Search Results
Results 651 - 700 of 4616
< 9 10 11 12 13 14 15 16 17 18 19 >
Koivistoinen A - - 2012
AIM: To identify linear peptide homing to non-small cell lung cancer (NSCLC) tumor cells using ex vivo phage display method. MATERIALS AND METHODS: Twenty-six clinical patient samples were used to identify linear homing peptide, which was exposed to NSCLC cell cultures and control cell lines to determine cell binding affinity ...
Meckel Stephan - - 2012
INTRODUCTION: 4D phase contrast MR imaging (4D PC MRI) has been introduced for spatiotemporal evaluation of intracranial hemodynamics in various cerebrovascular diseases. However, it still lacks validation with standards of reference. Our goal was to compare blood flow quantification derived from 4D PC MRI with transcranial ultrasound and 2D PC ...
Sadahiro Sotaro - - 2012
The most common site of metastases in patients with colorectal cancer is the liver. Hepatic resection is considered to be the treatment of choice for liver metastasis from colorectal cancer; however, hepatic resection can be performed in only 20 or 25 % of all patients. Recurrence develops in the remnant liver ...
Wang Hongyuan - - 2012
A modeling and validation method of photometric characteristics of the space target was presented in order to track and identify different satellites effectively. The background radiation characteristics models of the target were built based on blackbody radiation theory. The geometry characteristics of the target were illustrated by the surface equations ...
Skafida Valeria - - 2012
OBJECTIVES: To examine how transnational tobacco companies (TTCs) tried to penetrate the Bulgarian cigarette market and influence tobacco excise tax policy after the fall of communism and during Bulgaria's accession to the European Union (EU). DESIGN: Analysis of internal tobacco industry documents supplemented by analysis of press coverage, tobacco industry ...
Uddin Fatema S - - 2012
BACKGROUND: Obesity is a risk factor for colorectal cancer, and colonoscopy can be technically challenging in obese patients. It has been proposed (with little supporting data) that prone positioning of obese patients might facilitate a difficult colonoscopy. AIM: The aim of this study was to determine if starting colonoscopy in ...
Bonomo Silvia - - 2012
Dihydroorotate dehydrogenase (DHODH) is an important drug target due to its prominent role in pyrimidine biosynthesis. Leflunomide and brequinar are two well-known DHODH inhibitors, which bind to the enzyme in the same pocket with different binding modes. We have recently realized a series of new inhibitors based on the 4-hydroxy-1,2,5-oxadiazole ...
Millan N M - - 2012
It is well established that chromosomes occupy distinct positions within the interphase nuclei, conferring a potential functional implication to the genome. In addition, alterations in the nuclear organisation patterns have been associated with disease phenotypes (e.g. cancer or laminopathies). The human sperm is the smallest cell in the body with ...
Tang Nelson L S - - 2012
BACKGROUND: Breast cancer patients regularly undergo adjuvant chemotherapies following surgery. However, these treatments are largely associated with chemotherapeutic toxicities ranging from nausea to severe myelosuppression. In this investigation, we examined the effects of four SNPs in NR1I2, CYP3A4 and CYP3A5 genes on chemotherapy-induced severe neutropenia in 311 female Chinese breast ...
Paterson R Russell M - - 2012
Many fungi have significant industrial applications or biosafety concerns and maintaining the original characteristics is essential. The preserved fungi have to represent the situation in nature for posterity, biodiversity estimations, and taxonomic research. However, spontaneous fungal mutations and secondary metabolites affecting producing fungi are well known. There is increasing interest ...
Al-Herz Waleed - - 2012
Major Histocompatibility Complex (MHC) class II deficiency is a combined primary immunodeficiency disease that leads to overwhelming and recurrent infections. It was found to account for 19 % of combined immune deficiency cases in the National Primary Immunodeficiency Disorders Registry in Kuwait, a country with high prevalence of consanguinity. We present ...
Luhmann Andrew - - 2012
Carbon sequestration experiments were conducted on uncemented sediment and lithified rock from the Eau Claire Formation, which consisted primarily of K-feldspar and quartz. Cores were heated to accentuate reactivity between fluid and mineral grains and to force CO2 exsolution. Measured permeability of one sediment core ultimately reduced by four orders ...
