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Results 501 - 550 of 2645
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Schmier Jordana K - - 2012
BACKGROUND: Topical β-blockers are commonly prescribed for primary open-angle glaucoma. Existing research is limited regarding respiratory or cardiovascular events that may result from using these topical β-blockers. OBJECTIVE: To evaluate inpatient and outpatient service encounters and payments associated with the topical adjunctive use of the β-blocker timolol for glaucoma. STUDY ...
Du Peng - - 2012
Four novel metal-organic frameworks (MOFs) based on high-nuclear metal carboxylate clusters, namely, [Zn(4)(L)(2)(μ(3)-OH)(2)(H(2)O)(1.5)]·2H(2)O (), [Zn(5)Na(L)(2)(μ(3)-OH)(4)(CH(3)CH(2)O)(H(2)O)(2)] (), [Cd(4)(L)(2)(BIME)(0.5)(μ(3)-OH)(2)(H(2)O)(1.5)]·2H(2)O (), and [Zn(4)(L)(2)(BET)(0.5)(μ(3)-OH)(2)(H(2)O)] (), where H(3)L = (3,5-dicarboxyl-phenyl)-(4-(2'-carboxyl-phenyl)-benzyl)ether, BET = 1,1'-(2'-oxybis(ethane-2,1-diyl))bis(1,2,4-triazol-1-yl), BIME = 1,2-bis(imidazol-1-yl)ethane, have been synthesized under hydrothermal conditions. In , each planar octanuclear zinc cluster [Zn(8)(μ(3)-OH)(8)(CO(2))(12)(H(2)O)(3)] is linked by twelve L ...
Hartmann-Fritsch Fabienne - - 2012
PURPOSE: Human amniotic fluid comprises cells with high differentiation capacity, thus representing a potential cell source for skin tissue engineering. In this experimental study, we investigated the ability of human amniotic fluid derived cells to substitute dermal fibroblasts and support epidermis formation and stratification in a humanized animal model. METHODS: ...
Román V - - 2012
RATIONALE: Cariprazine (RGH-188) is a D(3)-preferring dopamine D(3)/D(2) receptor partial agonist antipsychotic candidate for the treatment of schizophrenia and bipolar mania. Substance abuse is a frequent comorbidity of both disorders and is associated with serious health issues. Based on preclinical efficacy, dopamine D(2) and D(3) receptor partial agonists and antagonists ...
de Haan M C - - 2012
OBJECTIVES: Computed tomography (CT) colonography cost assumptions so far ranged from <euro>346 to <euro>594 per procedure, based on clinical CT reimbursement rates. The aim of our study was to estimate the costs in a screening situation. METHODS: Data were collected within an invitational population-based CRC screening trial (n = 2,920, age 50-75 years) ...
Scheider Linda - - 2012
Domestic dogs comprehend human gestural communication flexibly, particularly the pointing gesture. Here, we examine whether dogs interpret pointing informatively, that is, as simply providing information, or rather as a command, for example, ordering them to move to a particular location. In the first study a human pointed toward an empty ...
Shi Yongli - - 2012
To improve the poor compatibility among different components of Drug-in-adhesive type patch, two novel plasters (Drug-in-fiber and Drug-in-adhesive/fiber) were developed based on ibuprofen (IBU)-loaded fiber mats. These fibrous mats were fabricated via electrospinning of cellulose acetate/poly(vinylpyrrolidone) composites in a binary solvent of N,N-dimethyl acetamide/acetone. Physical status studies suggested that Drug-in-fiber ...
Kennett Douglas J - - 2012
The role of climate change in the development and demise of Classic Maya civilization (300 to 1000 C.E.) remains controversial because of the absence of well-dated climate and archaeological sequences. We present a precisely dated subannual climate record for the past 2000 years from Yok Balum Cave, Belize. From comparison ...
Malt Barbara C - - 2012
It is widely assumed that artifacts fall into distinct kinds. These kinds are generally identified by appeal to words-chair versus stool versus bowl versus vase, and so on. But contextual and cross-linguistic variation in what artifacts are grouped together by name raise questions about whether artifacts indeed do fall into ...
Endres Michaela - - 2012
ABSTRACT: BACKGROUND: Scaffold-assisted autologous chondrocyte implantation is an effective clinical procedure for cartilage repair. From the regulatory point of view, the ovine model is one of the suggested large animal models for pre-clinical studies. The aim of our study was to evaluate the in vitro re-differentiation capacity of expanded ovine ...
