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Ryu C H - - 2012
BackgroundCancer progression and non-cancer-related morbidities can affect the quality of life and survival of patients with head and neck squamous cell carcinomas (HNSCC). The aim of this study was to investigate the risk factors for the development of non-cancer health events (NCHEs) in HNSCC.Patients and methodsThe study involved 465 previously-untreated ...
Levy Robert M - - 2012
OBJECTIVE.: This systematic safety review reports multicenter safety results of symptomatic lumbar spinal stenosis (LSS) patients treated with percutaneous lumbar decompression. DESIGN.: All percutaneous lumbar decompression institutional review board-approved study patients, as well as a retrospective safety survey, were included in this review. METHODS.: All study centers followed the same ...
Matano Yoshihiro - - 2012
The synthesis, structures, optical and electrochemical properties, and aromaticity of a series of 5,15-diaza-10,20-dimesitylporphyrins (M-DAP; M = Pb, H(2), Ni, Pd, Pt, Zn; mesityl = 2,4,6-trimethylphenyl) are reported. Treatment of mesityl-substituted bis(5,5'-dibromodipyrrin) with sodium azide in the presence of lead(II) acetylacetonate afforded Pb-DAP, which was quantitatively converted to H(2)-DAP by ...
Stojek Monika - - 2012
BACKGROUND: Increasing numbers of emerging adult women are engaging in heavy drinking behavior, placing them at risk of negative outcomes and alcohol use disorders (AUDs). The purpose of this study was to examine the influence of 5 pathways to impulsive behavior (negative urgency [NU], positive urgency, lack of deliberation [DEL], ...
Thomaston Jessica - - 2012
As a target of anti-viral drugs, the influenza A M2 protein has been the focus of numerous structural studies and has been extensively explored as a model ion channel. In this study we capitalize on the expanding body of high-resolution structural data available for the M2 protein to design and ...
Kano Koji - - 2012
A supramolecular diatomic receptor, hemoCD, was modified with PEGylated dendrons to extend its circulation time in the bloodstream. The core component was 4-oxo-4-[[4-(10,15,20-tris(4-sulfonatophenyl)-21H,23H-porphin-5-yl)phenyl]amino]butanoic acid (Por-COOH). The building block of the dendrons was Fmoc-4-amino-4-(2-carboxyethyl)heptanedioic acid (FmocTA), which was condensed with α-amino-ω-methoxy-poly(ethylene glycol) (PEG5000-NH2) to yield an FmocG1-dendron. After deprotection, the G1-dendron ...
Qiu Hong - - 2012
OBJECTIVE: This was a retrospective cohort study of type 2 diabetes patients, to evaluate the association between initial metformin or sulfonylurea treatment and cancer incidence. RESEARCH DESIGN AND METHODS: Patients identified in the U.K. Clinical Practice Research Datalink (CPRD), previously General Practice Research Database, during 1995-2008 who were initially stabilized ...
Xu Xin - - 2012
Genetic variation and candidate genes associated with breast cancer susceptibility have been identified. Identifying molecular interactions between associated genetic variation and cellular proteins may help to better understand environmental risk. Human MCS5A1 breast cancer susceptibility associated SNP rs7042509 is located in F-box protein 10 (FBXO10). An orthologous Rattus norvegicus DNA-sequence ...
Chen Feng - - 2012
Herein, using DNA adenine methylation (Dam) methyltransferase (MTase) as a model analyte, a novel fluorescence sensing strategy was developed for facile, rapid and highly sensitive detection of the activity and inhibition of the target based on methylation-blocked enzymatic recycling amplification. In this sensing system, nicking endonuclease Nt.AlwI with the methylation-sensitive ...
Zhang Chao - - 2012
  The gelatin was added into pullulan films to improve their performances and lower their cost. The gelatin addition raised the tensile strength of the gelatin-pullulan composite films, and reduced the oxygen permeability. The cost of composite films was reduced comparing to that of the pullulan films. Moreover, the molecular ...
Alphey Magnus S - - 2012
Glucose-1-phosphate thymidylyltransferase (RmlA) catalyzes the condensation of glucose-1-phosphate (G1P) with deoxy-thymidine tri-phosphate (dTTP) to yield dTDP-L-rhamnose and pyrophosphate. This is the first step in the L-rhamnose biosynthetic pathway. L-rhamnose is an important component of the cell wall of many microorganisms, including Mycobacterium tuberculosis and Pseudomonas aeruginosa. Here we describe the ...
Chepelin Oleg - - 2012
The first molecular capsule based on an [Ir(ppy)2]+ unit (ppy = 2-phenylatopyridine) has been prepared. Following the development of a method to resolve rac-[(Ir(ppy)2Cl)2] into its enantiopure forms, homochiral Ir6L4 octahedra where obtained with the tritopic 1,3,5-tricyanobenzne. Solution studies suggest that four of the associated counteranions reside within the cavity, ...