An Rong Rong - - 2012
The influence of the elastic modulus of a tumor (EMT) on the laser-generated thermoelastic force source and ultrasound waves are investigated by using the finite element method. Taking into account the effects of thermal diffusion, optical penetration, and finite duration of laser pulse, the transient temperature distribution is obtained. Applying ...
Mudhar Hardeep Singh - - 2012
BACKGROUND/AIMS: A retrospective service evaluation identified seven patients who developed local conjunctival metastases (LCMs) of the conjunctiva after a primary diagnosis of conjunctival invasive melanoma. The study was conducted to identify the clinico-pathological characteristics and implications of these LCMs. METHODS: Seven patients with primary conjunctival melanoma seen by the ocular ...
Lomas R J - - 2012
The objective of this study was to design and test a protocol for the validation of banking methodologies for arterial allografts. A series of in vitro biomechanical and biological assessments were derived, and applied to paired fresh and banked femoral arteries. The ultimate tensile stress and strain, suture pullout stress ...
Ichida Hirofumi - - 2012
BACKGROUND: We assessed the benefit of hepatic and pulmonary resections in patients with liver and lung recurrences, respectively, after resection of esophageal carcinoma. METHODS: The study population consisted of 138 consecutive patients with recurrent esophageal carcinoma after esophagectomy conducted between 2003 and 2005. The pattern, timing of appearance, and the ...
Jetschke Sylvia - - 2012
We investigated the photodarkening (PD) kinetics of two fiber series with variation of the Yb content for constant Al concentration or constant ratio of Al/Yb, respectively. The results show the outstanding importance of the absolute value of Al concentration also in the case of fibers with strongly reduced Yb content. ...
Martini Paolo - - 2012
Despite a clear ability to detect temporal modulations of visual stimuli in excess of 50 Hz, temporal individuation and serial order judgment tasks can be performed only when stimuli alternate at much slower rates, and the nature of such sluggishness remains unclear. One example of a task with a slow temporal ...
Lee Jan Hau - - 2012
BACKGROUND: High flow nasal cannula (HFNC) systems utilize higher gas flow rates than standard nasal cannulae. The use of HFNC as a respiratory support modality is increasing in the infant, pediatric, and adult populations as an alternative to non-invasive positive pressure ventilation. OBJECTIVES: This critical review aims to: (1) appraise ...
Hewitt Gillian - - 2012
Participatory approaches are a popular and entrenched strategy in community development, yet a number of unresolved issues and tensions persist regarding the definition, rationales, outcomes and ethics of participation. Despite its popularity there are relatively few examples of participatory projects with older people or in institutional settings so their potential ...
Pae Chi-Un - - 2012
A number of different antidepressants, each with unique pharmacological profiles, are used for treatment of major depressive disorder (MDD); however, these drugs have been found in placebo-controlled, large practical clinical trials to have limited efficacy for achieving full recovery in MDD patients. In particular, when depressed patients have pain symptoms, ...
Lodde M - - 2012
OBJECTIVE: A second transurethral resection of the bladder (TURB) is recommended for high-grade bladder cancer (BC) yet yields negative results in over half of the cases. Aim of this study was to identify prognostic indicators of a positive second TURB or the need for a subsequent cystectomy. MATERIALS AND METHODS: ...
Jakovljevic Mihajlo B - - 2012
The past 23 years of post-socialist restructuring of health system funding and management patterns has brought many changes to small Balkan markets, putting them under increasing pressure to keep pace with advancing globalization. Socioeconomic inequalities in healthcare access are still growing across the region. This uneven development is marked by the ...
Sui Guo-Yuan - - 2012
BACKGROUND: Epidemiologists have recently investigated sunlight exposure as a risk factor for age-related macular degeneration (AMD), but there remains an ongoing dispute over this association due to insufficient evidence and unreliable data. OBJECTIVES: To analyse comprehensively the epidemiological literature concerning the association between AMD and sunlight exposure. METHODS: We systematically ...
Ippolito Davide - - 2012
PURPOSE: To assess the additional functional vascular information and the relationship between perfusion measurements and glucose metabolism (SUVmax) obtained by including a perfusion CT study in a whole-body contrast-enhanced PET/CT protocol in primary lung cancer lesions. METHODS: Enrolled in this prospective study were 34 consecutive patients with a biopsy-proven diagnosis ...
Peiró A M - - 2012
BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most abused recreational drugs. Its usual pattern of misuse includes repeated doses taken over a short time period that could influence MDMA pharmacology and toxicity. OBJECTIVE: This study aims to evaluate the pharmacokinetics and pharmacologically induced effects of two MDMA consecutive doses ...