Baciewicz Anne M - - 2012
Abstract Background: Rifampin is a potent inducer of both cytochrome P-450 oxidative enzymes and the P-glycoprotein transport system. Among numerous well-documented, clinically significant interactions, examples include warfarin, oral contraceptives, itraconazole, digoxin, verapamil, simvastatin, and human immunodeficiency virus-related protease inhibitors. Rifabutin reduces serum concentrations of antiretroviral agents, but less so than ...
Oliveira Boaz Galdino de - - 2012
In this paper, the intermolecular structural study asserted by the vibrational analysis in the stretch frequencies of hydrogen bonds (πH) and dihydrogen bonds (H(-δ)H(+δ)) have definitively been revisited by means of calculations carried out by Density Functional Theory (DFT) and topological parameters derived from the classic treatise of the Quantum ...
Nishida Yoshihiro - - 2012
Although Paget's disease of bone (PDB) is common in western countries, it is extremely rare in Asian ones including Japan. Recently, oral risedronate (17.5 mg once daily) was approved in Japan as a treatment of PDB besides calcitonin and etidronate. However, there are few data regarding the efficacy of this agent, ...
Kolesarova A - - 2012
The aim of this study was to examine possible effects of bee pollen added to the feed mixture (FM) on rat ovarian functions (secretion activity and apoptosis). We evaluated the bee pollen effect on the release of insulin-like growth factor I (IGF-I) and steroid hormones (progesterone and estradiol), as well ...
Zhou Tian-Biao - - 2012
PAX2, a nuclear transcription factor in renal development, is strongly expressed during kidney development and plays an important role in kidney development, differentiation, and renal cell proliferation. PAX2 is expressed in epithelial cells of fetal kidneys and its expression is up-regulated in certain pathologic conditions. However, the transcription activation of ...
Qian Zhao - - 2012
Hydrogen desorption from a LiH + NH(3) mixture is very difficult due to the formation of the stable LiNH(4) compound. Using cluster models and first-principles theory, we demonstrate that the C(60) molecule can in fact significantly improve the thermodynamics of ammonia-mediated hydrogen desorption from LiH due to the stabilization of the intermediate ...
Feng Xue-Min - - 2012
AIMS: In this study, we investigated the peripheral mechanisms underlying the metabolic side effects of fluoxetine (FLX) by focusing on hepatic lipid metabolism. METHODS: Primary mouse hepatocytes were prepared from male mice by the two-step perfusion method. The lipid accumulation in primary mouse hepatocytes was analyzed via neutral oil staining. ...
Karkheiran Siamak - - 2012
In this study, a consanguineous family with progressive myoclonus epilepsy (PME) was clinically examined and molecularly investigated to determine the molecular events causing disease. Since exclusion of known genes indicated that novel genes causing PME still remained unidentified, homozygosity mapping, exome sequencing, as well as validation and disease-segregation analyses were ...
Kai Dan - - 2012
Nanofibers are attractive substrates for tissue regeneration applications because they structurally mimic the native extracellular matrix. Electrospinning has been recognized as one of the most efficient techniques to fabricate polymer nanofibers. Recent research has demonstrated that cellular responses, for example attachment, proliferation and differentiation, can be modulated by tuning nanofiber ...
Sweetman DU - - 2012
Acute kidney injury (AKI) is a common complication of neonatal encephalopathy (NE). The accurate diagnosis of neonatal AKI, irrespective of the cause, relies on suboptimal methods such as identification of rising serum creatinine, decreased urinary output and glomerular filtration rate. Studies of AKI biomarkers in adults and children have shown ...
Lillemo Morten - - 2012
Spot blotch caused by Bipolaris sorokiniana is a major disease of wheat in warm and humid wheat growing regions of the world including south Asian countries such as India, Nepal and Bangladesh. The CIMMYT bread wheat line Saar which carries the leaf tip necrosis (LTN)-associated rust resistance genes Lr34 and ...
Lu T - - 2012
MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs, which are evolutionarily conserved and function as regulators of gene expression. These molecules are involved in numerous biological processes including differentiation, development, proliferation and apoptosis. Further investigation identifies that miRNAs may act as either potent oncogenes or tumor-suppressor genes, linking to cancer ...
Tonni Gabriele - - 2012
INTRODUCTION: Prenatal counselling in case of fetal obstructive uropathies still represents a clinical dilemma, despite ultrasound detection of lower urinary tract obstruction has greatly advanced during recent years as well as fetal intervention techniques. MATERIALS AND METHODS: A systematic review of the relevant literature on the topic was performed, with ...
