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Results 701 - 750 of 2649
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Marcucci G - - 2012
AIM:Carotid artery angioplasty and stenting (CAS) has emerged as an alternative treatment for extra cranial carotid artery stenosis in stroke prevention. Nevertheless concerns are remaining about the long-term durability as hemodynamic in-stent restenosis (ISR) after CAS are increasing and usually treated again by endovascular approach. This preliminary study, instead, albeit ...
Wildi Lukas Martin - - 2012
OBJECTIVE: To evaluate the impact of two MRI sequences on cartilage defect assessment in knee OA patients and the sensitivity to change over time comparing cartilage defect (semi-quantitative) with cartilage volume loss (quantitative) methods. METHODS: GRE and IW-FSE sequences were compared. Knee OA MRI were from two 2-year studies (cohort ...
Bouyer Patrice G PG Department of Surgery, The University of Chicago, Chicago, IL 60637, USA. - - 2013
Colonic chloride secretion is regulated via the neurohormonal and immune systems. Exogenous chemicals (e.g., butyrate, propionate) can affect chloride secretion. Capsaicin, the pungent ingredient of the chili peppers, exerts various effects on gastrointestinal function. Capsaicin is known to activate the transient receptor potential vanilloid type 1 (TRPV1), expressed in the ...
Klosterbuer Abby S - - 2012
The aim of this study was to determine the effects of three novel fibers on satiety and serum parameters. In a randomized, double-blind, crossover design, fasted subjects (n=20) consumed a low-fiber control breakfast or 1 of 4 breakfasts containing 25 g fiber from soluble corn fiber (SCF) or resistant starch ...
Ricci Zaccaria - - 2012
ABSTRACT: If permissive hypercapnia is used in the context of protective ventilation for patients with acute respiratory distress syndrome, it must be highlighted that the alveoli in these patients are still exposed to significant stress. Similarly, early renal replacement therapy is not necessarily a protective therapy for acute kidney injury ...
Korjoukov Ilia - - 2012
Visual perception starts with localized filters that subdivide the image into fragments that undergo separate analyses. The visual system has to reconstruct objects by grouping image fragments that belong to the same object. A widely held view is that perceptual grouping occurs in parallel across the visual scene and without ...
Sizova Irina - - 2012
The unicellular green alga Chlamydomonas reinhardtii is a versatile model for fundamental and biotechnological research. A wide toolset for genetic manipulation has been developed for this alga, but specific modification of nuclear genes is still not routinely possible. Here, we present a nuclear gene targeting strategy for Chlamydomonas that is ...
Grönwall Caroline - - 2012
Naturally arising IgM antibodies, which recognize neo-determinants on apoptotic cell (AC) membranes, are present from birth and can be further induced by AC challenge. Such naturally arising IgM antibodies can suppress proinflammatory responses to purified agonists for Toll-like receptors (TLRs), as well as block the induction of IgG immune complex-induced ...
McClintic Abbi M AM Department of Neurological Surgery, University of Washington, Seattle, Washington 98195-6470, - - 2013
Potential peripheral sources of pain from subcutaneous tissue can require invasive evocative tests for their localization and assessment. Here, we describe studies whose ultimate goal is development of a noninvasive evocative test for subcutaneous, painful tissue. We used a rat model of a focal and subcutaneous neuroma to test the ...
Seidenberg Andrew B - - 2012
OBJECTIVE: New tobacco control policies have been introduced in Massachusetts which restrict tobacco product sales in pharmacies. The purpose of this investigation was to outline the scope of pharmacy involvement in the tobacco market by assessing the availability and range of tobacco products sold in Massachusetts pharmacies. METHODS: Public listings ...
Patel Vishal V Department of Internal Medicine/Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, MC 8856, Dallas, TX 75390, USA. - - 2012
MicroRNAs (miRNAs) contribute to the regulation of early kidney development, but their role during later stages of renal tubule maturation is not well understood. Here, we found that ablation of the miRNA-processing enzyme Dicer from maturing renal tubules produces tubular and glomerular cysts in mice. Inactivation of Dicer is associated ...
Raymo Françisco M - - 2012
We investigated the isomerization of the simplest member of a family of photochromic oxazines with the aid of density functional theory, using three different functionals. Specifically, we simulated the thermal interconversion of the two enantiomers, associated with this compound, and established that the opening of the oxazine ring dictates the ...
de Moraes Mariana Teichner - - 2012
OBJECTIVE.: To evaluate the frequency of MetS in DM patients and to analyze the possible association of MetS with traditional cardiovascular disease (CVD) risk factors and DM-related clinical and laboratorial features. METHODS.: The present cross-sectional single-center study included 84 DM patients and 105 healthy controls. MetS was diagnosed according to ...
