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Christensen Niels Peter Aae - - 2012
PURPOSE: To investigate the heating-induced dehydration and melting behavior of the trihydrate phase of the calcium salt of atorvastatin. METHODS: Multivariate curve resolution (MCR) was used to decompose a variable-temperature synchrotron X-ray powder diffraction (VT-XRPD) data matrix into diffraction patterns and concentration profiles of pure drug phases. RESULTS: By means ...
Dave Richa - - 2012
Thiol metabolism is the primary detoxification strategy by which rice plants tolerate arsenic (As) stress. In light of this, it is important to understand the importance of harmonised thiol metabolism with As accumulation and tolerance in rice plant. For this aim, tolerant (T) and sensitive (S) genotypes were screened from ...
McColl Helen - - 2012
Little is known about the nutritional status of pregnant women with severe mental illness. We therefore carried out a systematic review to investigate whether pregnant women and childbearing aged women with severe mental illness have significantly greater nutritional deficiencies compared with pregnant women and childbearing aged women with no mental ...
Wesselius Anke - - 2012
In the present study we investigated whether single nucleotide polymorphisms (SNPs) in the P2RX ( 4 ), which alter the P2X ( 4 ) R function, are associated with the development of osteoporosis and whether an interaction between the P2X ( 4 ) R and P2X ( 7 ) R ...
Shetty Ritu A - - 2012
Coenzyme Q10 (CoQ) is widely available as a dietary supplement and remains under consideration as a treatment for age-associated neurodegenerative conditions. However, no studies have determined if supplementation, initiated relatively late in life, could have beneficial effects on mild functional impairments associated with normal brain aging. Accordingly, the current study ...
Al-Khashman Omar Ali - - 2012
Wet atmospheric samples were collected from different locations in the southern region of Jordan during a 5-year period (October 2006 to May 2011). All samples were analyzed for pH, EC, major ions (Ca(2+), Mg(2+), Na(+), K(+), HCO(3) (-), Cl(-), NO(3) (-), and SO(4) (2-)), and trace metals (Fe(2+), Al(3+),Cu(2+), Pb(2+), ...
Jafari Najmeh - - 2012
PURPOSE: Psychological distress and morbidity are common consequences of diagnosis and treatment of breast cancer and associated with poor quality of life (QOL). Spiritual well-being is an important aspect of QOL, but little is known about the spiritual well-being and its relationship with QOL in patients of different cultures such ...
Itoh Soichiro - - 2012
This study was performed to investigate the effects of the co-administration of proton pump inhibitor (PPI) on the efficacy of bisphosphonate (BP) treatment for osteoporosis. A total of 180 women with low bone mineral density were randomly divided into four groups, one in which sodium risedronate was administered with sodium ...
Bancroft Tyler D - - 2012
The encoding of irrelevant stimuli into the memory store has previously been suggested as a mechanism of interference in working memory (e.g., Lange & Oberauer, Memory, 13, 333-339, 2005; Nairne, Memory & Cognition, 18, 251-269, 1990). Recently, Bancroft and Servos (Experimental Brain Research, 208, 529-532, 2011) used a tactile working ...
Kuntz Ludwig - - 2012
In a hospital environment that demands a careful balance between commercial and clinical interests, the extent to which physicians are involved in hospital leadership varies greatly. This paper assesses the influence of the extent of this involvement on staff-to-patient ratios. Using data gathered from 604 hospitals across Germany, this study ...
Kocaeli Hasan - - 2012
BACKGROUND: The artery of Percheron (AOP) is a single thalamoperforating arterial trunk that provides bilateral supply to the paramedian thalami and the rostral midbrain. As this rare anatomical variant artery may be involved in endovascular procedures or encountered surgically during basilar terminus aneurysms, the present study was warranted. METHOD: Thirty-four ...
Rades D - - 2012
BACKGROUND: To create a validated scoring system predicting survival of breast cancer patients with metastatic spinal cord compression (MSCC). PATIENTS AND METHODS: Of 510 patients, one half were assigned to either the test or the validation group. In the test group, eight pretreatment factors (age, performance status, number of involved ...
Lee Woan-Ruoh - - 2012
PURPOSE: To evaluate skin permeation enhancement mediated by fractional laser for different permeants, including hydroquinone, imiquimod, fluorescein isothiocyanate-labeled dextran (FD), and quantum dots. METHODS: Skin received a single irradiation of a fractional CO(2) laser, using fluence of 2 or 4 mJ with densities of 100 ∼ 400 spots/cm(2). In vitro and in ...