Pescosolido N - - 2012
AIM: To establish a threshold value of intraocular pressure (IOP) increase after the closed-eyelid test (CET) that correlates with the highest probability of developing overt primary open-angle glaucoma (OAG) in an Italian native population from 1980 to 2010. METHODS: Retrospective analysis of data obtained from 161 patients with ocular hypertension ...
Dib Julián Rafael - - 2012
Micrococci are Gram-positive G + C-rich, nonmotile, nonspore-forming actinomycetous bacteria. Micrococcus comprises ten members, with Micrococcus luteus being the type species. Representatives of the genus play important roles in the biodegradation of xenobiotics, bioremediation processes, production of biotechnologically important enzymes or bioactive compounds, as test strains in biological assays for lysozyme and ...
Magari Tomohiro - - 2012
Abstract Objective. This study examined the effects of androgen deprivation on bladder blood flow (BBF) and bladder function during the acute phase in castrated rats. Material and methods. Nine-week-old male Wistar rats were divided into six groups as follows: 24 h post-sham-operation (24hPS), no operation (control), 24 h post-castration (24hPC), ...
Sirignano P - - 2012
AIM:Litigation concerning medical activities is constantly increasing, as society becomes more and more "protective" of citizens who may have suffered any wrong due to malpractice. However, we should bear in mind that the percentage of claims liquidated is minimal. METHODS: From January 2009 to December 2011, 63 claims involving vascular ...
Zhang Hui - - 2012
Abstract Objectives. Recent epidemiological studies suggest that metformin treatment may reduce the risks of cancer and overall cancer mortality among patients with diabetes mellitus (DM). However, data on hepatocellular carcinoma (HCC) are very limited and inconsistent. This meta-analysis was designed to pool data currently available to determine the association between ...
An Chansik - - 2012
OBJECTIVES: To determine the importance of arterial enhancement in diagnosing small (<3 cm) hepatocellular carcinomas (HCCs) and to evaluate the added value of dynamic subtraction magnetic resonance imaging (MRI) in detecting arterial enhancement in small (<3 cm) hepatic nodules in high-risk patients. METHODS: Eighty-six patients with 135 pathologically confirmed small (<3 cm) hepatic ...
Ruan Zhi-Ping - - 2012
Although Bmi1 is well established as one of the most commonly activated oncogenes, the precise role of Bmi1 during hepatocarcinogenesis remains unclear. In addition, Bmi1 provides a potential therapeutic target for the future treatment of hepatocellular carcinoma (HCC). In this study, the expression of Bmi1 in HCC tissues was evaluated ...
Pandey Swaroop Kumar - - 2012
SUMMARY Quinine (QN) and quinidine (QND) have been commonly used as effective and affordable antimalarials for over many years. Quinine primarily is used for severe malaria treatment. However, plasmodia resistance to these drugs and poor patient compliance limits their administration to the patients. The declining sensitivity of the parasite to ...
Jacobs Bram - - 2012
BACKGROUND: With this study we aimed to design validated outcome prediction models in moderate and severe traumatic brain injury (TBI) using demographic, clinical, and radiological parameters. METHODS: Seven hundred consecutive moderate or severe TBI patients were included in this observational prospective cohort study. After inclusion, clinical data were collected, initial ...
Gounant Valérie - - 2012
Lung cancer is a common and serious disease, only early stage are curable. It is a logical candidate for a screening policy, especially as current and former smokers are easy to identify. The inefficiency of the chest radiograph is now proven, while the low-dose CT has shown promising data following ...
Sawada Akihito - - 2012
Aseptic meningitis and acute parotitis have been observed after mumps vaccination. Mumps outbreaks have been reported in Japan because of low vaccine coverage, and molecular differentiation is required to determine whether these cases are vaccine associated. RT-nested PCR was performed in the small hydrophobic gene region, and viruses were differentiated ...
Akagi Yoshito - - 2012
Radical surgical treatment for very low rectal cancer near the anus has generally involved abdominoperineal resection. Various sphincter-saving operations have been developed for such tumors to optimize the patients' postoperative quality of life. Current protocols focus on intersphincteric resection (ISR), which differs from conventional hand-sewn coloanal anastomosis (CAA) after low ...
Fontana M - - 2012
Risk-based, patient-centred decision-making, supported by best available evidence is an essential component for the correct prevention, control and management of dental caries. This article reviews the importance of caries risk assessment in adults as a prerequisite for appropriate caries preventive and treatment intervention decisions. A clinical case will be used ...
