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McDermott Ryan - - 2012
Metastatic brain tumors provide a formidable obstacle in the survival of affected cancer patients, an obstacle that current treatment is essentially ineffective against. Our understanding of the metastatic cascade has demonstrated the role of incorrectly regulated protein expression and proved it to be a crucial component of this process. Recently, ...
Levine R - - 2012
The prevalence of overweight and obesity is rising in many developed and developing countries and, most worryingly, among children. Within the EU, Scotland has the highest prevalence, more than twice that of the Netherlands, and in England almost a quarter of children now enter primary school either overweight or obese, ...
Polidori Andrea - - 2012
A study was conducted to investigate the effectiveness of three air purification systems in reducing the exposure of children to air contaminants inside nine classrooms of three Southern California schools. Continuous and integrated measurements were conducted to monitor the indoor and outdoor concentrations of ultrafine particles (UFPs), fine and coarse ...
Cao Xingjian - - 2012
C-terminal binding protein 2 (CtBP2), as a transcriptional repressor, plays an essential role in development and tumorigenesis. However, its distribution and function in peripheral system lesion and repair are still unknown. Here, we investigated the spatiotemporal expression of CtBP2 in rat sciatic nerve crush model. Western blot analysis revealed that ...
Gupta Renu - - 2012
Axial dispersion is an important parameter in the performance of packed bed reactors. A lot of fluids exhibit non-Newtonian behaviour but the effect of rheological parameters on axial dispersion is not available in literature. The effect of rheology on axial dispersion has been analysed for viscoinelastic and viscoelastic non-Newtonian fluids. ...
Ragnarson Tennvall Gunnel - - 2012
Biological drugs are expensive, but can reduce symptoms and increase quality of life for patients with psoriasis. The aim of this study was to examine quality of life, disease severity and treatment satisfaction in Danish, Finnish and Swedish patients with psoriasis. Based on 12 months' data from patient surveys and ...
Kang Eun-Ju - - 2012
OBJECTIVES: To evaluate the feasibility of free-breathing coronary computed tomography angiography (CCTA) in adults using with a 320-detector multidetector CT (MDCT). METHODS: In 74 patients who underwent CCTA, 37 CCTA examinations were performed during free-breathing, and the remaining 37 CCTA examinations were produced with the standard breath-holding method. The quality ...
Withers Mellissa - - 2012
The challenges of meeting global health care needs in communities throughout the developing world are becoming increasingly complex. Understanding what motivates volunteers is important for organizations that seek to harness and develop long-term volunteers in order to meet the need for global health care services. Here we report a case ...
Davis John W - - 2012
It is now established that an experienced, dedicated robotic surgeon can perform a high quality extended template pelvic lymph node dissection at the time of robot-assisted radical cystectomy. The evidence for this conclusion can be seen in comparing absolute lymph node counts, percent positive lymph nodes, and oncologic outcomes from ...
Gaudana Ripal - - 2012
Formulation development of protein therapeutics using polymeric nanoparticles has found very little success in recent years. Major formulation challenges include rapid denaturation, susceptibility to lose bioactivity in presence of organic solvents and poor encapsulation in polymeric matrix. In the present study, we have prepared hydrophobic ion pairing (HIP) complex of ...
He Jing - - 2012
The motilin receptor gene was lost in the ancestral lineage of rodents. Subsequently, the gene encoding its ligand, motilin, has experienced different evolutionary fates. Previous genomic analyses had shown that the motilin gene (MLN) became a pseudogene independently in the lineages leading to the guinea pig and the common ancestor ...
Becker-Finco A - - 2012
SUMMARY The factors that characterize Acanthamoeba strains as harmless or potentially pathogenic have not been elucidated. Analysing the in vitro and in vivo parameters of Acanthamoeba samples, including heat tolerance at temperatures close to that of the human body, cytopathic effects, and their ability to cause infections in animals, has ...
Ghadi Fereshteh Ezzati - - 2012
PURPOSE: The present study was conducted to elucidate the potential of selenium supplementation, if any, in affording chemoprevention by modulating the altered cancer markers and ultrastructural changes in dimethyl hydrazine (DMH)-induced colorectal carcinogenesis in rats. METHODS: The rats were segregated into four groups, viz., normal control, DMH treated, selenium treated, ...
