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Results 701 - 750 of 2645
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Ross-Hansen K - - 2012
Background:  While contact sensitization is frequent in the general population and arises from excessive or repeated skin exposure to chemicals and metals, little is known about genetic susceptibility. Objectives:  To determine the role of glutathione s-transferases (GST) and claudin-1 (CLDN1) gene polymorphisms on the risk of contact sensitization taking common ...
Yang Hongfang - - 2012
Graphene oxide has attracted intense research interest recently because the graphene oxide synthesis route, as a promising alternative for cost-effective mass production of graphene, has been explored. To further study the oxidation process and possible mechanism and to explore applicability of the oxidized products, we have performed a computational study ...
Amenta Simona - - 2012
BACKGROUND: Previous research has shown that deficits in the domain of emotions strongly characterize alcoholism. Patients diagnosed with alcoholism show impairments in emotional mimic recognition, as well as in the domain of emotional prosody. These data suggest that male alcoholics might suffer from a generalized emotional impairment associated with dysfunctions ...
Fernández-Pérez Francisco - - 2012
Context: Catharanthus roseus (L.) G. Don (Apocynaceae) is a medicinal plant that produces more than 130 alkaloids, with special attention given to the production of the anti-hypertensive monomeric indole alkaloids, serpentine and ajmalicine, and the antitumor dimeric alkaloids, vinblastine and vincristine. Objective: This study evaluated the cytotoxic activity of the ...
Wang Dong-Hong - - 2012
Porous BiOCl micro-flowers constructed from ultrathin nanosheets with nearly 100% {001} facets exposed were selectively prepared. The exposed {001} facets terminated with a high density of oxygen atoms and are not only favorable for the adsorption of the cationic dye RhB but also can accumulate the photogenerated electrons injected from ...
Hurst Samia A - - 2012
BACKGROUND: Decisions regarding Cardio-Pulmonary Resuscitation (CPR) and Do Not Attempt Resuscitation (DNAR) orders remain demanding, as does including patients in the process. OBJECTIVES: To explore physicians' justification for CPR/DNAR orders and decisions regarding patient inclusion, as well as their reports of how they initiated discussions with patients. METHODS: We administered ...
Lai Kevin - - 2012
Phenotypic compound screens can be used to identify novel targets in signaling pathways and disease processes, but the usefulness of these screens depends on the ability to quickly determine the target and mechanism of action of the molecules identified as hits. One fast route to discovering the mechanism of action ...
Pautier P - - 2012
BackgroundThere is no proven benefit of adjuvant treatment of uterine sarcoma (US). SARCGYN phase III study compared adjuvant polychemotherapy followed by pelvic radiotherapy (RT) (arm A) versus RT alone (arm B) conducted to detect an increase ≥ 20% of 3-year PFS.MethodsPatients with FIGO stage ≤ III US, physiological age ≤ 65 years; chemotherapy: four cycles ...
Sun Lei - - 2012
Mitochondrial biogenesis disorders appear to play an essential role in cardiac dysfunction. Acetylcholine as a potential pharmacologic agent exerts cardioprotective effects. However, its direct action on mitochondria biogenesis in acute cardiac damage due to ischemia/reperfusion (I/R) remains unclear. The present study determined the involvement of mitochondrial biogenesis and function in ...
Rojas Gertrudis - - 2012
The structurally related gangliosides N-glycolyl GM3 and N-acetyl GM3 are potential targets for tumor immunotherapy. 14F7 is a monoclonal antibody able to discriminate the tumor-specific antigen N-glycolyl GM3 from the closely related N-acetyl GM3 on the basis of the presence of a single additional hydroxyl group in the former. A ...
Dacey Marie - - 2012
Background: There is a need for effective continuing medical education (CME) programs to increase healthcare providers' knowledge and skills in lifestyle medicine so that healthcare providers are better equipped to assist patients in adopting and maintaining healthier lifestyle behaviors. Aims: To evaluate the impact of five live face-to-face CME programs ...
Ko Jooyeon - - 2012
BACKGROUND: The "Gross Motor Function Measure" (GMFM-88) is a commonly used measure for evaluating gross motor function in children with cerebral palsy (CP). The relative reliability of GMFM-88 has been assessed in children with CP. However, little information is available about the absolute reliability or responsiveness of GMFM-88. OBJECTIVE: The ...
