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Symeonidis D D Department of General Surgery, University Hospital of Larissa, Aulidos 7, 41335, Larissa, Greece. - - 2013
Our group evaluated on a pilot basis open inguinal hernia repair with the use of a fully absorbable mesh aiming to take mesh inguinal hernia repair one step forward. The purpose of the present study was to assess the long-term results of the proposed technique. Patients that were included in ...
Vesper Stephen S National Exposure Research Laboratory (NERL), United States (US) Environmental Protection Agency, Cincinnati, OH 45268, USA. - - 2013
Mold in water-damaged homes has been linked to asthma. Our objective was to test a new metric to quantify mold exposures in asthmatic children's homes in three widely dispersed cities in the United States. The Environmental Relative Moldiness Index (ERMI) metric was created by the US Environmental Protection Agency, with ...
Wang Yan Y Laboratory of Muscle Biology and Sarcopenia, Department of Exercise Physiology, and Center for Cardiovascular and Respiratory Sciences, Robert C. Byrd Health Sciences Center, West Virginia University School of Medicine, Morgantown, WV 26506, - - 2013
β-Catenin is essential for muscle development because it regulates both cadherin-mediated cell-cell adhesion and canonical Wingless and Int1 (Wnt) signaling. The phosphorylation of β-catenin by glycogen synthase kinase-3β (GSK-3β) at serine31/37/threonine41 regulates its stability and its role in canonical Wnt signaling. In this study, we have investigated whether the N-terminal ...
Borcar Apurva A Department of Biological Sciences, Division of Cellular, Developmental and Integrative Biology, Louisiana State University, Baton Rouge, LA 70803, USA. - - 2013
Induction of HIF-1α by oxygen limitation promotes increased phosphorylation and catalytic depression of mitochondrial pyruvate dehydrogenase (PDH) and an enhanced glycolytic poise in cells. Cobalt chloride and desferrioxamine are widely used as mimics for hypoxia because they increase the levels of HIF-1α. We evaluated the ability of these agents to ...
Kato Kei K Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, - - 2013
To confirm the feasibility and safety of granulocyte colony-stimulating factor (G-CSF) for treating spinal neuropathic pain associated with compression myelopathy, we have initiated an open-label single-center prospective clinical trial. Between January 2009 and February 2011, 17 patients were accrued and were divided into two groups. One group included 7 patients ...
Olvet Doreen M DM Zucker Hillside Hospital, Psychiatry Research, North Shore-Long Island Jewish Health System, Glen Oaks, New York, NY, USA. - - 2013
The importance of early intervention strategies has recently been recognised in the field of psychiatry. Although early intervention strategies in schizophrenia have been extensively studied, recent efforts to identify individuals who are at increased risk for other disorders, such as bipolar disorder, have gained significant interest. There is some available ...
Bülow Robin R Department of Radiology and Neuroradiology, Ernst Moritz Arndt University of Greifswald, Ferdinand-Sauerbruch-Straße NK, Greifswald 17475, Germany. - - 2013
To investigate the reliability of diffusion-weighted magnetic resonance imaging (DW-MRI) for staging liver fibrosis in the presence of fat and iron. Ninety-five patients, including 48 men and 47 women, aged 57.0 ± 14.2 years, underwent liver biopsy. Ninety-six samples were histologically staged for liver fibrosis (0-Ishak score 0; 1-Ishak score ...
Sharpe Erica E Department of Chemistry and Biomolecular Science, Potsdam, NY 13699-5810, - - 2013
With increased awareness of nutrition and the advocacy for healthier food choices, there exists a great demand for a simple, easy-to-use test that can reliably measure the antioxidant capacity of dietary products. We report development and characterization of a portable nanoparticle based-assay, similar to a small sensor patch, for rapid ...
Pazahr Shila S Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Rämistr. 100, 8091 Zurich, Switzerland. - - 2013
To assess the feasibility of magnetization transfer (MT) imaging of the bowel wall in patients with Crohn's disease (CD), and to evaluate its utility for the detection of intestinal fibrosis. In this prospective study, 31 patients (age 39.0 ± 13.2 years) with CD were examined in a 1.5T MR scanner. To establish a ...
