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Results 601 - 650 of 2649
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van de Ven Wendy J M - - 2013
To estimate the required spatial alignment accuracy for correctly grading 95 % of peripheral zone (PZ) prostate cancers using a system for multiparametric magnetic resonance (MR)-guided ultrasound (US) biopsies. PZ prostate tumours were retrospectively annotated on multiparametric MR series using prostatectomy specimens as reference standard. Tumours were grouped based on ...
Heser K - - 2012
BACKGROUND: Whether late-onset depression is a risk factor for or a prodrome of dementia remains unclear. We investigated the impact of depressive symptoms and early- v. late-onset depression on subsequent dementia in a cohort of elderly general-practitioner patients (n = 2663, mean age = 81.2 years). Method Risk for subsequent dementia was estimated over ...
Wiklund Martin - - 2012
In part 21 of the tutorial series "Acoustofluidics - exploiting ultrasonic standing wave forces and acoustic streaming in microfluidic systems for cell and particle manipulation", we review applications of ultrasonic standing waves used for enhancing immunoassays and particle sensors. The paper covers ultrasonic enhancement of bead-based immuno-agglutination assays, bead-based immuno-fluorescence ...
Chevallier Coralie - - 2012
Diminished social attention is often considered to be a central deficit in autism spectrum disorders (ASDs). We further investigate this hypothesis by measuring the distracting power of social and non-social stimuli in the context of a Stroop task among children with ASD and typically developing controls (TDCs). Our results show ...
Ben-Hadj-Khalifa Sonia - - 2012
Background: Monocytes and factor Xa (FXa) are procoagulant agents implicated in the physio-pathological processes of atherosclerosis and thrombosis. Objective: we evaluated the anticoagulant effect of the anti-inflammatory cytokine IL-10 on an FXa-activated human monocyte (Hu-monocyte) procoagulant phenotype. Methods: Hu-monocytes were purified by elutriation and activated by FXa. The effect of ...
Hautzel Hubertus - - 2012
Background: When applying the recommended standard doses of recombinant human TSH (rhTSH) in the diagnostic / therapeutic course of patients with differentiated thyroid cancer (DTC) the resulting peak TSH levels vary extensively. Previous studies applying multivariate statistics identified patient-inherent variables influencing the rhTSH / peak TSH relation. However, those results ...
Yang Xinying - - 2012
ACTG-toxin H (AH) originates from Alternaria sp. In this study, we explored the molecular mechanism underlying the anti-inflammatory properties of AH. Treatment with AH inhibited lipopolysaccharide (LPS)-induced interleukin-6, IL-1β, inducible nitric oxide synthase, and cyclooxygenase-2 expression and nitric oxide production. Furthermore, AH inhibited LPS-induced P38 MAPK and Akt activation in ...
Sreedhara Alavattam - - 2012
The reduction of singlet oxygen to hydrogen peroxide via the antibody catalyzed water oxidation pathway (ACWOP) has been reported (Nieva and Wentworth, Trends in Biochem. Sci, 2004, 29, 274-278). While conserved and buried tryptophans in the antibody are thought to play a major role in this pathway, our studies with ...
Sajid M S - - 2012
OBJECTIVE: To systematically compare the tacker mesh fixation (TMF) with the suture mesh fixation (SMF) in laparoscopic incisional and ventral hernia (LIVH) repair. METHODS: Trials evaluating the TMF with the SMF in LIVH repair were analysed using the statistical tool RevMan(®). Combined dichotomous and continuous data were expressed as odds ...
Zhou Bin - - 2012
Wt1-Cre-based tools are important reagents for studying epicardial cell fate and gene function. To better describe the properties of Wt1-Cre-based tools to enhance their use in Cre-loxP-based experiments. In contrast to recently reported results, we show that constitutive Wt1(GFPCre) in combination with certain Cre-activated reporters can be used to trace ...
Isikdemir F - - 2012
The aim of this study was to evaluate and compare the effects of 5-lipoxygenase enzyme (5-LO) inhibitor zileuton and cysteinyl leukotrienes receptor (CysLT1R) antagonist montelukast in testicular torsion/detorsion (T/D) injury model in rats. Rats were anesthetised with 75 mg kg(-1) ketamine hydrochloride and 8 mg kg(-1) xylazine intraperitoneal before the operation. Torsion was created ...
Rudi Knut - - 2012
Ribosomal RNA (rRNA) genes are universal for all living organisms. Yet, the correspondence between genome composition and rRNA phylogeny remains poorly known. The aim of this work was to use the information from genome sequence databases to address the correlation between rRNA gene phylogeny and total gene composition in bacteria. ...
