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Polk Sarah S Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. - - 2013
A clear understanding of local transmission dynamics is a prerequisite for the design and implementation of successful HIV prevention programs. There is a tremendous need for such programs geared towards young African-American women living in American cities with syndemic HIV and injection drug use. In some of these American cities, ...
Zaltz Ira I Department of Orthopedic Surgery, William Beaumont Hospital, Royal Oak, MI, - - 2013
The crossover sign is a radiographic finding associated with cranial acetabular retroversion and has been associated with pincer-type femoroacetabular impingement (FAI) in patients with hip pain. Variable morphology, location, and size of the anterior inferior iliac spine (AIIS) may contribute to the crossover sign even in the absence of retroversion. ...
Zanjani Hadi S HS UMR 7102, CNRSet Université Pierre et Marie Curie, 9 Quai St. Bernard, Paris, France. - - 2013
Recent studies using both dissociated and organotypic cell cultures have shown that heterozygous Lurcher (Lc/+) Purkinje cells (PCs) grown in vitro share many of the same survival and morphological characteristics as Lc/+ PCs in vivo. We have used this established tissue culture system as a valuable model for studying cell ...
Beckwith Jonathan G JG Simbex, Lebanon, NH 03766, USA. - - 2013
This study compares the frequency and severity of head impacts sustained by football players on days with and without diagnosed concussion and to identify the sensitivity and specificity of single-impact severity measures to diagnosed injury. One thousand two hundred eight players from eight collegiate football teams and six high school ...
Martini Douglas D School of Kineisology, Neurotrauma Research Laboratory, University of Michigan, Ann Arbor, MI 48109-2013, - - 2013
Recent literature suggests that subconcussive impacts may influence cognitive functioning across the life span. These effects are suggested to manifest as functional and possibly structural changes. Head impact biomechanics during American football have been characterized from the high school to professional level, but style of play has not been considered. ...
Beckwith Jonathan G JG Simbex, Lebanon, NH 03766, USA. - - 2013
Concussions are commonly undiagnosed in an athletic environment because the postinjury signs and symptoms may be mild, masked by the subject, or unrecognized. This study compares measures of head impact frequency, location, and kinematic response before cases of immediate and delayed concussion diagnosis. Football players from eight collegiate and six ...
Bruning Rebecca S RS Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, - - 2013
Antithrombotic therapy with oral aspirin (ASA) or clopidogrel (CLO) (Plavix; Bristol-Myers Squibb, Bridgewater, NJ) is associated with an attenuated skin vasodilator response and a greater rate of rise in core temperature in healthy, middle-age individuals during passive heating in a water perfused suit. The present double-blind, crossover study examined the ...
Shiels Rosch Keri K Laboratory for Neurocognitive and Imaging Research, Kennedy Krieger Institute, 716 North Broadway, Baltimore, MD 21205, USA. - - 2013
Increased intrasubject variability (ISV), or short-term, within-person fluctuations in behavioral performance is consistently found in Attention-Deficit/Hyperactivity Disorder (ADHD). ADHD is also associated with impairments in motor control, particularly in boys. The results of the few studies that have examined variability in self-generated motor output in children with ADHD have been ...
Saito Eiji E Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, - - 2013
Biomineral coatings have been extensively used to enhance the osteoconductivity of polymeric scaffolds. Numerous porous scaffolds have previously been coated with a bone-like apatite mineral through incubation in simulated body fluid (SBF). However, characterization of the mineral layer formed on scaffolds, including the amount of mineral within the scaffolds, often ...
Boyle Patrick J PJ Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom. - - 2013
The objective was to develop and evaluate a new sentence test, the Sentence Test with Adaptive Randomized Roving levels, intended to emulate everyday listening experience, using both normal-hearing (NH) and cochlear implant (CI) groups, examining practicality, learning, test-retest variability, and interlist variability. In experiment 1, each of 25 NH adults ...
Helfer Karen S KS Department of Communication Disorders, University of Massachusetts Amherst, Amherst, MA 01003, USA. - - 2013
The purpose of this study was to examine differences between older and younger listeners in the ability to sequentially attend to and ignore words. Participants (n = 13 older adults and 13 younger adults) completed a temporally interleaved word recognition task. On each trial, 10 words were presented, and participants ...