Charland Katia M - - 2012
Please cite this paper as: Charland et al.(2012) Relationship between community prevalence of obesity and associated behavioral factors and community rates of influenza-related hospitalizations in the United States. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12019. Background  Findings from studies examining the association between obesity and acute respiratory infection are inconsistent. Few ...
Ng Shi-Yan - - 2012
Pluripotency refers to the self-renewal of undifferentiated embryonic stem cells (ESCs), and is maintained by a tightly regulated gene regulatory network involving an intricate interplay between transcription factors and their genomic targets, as well as epigenetic processes that influence gene expression. Long non-coding RNAs (lncRNAs) are newly discovered members of ...
Niewald Amber - - 2012
Implantable cardioverter defibrillators (ICDs) reduce mortality in selected patients at risk for life-threatening heart arrhythmias, and their use is increasingly common. However, these devices also confer risk for delivery of unexpected painful shocks during the dying process, thus reducing the quality of palliative care at the end of life. This ...
Medow Marvin S MS Department of Pediatrics, New York Medical College and The Center for Pediatric Hypotension, Hawthorne, New York 10532, USA. - - 2013
Local cutaneous heating causes vasodilation as an initial first peak, a nadir, and increase to plateau. Reactive oxygen species (ROS) modulate the heat plateau in healthy controls. The initial peak, due to C-fiber nociceptor-mediated axon reflexes, is blunted with local anesthetics and may serve as a surrogate for the cutaneous ...
Yang Jun - - 2012
OBJECTIVE: Mutations in the bone morphogenetic protein type II receptor (BMPR-II) are responsible for the majority of cases of heritable pulmonary arterial hypertension (PAH), and BMPR-II deficiency contributes to idiopathic and experimental forms of PAH. Sildenafil, a potent type-5 nucleotide-dependent phosphodiesterase inhibitor, is an established treatment for PAH, but whether ...
Gonzalez-Angulo A M AM Departments of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Unit 1354, 1515 Holcombe Boulevard, Houston, TX 77030-4009, - - 2013
The purpose of this study was to determine the functional proteomic characteristics of residual breast cancer and hormone receptor (HR)-positive breast cancer after neoadjuvant systemic chemotherapy, and their relationship with patient outcomes. Reverse phase protein arrays of 76 proteins were carried out. A boosting approach in conjunction with a Cox ...
Lübbeke Anne - - 2012
In experimental studies, statin use has been associated with reduction of osteoclastic activity and promotion of bone formation around implants. Moreover, a large clinical study recently reported a substantially reduced risk of revision for aseptic loosening among statin users with THA. Our objective was to evaluate the influence of statin ...
Aras Urvi - - 2012
We investigated the effect of phenethyl isothiocyanate (PEITC), a component of cruciferous vegetables, on the initiation and progression of cancer in a chemically-induced estrogen-dependent breast cancer model. Breast cancer was induced in female Sprague Dawley rats (8 weeks old) by the administration of N-methyl nitrosourea (NMU). Animals were administered 50 or ...
Yancura Loriena A - - 2012
Objectives.Race has been found to predict justifications for caregiving in family caregivers for older adults. However, little is known about this relationship in another type of family caregiver, Grandparents Raising Grandchildren (GRG). This study examined relationships between race and justifications for caregiving in Asian American, Native Hawaiian, and White GRG.Method.A ...
Zafar M U - - 2012
Background: Hemostatic benefits of platelet transfusions in thienopyridine-treated acute coronary syndrome (ACS) patients may be compromised by residual metabolite in circulation. Objectives: To estimate the earliest time after a prasugrel loading-dose when added platelets are no longer inhibited by prasugrel-active-metabolite (PAM). Methods: Baseline platelet reactivity of healthy subjects (n=25, 30±5 years, 68% male) ...
Tsai Jack - - 2012
This study examined lifetime exposure to traumatic events as reported by 581 homeless female veterans enrolled in a Homeless Women Veterans Program across 11 sites to characterize the types of trauma they experienced; their correlation with baseline characteristics; and their association with housing, clinical outcomes, and psychosocial functioning over a ...
Zhou Di - - 2012
We present a three-dimensional density functional approach to investigate heterogeneous nucleation behaviors of Lennard-Jones fluid on solid walls. In the theoretical calculation, fast Fourier transforms to compute the convolutions of Euler-Lagrange equation enables a high-efficient algorithm in three-dimensional space. The density distributions of a growing nucleus are presented to account ...