Prucnal Slawomir - - 2012
One of the solutions enabling performance progress, which can overcome the downsizing limit in silicon technology, is the integration of different functional optoelectronic devices within a single chip. Silicon with its indirect band gap has poor optical properties, which is its main drawback. Therefore, a different material has to be ...
Deng Nan - - 2012
A novel kind of aptamer modified organic-inorganic hybrid silica monolithic capillary column has been developed, via the covalent bonding of 5'-NH2-modified aptamer for human α-thrombin on hybrid silica monolith, prepared by sol-gel method, with tetraethoxysilane and 3-aminopropyltriethoxysilane as precursors. Due to the large specific surface area of the hybrid matrix, ...
Bonillo Baltasar - - 2012
Lewis acids promote the polymerization of several 2-chloroalkylenedioxythiophenes, providing high-molecular-weight conjugated polymers. The proposed mechanism is a cationic chain-growth polymerization, as confirmed by end-capping reactions and a linear correlation of molecular weight with percent conversion. The "living" character of this process was used to prepare new block copolymers.
Serrano D P - - 2012
Great interest has arisen in the past years in the development of hierarchical zeolites, having at least two levels of porosities. Hierarchical zeolites show an enhanced accessibility, leading to improved catalytic activity in reactions suffering from steric and/or diffusional limitations. Moreover, the secondary porosity offers an ideal space for the ...
Symeonidis D D Department of General Surgery, University Hospital of Larissa, Aulidos 7, 41335, Larissa, Greece. - - 2013
Our group evaluated on a pilot basis open inguinal hernia repair with the use of a fully absorbable mesh aiming to take mesh inguinal hernia repair one step forward. The purpose of the present study was to assess the long-term results of the proposed technique. Patients that were included in ...
Ponnuswamy Nandhini - - 2012
Molecular knots remain difficult to produce using the current synthetic methods of chemistry because of their topological complexity. We report here the near-quantitative self-assembly of a trefoil knot from a naphthalenediimide-based aqueous disulfide dynamic combinatorial library. The formation of the knot appears to be driven by the hydrophobic effect and ...
Pananwala Hasitha - - 2012
BACKGROUND: Solitary necrotic nodule of the liver (SNNL) is a rare benign lesion with an uncertain aetiology. There are no typical diagnostic clinical or radiological features, and this lesion is usually detected incidentally during imaging for other purposes. METHODS: We describe the clinical and radiological findings in three patients with ...
Berger Gregory L - - 2012
Genome-wide association studies (GWAS) provide an opportunity to examine the genetic architecture of quantitatively inherited traits in breeding populations. The objectives of this study were to use GWAS to identify chromosome regions governing traits of importance in six-rowed winter barley (Hordeum vulgare L.) germplasm and to identify single-nucleotide polymorphisms (SNPs) ...
Sanguanmith Sunuchakan - - 2012
In the spirit of the radiation chemical "spur model", the lifetime of a spur (τ(s)) is an important indicator of overlapping spurs and the establishment of homogeneity in the distribution of reactive species created by the action of low linear energy transfer (LET) radiation (such as fast electrons or γ ...
Kothavade R J - - 2012
Rapidly growing mycobacteria (RGM) are known to cause pulmonary, extra-pulmonary, systemic/disseminated, and cutaneous and subcutaneous infections. The erroneous detection of RGM that is based solely on microscopy, solid and liquid cultures, Bactec systems, and species-specific polymerase chain reaction (PCR) may produce misleading results. Thus, inappropriate therapeutic measures may be used ...
Huo J - - 2012
Multiple myeloma (MM) is an incurable malignancy of terminally differentiated B lymphoid cells. Here, we investigated the role of Fas apoptosis inhibitory molecule (FAIM) in MM. We demonstrated that IGF-1 treatment up-regulated FAIM expression in MM cells in a dose-dependent manner. Silencing of FAIM expression attenuates Akt signaling downstream of ...
Goffman Lisa - - 2012
ABSTRACT The aim of this study was to determine, using speech error and articulatory analyses, whether the binary distinction between iambs and trochees should be extended to include additional prosodic subcategories. Adults, children who are normally developing, and children with specific language impairment (SLI) participated. Children with SLI were included ...
Voet Vincent S D - - 2012
The fabrication of nanoporous poly(vinylidene fluoride) (PVDF) and PVDF/nickel nanocomposites from semicrystalline block copolymer precursors is reported. Polystyrene-block-poly(vinylidene fluoride)-block-polystyrene (PS-b-PVDF-b-PS) is prepared through functional benzoyl peroxide initiated polymerization of VDF, followed by atom transfer radical polymerization (ATRP) of styrene. The crystallization of PVDF plays a dominant role in the formation ...