Dan Shan S BGI-Shenzhen, Shenzhen, - - 2012
To report the performance of massively parallel sequencing (MPS) based prenatal noninvasive fetal trisomy test based on cell-free DNA sequencing from maternal plasma in a routine clinical setting in China. The MPS-based test was offered as a prenatal screening test for trisomies 21 and 18 to pregnant women in 49 ...
Kushnareva Y E YE Apoptosis & Cell Death Program, Sanford Burnham Institute for Medical Research, La Jolla, CA 92037, - - 2013
Optic atrophy 1 (OPA1) mutations cause dominant optic atrophy (DOA) with retinal ganglion cell (RGC) and optic nerve degeneration. The mechanism for the selective degeneration of RGCs in DOA remains elusive. To address the mechanism, we reduced OPA1 protein expression in cell lines and RGCs by RNA interference. OPA1 loss ...
Wahlster Lara L Department of Neurology, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital, Harvard Medical School, CNY 114, 16th Street, Charlestown, MA 02129, USA. - - 2013
Accumulation of amyloid-β (Aβ) and neurofibrillary tangles in the brain, inflammation and synaptic and neuronal loss are some of the major neuropathological hallmarks of Alzheimer's disease (AD). While genetic mutations in amyloid precursor protein and presenilin-1 and -2 (PS1 and PS2) genes cause early-onset familial AD, the etiology of sporadic ...
Drakesmith Hal H Molecular Immunology Group and Medical Research Council (MRC) Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK. - - 2012
Iron lies at the center of a battle for nutritional resource between higher organisms and their microbial pathogens. The iron status of the human host affects the pathogenicity of numerous infections including malaria, HIV-1, and tuberculosis. Hepcidin, an antimicrobial-like peptide hormone, has emerged as the master regulator of iron metabolism. ...
- - 2012
The candidate malaria vaccine RTS,S/AS01 reduced episodes of both clinical and severe malaria in children 5 to 17 months of age by approximately 50% in an ongoing phase 3 trial. We studied infants 6 to 12 weeks of age recruited for the same trial. We administered RTS,S/AS01 or a comparator ...
Lekawanvijit Suree S Department of Epidemiology and Preventive Medicine, Centre of Cardiovascular Research and Education in Therapeutics, Monash University, Melbourne, Victoria 3004, - - 2012
Cardiorenal syndrome is a condition in which a complex interrelationship between cardiac dysfunction and renal dysfunction exists. Despite advances in treatment of both cardiovascular and kidney disease, cardiorenal syndrome remains a major global health problem. Characteristic of the pathophysiology of cardiorenal syndrome is bidirectional cross-talk; mediators/substances activated by the disease ...
Yu Lan L Division of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, 1150 St. Nicholas Avenue, Room 620, New York, NY 10032, USA. - - 2013
Congenital diaphragmatic hernia (CDH) is characterized by incomplete formation of the diaphragm occurring as either an isolated defect or in association with other anomalies. Genetic factors including aneuploidies and copy number variants are important in the pathogenesis of many cases of CDH, but few single genes have been definitively implicated ...
Depry Charlene C Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, - - 2013
Cells rely on a complex, interconnected network of signaling pathways to sense and interpret changes in their extracellular environment. The development of genetically encoded fluorescent protein (FP)-based biosensors has made it possible for researchers to directly observe and characterize the spatiotemporal dynamics of these intracellular signaling pathways in living cells. ...
Groenewald Cornelius B CB Department of Anesthesiology and Pain Medicine, Seattle Children's Hospital, University of Washington, Seattle, WA 98105, USA. - - 2013
Patients with congenital supravalvar aortic stenosis (SVAS) with associated biventricular outflow tract obstruction and coronary artery abnormalities have a tenuous myocardial oxygen supply/demand relationship. They are at increased risk of acute myocardial ischemia and sudden death, especially during anesthesia. Furthermore, resuscitation during cardiac arrest is frequently unsuccessful. We report a ...