Yang En-Cui - - 2012
Four magnetic samples with different building blocks and dimensionalities, {[Cu(4)(atr)(2)(μ(3)-OH)(2)(sip)(2)]·4H(2)O}(n) (), {[Cu(4)(atr)(2)(H(2)O)(8)(μ-OH)(2)(sip)(2)]·1.3CH(3)OH·0.7H(2)O}(n) (), {[Cu(3)(atr)(4)(H(2)O)(2)(sip)(2)]·4H(2)O}(n) () and {[Cu(3)(atr)(4)(H(2)O)(2)(μ(3)-OH)(sip)(Hsip)]·2CH(3)OH·2.75H(2)O}(n) () (atr = 4-amino-1,2,4-triazole and sip(3-) = 5-sulfoisophthalate), were obtained and characterized structurally and magnetically. Complex exhibits a three-dimensional (3D) robust framework with butterfly-like Cu(II)(4) clusters periodically extended by tetratopic sip(3-) connectors. Complex ...
Eichholzer Monika - - 2013
The aim of this study is to evaluate racial variation in umbilical cord blood concentration of vitamin D and to explore its correlation with markers of the insulin-like growth factor axis (IGFs) and sex steroid hormones in white and black male neonates. In 2004-2005, venous umbilical cord blood samples were ...
Bliksrud Yngve T - - 2012
Hereditary tyrosinemia type I (HT1) is an autosomal recessive disease caused by a deficiency in human fumarylacetoacetate (FAA) hydrolase (FAH), which is the last enzyme in the catabolic pathway of tyrosine. Several reports suggest that intracellular accumulation of intermediates of tyrosine catabolism, such as FAA and succinylacetone (SA) is important ...
Gabudean A M - - 2012
Surface-enhanced Raman scattering (SERS) nano-tags are of increasing interest in biomedical research as viable alternatives to bio-imaging techniques based on semiconductor quantum dots or fluorescent molecules. In this work, we fabricate silica-coated gold nanorods (AuNRs) encoded with two molecular labels to operate as highly effective spectroscopic nano-tags in near-infrared SERS ...
Pescosolido N - - 2012
AIM: To establish a threshold value of intraocular pressure (IOP) increase after the closed-eyelid test (CET) that correlates with the highest probability of developing overt primary open-angle glaucoma (OAG) in an Italian native population from 1980 to 2010. METHODS: Retrospective analysis of data obtained from 161 patients with ocular hypertension ...
Dib Julián Rafael - - 2012
Micrococci are Gram-positive G + C-rich, nonmotile, nonspore-forming actinomycetous bacteria. Micrococcus comprises ten members, with Micrococcus luteus being the type species. Representatives of the genus play important roles in the biodegradation of xenobiotics, bioremediation processes, production of biotechnologically important enzymes or bioactive compounds, as test strains in biological assays for lysozyme and ...
Magari Tomohiro - - 2012
Abstract Objective. This study examined the effects of androgen deprivation on bladder blood flow (BBF) and bladder function during the acute phase in castrated rats. Material and methods. Nine-week-old male Wistar rats were divided into six groups as follows: 24 h post-sham-operation (24hPS), no operation (control), 24 h post-castration (24hPC), ...
Sirignano P - - 2012
AIM:Litigation concerning medical activities is constantly increasing, as society becomes more and more "protective" of citizens who may have suffered any wrong due to malpractice. However, we should bear in mind that the percentage of claims liquidated is minimal. METHODS: From January 2009 to December 2011, 63 claims involving vascular ...
Pazahr Shila S Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Rämistr. 100, 8091 Zurich, Switzerland. - - 2013
To assess the feasibility of magnetization transfer (MT) imaging of the bowel wall in patients with Crohn's disease (CD), and to evaluate its utility for the detection of intestinal fibrosis. In this prospective study, 31 patients (age 39.0 ± 13.2 years) with CD were examined in a 1.5T MR scanner. To establish a ...
Zhang Hui - - 2012
Abstract Objectives. Recent epidemiological studies suggest that metformin treatment may reduce the risks of cancer and overall cancer mortality among patients with diabetes mellitus (DM). However, data on hepatocellular carcinoma (HCC) are very limited and inconsistent. This meta-analysis was designed to pool data currently available to determine the association between ...
An Chansik - - 2012
OBJECTIVES: To determine the importance of arterial enhancement in diagnosing small (<3 cm) hepatocellular carcinomas (HCCs) and to evaluate the added value of dynamic subtraction magnetic resonance imaging (MRI) in detecting arterial enhancement in small (<3 cm) hepatic nodules in high-risk patients. METHODS: Eighty-six patients with 135 pathologically confirmed small (<3 cm) hepatic ...