Long Jilan - - 2012
A metal-organic framework with open 2,2'-bipyridine sites can efficiently activate molecular oxygen for selective oxidation of a variety of saturated hydrocarbons with unprecedented activities and selectivities.
Steen Håkan C HC Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, - - 2013
STAT2 is a positive modulator of the transcriptional response to type I interferons (IFNs). STAT2 acquires transcriptional function by becoming tyrosine phosphorylated and imported to the nucleus following type I IFN receptor activation. Although most STAT proteins become dually phosphorylated on specific tyrosine and serine residues to acquire full transcriptional ...
Park K H - - 2012
AIM: Preoperative radiological identification of the Adamkiewicz artery and intraoperative neurologic monitoring are known to be helpful for preventing paraplegia after thoracoabdominal aorta replacement. To answer whether they should be used routinely, we investigated the incidence of spinal cord ischemia after extensive descending aortic repair without using such modalities. METHODS: ...
Nardini Andrea - - 2012
The 'ionic effect', i.e., changes in xylem hydraulic conductivity (k(xyl)) due to variation of the ionic sap composition in vessels, was studied in four Acer species growing in contrasting environments differing in water availability. Hydraulic measurements of the ionic effect were performed together with measurements on the sap electrical conductivity, ...
Pichierri Angelo - - 2012
Postoperative extradural hematoma (POEH) is a possible complication after head surgery, often neglected in the literature. In a single surgeon experience we found 13 cases of POEH (0.8%). We distinguished two subtypes: (1) larger hematomas (>40 cc) with typical features and overt clinical picture that always needed evacuation, and (2) ...
Sadik Nermin A H - - 2012
This study investigated the potential role of folate in the dimethylhydrazine (DMH) colon cancer model in male Wistar rats. For induction of colon cancer, group 1 rats were injected subcutaneously with 30 mg DMH/kg body weight weekly for 30 wk. Group 2 received DMH vehicle. Group 3 rats received DMH as ...
Nissen-Lie Helene A - - 2012
Abstract The need for psychotherapy research to understand the therapist effect has been emphasized in several studies. In a large naturalistic study (255 patients, 70 therapists), this topic was addressed using therapists' self-assessed difficulties in practice and interpersonal functioning in therapeutic work as predictors of patient outcome in three conventional ...
Ganguli Kriston K Mucosal Immunology Laboratory, Division of Pediatric Gastroenterology, Massachusetts General Hospital for Children, 114 16th St. (114-3503), Charlestown, MA 02192-4404, USA. - - 2013
Necrotizing enterocolitis (NEC), an extensive intestinal inflammatory disease of premature infants, is caused, in part, by an excessive inflammatory response to initial bacterial colonization due to the immature expression of innate immune response genes. In a randomized placebo-controlled clinical trial, supplementation of very low birth weight infants with probiotics significantly ...
Hioe Johnny - - 2012
S-Adenosylmethionine (SAM) plays an essential role in a variety of enzyme-mediated radical reactions. One-electron reduction of SAM is currently believed to generate the C5'-desoxyadenosyl radical, which subsequently abstracts a hydrogen atom from the actual substrate in a catalytic or a non-catalytic fashion. Using a combination of theoretical and experimental bond ...
Stranges P Benjamin - - 2012
The accurate design of new protein-protein interactions is a longstanding goal of computational protein design. However, most computationally designed interfaces fail to form experimentally. This investigation compares five previously described successful de novo interface designs with 158 failures. Both sets of proteins were designed with the molecular modeling program Rosetta. ...
Giordanetto Fabrizio - - 2012
AMP-activated protein kinase (AMPK), a heterotrimeric protein complex with serine/threonine kinase activity has a central role in controlling cellular energy expenditure. Small molecule-based activation of AMPK represents an attractive therapeutic proposition because of AMPK's ability to regulate several anabolic and catabolic pathways that are critical to the development of metabolic ...
Mediratta Neeraj - - 2012
OBJECTIVES: Coronary artery bypass graft (CABG) is performed for symptomatic and prognostic reasons. We aimed to determine the factors that contribute to in-hospital mortality and long-term survival in young patients (aged less than 65) undergoing CABG. METHODS: A prospective database was retrospectively analysed and cross-correlated with the United Kingdom's Strategic ...
Reyes Edwin E EE Committee on Immunology, The University of Chicago, Chicago, IL, - - 2013
In the adult human prostate CD133 expression is thought to mark rare prostate epithelial stem cells and malignant tumor stem/initiating cells. Such putative stem cell populations are thought to proliferate slowly, but possess unlimited proliferative potential. Based on this, we hypothesized that CD133(pos) prostate cancer cells proliferate slower than CD133(neg) ...