Li Qing Q Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangdong, - - 2013
The ectopic expression of transcription factors for reprogramming human somatic cells to a pluripotent state represents a valuable resource for the development of in vitro-based models for human disease and has great potential in regenerative therapies. However, the majority of studies have used skin fibroblasts to generate induced pluripotent stem ...
Tachibana Yurika Y Laboratory of Animal Breeding, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, - - 2013
Despite enormous efforts, biochemical and molecular mechanisms associated with equine reproduction, particularly processes of pregnancy establishment, have not been well characterized. Previously, PCR-selected suppression subtraction hybridization analysis was executed to identify unique molecules functioning in the equine endometrium during periods of pregnancy establishment, and granzyme B (GZMB) cDNA was found ...
Chakkalakal Rosette J RJ Division of General Internal Medicine and Public Health, Department of Internal Medicine, Vanderbilt University School of Medicine, 1215 21st Ave South, 6000 Medical Center East, NT, Nashville, TN 37232-8300, USA. - - 2013
Physical examination remains an important part of the initial evaluation of patients presenting with chest pain but little is known about the effect of patient gender on physician performance of the cardiovascular exam. To determine if resident physicians are less likely to perform five key components of the cardiovascular exam ...
Lewis Adam M AM Department of Psychological and Quantitative Foundations, University of Iowa, Iowa City, IA 52242, - - 2013
While depression has been associated with infertility treatments, it is not routinely assessed in women prior to undergoing in vitro fertilization (IVF) treatment. Findings are mixed regarding the degree to which women report depression prior to IVF. The purpose of this study was to (1) examine response profiles in women ...
Monk Timothy H TH Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. - - 2013
The aim of this study was to explore how the level of shiftwork exposure during an individual's working life might be related to subjectively reported sleep quality and timing during retirement. Telephone interviews regarding past employment and sleep timing and quality (among other variables) were conducted using a pseudo-random age-targeted ...
Flaig Benno B Institute of Forensic Medicine, Goethe-University, Kennedyallee 104, 60596 Frankfurt/Main, Germany. - - 2013
In international epidemiological studies, associations between suicides and body height, or body mass index (BMI) were found. Because of the recently growing number of suicides in Germany, a closer look on different anthropometric measures of suicide victims autopsied at the Institute of Forensic Medicine of the Goethe-University in Frankfurt/Main, Germany, ...
Chen L L Division of Hematology/Oncology, Children's Hospital, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, - - 2013
The t(10;11)(p12;q23) translocation and the t(10;11)(p12;q14) translocation, which encode the MLL (mixed lineage leukemia)-AF10 and CALM (clathrin assembly lymphoid myeloid leukemia)-AF10 fusion oncoproteins, respectively, are two recurrent chromosomal rearrangements observed in patients with acute myeloid leukemia and acute lymphoblastic leukemia. Here, we demonstrate that MLL-AF10 and CALM-AF10-mediated transformation is dependent ...
Zhao Yanhui Y Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, - - 2013
More than a decade of research work in optofluidics has yielded a large catalogue of optofluidic elements that can manipulate light at the micro-scale (e.g., lenses, prisms). Although these elements have proven useful for many on-chip processes (e.g., miniaturized flow cytometry, interferometry and sample spectroscopy), certain deficiencies have precluded their ...
Sakamoto Keizo K Department of Orthopaedic Surgery, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan. - - 2013
Maintaining or improving motor (balance) ability is essential to extending the healthy lifespan of elderly people, and developing effective and efficient strategies to prevent falls of elderly people is an urgent. The purpose of this study was to determine the effects of balance exercise on fall and fracture prevention for ...
Dougherty Donald M DM Department of Psychiatry, The University of Texas Health Science Center at San Antonio, NRLC MC 7793, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. - - 2013
Marijuana is a popular drug of abuse among adolescents, and they may be uniquely vulnerable to resulting cognitive and behavioral impairments. Previous studies have found impairments among adolescent marijuana users. However, the majority of this research has examined measures individually rather than multiple domains in a single cohesive analysis. This ...