Ye Liping - - 2012
The dimeric status of nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC) is obligatory for its catalyzing activity to synthesis the second messenger cyclic guanosine monophosphate (cGMP), which leads to vasodilatation. The present study was conducted to determine whether or not the dimerization of sGC is modulated by thiol-reducing agents and ...
Alemany R - - 2012
Soon after the discovery that viruses cause human disease, started the idea of using viruses to treat cancer. After the initial indiscriminate use, crude preparations of each novel virus in the early twentieth century, a second wave of virotherapy blossomed in the 60s with purified and selected viruses. Responses were ...
Teo Lynette L S - - 2012
Isolated cleft mitral valve (ICMV) is a rare entity not known to be related to pulmonary atresia with ventricular septal defect (PA-VSD). This report describes the use of cardiovascular magnetic resonance (CMR) imaging to diagnose ICMV in a patient with repaired PA-VSD who presented with incidental severe mitral regurgitation (MR) ...
Qiao Shigang - - 2012
PURPOSE: Delayed volatile anesthetic preconditioning (APC) can protect against myocardial ischemia/reperfusion (I/R) injury; the delayed phase is called the second window of protection (SWOP), but the underlying mechanism is unclear. Nuclear factor-κB (NF-κB) is involved in the myocardial protection conferred by APC in the acute phase; autophagy has been reported ...
Purevsuren Jamiyan - - 2012
Mitochondrial fatty acid oxidation (FAO) disorders are caused by defects in one of the FAO enzymes that regulates cellular uptake of fatty acids and free carnitine. An in vitro probe acylcarnitine (IVP) assay using cultured cells and tandem mass spectrometry is a tool to diagnose enzyme defects linked to most ...
Spence Scott E - - 2012
Straightforward novel methods for stabilizing, tuning, and controlling a twin Mach-Zehnder interferometer for the purpose of observing a subtle dynamical quantum nonlocality effect in a recent optical experiment are presented and discussed. Weak measurements were required for observing a subtle quantum dynamical nonlocality effect that reveals itself in a change ...
Baghdadi Muhammad - - 2012
Cancer vaccines have been developed to instruct the endogenous immune responses to autologous tumors and to generate durable clinical responses. However, the therapeutic benefits of cancer vaccines remain insufficient due to the multiple immunosuppressive signals delivered by tumors. Thus, to improve the clinical efficacy of cancer immunotherapy, it is important ...
Krasikova Alla - - 2012
Exploration into morphofunctional organisation of centromere DNA sequences is important for understanding the mechanisms of kinetochore specification and assembly. In-depth epigenetic analysis of DNA fragments associated with centromeric nucleosome proteins has demonstrated unique features of centromere organisation in chicken karyotype: there are both mature centromeres, which comprise chromosome-specific homogeneous arrays ...
Lv Xiaomei - - 2012
We constructed a biosynthetic pathway of isoprene production in Escherichia coli by introducing isoprene synthase (ispS) from Populus alba. 1-deoxy-D-xylulose 5-phosphate synthase (dxs), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr) and isopentenyl diphosphate (IPP) isomerase (idi) were overexpressed to enhance the isoprene production. The isoprene production was improved 0.65, 0.16, and 1.22 fold ...
Chen Cui - - 2012
PURPOSE: Platinum-based chemotherapy is the recognized first-line treatment for metastatic nasopharyngeal carcinoma (NPC). However, no standard treatment regimens have been established. This phase II study was designed to evaluate the efficacy and safety of a paclitaxel, cisplatin and 5-FU combination in metastatic and/or recurrent NPC. METHODS: Patients with evaluable metastatic ...
Davis Tessa - - 2012
PURPOSE: It is recognised that paediatric prescribing errors are prevalent, and that most are made by junior doctors; however, detecting errors in order to demonstrate actual error rates can be difficult. There is evidence to suggest that dosing errors are the most common type of prescribing error in practice, but ...
Nutaratat Pumin - - 2012
A Gram-negative, coccobacilli, non-spore forming and non-motile bacterium, designated PN1(T), was isolated from a banana leaf collected in Mattra island, Thailand. This isolate was observed to grow optimally at 30 °C and pH 7.0, and to grow with 0-3 % NaCl. Comparative 16S rRNA gene sequence analysis showed that strain PN1(T) is ...