Heimbach J K - - 2012
Obesity is increasingly common before and after liver transplantation (LT), yet optimal management remains unclear. Our aim was to analyze the effectiveness of a multidisciplinary protocol for obese patients requiring LT, including a noninvasive pretransplant weight loss program, and a combined LT plus sleeve gastrectomy (SG) for obese patients who ...
Wissgott C - - 2012
AIM:The study objective was to examine the application of excimer laser atherectomy (ELA) in patients with refractory occlusions in femoropopliteal arteries, where the initial conventional percutaneous transluminal angioplasty (PTA) recanalization attempts, were unsuccessful. METHODS: The average age of the 40 patients (32 men, 8 women) included in this study was ...
Dawid Corinna - - 2012
Sensory-directed fractionation of extracts prepared from raw and cooked asparagus (Asparagus officinalis L.), respectively, followed by LC-TOF-MS, LC-MS/MS, and 1D/2D-NMR experiments revealed the chemical structures of nine bitter tasting mono- and bidesmotic saponins as well as the previously not reported 1,2-dithiolan-4-carboxylic acid 6-D-α/β-glucopyranose ester exhibiting an interesting buttery mouth-coating effect. ...
Roth Christian - - 2012
BACKGROUND AND PURPOSE: The aim of our study was to examine surgical practice in the therapy of spontaneous intracerebral hemorrhage in Germany over a period of 10 years. METHODS: In 1999 and 2009 a questionnaire with 10 different cases of spontaneous intracerebral hemorrhage was sent to all neurosurgical centers in ...
Echegoyen Carlos - - 2012
Abstract Understanding the relationship between a search algorithm and the space of problems is a fundamental issue in the optimization field. In this paper, we lay the foundations to elaborate taxonomies of problems under estimation of distribution algorithms (EDAs). By using an infinite population model and assuming that the selection ...
Hayes Don D - - 2012
We present a patient that is the index case of pulmonary arterial hypertension (PAH) in a child due to the bone morphogenetic protein type II (BMPR2) missense mutation p.K230N, also known as c.690A>T. Missense mutations typically have earlier onset and more severe disease in PAH, so pulmonologists should be aware ...
Molt Robert W - - 2012
We have identified the major conformers of CL-20 explosive, otherwise known as 2,4,6,8,10,12- hexanitrohexaazaisowurtzitane, more formally known as 2,4,6,8,10,12-hexanitrohexaazatetracyclo [5.5.0.0]-dodecane, via Monte-Carlo search in conformational space through molecular mechanics and subsequent quantum mechanical refinement using perturbation theory. Our search produced enough conformers to account for all of the various forms ...
Murdoch Barbara - - 2012
Lifelong neurogenesis in the mouse olfactory epithelium (OE) is regulated by the response of stem/progenitor cells to local signals, but embryonic and adult OE progenitors appear to be quite different - with potentially different mechanisms of regulation. A recently identified progenitor unique to embryonic OE - the nestin+ radial glia-like ...
Hu Zejun - - 2012
A thorough understanding of the genetic basis of rice grain traits is critical for the improvement of rice varieties. In this study, we generated an F(2) population by crossing the large-grain japonica cultivar CW23 with Peiai 64 (PA64), an elite indica small-grain cultivar. Using QTL analysis, 17 QTLs for five ...
Sizova Irina - - 2012
The unicellular green alga Chlamydomonas reinhardtii is a versatile model for fundamental and biotechnological research. A wide toolset for genetic manipulation has been developed for this alga, but specific modification of nuclear genes is still not routinely possible. Here, we present a nuclear gene targeting strategy for Chlamydomonas that is ...
Seidenberg Andrew B - - 2012
OBJECTIVE: New tobacco control policies have been introduced in Massachusetts which restrict tobacco product sales in pharmacies. The purpose of this investigation was to outline the scope of pharmacy involvement in the tobacco market by assessing the availability and range of tobacco products sold in Massachusetts pharmacies. METHODS: Public listings ...
Raymo Françisco M - - 2012
We investigated the isomerization of the simplest member of a family of photochromic oxazines with the aid of density functional theory, using three different functionals. Specifically, we simulated the thermal interconversion of the two enantiomers, associated with this compound, and established that the opening of the oxazine ring dictates the ...
de Moraes Mariana Teichner - - 2012
OBJECTIVE.: To evaluate the frequency of MetS in DM patients and to analyze the possible association of MetS with traditional cardiovascular disease (CVD) risk factors and DM-related clinical and laboratorial features. METHODS.: The present cross-sectional single-center study included 84 DM patients and 105 healthy controls. MetS was diagnosed according to ...