Kurian Allison W AW Department of Medicine, Stanford University School of Medicine, Stanford, CA, - - 2013
Chemotherapy regimens for early stage breast cancer have been tested by randomized clinical trials, and specified by evidence-based practice guidelines. However, little is known about the translation of trial results and guidelines to clinical practice. We extracted individual-level data on chemotherapy administration from the electronic medical records of Kaiser Permanente ...
Anthonappa R P RP Faculty of Medicine, Dentistry and Health Sciences, School of Dentistry, The University of Western Australia, Perth, WA, Australia. - - 2013
Several papers have been published to illustrate the effectiveness of mineral trioxide aggregate (MTA) as a pulpotomy medicament. Most of these reports do not offer a critical assessment on the data quality. Therefore, this review evaluated whether the currently available evidence is of an appropriate quality to support the long-term ...
Ståhl M K MK Department of Physical and Rehabilitation Medicine, Hatanpää Hospital, Tampere, Finland. - - 2013
Prevalence of neck pain has increased among adolescents. The origins of adult chronic neck pain may lie in late childhood, but for early prevention, more information is needed about its aetiology. We investigated the relative roles of genetic and environmental factors in early adolescent neck pain with a classic twin ...
Gao Tielong T Department of Chemistry, Georgia State University, Atlanta, GA 30302, - - 2013
Histone acetyltransferases (HATs) catalyze the acetylation of specific lysine residues in histone and nonhistone proteins. Recent studies showed that acetylation is widely distributed among cellular proteins, suggestive of diverse functions of HATs in cellular pathways. Nevertheless, currently available assays for HAT activity study are still quite limited. Here, we evaluated ...
Lin Hui-Ju HJ Department of Medical Research, China Medical University Hospital, Taichung, - - 2013
To identify genetic variants that predispose to type 2 diabetes (T2D) with cataract. Genome-wide association study (GWAS) of T2D patients with cataract, as graded by Lens Opacities Classification System (LOCS). A total of 109 T2D patients with cataract score equal to or above 10 designated as the study group, 649 ...
Meroni R R Department of Rehabilitation Medicine, Zucchi Clinical Institutes, Monza, Italy. - - 2013
The presence of a post-traumatic psychiatric disorder in patients with acute injuries may have adverse effects on outcomes. In this study our aims were: (1) to assess the frequency of psychiatric disorders after a cerebrovascular accident or traumatic injury requiring rehabilitation; (2) to examine whether there was any correlation between ...
Ohno Akira A Department of Microbiology and Infectious Diseases, Toho University, Japan. - - 2013
Antimicrobial growth promoters (AGPs) have been banned and phased out because their use has been linked to the emergence and spread of antibiotic-resistant pathogens; however, the ban has had a marked impact on livestock production, and feed additive alternatives to AGPs are required. We focused on green tea leaves as ...
Kutter Annette P N AP Section of Anesthesiology, Equine Department, Vetsuisse Faculty of University of Zurich, Zurich, Switzerland. - - 2013
Modern high volume-low pressure (HVLP) endotracheal tubes (ETT) cuffs can seal the trachea using baseline cuff pressures (CP) lower than peak inspiratory airway pressures (PIP). The aim of the study was to determine whether this technique reduces the damage to the tracheal mucosa compared to constant CP of 20 cmH(2)O. ...
Ostan R R Department of Experimental Pathology, University of Bologna, Via San Giacomo, 12, 40126, Bologna, - - 2013
With aging, an increased prevalence of a clustering of metabolic abnormalities has been observed. These abnormalities include obesity, dyslipidemia, hypertension, and insulin resistance and are collectively known as metabolic syndrome (MetS), a low-grade, systemic, inflammatory condition associated with an increased risk of cardiovascular disease, diabetes, and other adverse health outcomes. ...
Long Jilan - - 2012
A metal-organic framework with open 2,2'-bipyridine sites can efficiently activate molecular oxygen for selective oxidation of a variety of saturated hydrocarbons with unprecedented activities and selectivities.
