. In the Mediterranean area, lacertid lizards are the most abundant vertebrate group in agroecosystems, and have been identified as potential model species for reptile ...
Huang Y - - 2012
BACKGROUND: Surgical resection remains the principal treatment for advanced gastric cancer. However, one of the difficulties in radical D2 lymphadenectomy is the identification of the vascular abnormalities around the stomach, especially abnormal hepatic artery. The hepatic artery arising from the superior mesenteric artery shows great variations, and whether or not ...
Giani I - - 2012
The Italian society of colo-rectal surgery (SICCR) is dedicated to improving the study, prevention and management of the diseases of the colon, rectum and anus. One of the aims of the society is to establish guidelines to the treatment of these diseases. These guidelines are based on the international literature ...
Kobayashi Tominari - - 2012
Virus particles are promising vehicles and templates for vaccination, drug delivery and material sciences. Although infectious picornaviruses can be synthesized from genomic or synthetic RNA by cell-free protein expression systems derived from mammalian cell extract, there has been no direct evidence that authentic viral particles are indeed synthesized in the ...
Cheng Gong - - 2012
A soil metagenomic library was constructed and screened for clones that conferred fosfomycin resistance. A novel protein with 46 % identity to UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Desulfuromonas acetoxidans DSM 684 (GenBank accession number: ZP_01311756) was identified. Multiple sequence alignment revealed that the novel protein was a natural MurA, in which ...
Qiao Jun J Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing 210008, - - 2013
The purpose of this study was to investigate the incidence of neural axis abnormalities in patients with presumed "idiopathic" thoracolumbar or lumbar scoliosis by magnetic resonance imaging (MRI) and try to determine which clinical and radiographic characteristics correlate with neural axis abnormalities on MRI in these patients. The database of ...
Yamani Yusuke - - 2012
A pair of experiments investigated the architecture of visual processing, parallel versus serial, across high and low levels of spatial interference in a divided attention task. Subjects made speeded judgments that required them to attend to a pair of color-cued objects among gray filler items, with the spatial proximity between ...
Bagdasarov Zhanna - - 2012
Cases have been employed across multiple disciplines, including ethics education, as effective pedagogical tools. However, the benefit of case-based learning in the ethics domain varies across cases, suggesting that not all cases are equal in terms of pedagogical value. Indeed, case content appears to influence the extent to which cases ...
Defazio Giovanni G Department of Neuroscience and Sensory Organs, 'Aldo Moro' University of Bari, Piazza Giulio Cesare, Bari 2-70124, Italy. - - 2013
To investigate the frequency and the main clinical features of tremor in primary adult-onset dystonia (PAOD). This cross-sectional study was conducted on 429 patients with PAOD from eight Italian movement disorder centres. Of the 429 dystonic patients, 72 (16.7%) had tremor. Although sex and age at dystonia onset were similar ...
Vidal Josep J Exercise and Sports Science Research Group, University of Balearic Islands, Ctra. Valldemossa km.7'5, Edifici Guillem Cifre de Colonya, Palma of Majorca 07122, Spain. - - 2013
Population based studies have demonstrated that children and adolescents often complain of low back pain. A group-randomized controlled trial was carried out to investigate the effects of a postural education program on school backpack habits related to low back pain in children aged 10-12 year. The study sample included 137 ...
Auner Alexander W - - 2012
PURPOSE: Create a Raman spectroscopic database with potential to diagnose cancer and investigate two different diagnostic methodologies. Raman spectroscopy measures the energy of photons scattered inelastically by molecules. These molecular signatures form the basis of identifying complex biomolecules and can be used to differentiate normal from neoplastic tissue. METHODS: 1,352 ...
Makey Ghaith - - 2012
This paper introduces a new modification for the well-known binary detour phase method, which is largely used to represent Fourier holograms; the modification utilizes gray scale level control provided by a liquid crystal spatial light modulator to improve the traditional binary detour phase. Results are shown by both simulation and ...
Sheng Guodong - - 2012
This work determined the influence of humic acid (HA) and fulvic acid (FA) on the interaction mechanism and microstructure of Ni(II) onto diatomite by using batch experiments, X-ray photoelectron spectroscopy (XPS), and extended X-ray absorption fine structure (EXAFS) methods. Macroscopic and spectroscopic experiments have been combined to see the evolution ...
< 10 11 12 13 14 15 16 17 18 19 20 >