Charland Katia M - - 2012
Please cite this paper as: Charland et al.(2012) Relationship between community prevalence of obesity and associated behavioral factors and community rates of influenza-related hospitalizations in the United States. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12019. Background  Findings from studies examining the association between obesity and acute respiratory infection are inconsistent. Few ...
Ng Shi-Yan - - 2012
Pluripotency refers to the self-renewal of undifferentiated embryonic stem cells (ESCs), and is maintained by a tightly regulated gene regulatory network involving an intricate interplay between transcription factors and their genomic targets, as well as epigenetic processes that influence gene expression. Long non-coding RNAs (lncRNAs) are newly discovered members of ...
Bunnik Eline M - - 2012
Broad genome-wide testing is increasingly finding its way to the public through the online direct-to-consumer marketing of so-called personal genome tests. Personal genome tests estimate genetic susceptibilities to multiple diseases and other phenotypic traits simultaneously. Providers commonly make use of Terms of Service agreements rather than informed consent procedures. However, ...
Rouxel Cédric - - 2012
The photophysical and two-photon absorption (TPA) properties of biphotonic chromophores with one or two phenol pendant units were studied and compared with that of a model biphotonic quadrupolar chromophore. A water-soluble dendritic structure was then synthesized by using the pendant moieties as starting points for the construction of dendritic branches. ...
Dinh Michael M - - 2012
OBJECTIVES: To describe the relationship between waiting time and patient satisfaction, and to determine predictors of overall care rating in an emergency department (ED) fast-track setting. METHODS: A convenience sample of patients triaged to a fast-track unit were surveyed. Patient satisfaction was scored using a validated survey instrument, as well ...
Block F - - 2012
Drug-induced seizures are in view of a constantly ageing population and increasingly frequent polypharmacotherapy an increasing problem in daily routine praxis. Identification of potentially seizure-inducing drugs may help generating risk profiles for individual patients. Drug-induced seizures have often been seen as a complication of psychopharmacological therapy, but its occurrence has ...
Kalra Mannudeep K - - 2012
BackgroundOptimization of CT radiation dose is important for children due to their higher risk of radiation-induced adverse effects. Anatomical structures with high inherent contrast, such as bones can be imaged at very low radiation doses by optimizing scan parameters.PurposeTo assess feasibility of sub-milliSievert whole spine CT scanning protocol for evaluation ...
Iskra Timothy - - 2012
Most mAb platform purification processes consist of an affinity capture step followed by 1 or 2 polishing steps. An understanding of the performance linkages between the unit operations can lead to robust manufacturing processes. In this study, a weak-partitioning anion-exchange chromatography polishing step used in a mAb purification process was ...
Oms Olivier - - 2012
Polyoxometalates covalently linked to one or two spiropyran entities have been isolated. These organic-inorganic hybrids exhibit multi-electrochromic and photochromic properties.
Takahashi Yuichiro - - 2012
OBJECTIVE: To describe the safety and efficacy of thoracoamniotic shunting for fetal pleural effusion using a double-basket catheter with a very small diameter (1.47 mm). METHOD: In this 2-year multicenter, prospective single-arm clinical study registered with the University hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN00001095); shunting was performed between ...
Zhang Xiaoying - - 2012
Four novel Cu(II) complexes {Na[Cu(4)(hmp)(4)(CHOO)(3)](ClO(4))(2)·H(2)O}(n) (), [Cu(8)(hmp)(8)(CH(3)COO)(6)](ClO(4))(2) (), [Cu(4)(hmp)(4)(CH(3)CN)(2)(ClO(4))(2)(H(2)O)(2)](ClO(4))(2) (), and [Cu(4)(hmp)(4)(CH(3)COO)(2)(H(2)O)(4)](ClO(4))(2)·2H(2)O () with Hhmp = 2-(hydroxymethyl)pyridine were prepared by structural modulation at room temperature. Taking advantage of the steric hindrance of the ancillary ligands, the 1D copper chain () is successfully cut down into the octa-nuclear copper cluster () ...
Henry L - - 2012
AIM: Early and late outcomes following cardiac surgery may be adversely affected in patients with chronic lung disease (CLD) and the presence of CLD is definition dependent. The purpose of this study was to compare the Society of Thoracic Surgeons (STS) definitions for CLD to the modified American Thoracic Society ...