Xu Peng - - 2012
This paper proposes an integral method to achieve a more accurate weighting matrix that makes very positive contributions to the image reconstruction in inertial confinement fusion research. Standard algebraic reconstruction techniques with a positivity constraint included are utilized. The final normalized mean-square error between the simulated and reconstructed projection images ...
Pilliar Robert M - - 2012
Porous calcium polyphosphate (CPP) is being investigated for fabrication of novel biodegradable bone substitutes. In this study, porous CPP implants formed by conventional CPP powder packing and using a two-step sinter/anneal process was used to form 20 and 30 vol % porous samples displaying relatively high strength. These were implanted ...
Mangold Stefanie - - 2012
Zinc can occur in extremely high concentrations in acidic, heavy metal polluted environments inhabited by acidophilic prokaryotes. Although these organisms are able to thrive in such severely contaminated ecosystems their resistance mechanisms have not been well studied. Bioinformatic analysis of a range of acidophilic bacterial and archaeal genomes identified homologues ...
Liu Xin - - 2012
PURPOSE: The aim was to assess the effects of a Tai Chi-based program on health-related quality of life (HR-QOL) in people with elevated blood glucose or diabetes who were not on medication for glucose control. METHOD: 41 participants were randomly allocated to either a Tai Chi intervention group (N = 20) or ...
Roy Soumyajit - - 2012
Giant cell tumour (GCT) constitutes about 5 % of all skeletal tumors. They rarely occur in the skull. When involved, they preferentially involve the sphenoid or temporal bones. Skull-base GCTs generally present with multiple cranial nerves involvement, most commonly sixth followed by the third cranial nerve. We describe a case of ...
Delort Estelle - - 2012
Oyster leaf (Mertensia maritima), also called vegetarian oyster, has a surprising oyster-like aroma. Its volatile composition was investigated here for the first time. In total, 109 compounds were identified by gas chromatography/mass spectrometry (GC/MS) and quantified by GC-FID. The use of GC-olfactometry on both polar and non-polar columns allowed us ...
Bauer Patricia J - - 2012
Memory is of fundamental importance for cognitive, social, and educational function, making it a target for neuropsychological assessment. The subject of this review is one particular type of memory, namely, episodic memory of unique events and experiences. Episodic memory allows for rapid, even one-trial learning of new information and retention ...
Chen J - - 2012
OBJECTIVE: von Hippel-Lindau (VHL) disease is a hereditary tumor syndrome predisposed to the development of tumors in a variety of body organs. The major etiopathogenesis of VHL is a mutation of the VHL tumor-suppressor gene on the short arm of chromosome 3 (3p25-26). We report on the clinical and molecular ...
Han Dongfei - - 2012
A gene encoding p-anisaldehdye dehydrogenase (PAADH), which catalyzes the oxidation of p-anisaldehdye to p-anisic acid, was identified to be clustered with the trans-anethole oxygenase (tao) gene in Pseudomonas putida JYR-1. Heterologously expressed PAADH in E. coli catalyzed the oxidation of vanillin, veratraldehyde and piperonal to the corresponding aromatic acids, vanillic ...
Figueras J - - 2012
PURPOSE: This prospective observational study assessed the efficacy of bevacizumab in combination with chemotherapy as preoperative treatment to downsize tumours for radical resection in patients with unresectable metastatic colorectal cancer (mCRC). PATIENTS/METHODS: Patients with mCRC initially unresectable according to predefined criteria were included. Preoperative treatment consisted of bevacizumab (5 mg/kg) combined ...
Bullingham Roy - - 2012
BACKGROUND: The nonsteroidal anti-inflammatory drug (NSAID) ketorolac tromethamine shows higher plasma concentrations and a longer plasma half-life in adults ≥65 years of age than in subjects aged <65 years, after intramuscular administration. An intranasal formulation of ketorolac tromethamine is approved for short-term treatment of moderate to moderately severe pain requiring analgesia at ...
Wright F L - - 2012
RATIONALE: Previous research suggests that the acute anorectic effect of cannabinoid CB1 receptor antagonist/inverse agonists may be secondary to response competition from the compulsive scratching and grooming syndrome characteristic of these agents. OBJECTIVES: As the pruritic effect of rimonabant can be attenuated by the opioid receptor antagonist naloxone, these studies ...
< 9 10 11 12 13 14 15 16 17 18 19 >