Bianchetti Laurent - - 2012
ABSTRACT: BACKGROUND: Single Base Substitutions (SBS) that alter transcripts expressed in cancer originate from somatic mutations. However, recent studies report SBS in transcripts that are not supported by the genomic DNA of tumor cells. METHODS: We used sequence based whole genome expression profiling, namely Long-SAGE (L-SAGE) and Tag-seq (a combination ...
Herb Jason - - 2012
The importance of pre-nucleation cluster stability as the key parameter controlling nucleation of atmospheric airborne ions is well-established. In the present paper, large ternary ionic (HSO4)(H2SO4)m(NH3)(H2O)n clusters have been studied using Density Functional Theory (DFT) and composite ab initio methods. Twenty classes of clusters have been investigated and thermochemical properties ...
Huo Peng - - 2012
Hydrogen bonds are important in supramolecular chemistry and responsible for proton transfer processes. This manuscript reports new hydrogen-bonding systems of redox-active acid-base assemblies consisting of dimethylthio-tetrathiafulvalene dicarboxylic acid (H(2)L) coupled with pyridine (py), 2,2'-bipyridine (2,2'-bpy), and 4,4'-bipyridine (4,4'-bpy). The (1)H NMR chemical shifts of the pyridines and the redox potential ...
Tiedemann Anne - - 2012
BACKGROUND: Hospital emergency departments (EDs) treat a high proportion of older people, many as a direct consequence of falling. OBJECTIVE: To develop and externally validate a fall risk screening tool for use in hospital EDs and to compare the tool's predictive ability to existing screening tools. METHODS: This prospective cohort ...
Peat Andrew J - - 2012
A new series of non-nucleoside reverse-transcriptase inhibitors based on an imidazole-amide biarylether scaffold has been identified and shown to possess potent antiviral activity against HIV-1, including the NNRTI resistant Y188L-mutated virus. X-ray crystallography of inhibitors bound to reverse transcriptase, including a structure of the Y188L RT protein, was used extensively ...
Mehta Fulya - - 2012
Background: Feedback is important in learning, including in workplace-based assessments. Aim: To explore trainee's perceptions of the educational value of case-based discussions (CBDs) specifically focusing on feedback. Methods: An online questionnaire and interviews obtaining detailed descriptions of paediatric trainees at UK specialist training levels 1 and 2 views and experiences ...
Eghbalsaied Shahin - - 2012
Transgenic mammals have been produced by using sperm as vector for exogenous DNA (sperm-mediated gene transfer or SMGT) in combination with artificial insemination (AI). Our study evaluated if SMGT could also be achieved in combination with in vitro fertilisation (IVF) to efficiently produce transgenic bovine embryos. We assessed binding and ...
Rudzinski Erin R - - 2012
Abstract Chronic villitis of unknown etiology (VUE) occurs in approximately 5-10% of third trimester placentas. It is characterized by lymphohistiocytic infiltration of the placental chorionic villi. VUE is associated with fetal growth restriction, preterm birth, and recurrent pregnancy loss. Accumulating evidence suggests that VUE may represent a host-versus-graft reaction, analogous ...
Bekhet Abir K - - 2012
Background: Approximately 2.8 million people in the United States are diagnosed with autism spectrum disorder (ASD). Family caregivers manage many aspects of their care, which is demanding, overwhelming, and can affect their mental health. Objective: This study examined the effects of caregiver burden (risk factor) and positive cognitions (protective factors) ...
Mackintosh L J - - 2012
Background:  Organ transplant recipients have an increased risk of skin cancers. A specialist dermatology clinic for renal transplant recipients (RTRs) was established in 2005. Objectives:  To analyse the type and incidence of skin cancers in prevalent patients attending after renal transplant in the West of Scotland and analyse the impact ...
Vuong Cuong D - - 2012
Please cite this paper as: Vuong et al. (2012). The genetic match between vaccine strains and circulating seasonal influenza A viruses in Vietnam, 2001-2009. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12038. Background  Vietnam is currently developing domestic capability to manufacture influenza vaccines but information on the genetic and antigenic characteristics of ...
Iribarren Carlos - - 2012
Asthma has been associated with increased cardiovascular disease (CVD) risk. The authors ascertained the association of asthma with CVD and the roles that sex, concurrent allergy, and asthma medications may play in this association. They assembled a cohort of 203,595 Northern California adults with asthma and a parallel asthma-free referent ...
Bannani Fatma - - 2012
The high-nuclearity polyoxothiomolybdate [H8Mo84S48O188(H2O)12(CH3COO)24]32- has been prepared and characterized by single-crystal X-ray crystallography and spectroscopically (1H NMR, IR and Raman, UV-vis). The solid-state structure reveals an unprecedented and intriguing arrangement comprising a nanoscaled anionic cube. The surprisingly open structure of this {Mo84}-type cubic box features a large inner void, accessible ...