Giuliani P - - 2012
Guanosine has been reported to exert neuroprotective effects. We recently reported that, following intraperitoneal (i.p.) injection to rats, it resulted to be widely distributed. Its metabolic product guanine also rapidly increased in all the tissues, including brain, after i.p. injection of guanosine and consistently we found a significant enzymatic activity ...
Araie Makoto - - 2012
In addition to classical stereo-disc photography, various glaucoma imaging devices were developed in the last two decades to quantitatively measure and record glaucoma-related structural parameters of the eye. In determining whether or not the glaucomatous damage progressed from baseline and in estimating the number of test results' optimal frequency needed ...
Franco Satiko Shimada - - 2012
BACKGROUND: patients with mitral valve disease can progress to having pulmonary congestion, which increases the work the respiratory muscles. This overload can change the breathing pattern with a predominance of rib cage displacement or presence of paradoxical movements. OBJECTIVE: a) to study the breathing pattern and thoracoabdominal movement of patients ...
Johnson Mary Ann - - 2012
It is estimated that by 2050 there will be 2 billion people aged 60 years and older in the world. The evidence base for the health benefits of good nutrition and physical activity, as well as weight loss among overweight and obese adults, is growing and a number of policies ...
Wong Him Cheng - - 2012
The stability and association of polymer-fullerene films upon thermal annealing depends strongly on exposure to light, even at ambient conditions. As a result, dewetting of nanocomposite films can be prevented and the characteristic lengthscales of phase separated morphologies finely tuned. Coupling photopatterning with either self-organization process provides a powerful route ...
Babacan-Yildiz Gulsen - - 2012
ABSTRACT Background: The aim was to develop a brief screening battery, Cognitive State Test (COST), for detecting the presence of dementia in both illiterate and literate patients and to assess its validity and reliability. Methods: COST is a cognitive screening tool that consists of almost all cognitive domains. It takes ...
Ohnishi Takashi - - 2012
Previously, we proposed a 2D/3D registration method that uses Powell's algorithm to obtain 3D motion of a knee joint by 3D computed-tomography and bi-plane fluoroscopic images. The 2D/3D registration is performed consecutively and automatically for each frame of the fluoroscopic images. This method starts from the optimum parameters of the ...
Das Rahul K - - 2012
N-type inactivation of potassium channels is controlled by cytosolic loops that are intrinsically disordered. Recent experiments have shown that the mechanism of N-type inactivation through disordered regions can be stereospecific and vary depending on the channel type. Variations in mechanism occur despite shared coarse grain features such as the length ...
Kandiah P - - 2012
Aim This prospective, randomised, parallel, controlled study was conducted firstly to compare the onset of local anaesthesia (LA) when using the conventional technique versus the Wand computer-controlled LA and secondly to assess the pain experience in children.Method Thirty children were randomly allocated to the treatment group (Wand) or the control ...
Prakash Om - - 2012
Despite tremendous advances in microbial ecology over the past two decades, traditional cultivation methods have failed to grow ecologically more relevant microorganisms in the laboratory, leading to a predominance of weed-like species in the world's culture collections. In this review, we highlight the gap between culture-based and culture-independent methods of ...
Verberkmoes N J - - 2012
AIM: The PAS-Port® Proximal Anastomosis System (Cardica, Inc, Redwood City, CA, USA) has been used worldwide since March 2003. The objective of the present study was to evaluate the clinical outcome of the PAS-Port® Proximal Anastomosis System. METHODS:All the patients who underwent off-pump coronary artery bypass grafting in the Catharina ...
Liu Guoqing - - 2012
Palindromic sequences are important DNA motifs related to gene regulation, DNA replication and recombination, and thus, investigating the evolutionary forces shaping the distribution pattern and abundance of palindromes in the genome is substantially important. In this article, we analyzed the abundance of palindromes in the genome, and then explored the ...
Tan Grace Hwei Ching - - 2012
PURPOSE: The liver and peritoneum are common sites of colorectal metastases. Hepatectomy for colorectal liver metastases (CLM) is considered gold standard treatment. We attempt to compare the survival outcomes for CLM patients after hepatectomy to that of patients with colorectal peritoneal metastases (CPM) who underwent cytoreductive surgery (CRS) and hyperthermic ...
Lang F U - - 2012
OBJECTIVE: In the past, the comparability of empirical studies that examined the course and outcome of schizophrenia was limited by their use of different diagnostic systems. Focussing on the psychopathological long-term outcome, the present article aims to review follow-up studies that used modern operationalized diagnostic criteria for schizophrenia (DSM-III, DSM-III-R, ...
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