Bunupuradah Torsak T The Thai Red Cross AIDS Research Centre, Bangkok, Thailand. - - 2013
Excess risks for death/opportunistic disease in adults randomized to CD4-driven planned treatment interruption (PTI) in the Strategies for Management of Antiretroviral Therapy (SMART) trial remained after antiretroviral therapy (ART) re-initiation. Risks for children following PTI were evaluated in long-term follow-up of children in the PENTA 11 trial. Children with HIV ...
Cree-Green Melanie - - 2013
Type 2 diabetes (T2DM), historically an adult disease, is now increasingly prevalent in obese youth. Poor diet and increased sedentary behavior contribute to the increasing rates of obesity in youth, yet not all obese children develop T2DM. In general, T2DM is characterized by both insulin resistance (IR) and pancreatic beta-cell ...
Thurtell Matthew J MJ Department of Ophthalmology & Visual Sciences, University of Iowa, 200 Hawkins Dr PFP, Iowa City, IA, 52242, USA, - - 2013
Idiopathic intracranial hypertension (IIH, pseudotumor cerebri) is a syndrome of elevated intracranial pressure of unknown cause that occurs predominantly in obese women of childbearing age. It is a diagnosis of exclusion and, therefore, other causes of increased intracranial pressure must be sought with history, imaging, and cerebrospinal fluid examination before ...
Langer Steve G SG Mayo Clinic, Rochester, MN, USA. - - 2013
Recent information technology literature, in general, and radiology trade journals, in particular, are rife with allusions to the "cloud" suggesting that moving one's compute and storage assets into someone else's data center magically solves cost, performance, and elasticity problems. More likely, one is only trading one set of problems for ...
Taqueti Viviany R VR Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02114, - - 2013
Complications of atherosclerosis and thrombosis are leading causes of death worldwide. While experimental investigations have yielded valuable insights into key molecular and cellular phenomena in these diseases of medium- and large-sized vessels, direct visualization of relevant in vivo biological processes has been limited. However, recent developments in molecular imaging technology, ...
Papaleontiou Maria M Division of Metabolism, Endocrinology, and Diabetes, Department of Medicine, University of Michigan Health System, University of Michigan, Ann Arbor, Michigan, - - 2013
There is variation in the use of radioactive iodine (RAI) as treatment for well-differentiated thyroid cancer. The factors involved in physician decision-making for RAI remain unknown. We surveyed physicians involved in postsurgical management of patients with thyroid cancer from 251 hospitals. Respondents were asked to rate the factors important in ...
Hu Shijun S Department of Medicine, Division of Cardiology, Stanford University, Stanford, California, - - 2013
MicroRNAs (miRNAs) have emerged as critical regulators of gene expression through translational inhibition and RNA decay and have been implicated in the regulation of cellular differentiation, proliferation, angiogenesis, and apoptosis. In this study, we analyzed global miRNA and mRNA microarrays to predict novel miRNA-mRNA interactions in human embryonic stem cells ...
De Souza Yvonne G YG Department of Orofacial Sciences and the AIDS Research Institute, University of California San Francisco, San Francisco, CA 94143-0422, USA. - - 2013
The review explores the field of biobanking as it has evolved from a simple collection of frozen specimens to the virtual biobank. Biorepository and biospecimen science has evolved in response to the changing landscape of external regulatory pressures, the advances made in the biological sciences, and the advent of the ...
Sciaranghella Gaia - - 2013
To define the impact of chronic viremia and associated immune activation on B-cell exhaustion in HIV infection. Progressive HIV infection is marked by B-cell anergy and exhaustion coupled with dramatic hypergammaglobulinemia. Although both upregulation of CD95 and loss of CD21 have been used as markers of infection-associated B-cell dysfunction, little ...
Chan Deva D - - 2013
Osteoarthritis (OA) is a debilitating disease that reflects a complex interplay of biochemical, biomechanical, metabolic and genetic factors, which are often triggered by injury, and mediated by inflammation, catabolic cytokines and enzymes. An unmet clinical need is the lack of reliable methods that are able to probe the pathogenesis of ...
Mina Petros P Bristol Center for Complexity Sciences, University of Bristol, Bristol, UK. - - 2013
Population-level measurements of phenotypic behaviour in biological systems may not necessarily reflect individual cell behaviour. To assess qualitative changes in the behaviour of a single cell, when alone and when part of a community, we developed an agent-based model describing the metabolic states of a population of quorum-coupled cells. The ...
Jones Nick S NS Department of Mathematics, Imperial College London, London, - - 2013
Biological data objects often have both of the following features: (i) they are functions rather than single numbers or vectors, and (ii) they are correlated owing to phylogenetic relationships. In this paper, we give a flexible statistical model for such data, by combining assumptions from phylogenetics with Gaussian processes. We ...