Zhang Ming-Zhen - - 2012
Quantum dots (QDs) fluorescent probes based on oligonucleotide aptamers and peptides with specific molecular recognition have attracted much attention. In this paper, CdSe/ZnS QDs probes for targeted delivery to mouse and human cells using aptamer GS24 and peptide T7 specific to mouse/human transferrin receptors were developed. Capillary electrophoresis analyses indicated ...
Kheirandish R - - 2012
This study was set to investigate whether the adverse effects of long-term copper (Cu) consumption on testicular tissue could be prevented by zinc (Zn) administration. Forty-five mature male rats were randomly divided into one control and two treatment groups. The first treatment group received copper sulfate (Cu experimental group). The ...
Wang Ian J - - 2012
Investigating the properties of ecological landscapes that influence gene flow among populations can provide key insights into the earliest stages of biological divergence. Both ecological and geographical factors can reduce gene flow, which can lead to population divergence, but we know little of the relative strengths of these phenomena in ...
Gilbert Emilee - - 2012
Research has increasingly recognised the profound impact that cancer can have upon embodied subjectivity. However, there has been little acknowledgement of the centrality of sexuality to subjectivity, and marginalisation of the experiences of intimate partners of people with cancer. This Australian qualitative study explores the post-cancer experiences of embodied sexual ...
Beck Kathryn L - - 2012
PURPOSE: To investigate associations between dietary patterns and suboptimal iron status in premenopausal women living in Auckland, New Zealand. METHODS: Premenopausal women (n = 375; 18-44 years) were included in this cross-sectional analysis. Suboptimal iron status was defined as serum ferritin <20 μg/L. Participants completed a 144-item iron food frequency questionnaire (FeFFQ) and a ...
Di Lorenzo Cherubino C Department of Neurology, Sapienza-University of Rome, Polo Pontino, Rome, - - 2013
Repetitive transcranial magnetic stimulation (rTMS) affects cortical excitability according to the frequency of stimulation. Few data are available on the influence of rTMS applied over the primary motor cortex (M1) on motor performances in healthy volunteers. The aim of this study was to determine, through kinematic analysis, whether rTMS over ...
Mantri Sneha S - - 2012
OBJECTIVES: The aim of this study was to evaluate Candida colonisation in the dentures with silicone soft liner in diabetic and non-diabetic patients and to assess the antifungal efficacy of chlorhexidine gluconate on Candida colonies. MATERIALS AND METHODS: Thirty patients with resorbed ridges, fifteen each in the diabetic and non-diabetic ...
Dumond Jarrett J - - 2012
UV roll-to-roll nanoimprinting at high resolution is still a relatively unexplored field of study with far-reaching application potential. One enabling technology that is particularly worthy of attention is mass production of high resolution resin moulds via UV roll-to-roll nanoimprinting at such high throughput and low cost that they can be ...
Luo Jian - - 2012
A novel dinuclear platinum complex of (dfppy-mhb-dfppy)Pt(2)(acac)(2) was synthesized and characterized, where dfppy-mhb-dfppy is a binary C^N cyclometalated ligand containing two bridged 2,4-difluorophenylpyridine (dfppy) units and acac is 2,4-pentanedione anion. Compared to previously reported dinuclear platinum complexes with a binary ancillary ligand, this dinuclear platinum complex showed more intense excimer ...
Geldhof G John - - 2012
The positive youth development perspective, a strength-based relational developmental systems model that focuses on mutually influential relationships between individuals and contexts, has been used to study thriving across the second decade of life. However, more attention has been paid empirically to identifying the features of the individual (e.g., intentional self ...
van Bergen Christiaan J A - - 2012
Osteochondral defects of the talus pose a difficult therapeutic challenge. An experimental animal model of the ankle joint is not available. The aim of this study was to test a newly developed animal model for osteochondral defects of the ankle in vivo. Osteochondral defects were created in the talus of ...
Mueller F - - 2012
BACKGROUND: This study was initiated to assess the quantitative impact of patient anthropometrics and dihydropyrimidine dehydrogenase (DPYD) mutations on the pharmacokinetics (PK) of 5-fluorouracil (5FU) and to explore limited sampling strategies of 5FU. PATIENTS AND METHODS: We included 32 patients with gastrointestinal malignancies, receiving 46-h continuous-infusional 5FU and performed PK-sampling ...
Nakamichi Kazuo - - 2012
Progressive multifocal leukoencephalopathy (PML) is caused by JC polyomavirus (JCV) infection in the brain. JCV isolates from PML patients have variable mutations in the non-coding control region (NCCR) of the genome. This study was conducted to examine sequential changes in NCCR patterns of JCV isolates obtained from the cerebrospinal fluid ...