Ruan Zhi-Ping - - 2012
Although Bmi1 is well established as one of the most commonly activated oncogenes, the precise role of Bmi1 during hepatocarcinogenesis remains unclear. In addition, Bmi1 provides a potential therapeutic target for the future treatment of hepatocellular carcinoma (HCC). In this study, the expression of Bmi1 in HCC tissues was evaluated ...
Flaig Benno B Institute of Forensic Medicine, Goethe-University, Kennedyallee 104, 60596 Frankfurt/Main, Germany. - - 2013
In international epidemiological studies, associations between suicides and body height, or body mass index (BMI) were found. Because of the recently growing number of suicides in Germany, a closer look on different anthropometric measures of suicide victims autopsied at the Institute of Forensic Medicine of the Goethe-University in Frankfurt/Main, Germany, ...
Bernardo P L - - 2012
Among double perovskites, the interpretation of the magnetic, thermal and transport properties of Sr(2)YRuO(6) remains a challenge. Characterization using different techniques reveals a variety of features that are not understood, described as anomalous, and yields contradictory values for several relevant parameters. We solved this situation through detailed susceptibility, specific heat, ...
Unyó C - - 2012
BACKGROUND:Strength training has been proposed by several authors to treat Lateral Epicondylitis. However, there is still a lack of information concerning muscle weakness and its relationship to imbalances and fatigability of forearm muscles during dynamic conditions in subjects after epicondylitis recovery. AIM:To analyze the relationship between lateral humeral epicondylitis, and ...
Peng Judy - - 2012
Biotechnology Journal talks to Prof. Stanley Cohen after his plenary lecture at the International Biotechnology Symposium, Sept 2012, in Daegu, Korea.
Arata Satoru - - 2012
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide expressed widely in nervous tissues. PACAP-knockout ((-/-) ) mice display a sudden infant death syndrome (SIDS)-like phenotype, although the underlying physiological mechanism to explain this remains unclear. Here, we report on the presence of abnormal respiratory activity in PACAP(-/-) mice under hypoxic ...
Pape┼żíková Ivana - - 2012
ABSTRACT Endothelial dysfunction characterized by decreased nitric oxide (NO) bioavailability is the first stage of coronary artery disease. It is known that one of the factors associated with an increased risk of coronary artery disease is a high plasma level of uric acid. However, causative associations between hyperuricaemia and cardiovascular ...
Li Qinmin - - 2012
In order to find the correlation between transgelin gene (TAGLN) and colorectal carcinoma occurrence, we investigated the expression of TAGLN in colorectal carcinoma tissue samples and colorectal carcinoma LoVo cells. Meanwhile, the effects of TAGLN on the characteristics of LoVo cells were also examined. The expressions of TAGLN in colorectal ...
Melin Céline - - 2012
Specialized primary afferents, although they terminate in different laminae within the dorsal horn (DH), are known to interact through local circuit excitatory and inhibitory neurons. That a loss of segmental inhibition probably contributes to persistent pain hypersensitivity during chronic pain raises the question as to how disinhibition-induced changes in cross-modal ...
Jiao Yong-Gang - - 2012
Dopamine receptor 1 (D(1)R) plays an essential role in regulating respiratory activity in mammals, however, little is known about how this receptor acts to modulate the basic respiratory rhythmogenesis. Here, by simultaneously recording the discharge activities of biphasic expiratory (biphasic E) neurons/inspiratory (I) neurons and the XII nerve rootlets from ...
Chakkalakal Rosette J RJ Division of General Internal Medicine and Public Health, Department of Internal Medicine, Vanderbilt University School of Medicine, 1215 21st Ave South, 6000 Medical Center East, NT, Nashville, TN 37232-8300, USA. - - 2013
Physical examination remains an important part of the initial evaluation of patients presenting with chest pain but little is known about the effect of patient gender on physician performance of the cardiovascular exam. To determine if resident physicians are less likely to perform five key components of the cardiovascular exam ...
Domanico D - - 2012
X-linked Retinoschisis is a bilateral retinal disease with a recessive X-linked inheritance, characterized by a macular involvement. Maculopathy consists of bilateral star-shaped microcystic changes. Peripheral retina is sometimes involved with schisis. In two years, were examined 10 eyes of 5 male patients (age range 20-25 years old) with X-linked Juvenile ...
Wallerstedt Anna - - 2012
Abstract Objective. The aim of this study was to identify preoperative patient and tumour-related factors associated with 12 months postoperative urinary incontinence. Material and methods. In total, 1529 men who had undergone radical prostatectomy for clinically localized prostate cancer between September 2008 and February 2010 at 15 Swedish hospitals completed ...