Cantarini Luca - - 2012
OBJECTIVES: Idiopathic recurrent acute pericarditis (IRAP) represents the most troublesome complication of acute pericarditis and is an autoimmune process. White adipose tissue produces more than 50 adipokines that participate in inflammation and autoimmunity. This study investigated whether serum leptin, resistin, visfatin and adiponectin are increased in IRAP versus healthy controls ...
Huh Jin Won - - 2012
BACKGROUND: The Surviving Sepsis Campaign (SSC) to improve patient outcomes in severe sepsis and septic shock contains recommendations for protocolised resuscitation including early goal-directed therapy (EGDT) resuscitation. In EGDT, central venous oxygen saturation (ScvO(2)) is measured as the target monitoring value. The objective of this study was to determine whether ...
Sharifi Roya - - 2012
Context: Silymarin, a flavonolignan from Silybum marianum (L.) Gaertn. (Asteraceae), has been reported to have antioxidant and anti-inflammatory properties. Therefore, it may be worthwhile to study the effect of silymarin on wound healing. Objective: To evaluate the effect of silymarin on human fibroblast cells in an in vitro model of ...
Paxton Christian N - - 2012
OBJECTIVE: Chromosome analysis is the traditional method for detecting genetic abnormalities in products of conception, but it is prone to a high failure rate because of the requirement for cell culture. Molecular genetic tests do not require cell culture, but are either more expensive (e.g. chromosomal microarray) or less sensitive ...
Pelton Matthew - - 2012
It has recently become possible to chemically synthesize atomically flat semiconductor nanoplatelets with monolayer-precision control over the platelet thickness. It has been suggested that these platelets are quantum wells; that is, carriers in these platelets are confined in one dimension but are free to move in the other two dimensions. ...
Fardal Oystein - - 2012
Background There is weak evidence to support the benefit of periodontal maintenance therapy in preventing tooth loss. In addition, the effects of long-term periodontal treatment on general health are unclear. Materials/Methods Compliant and partially compliant patients (15-25 years follow-up) in private practice were observed for oral and systemic health changes. ...
Kennedy Matthew Robert - - 2012
π -π interactions are integral to many areas of chemistry, biochemistry, and materials sci- ence. Here we use electronic structure theory to analyze how π -π interactions change as the π -systems are curved in model complexes based on coronene and corannulene dimers. Cur- vature redistributes electronic charge in the ...
Antunes Carina Ferlin - - 2012
Abstract Objective: To investigate the effects of the standard (Class II) Balters bionator in growing patients with Class II malocclusion with mandibular retrusion by using morphometrics (thin-plate spline [TPS] analysis). Materials and Methods: Thirty-one Class II patients (17 male and 14 female) were treated with the Balters bionator (bionator group). ...
Fortes Francisco J - - 2012
A review article on laser-induced breakdown spectroscopy is presented. It focuses on developments in LIBS over the years 2008 - 2012. After introducing the general information sources of LIBS, the paper discusses the advancement in the understanding of fundamental principles of LIBS and the excitation strategies based on dual and ...
Masuda Masaharu - - 2012
AIMS: Diastolic late mitral annular velocity (a') measured by transthoracic echocardiography (TTE) is reported to represent left atrial (LA) pump function and the severity of LA remodelling. The purpose of this study is to investigate the association between a' and LA blood stasis in patients with non-valvular paroxysmal atrial fibrillation. ...
Di Costanzo G G - - 2012
Life-long hepatitis B immunoglobulin (HBIG) administration is a main component of prophylactic strategy to prevent hepatitis B virus (HBV) reinfection after liver transplantation (LT). Long-term effects of HBIG treatment are known only for intravenous (IV) and intramuscular formulations. To evaluate safety and efficacy of self-administered SC HBIG, 135 LT patients ...
Kukul Guven F Mutlu - - 2012
Crimean-Congo hemorrhagic fever (CCHF) is a disease with a severe course including acute viral hemorrhagic fever, ecchymosis, thrombocytopenia, hepatic function disorder and high mortality. Myeloperoxsidase (MPO) is an enzyme located in the neutrophile granules and plays an important role in the destruction of the phagocytosed microorganisms. The aim of this ...
Tokar Erik - - 2012
Inorganic arsenic in the drinking water is a multi-site human carcinogen that potentially targets the kidney. Recent evidence also indicates developmental arsenic exposure impacts renal carcinogenesis in humans and mice. Emerging theory indicates that cancer may be a disease of stem cells (SCs), and there are abundant active SCs during ...