Rodrigues Juan R - - 2012
Context: Characterization of the pro-oxidant activity of QNACR. Objectives: Reactive oxygen species (ROS) induce cellular damage and represent unique opportunities to kill malignant cells. In this study, we synthesized and evaluated the new compound, (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate (QNACR) as potential pro-oxidative agent against breast cancer. Methods: Oxidative stress biomarkers such ...
Kirk Benjamin B - - 2012
The phenylperoxyl radical has long been accepted as a critical intermediate in the oxidation of benzene and an archetype for arylperoxyl radicals in combustion and atmospheric chemistry. Despite being central to many contemporary mechanisms underpinning these chemistries, reports of the direct detection or isolation of phenylperoxyl radicals are rare and ...
Madhu Sheri - - 2012
Cyanide is one of the most toxic inorganic anions, it is very harmful to human health but extremely useful in industrial activities. Herein, we used our recently reported boradiazaindacene (BODIPY) dye, 3,5-diformyl-borondipyrromethene (BODIPY ) as an exclusive chemodosimetric and colorimetric sensor for CN(-) ion. Cyanide ion attacks the carbonyl groups ...
Wickens David J - - 2012
During external fixation, temporary implants are used to penetrate the skin, muscle and bone to support severely fractured bones. This creates a biologically critical interface at the site of entry, which potentially allows a risk of infection. The aim of this study, therefore, was to investigate potential antimicrobial nanocomposites to ...
Vanhoutte Davy D Cardiovascular Diseases, University Hospitals Leuven, and Department of Cardiovascular Sciences, KU Leuven, Belgium. - - 2013
The cardiac extracellular matrix is highly involved in regulating inflammation, remodelling, and function of the heart. Whether matrix alterations relate to the degree of inflammation, fibrosis, and overall rejection in the human transplanted heart remained, until now, unknown. Expression of matricellular proteins, proteoglycans, and metalloproteinases (MMPs) and their inhibitors (TIMPs) ...
Spégel Peter P Unit of Molecular Metabolism, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Malmö, Sweden. - - 2013
Mutations in the gene encoding glucokinase (GCK) cause a mild hereditary form of diabetes termed maturity-onset diabetes of the young (MODY)2 or GCK-MODY. The disease does not progress over time, and diabetes complications rarely develop. It has therefore been suggested that GCK-MODY represents a metabolically compensated condition, but experimental support ...
Chen Sifang - - 2012
Objective To evaluate the feasibility and limitations of the contralateral approach to unruptured superior hypophyseal artery (SHA) aneurysms.Methods Data regarding eight cases of superior hypophyseal artery aneurysms operated on by a contralateral pterional approach at our center from January 2008 to September 2010 were collected and evaluated retrospectively. Of these eight cases, ...
Shi Hui - - 2012
PURPOSE: To investigate the effect of topical administration of peroxiredoxin6 (PRDX6) on ultraviolet-induced corneal injury. METHODS: Corneal transparency and neo-vascularization were observed with a slit-lamp microscope and H&E staining. The oxidative damage was determined with a commercial malondialdehyde (MDA) kit. The expressions of PRDX6, polymorphonuclear neutrophil (PMN), VEGF and PEDF ...
van Wandelen Loek T M - - 2012
Kinases present an attractive target for drug development, since they are involved in vital cellular processes and are implicated in a variety of diseases, such as cancer and diabetes. However, obtaining selectivity for a specific kinase over others is difficult since many current kinase inhibitors exclusively target the highly conserved ...
Morandini Ana Carolina - - 2012
Background: In a previous report, it was shown that Toll-like receptor (TLR) 2 knockdown modulates Interleukin (IL)-6 and IL-8 but not the chemokine CXCL12, an important mediator with inflammatory and proangiogenic effects, in human gingival fibroblasts (HGF) and human periodontal ligament fibroblasts (HPLF). This study investigated whether knocking down two ...
Pellicer Adelina - - 2012
Background:Inodilators are routinely used in cardiovascular surgery with cardiopulmonary bypass (CPB). Information regarding safety and tolerability of the novel molecule, levosimendan, in newborns is anecdotal; no pharmacokinetic data in this population are available.Methods:Phase I, randomised, blind study. Neonates undergoing surgical repair for congenital heart defects received step-wise dose increases of ...
Cohen Yoram - - 2012
Because a variety of human-related activities, engineer-ed nanoparticles (ENMs) may be released to various environmental media and may cross environmental boundaries, and thus will be found in most media. Therefore, the potential environmental impacts of ENMs must be assessed from a multimedia perspective and with an integrated risk management approach ...
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