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Results 201 - 250 of 2097
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Sozeri Betul - - 2012
BACKGROUND: In patients with systemic lupus erythematous (SLE) late-onset deaths are due to morbid cardiovascular changes (CVCs). Inflammatory and immune-mediated mechanisms are involved in promoting atherosclerosis development in SLE that is reflected in both functional and morphological changes in the cardiovascular system. The aim of our study was to determine ...
Kim Jong H - - 2012
An effective strategy for significantly increasing the organic transistor mobility with simultaneous reduction of threshold voltage utilizing discontinuous nano-patches of charge-transfer doping layer is demonstrated. By overlaying the nano-patches on top of a given semiconducting film, mobility and threshold voltage of p-type pentacene were remarkably improved to 4.52 cm(2) V(-1) ...
Hosmer Jaclyn M - - 2012
PURPOSE: To develop liquid crystalline phases with monoglycerides, and assess whether the monoglyceride type favors cutaneous over transdermal paclitaxel delivery. METHODS: BRIJ-based lamellar phases were prepared with 0.5% paclitaxel and 20% of either monocaprylin (LP-MC), monomyristolein (LP-MM) or monoolein (LP-MO). Skin electrical resistance, drug release and cutaneous delivery in vitro ...
Golestanirad Laleh - - 2012
This paper provides a theoretical assessment of the safety considerations encountered in the simultaneous use of transcranial magnetic stimulation (TMS) and neurological interventions involving implanted metallic electrodes, such as electrocorticography. Metal implants are subject to magnetic forces due to fast alternating magnetic fields produced by the TMS coil. The question ...
Joly Claire - - 2012
The impact of the insecticide chlorpyrifos (CPF) on the mammalian digestive system has been poorly described. The present study aimed at evaluating the effect of chronic, low-dose exposure to CPF on the composition of the gut microbiota in a Simulator of the Human Intestinal Microbial Ecosystem: the SHIME® and in ...
Urai H - - 2012
Delayed onset muscle soreness (DOMS) is reduced when the same exercise is repeated after a certain interval. However, the mechanism for this adaptation, called a repeated bout effect, is still not well understood. Recently, we showed that upregulated nerve growth factor (NGF) triggered by B2 bradykinin receptor (B2R) activation in ...
Xu Fang - - 2012
Multiplex PCR amplification of microsatellites has significantly increased the throughput and decreased the costs of genotyping. We have developed two highly polymorphic microsatellite multiplexes for Populus euphratica, the only tree species found in desert regions of Western China and adjacent Central Asian countries. The first of these multiplex kits comprises ...
Paletto Alessandro - - 2012
Values are generally defined as social facts that orientate individual and collective actions, and consequently influence political, economic and social systems. The evaluation of natural resource values is considered an important instrument to support decision making in environmental policy. The forest is an important renewable resource that provides a mix ...
Kitano Hisataka - - 2012
BACKGROUND: Expression of FasL in cancer cells is currently being explored as a potential cancer therapy. Because high levels of FasL are necessary for effective treatment, current methods typically rely on use of highly efficient viral vectors. However, because viral vector-based gene therapy is associated with certain risks, the development ...
Mollica Adriano - - 2012
AM94 is a fluorinated analog of biphalin with non-hydrazine linker that has an in vitro affinity for μ-opioid and δ-opioid receptors tenfold higher than biphalin. Furthermore, in vivo evaluation in rats showed that AM94 has in hot plate test - after both intracerebroventricular and intravenous administrations - a greater and ...
Kwak Minyoung - - 2012
OBJECTIVES: Post-traumatic stress symptoms (PTSS) have been identified as a meaningful indicator of distress in cancer survivors. Distinct from young adult survivors of childhood cancer, young people diagnosed with cancer as adolescents and young adults (AYAs) face unique psychosocial issues; however, there is little published research of PTSS in the ...
Wedley Amy L - - 2012
Enteropathogenic Escherichia coli (EPEC) is usually associated with outbreaks and sporadic cases of severe infantile diarrhoea in the developing world, and less commonly with sporadic cases in developed countries. Very little evidence indicates that EPEC is a food-borne pathogen for adults. In a previous study, two groups of adult travellers ...
Soto E - - 2012
Francisella noatunensis subsp. orientalis (Fno) (syn. F. asiatica) is an emergent Gram-negative facultative intracellular bacterium. Although it is considered one of the most pathogenic bacteria in fish, there are no commercially available treatments or vaccines. The objective of this project was to determine the most efficacious concentration of florfenicol (FFC) [10, ...
Shaker Olfat G - - 2012
Visceral adipose fat has been claimed to be the link between obesity and insulin resistance through the released adipokines. This study aimed to assess the expression of vaspin as one of the recent adipokines in rats abdominal subcutaneous and visceral fat in diet-induced obese (DIO) and in DIO performing 3 weeks ...
Laviv Yosef - - 2012
Histiocytic sarcoma is a rare, lymphohematopoietic malignant neoplasm composed of tumor cells showing morphologic and immunophenotypic features of mature tissue histiocytes. Involvement of the central nervous system (CNS) as either a part of a systemic disease or as a primary lesion has rarely been described so far. We present a ...
Patrizia Messi - - 2012
Three Legionella pneumophila strains isolated from municipal hot tap water during a multicentric Italian survey and belonging to serogroups 1, 6, 9 and the reference strain Philadelphia-1 were studied to determine the intracellular replication capability and the cytopathogenicity in human monocyte cell line U937 and in an Acanthamoeba polyphaga strain. ...