Gessi Marco - - 2012
Primary Hodgkin's lymphomas of the central nervous system (CNS) as well as cerebral involvement as the first manifestation of a systemic Hodgkin's disease are very rare. CNS involvement usually occurs in patients with advanced or relapsing systemic disease. Because primary CNS Hodgkin's lymphoma may present unexpected and sometimes misleading clinical ...
Arenas da Silva L F - - 2012
For patients with lower urinary tract symptoms (LUTS), α1-adrenoreceptor inhibitors and 5-alpha reductase inhibitors as well as their combination are considered the gold standard. In addition, anticholinergic agents are being introduced as monotherapy or in combination with α1-adrenocepetor inhibitors for patients with predominant storage disorders. Phosphodiesterase 5 (PDE5) inhibitors are ...
Dubinska-Magiera Magda - - 2012
The aim of this review article is to evaluate the current knowledge on associations between muscle formation and regeneration and components of the nuclear lamina. Lamins and their partners have become particularly intriguing objects of scientific interest since it has been observed that mutations in genes coding for these proteins ...
da Rosa João Carlos Fraga - - 2013
The gas station attendants are exposed daily to chemical agents that compose gasoline, such as BTEX (benzene, toluene, ethylbenzene, and xylene), and the exposure to these agents can cause a variety of effects on the human health. Among the various possible cell alterations associated with these exposures are the formation ...
El-Sherbeni Ahmed A - - 2013
Cytochrome P450 (P450)-derived arachidonic acid (AA) metabolites serve pivotal physiological roles. Therefore, it is important to determine the dominant P450 AA monooxygenases in different organs. We investigated the P450 AA monooxygenases protein expression as well as regioselectivity, immunoinhibition, and kinetic profile of AA epoxygenation and hydroxylation in rat heart, lung, ...
Heimbach Tycho - - 2013
Practical food effect predictions and assessments were described using in silico, in vitro, and/or in vivo preclinical data to anticipate food effects and Biopharmaceutics Classification System (BCS)/Biopharmaceutics Drug Disposition Classification System (BDDCS) class across drug development stages depending on available data: (1) limited in silico and in vitro data in ...
Weber Benjamin - - 2013
The pharmacokinetic (PK) behavior of inhaled drugs is more complicated than that of other forms of administration. In particular, the effects of certain physiological (mucociliary clearance and differences in membrane properties in central and peripheral (C/P) areas of the lung), formulation (as it relates to drug deposition and particle dissolution ...
Perez Ruixo Juan Jose - - 2013
While therapeutic proteins (TP), particularly recombinant human proteins and fully human monoclonal antibodies, are designed to have a low immunogenic potential in humans, a clinical immune response does sometimes occur and cannot be predicted from preclinical studies. Changes in TP pharmacokinetics may be perceived as an early indication of antibody ...
Feller Julian J OrthoSport Victoria, Richmond, VIC, Australia. - - 2013
Rates of return to pre-injury sport following anterior cruciate ligament (ACL) reconstruction are less than might be expected from standard outcome measures and there appears to be a rapid decline in sporting participation after two to three years. There are many factors that influence whether an individual will return to ...
Levine R - - 2012
The prevalence of overweight and obesity is rising in many developed and developing countries and, most worryingly, among children. Within the EU, Scotland has the highest prevalence, more than twice that of the Netherlands, and in England almost a quarter of children now enter primary school either overweight or obese, ...
Polidori Andrea - - 2012
A study was conducted to investigate the effectiveness of three air purification systems in reducing the exposure of children to air contaminants inside nine classrooms of three Southern California schools. Continuous and integrated measurements were conducted to monitor the indoor and outdoor concentrations of ultrafine particles (UFPs), fine and coarse ...
Cao Xingjian - - 2012
C-terminal binding protein 2 (CtBP2), as a transcriptional repressor, plays an essential role in development and tumorigenesis. However, its distribution and function in peripheral system lesion and repair are still unknown. Here, we investigated the spatiotemporal expression of CtBP2 in rat sciatic nerve crush model. Western blot analysis revealed that ...
Gupta Renu - - 2012
Axial dispersion is an important parameter in the performance of packed bed reactors. A lot of fluids exhibit non-Newtonian behaviour but the effect of rheological parameters on axial dispersion is not available in literature. The effect of rheology on axial dispersion has been analysed for viscoinelastic and viscoelastic non-Newtonian fluids. ...