Goffin Jérôme M - - 2012
Using finite element analysis, we compared the biomechanical performance of a CT scan-based three-part trochanteric fracture model (31-A2 in the AO classification) stabilized with a sliding hip screw for nine different positions of the lag screw (3 × 3 arrangement, from anterior to posterior and from inferior to superior). Our results showed ...
Xie W - - 2012
Background:  Infantile haemangiomas (IHs) are benign tumors in infancy. Most patients suffering from IHs do not require treatment. However, if there is a dramatic aesthetic or functional impairment, treatment is needed. Currently the most promising therapy for complicated IHs is the oral administration of propranolol, but its mechanism is unclear. ...
Hooi Michelle Y S - - 2012
Racemisation is one of the most abundant modifications in long-lived proteins. It has been proposed that the accumulation of such modifications over time could lead to changes in tissues and ultimately human age-related diseases. Serine is one of the main amino acids involved in racemisation, however the site of D-Ser ...
Singh12 Balwinder - - 2012
ABSTRACT BACKGROUND: The incidence and outcomes of disseminated intravascular coagulation (DIC) are incompletely defined. Therefore, we aimed to evaluate the trends in incidence and outcomes of critically ill patients with DIC. METHODS: We conducted a population-based retrospective cohort study evaluating consecutively admitted adult (≥18 years) critically ill patients with DIC, ...
Meinicke Holger - - 2012
While pleuropulmonary involvement in systemic lupus erythematosus (SLE) is a common occurrence, shrinking lung syndrome (SLS) is a rare complication of SLE, particularly in children. We report on a teenager girl with a primary SLE diagnosis, which was based upon clinical, imaging, lung-function and histological findings ascertained to be compatible ...
Kani Kouichi - - 2012
Taxanes, including docetaxel, are widely used for the treatment of squamous cell carcinoma of the head and neck. However, the gastrointestinal toxicity of docetaxel has limited its high-dose clinical use. In this study, we examined the synergistic anticancer effects of combined low-dose docetaxel and γ-tocotrienol treatment on human oral cancer ...
Wang Guan - - 2012
Cyclic nucleotide phosphodiesterase type 5 (PDE5) is a prime drug target for treating the diseases associated with a lower level of the cyclic guanosine monophosphate (cGMP), which is a specific substrate for PDE5 hydrolysis. Here we report a series of novel PDE5 inhibitors with the new scaffold of monocyclic pyrimidin-4(3H)-one ...
van Rij M C - - 2012
BACKGROUND: Individuals at 50% risk of Huntington's disease (HD) who prefer not to know their carrier status, might opt for exclusion prenatal diagnosis (ePND) or exclusion preimplantation genetic diagnosis (ePGD). This study aims to provide a better understanding of couples' motives for choosing ePND or ePND, and surveys couples' experiences ...
Caponi S - - 2012
BackgroundThis multicenter study evaluated three candidate microRNAs (miRNAs) (miR-21, miR-155 and miR-101) as potential biomarkers in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas.Patients and methodsmiRNA expression was quantified by quantitative RT-PCR in 86 laser-microdissected specimens, including 65 invasive IPMNs, 16 non-invasive IPMNs and 5 normal pancreatic ductal tissues. Univariate ...
Wolfe Frederick - - 2012
OBJECTIVES: It has been proposed that fibromyalgia can be understood as a disorder of central sensitisation and dysregulation (CD) and that characteristic somatic symptoms are the result of 'central augmentation'. We examined this hypothesis by analysing sensory and non-sensory variables in the context of the updated (2010) American College of ...
He Jun - - 2012
Please cite this paper as: He et al. (2012) Amaryllidaceae alkaloids inhibit nuclear-to-cytoplasmic export of ribonucleoprotein (RNP) complex of highly pathogenic avian influenza virus H5N1. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12035. Background  Few drugs are currently licensed to treat influenza A infection, and new therapies are needed, especially for highly ...
Hernandez Ana R - - 2012
Despite over 30 years of work on the Wnt signaling pathway, the basic mechanism of how the extracellular Wnt signal increases the intracellular concentration of β-catenin is still contentious. Circumventing much of the detailed biochemistry, we used basic principles of chemical kinetics coupled with quantitative measurements to define the reactions ...
Singh Kiran - - 2012
Balanced diet is the natural source of micronutrients, such as folate and vitamins, vital for proper functioning of the body. One-carbon metabolic pathway along with folate and other vitamins plays an important role in DNA synthesis and in the establishment of epigenetic modifications like DNA/histone methylation. Spermatogenesis involves distinct cellular, ...
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