Huang Zhao - - 2012
Au-supported Pt-Au mixed atomic monolayer electrocatalyst was prepared by underpotential deposition of Cu on Au and then redox replacement with noble metal atoms, which shows an ultrahigh Pt-mass (or Pt-area) normalized specific electrocatalytic activity of 102 mA μg(Pt)(-1) (124 mA cm(Pt)(-2)) for oxidation of formic acid in acidic aqueous solution.
Odoom John Kofi - - 2012
ABSTRACT: BACKGROUND: Influenza A viruses that cause highly pathogenic avian influenza (HPAI) also infect humans. In many developing countries such as Ghana, poultry and humans live in close proximity in both the general and military populations, increasing risk for the spread of HPAI from birds to humans. Respiratory infections such ...
Schulman Carl I - - 2012
BACKGROUND: Social networking (SN) has become ubiquitous in modern culture. The potential consequences of revealing personal information through SN websites are not fully understood. OBJECTIVE: To assess familiarity with, usage of, and attitudes towards, SN websites by admissions offices at US medical schools and residency programmes. METHODS: A 26-question survey ...
Ha Tae Lin - - 2012
Annealing of MnO@SiO2 nanospheres in a reducing gas environment resulted in the transformation of the core-shell structure into a hollow structure as a result of outward diffusion of MnO species into the thermodynamically more stable silicate phase. When the hollow silicate nanospheres were oxidized, the interior cavities were refilled with ...
Sharma Anil - - 2012
PURPOSE: Increasing interest in the role of Class 3 Semaphorins (Sema3s) in plasticity and repair in the injured mammalian central nervous system prompted us to characterize changes in Sema3 expression after optic nerve (ON) injury. Methods: We used unilateral ON transection (ONT) and ON crush (ONC) models in conjunction with ...
Ryu C H - - 2012
BackgroundCancer progression and non-cancer-related morbidities can affect the quality of life and survival of patients with head and neck squamous cell carcinomas (HNSCC). The aim of this study was to investigate the risk factors for the development of non-cancer health events (NCHEs) in HNSCC.Patients and methodsThe study involved 465 previously-untreated ...
Shroff Rukshana R Nephro-Urology Unit, Great Ormond Street Hospital for Children and University College London Institute of Child Health, London, UK. - - 2013
Cardiovascular disease begins early in the course of renal decline and is a life-limiting problem in patients with CKD. The increased burden of cardiovascular disease is due, at least in part, to calcification of the vessel wall. The uremic milieu provides a perfect storm of risk factors for accelerated calcification, ...
Levy Robert M - - 2012
OBJECTIVE.: This systematic safety review reports multicenter safety results of symptomatic lumbar spinal stenosis (LSS) patients treated with percutaneous lumbar decompression. DESIGN.: All percutaneous lumbar decompression institutional review board-approved study patients, as well as a retrospective safety survey, were included in this review. METHODS.: All study centers followed the same ...
Singh Sanjay S Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, - - 2012
Nanotechnology has the potential to make smart drugs that would be capable of targeting cancer but not normal cells and to load combinations of cooperating agents into a single nanosized particle to more effectively treat this disease. However, to realize the full potential of this technology, the negative aspects associated ...
Matano Yoshihiro - - 2012
The synthesis, structures, optical and electrochemical properties, and aromaticity of a series of 5,15-diaza-10,20-dimesitylporphyrins (M-DAP; M = Pb, H(2), Ni, Pd, Pt, Zn; mesityl = 2,4,6-trimethylphenyl) are reported. Treatment of mesityl-substituted bis(5,5'-dibromodipyrrin) with sodium azide in the presence of lead(II) acetylacetonate afforded Pb-DAP, which was quantitatively converted to H(2)-DAP by ...
Stojek Monika - - 2012
BACKGROUND: Increasing numbers of emerging adult women are engaging in heavy drinking behavior, placing them at risk of negative outcomes and alcohol use disorders (AUDs). The purpose of this study was to examine the influence of 5 pathways to impulsive behavior (negative urgency [NU], positive urgency, lack of deliberation [DEL], ...
Thomaston Jessica - - 2012
As a target of anti-viral drugs, the influenza A M2 protein has been the focus of numerous structural studies and has been extensively explored as a model ion channel. In this study we capitalize on the expanding body of high-resolution structural data available for the M2 protein to design and ...
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