Gao Ji-Ping - - 2013
Most agronomic traits are governed by quantitative trait loci (QTLs) and exhibit continuous distribution in a segregating population. The hereditary characteristics of these traits are more complicated than those of monogenic traits. Detection and isolation of these QTLs can greatly improve crop production throughout the world. In recent times, significant ...
Yu Zhiming - - 2013
Root hairs are highly polarized long tubular outgrowths from the surface of epidermal trichoblast cells. Root hair development is a simple process that has facilitated for the study of cell fate determination and tissue differentiation in higher plants. Root hair patterning types in dicot and monocot plants are different. Rice ...
Sha Xueyan - - 2013
Artificial hybridization has probably been practiced since ancient time; however, the science of genetics did not initiate until Gregor Mendel conducted a series of crosses between different pure lines of garden pea and made careful observations and systematical analyses of their offspring. Artificial hybridization or crossing between carefully chosen parents ...
Jia Yulin - - 2013
Sheath blight disease of rice caused by the soilborne fungal pathogen Rhizoctonia solani has been a major disease of rice with a serious threat to stable rice production worldwide. Although various cultural practices have been used to manage the disease, it is advantageous and important to screen rice germplasm and ...
Warthmann Norman - - 2013
Artificial microRNAs (amiRNAs) have been shown to facilitate efficient gene silencing with high specificity to the intended target gene(s). For the plant breeder, gene silencing by artificial miRNAs will certainly accelerate gene discovery, because it allows targeting of all genes in a mapping interval, independent of the genetic background. In ...
Cooper Jennifer L - - 2013
Mutagenesis is frequently used to test gene function and to aid in crop improvement. Targeting Induced Local Lesions in Genomes (TILLING) is a reverse genetic strategy first developed to identify induced point mutations in Arabidopsis. This general strategy has since been applied to many plant and animal species. Here, we ...
Jung Ki-Hong - - 2013
Despite the availability of the finished genome sequence and tools for its analyses, few rice genes have been characterized. Because Agrobacterium-mediated transformation causes random T-DNA insertions across the genome, T-DNA can be a good mutagen for functional genomics. Gene-indexed mutants with flanking sequences around inserted T-DNA are valuable resources for ...
Zhao Nan - - 2013
Plants emit volatile organic compounds (VOCs) from various organs. To understand the biological and ecological roles of plant VOCs as well as their biosynthesis, it is important to determine the quality and quantity of individual plant VOCs. Here we describe three techniques, including solid-phase microextraction, closed-loop stripping system, and an ...
Cho Kyoungwon - - 2013
Jasmonic acid (JA) and salicylic acid (SA) are critical signaling components involved in various aspects of plant growth, development, and defense. Their constitutive levels vary from plant to plant and also from tissue to tissue within the same plant. Moreover, their quantitative levels change when plant is exposed to biotic ...
Jagadeeswaran Guru - - 2013
Endogenous small RNAs can be grouped into several distinct classes of 21-nt-long microRNAs (miRNAs), short interfering RNAs (siRNAs), trans-acting siRNAs (tasiRNAs), and 24-nt long heterochromatic siRNAs. miRNAs are increasingly being recognized as significant effectors of gene regulation in a wide range of organisms. These molecules are typically ∼21-nt long and ...
Agrawal Ganesh Kumar - - 2013
Rice is one of the most important food and cereal crop plants in the world. Rice proteomics began in the 1990s. Since then, considerable progress has been made in establishing protocols from isolation of rice proteins from different tissues, organs, and organelles, to separation of complex proteins and to their ...
Peters B - - 2013
Among people living with HIV, the proportion of deaths attributed to chronic noninfectious comorbid diseases has increased over the past 15 years. This is partly a result of increased longevity in the era of highly active antiretroviral therapy (HAART), and also because HIV infection is related, causally or otherwise, to ...
Helliwell Emily E - - 2013
Rice diseases such as blast (Magnaporthe oryzae), sheath blight (Rhizoctonia solani) and bacterial blight (Xanthomonas oryzae pv oryzae) are a major obstacle to achieving optimal yields. To complement conventional breeding method, molecular and transgenic method represents an increasingly important approach for genetic improvement of disease resistance and reduction of pesticide ...
de Los Reyes Benildo G - - 2013
Rice is a chilling-sensitive plant that is particularly prone to injury during the early stages of seedling development and during flowering. Significant variation exists between subspecies with japonica cultivars generally being less sensitive than most indica cultivars. In most temperate and subtropical countries where rice is grown, crop damage often ...