Maher Kate - - 2012
Although minor in abundance in Earth's crust (U, 2-4 ppm; Th, 10-15 ppm) and in seawater (U, 0.003 ppm; Th, 0.0007 ppm), light actinides (Th, Pa, U, Np, Pu, Am, and Cm) are important environmental contaminants associated with anthropogenic activities such as the mining and milling of uranium ores, generation ...
McCarthy Kevin F - - 2012
OBJECTIVES: Spinal cord stimulation (SCS) is an efficacious therapy for chronic neuropathic pain whose precise mechanism of action is unclear. Mediators produced by glial and immune cells are now believed to modulate neuronal transmission and promote chronic neuropathic pain. We postulated a relationship between cerebrospinal fluid (CSF) concentrations of neuroimmune ...
Richy Nicolas - - 2012
N-Silyl oxaziridines were synthesized for the first time. Their tert-butyldiphenylsilyl (TBDPS) derivatives were stable reagents that were prepared on a multi grams scale, in three steps and in 44% overall yield from the corresponding benzylamines. They were mild electrophilic aminating reagents that reacted at room temperature with diversely substituted primary ...
Arrar Mehrnoosh - - 2012
Histone deacetylases (HDACs) repress transcription by deacetylating acetyllysines on specific histone tails. HDAC3 is implicated in neurodegenerative diseases, certain leukemias and even in disrupting HIV-1 latency. A recent crystal structure of HDAC3 in complex with the deacetylase activating domain (DAD) of its co-repressor complex revealed an inositol tetraphosphate (IP4) molecule ...
Sjöström Terje - - 2012
Precise surface nanopatterning is a promising route for predictable control of cellular behaviour on biomedical materials. There is currently a gap taking such precision engineered surfaces from the laboratory to clinically relevant implant materials such as titanium (Ti). In this work, anodization of Ti surfaces was performed in combination with ...
Winterstein Almut G - - 2012
BACKGROUND: Evidence on the effectiveness of respiratory syncytial virus (RSV) immunoprophylaxis with palivizumab in children with cystic fibrosis (CF) is lacking. METHODS: We utilized Medicaid Extract files from 27 states from 1999 to 2006 linked to the National Cystic Fibrosis Registry to establish a cohort of children 0-2 years with ...
Nakamura Hideo - - 2012
BackgroundAdvanced diagnostic and therapeutic developments may yield novel prognostic factors in patients with glioblastoma multiforme (GBM).PurposeTo validate the predictive values of pretreatment quantitative diffusion-weighted (DW) magnetic resonance imaging (MRI) and MRI performed within 72 h after surgery in patients with GBM.Material and MethodsBetween January 2000 and September 2009, 138 patients ...
Tavakol Mohsen - - 2012
Classical Test Theory has traditionally been used to carry out post-examination analysis of objective test data. It uses descriptive methods and aggregated data to help identify sources of measurement error and unreliability in a test, in order to minimise them. Item Response Theory (IRT), and in particular Rasch analysis, uses ...
Berkenbosch L - - 2012
Background: The Dutch postgraduate medical training has been revised to focus on seven competencies. The role as manager is one of these competencies. Recent studies show that this competency receives little attention during the residency training. In an earlier study, we discovered that residents perceived their competency as managers to ...
Huang Yao-Te - - 2012
Cardiovascular disease (CVD) is one of the major causes of mortality in diabetic patients. Mounting studies have shown that garlic exhibits, possibly through its anti-oxidant potential, diverse biological activities. In this study, we investigated the alleviating effects of garlic oil and its two major components, diallyl disulfide (DADS) and diallyl ...
Dawid Corinna - - 2012
Application of sequential solvent extraction and iterative chromatographic separation in combination with taste dilution analysis recently revealed a series of steroidal saponins as the key contributors to the typical bitter taste of white asparagus spears (Asparagus officinalis L.). Besides six previously reported saponins, (25R)-furost-5-en-3β,22,26-triol-3-O-[α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranoside]-26-O-β-D-glucopyranoside, (25R)-furostane-3β,22,26-triol-3-O-[α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranoside]-26-O-β-D-glucopyranoside, and (25S)-furostane-3β,22,26-triol-3-O-[α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranoside]-26-O-β-D-glucopyranoside, and 3-O-[{α-L-rhamnopyranosyl-(1→2)}{α-L-rhamnopyranosyl-(1→4)}-β-D-glucopyranosyl]-(25S)-spirost-5-ene-3β-ol were ...
Knijnenburg S L - - 2012
BackgroundOur study aimed to evaluate final height in a cohort of Dutch childhood cancer survivors (CCS) and assess possible determinants of final height, including height at diagnosis.Patients and methodsWe calculated standard deviation scores (SDS) for height at initial cancer diagnosis and height in adulthood in a cohort of 573 CCS. ...
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