Ragnarson Tennvall Gunnel - - 2012
Biological drugs are expensive, but can reduce symptoms and increase quality of life for patients with psoriasis. The aim of this study was to examine quality of life, disease severity and treatment satisfaction in Danish, Finnish and Swedish patients with psoriasis. Based on 12 months' data from patient surveys and ...
Kang Eun-Ju - - 2012
OBJECTIVES: To evaluate the feasibility of free-breathing coronary computed tomography angiography (CCTA) in adults using with a 320-detector multidetector CT (MDCT). METHODS: In 74 patients who underwent CCTA, 37 CCTA examinations were performed during free-breathing, and the remaining 37 CCTA examinations were produced with the standard breath-holding method. The quality ...
Withers Mellissa - - 2012
The challenges of meeting global health care needs in communities throughout the developing world are becoming increasingly complex. Understanding what motivates volunteers is important for organizations that seek to harness and develop long-term volunteers in order to meet the need for global health care services. Here we report a case ...
Davis John W - - 2012
It is now established that an experienced, dedicated robotic surgeon can perform a high quality extended template pelvic lymph node dissection at the time of robot-assisted radical cystectomy. The evidence for this conclusion can be seen in comparing absolute lymph node counts, percent positive lymph nodes, and oncologic outcomes from ...
Gaudana Ripal - - 2012
Formulation development of protein therapeutics using polymeric nanoparticles has found very little success in recent years. Major formulation challenges include rapid denaturation, susceptibility to lose bioactivity in presence of organic solvents and poor encapsulation in polymeric matrix. In the present study, we have prepared hydrophobic ion pairing (HIP) complex of ...
He Jing - - 2012
The motilin receptor gene was lost in the ancestral lineage of rodents. Subsequently, the gene encoding its ligand, motilin, has experienced different evolutionary fates. Previous genomic analyses had shown that the motilin gene (MLN) became a pseudogene independently in the lineages leading to the guinea pig and the common ancestor ...
Becker-Finco A - - 2012
SUMMARY The factors that characterize Acanthamoeba strains as harmless or potentially pathogenic have not been elucidated. Analysing the in vitro and in vivo parameters of Acanthamoeba samples, including heat tolerance at temperatures close to that of the human body, cytopathic effects, and their ability to cause infections in animals, has ...
Ghadi Fereshteh Ezzati - - 2012
PURPOSE: The present study was conducted to elucidate the potential of selenium supplementation, if any, in affording chemoprevention by modulating the altered cancer markers and ultrastructural changes in dimethyl hydrazine (DMH)-induced colorectal carcinogenesis in rats. METHODS: The rats were segregated into four groups, viz., normal control, DMH treated, selenium treated, ...
Yang En-Cui - - 2012
Four magnetic samples with different building blocks and dimensionalities, {[Cu(4)(atr)(2)(μ(3)-OH)(2)(sip)(2)]·4H(2)O}(n) (), {[Cu(4)(atr)(2)(H(2)O)(8)(μ-OH)(2)(sip)(2)]·1.3CH(3)OH·0.7H(2)O}(n) (), {[Cu(3)(atr)(4)(H(2)O)(2)(sip)(2)]·4H(2)O}(n) () and {[Cu(3)(atr)(4)(H(2)O)(2)(μ(3)-OH)(sip)(Hsip)]·2CH(3)OH·2.75H(2)O}(n) () (atr = 4-amino-1,2,4-triazole and sip(3-) = 5-sulfoisophthalate), were obtained and characterized structurally and magnetically. Complex exhibits a three-dimensional (3D) robust framework with butterfly-like Cu(II)(4) clusters periodically extended by tetratopic sip(3-) connectors. Complex ...
Bliksrud Yngve T - - 2012
Hereditary tyrosinemia type I (HT1) is an autosomal recessive disease caused by a deficiency in human fumarylacetoacetate (FAA) hydrolase (FAH), which is the last enzyme in the catabolic pathway of tyrosine. Several reports suggest that intracellular accumulation of intermediates of tyrosine catabolism, such as FAA and succinylacetone (SA) is important ...
Gabudean A M - - 2012
Surface-enhanced Raman scattering (SERS) nano-tags are of increasing interest in biomedical research as viable alternatives to bio-imaging techniques based on semiconductor quantum dots or fluorescent molecules. In this work, we fabricate silica-coated gold nanorods (AuNRs) encoded with two molecular labels to operate as highly effective spectroscopic nano-tags in near-infrared SERS ...