Tai Thomas H - - 2013
Chemical mutagenesis of rice has been used extensively to generate useful genetic variation for the purpose of breeding improved varieties. More recently, advances in high-throughput genotyping platforms have enabled the efficient detection of point mutations generated by chemical agents. This in turn has renewed interest in using traditional chemical mutagenesis ...
Jung Ki-Hong - - 2013
Transcriptome analysis using oligonucleotide microarrays is a powerful tool for detecting changes in genome-wide transcripts under a given biological condition. Although the rice genome sequence is available, the number of functionally characterized genes in rice is still very limited. Genome-wide transcriptome analysis is a useful tool for elucidating the functions ...
Yang Bing - - 2013
Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas oryzae pv. oryzicola (Xoc) cause bacterial blight and bacterial leaf streak in rice, respectively. Despite being very closely related, the pathogens colonize different tissues and cause distinct diseases. The diseases are economically important and also serve as model systems for studying plant-bacterial interactions. ...
Li Yong-Fang - - 2013
Small RNAs (microRNAs and other classes of endogenous small interfering RNAs) play important roles in a wide variety of biological processes. However, integration of small RNAs in diverse biological networks relies on the confirmation of their RNA targets. In plants, miRNAs negatively regulate mRNA targets by guiding a cleavage in ...
Batlang Utlwang - - 2013
Drought and salinity stresses seriously affect rice plant growth and yield. The growing need to improve rice cultivars for drought and salt tolerance requires the development of reproducible screening methods that simulate field conditions, and which provide quantitative data for statistical testing and selection of genotypes with differential responses. In ...
Greenham Trevor - - 2013
The use of plants as bioreactors for the large-scale production of recombinant proteins has emerged as an exciting area of research. The current shortages in protein therapeutics due to the capacity and economic bottlenecks faced with modern protein production platforms (microbial, yeast, mammalian) has driven considerable attention towards molecular pharming. ...
Mizoi Junya - - 2013
Abiotic stress is a major factor limiting productivity of rice crops in large areas of the world. Because plants cannot avoid abiotic stress by moving, they have acquired various mechanisms for stress tolerance in the course of their evolution. Enhancing or introducing such mechanisms in rice is one effective way ...
Walling Jason G - - 2013
Fluorescent in situ hybridization (FISH) is a powerful method to visualize DNA sequences in the context of the whole chromosome. Yet despite the value of FISH analysis for cytogenetic studies, there are surprisingly few labs that are able to adapt the technique for their experiments in chromosomal and genome biology. ...
Srivastava Vibha - - 2013
Site-specific gene integration is a powerful technique for ensuring stable transgene expression. Transgenic plants produced by conventional transformation techniques often display highly variable transgene expression, which is mostly attributed to integration patterns consisting of multiple copies of transgene constructs. Therefore, it is desirable to generate single-copy integrations, preferably in a ...
McFarlin Daniel R DR Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA. - - 2013
Granger causality analysis of functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent signal data allows one to infer the direction and magnitude of influence that brain regions exert on one another. We employed a method for upsampling the time resolution of fMRI data that does not require additional interpolation beyond the interpolation ...
Ma Jun J Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, - - 2013
The oocyte-to-zygote transition entails transforming a highly differentiated oocyte into totipotent blastomeres and represents one of the earliest obstacles that must be successfully hurdled for continued development. Degradation of maternal mRNAs, which likely lies at the heart of this transition, is characterized by a transition from mRNA stability to instability ...
Siegrist J J Psychosoziale Arbeitsbelastungsforschung, Life Science Center, Heinrich-Heine-Universität Düsseldorf, Merowingerplatz 1a, 40225 Düsseldorf, Deutschland. - - 2013
In view of highly prevalent stressful conditions in modern working life, in particular increasing work pressure and job insecurity, it is of interest to know whether specific constellations of an adverse psychosocial work environment increase the risk of depressive disorder among employed people. This contribution gives a short overview of ...
Du Xin-Gang - - 2012
Swertia punicea Hemsl. (Gentianaceae) are used mainly for the treatment of acute bilious hepatitis, cholecystitis, fever, intoxification and jaundice in China, as a traditional Chinese folk medicine. Xanthones as the main chemical components of Swertia punicea have many possible pharmacological properties, such as hepatoprotective and anti-HIV. In order to obtain ...
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