Blythe Karole L - - 2012
Ground state depletion with individual molecule return (GSDIM) is used to interrogate the location of individual fluorescence bursts from fluorophore-labelled DNA molecules on gold nanowire surfaces. Carboxytetramethyl rhodamine (TAMRA)-labelled double-stranded DNA molecules were bound to the surface of gold nanowires via gold-thiol linkages. Individual fluorescence bursts were spatially localized using ...
Aguayo Víctor M - - 2012
OBJECTIVE: To assess the effectiveness of facility-based care for children with severe acute malnutrition (SAM) in malnutrition treatment centres (MTC). DESIGN: Early detection and treatment of SAM using locally adapted protocols; assessment of programme outcomes, including survival, default, discharge and recovery rates. SETTING: All forty-eight MTC in Jharkhand, India. SUBJECTS: ...
Li Qi - - 2012
A novel fabrication method of polymer tubes with simple operation process and high yield is presented. N,N'-methylene bisacrylamide (MBA) polymer microtubes are fabricated via reversible addition-fragmentation chain transfer (RAFT) polymerization using MBA self-assembled fibers as both the template and monomer source. The resulting products are characterized by SEM, TEM, FTIR, ...
Ye Zi-Piao - - 2012
Models describing the light response of photosynthetic electron transport rate (ETR) are routinely used to determine how light absorption influences energy, reducing power and yields of primary productivity; however, no single model is currently able to provide insight into the fundamental processes that implicitly govern the variability of light absorption. ...
Manzotte Thais - - 2012
Human leucocyte antigen (HLA) DQB1*0602 allele, a well-known genetic risk factor for narcolepsy, has been associated with sleep parameters in healthy subjects. We aimed to assess the association of this allele with daytime sleepiness and altered sleep electroencephalogram characteristics in the general population and in patients with obstructive sleep apnoea ...
Buhrman M - - 2012
BACKGROUND: Chronic pain can be treated with cognitive behavioural therapy delivered in multidisciplinary settings. However, relapse is likely, and there is a need for cost-effective secondary interventions for persons with residual problems after rehabilitation. The aim of the present study was to investigate the effects of a guided Internet-delivered cognitive ...
Wu Miao - - 2012
Methylumbelliferyl-β-cellobioside (MUF -G2) is a convenient fluorogenic substrate for certain β-glycoside hydrolases ( GH ). However, hydrolysis of the aglycone is poor with GH family 6 enzymes ( GH6), despite strong binding. Prediction of the orientation of the aglycone of MUF -G2 in the +1 subsite of Hypocrea jecorina Cel6A ...
Yazdankhah Kenary A - - 2012
PURPOSE: The aim of the present randomized clinical trial was to compare feeling of a foreign body and the early and late outcomes after inguinal hernia repair with the heavyweight (HW) mesh and lightweight (LW) mesh during a 12-month follow-up at a single specialist center. MATERIALS AND METHODS: One hundred ...
Loughlin Kevin R - - 2012
The implications of the article by Anderson et al go far beyond monitoring of cystoscopies. We are in an era of a growing doctor shortage and retrenched healthcare budgets. There will be an increased need for innovative approaches to deliver healthcare more efficiently and economically. There are at least three ...
Drakesmith Hal H Molecular Immunology Group and Medical Research Council (MRC) Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK. - - 2012
Iron lies at the center of a battle for nutritional resource between higher organisms and their microbial pathogens. The iron status of the human host affects the pathogenicity of numerous infections including malaria, HIV-1, and tuberculosis. Hepcidin, an antimicrobial-like peptide hormone, has emerged as the master regulator of iron metabolism. ...
Pescosolido N - - 2012
AIM: To investigate the effect of luminance variations, as well as the oral administration of a food supplement, on the visual bioelectric response while using of Night Vision Goggles (NVG). METHODS: Two trials were performed, both enrolling healthy male aircrew members wearing NVG, and recording Visual Evoked Potentials (VEPs) from ...
Birnbaum Monica S - - 2012
Kornell and Bjork (Psychological Science 19:585-592, 2008) found that interleaving exemplars of different categories enhanced inductive learning of the concepts based on those exemplars. They hypothesized that the benefit of mixing exemplars from different categories is that doing so highlights differences between the categories. Kang and Pashler (Applied Cognitive Psychology ...
Mullen Michael T - - 2012
BACKGROUND: Seizures are common after intracerebral hemorrhage (ICH) but their impact on outcome is uncertain and prophylactic anti-convulsant use is controversial. We hypothesized that seizures would not increase the risk of in-hospital mortality in a large administrative database. METHODS: The study population included patients in the 2006 Nationwide Inpatient Sample ...
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