Kheirandish R - - 2012
This study was set to investigate whether the adverse effects of long-term copper (Cu) consumption on testicular tissue could be prevented by zinc (Zn) administration. Forty-five mature male rats were randomly divided into one control and two treatment groups. The first treatment group received copper sulfate (Cu experimental group). The ...
Wang Ian J - - 2012
Investigating the properties of ecological landscapes that influence gene flow among populations can provide key insights into the earliest stages of biological divergence. Both ecological and geographical factors can reduce gene flow, which can lead to population divergence, but we know little of the relative strengths of these phenomena in ...
Gilbert Emilee - - 2012
Research has increasingly recognised the profound impact that cancer can have upon embodied subjectivity. However, there has been little acknowledgement of the centrality of sexuality to subjectivity, and marginalisation of the experiences of intimate partners of people with cancer. This Australian qualitative study explores the post-cancer experiences of embodied sexual ...
Beck Kathryn L - - 2012
PURPOSE: To investigate associations between dietary patterns and suboptimal iron status in premenopausal women living in Auckland, New Zealand. METHODS: Premenopausal women (n = 375; 18-44 years) were included in this cross-sectional analysis. Suboptimal iron status was defined as serum ferritin <20 μg/L. Participants completed a 144-item iron food frequency questionnaire (FeFFQ) and a ...
Mantri Sneha S - - 2012
OBJECTIVES: The aim of this study was to evaluate Candida colonisation in the dentures with silicone soft liner in diabetic and non-diabetic patients and to assess the antifungal efficacy of chlorhexidine gluconate on Candida colonies. MATERIALS AND METHODS: Thirty patients with resorbed ridges, fifteen each in the diabetic and non-diabetic ...
Dumond Jarrett J - - 2012
UV roll-to-roll nanoimprinting at high resolution is still a relatively unexplored field of study with far-reaching application potential. One enabling technology that is particularly worthy of attention is mass production of high resolution resin moulds via UV roll-to-roll nanoimprinting at such high throughput and low cost that they can be ...
Luo Jian - - 2012
A novel dinuclear platinum complex of (dfppy-mhb-dfppy)Pt(2)(acac)(2) was synthesized and characterized, where dfppy-mhb-dfppy is a binary C^N cyclometalated ligand containing two bridged 2,4-difluorophenylpyridine (dfppy) units and acac is 2,4-pentanedione anion. Compared to previously reported dinuclear platinum complexes with a binary ancillary ligand, this dinuclear platinum complex showed more intense excimer ...
Geldhof G John - - 2012
The positive youth development perspective, a strength-based relational developmental systems model that focuses on mutually influential relationships between individuals and contexts, has been used to study thriving across the second decade of life. However, more attention has been paid empirically to identifying the features of the individual (e.g., intentional self ...
van Bergen Christiaan J A - - 2012
Osteochondral defects of the talus pose a difficult therapeutic challenge. An experimental animal model of the ankle joint is not available. The aim of this study was to test a newly developed animal model for osteochondral defects of the ankle in vivo. Osteochondral defects were created in the talus of ...
Mueller F - - 2012
BACKGROUND: This study was initiated to assess the quantitative impact of patient anthropometrics and dihydropyrimidine dehydrogenase (DPYD) mutations on the pharmacokinetics (PK) of 5-fluorouracil (5FU) and to explore limited sampling strategies of 5FU. PATIENTS AND METHODS: We included 32 patients with gastrointestinal malignancies, receiving 46-h continuous-infusional 5FU and performed PK-sampling ...
Nakamichi Kazuo - - 2012
Progressive multifocal leukoencephalopathy (PML) is caused by JC polyomavirus (JCV) infection in the brain. JCV isolates from PML patients have variable mutations in the non-coding control region (NCCR) of the genome. This study was conducted to examine sequential changes in NCCR patterns of JCV isolates obtained from the cerebrospinal fluid ...
Rodrigues Juan R - - 2012
Context: Characterization of the pro-oxidant activity of QNACR. Objectives: Reactive oxygen species (ROS) induce cellular damage and represent unique opportunities to kill malignant cells. In this study, we synthesized and evaluated the new compound, (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate (QNACR) as potential pro-oxidative agent against breast cancer. Methods: Oxidative stress biomarkers such ...
Kirk Benjamin B - - 2012
The phenylperoxyl radical has long been accepted as a critical intermediate in the oxidation of benzene and an archetype for arylperoxyl radicals in combustion and atmospheric chemistry. Despite being central to many contemporary mechanisms underpinning these chemistries, reports of the direct detection or isolation of phenylperoxyl radicals are rare and ...
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