Park K H - - 2012
AIM: Preoperative radiological identification of the Adamkiewicz artery and intraoperative neurologic monitoring are known to be helpful for preventing paraplegia after thoracoabdominal aorta replacement. To answer whether they should be used routinely, we investigated the incidence of spinal cord ischemia after extensive descending aortic repair without using such modalities. METHODS: ...
Nardini Andrea - - 2012
The 'ionic effect', i.e., changes in xylem hydraulic conductivity (k(xyl)) due to variation of the ionic sap composition in vessels, was studied in four Acer species growing in contrasting environments differing in water availability. Hydraulic measurements of the ionic effect were performed together with measurements on the sap electrical conductivity, ...
Pichierri Angelo - - 2012
Postoperative extradural hematoma (POEH) is a possible complication after head surgery, often neglected in the literature. In a single surgeon experience we found 13 cases of POEH (0.8%). We distinguished two subtypes: (1) larger hematomas (>40 cc) with typical features and overt clinical picture that always needed evacuation, and (2) ...
Sadik Nermin A H - - 2012
This study investigated the potential role of folate in the dimethylhydrazine (DMH) colon cancer model in male Wistar rats. For induction of colon cancer, group 1 rats were injected subcutaneously with 30 mg DMH/kg body weight weekly for 30 wk. Group 2 received DMH vehicle. Group 3 rats received DMH as ...
Nissen-Lie Helene A - - 2012
Abstract The need for psychotherapy research to understand the therapist effect has been emphasized in several studies. In a large naturalistic study (255 patients, 70 therapists), this topic was addressed using therapists' self-assessed difficulties in practice and interpersonal functioning in therapeutic work as predictors of patient outcome in three conventional ...
Hioe Johnny - - 2012
S-Adenosylmethionine (SAM) plays an essential role in a variety of enzyme-mediated radical reactions. One-electron reduction of SAM is currently believed to generate the C5'-desoxyadenosyl radical, which subsequently abstracts a hydrogen atom from the actual substrate in a catalytic or a non-catalytic fashion. Using a combination of theoretical and experimental bond ...
Stranges P Benjamin - - 2012
The accurate design of new protein-protein interactions is a longstanding goal of computational protein design. However, most computationally designed interfaces fail to form experimentally. This investigation compares five previously described successful de novo interface designs with 158 failures. Both sets of proteins were designed with the molecular modeling program Rosetta. ...
Mediratta Neeraj - - 2012
OBJECTIVES: Coronary artery bypass graft (CABG) is performed for symptomatic and prognostic reasons. We aimed to determine the factors that contribute to in-hospital mortality and long-term survival in young patients (aged less than 65) undergoing CABG. METHODS: A prospective database was retrospectively analysed and cross-correlated with the United Kingdom's Strategic ...
Huang Zhao - - 2012
Au-supported Pt-Au mixed atomic monolayer electrocatalyst was prepared by underpotential deposition of Cu on Au and then redox replacement with noble metal atoms, which shows an ultrahigh Pt-mass (or Pt-area) normalized specific electrocatalytic activity of 102 mA μg(Pt)(-1) (124 mA cm(Pt)(-2)) for oxidation of formic acid in acidic aqueous solution.
Odoom John Kofi - - 2012
ABSTRACT: BACKGROUND: Influenza A viruses that cause highly pathogenic avian influenza (HPAI) also infect humans. In many developing countries such as Ghana, poultry and humans live in close proximity in both the general and military populations, increasing risk for the spread of HPAI from birds to humans. Respiratory infections such ...
Schulman Carl I - - 2012
BACKGROUND: Social networking (SN) has become ubiquitous in modern culture. The potential consequences of revealing personal information through SN websites are not fully understood. OBJECTIVE: To assess familiarity with, usage of, and attitudes towards, SN websites by admissions offices at US medical schools and residency programmes. METHODS: A 26-question survey ...
Ha Tae Lin - - 2012
Annealing of MnO@SiO2 nanospheres in a reducing gas environment resulted in the transformation of the core-shell structure into a hollow structure as a result of outward diffusion of MnO species into the thermodynamically more stable silicate phase. When the hollow silicate nanospheres were oxidized, the interior cavities were refilled with ...
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