Hannink Gerjon - - 2012
Bone morphogenetic proteins (BMPs) are the most potent osteoinductive growth factors. However, a delivery system is essential to take advantage of the osteoinductive effect of BMPs. The purpose of this study was to develop a sustained delivery system for recombinant human bone morphogenetic protein-2 (BMP-2). We covalently attached heparin to ...
Raiten Jesse M - - 2012
After receiving a ventricular assist device, a patient experiences months of advances and setbacks in the ICU. She's one of a new subcategory of ICU patients: the chronically critically ill. Their stories reveal shortcomings of common perspectives on medical decision making.
Yiş Uluç - - 2012
The aim of this study is to evaluate the clinical, electroencephalographic and polysomnographic features of patients presenting with parasomnias. Cases who were admitted for differentiating parasomnias from epilepsy were included in the study. Clinical features of cases were recorded and routine sleep electroencephalography was obtained from all cases. Cases whose ...
Wang Yuan - - 2012
A series of trinitromethyl/trinitroethyl substituted derivatives of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo[5,5,0, 0(3.11),0(5.9)] dodecane (CL-20) were designed and investigated by theoretical methods. Intramolecular interactions between the trinitromethyl/trinitroethyl and the cage were investigated. The effects of trinitromethyl/trinitroethyl groups on stability of the parent compound are discussed. The results reveal a mutual influence of bond length ...
Harper J - - 2012
Surface melt on the Greenland ice sheet has shown increasing trends in areal extent and duration since the beginning of the satellite era. Records for melt were broken in 2005, 2007, 2010 and 2012. Much of the increased surface melt is occurring in the percolation zone, a region of the ...
Landré Vivien - - 2012
Understanding the determinants for site-specific ubiquitination by E3-ligase components of the ubiquitin-machinery is proving to be a challenge. Here we investigate the role of an E3-ligase docking site (Mf2-domain) in an intrinsically disordered domain of IRF-1, a short-lived IFN-γ regulated transcription factor, in ubiquitination of the protein. Ubiquitin modification of ...
Tabak Nili - - 2012
AIMS AND OBJECTIVES: To investigate the intentions of nurses and nursing students to telling the truth to patients and families, based on the Theory of Planned Behavior which examines intention to perform behaviours. BACKGROUND: In recent decades, the perception that patients have a moral and legal right to truthful and ...
Bhatti Irfan - - 2012
We performed a retrospective chart review of 50 youths with Autism Spectrum Disorder (ASD), prescribed amitriptyline (AMI) for hyperactivity and impulsivity. Data was systematically extracted from 50 outpatient clinic charts, including AMI treatment duration, dose, trough levels and adverse events. Mean age was 9.4 years (4.6-17.9); 40 were males and 10 ...
Bradley Robert H - - 2012
This study used data from the NICHD Study of Early Child Care and Youth Development to examine relations between parenting, self-control and externalizing behavior from early childhood to mid-adolescence (N = 956; 49.9 % male). Results indicated that maternal sensitivity, parental harshness and productive activity are related to externalizing problems but that patterns ...
Kute Vivek B - - 2012
BACKGROUND: Economic constraints in operating an effective maintenance dialysis program leaves renal transplantation as the only viable option for end-stage renal disease patients in India. Kidney paired donation (KPD) is a rapidly growing modality for facilitating living donor (LD) transplantation for patients who are incompatible with their healthy, willing LD. ...
Bongio Matilde - - 2012
Injectable bone substitutes (IBSs) represent an attractive class of ready-to-use biomaterials, both ceramic- and polymer-based, as they offer the potential benefit of minimally invasive surgery and optimal defect filling. Although in vitro assessments are the first step in the process of development, the safety and efficacy of an IBS strongly ...
Ebrahimizadeh Walead - - 2012
Vibrio cholerae is considered one of the major health threats in developing countries. Lack of efficient vaccine, short incubating time of the disease, and bacterium ability to survive in aquatic environment have made cholera one of the most epidemic diseases yet known. The lipopolysaccharide is one of the bacterium key ...
Yadav Pankaj - - 2012
Although, circadian clocks are believed to be involved in the regulation of life-history traits such as pre-adult development time and lifespan in fruit flies Drosophila melanogaster, there is very little unequivocal evidence either to support or refute this. Here we report the results of a long-term study aimed at examining ...
Yu Q - - 2012
BACKGROUND: Combined dexamethasone and tropisetron has been reported more effective than a single drug therapy in preventing postoperative nausea and vomiting (PONV). However, the safety use of dexamethasone has been questioned recently because of the risk of secondary adrenal deficiency. Therefore, we hypothesized that combined tropisetron and methylprednisolone, a short-lasting ...
Wang Xian-Huo - - 2012
Objective: The purpose of this study was to investigate the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and pharmacokinetics of ursolic acid liposomes (UAL), as a new drug, in healthy adult volunteers and patients with advanced solid tumors. Methods: All subjects received a single-dose of UAL (11, 22, 37, 56, ...
Hall Andrew Rennie - - 2012
Hall A R, Tsochatzis E, Morris R, Burroughs A K & Dhillon A P (2012) Histopathology Sample size requirement for digital image analysis of collagen proportionate area in cirrhotic livers Aims:   The requirements for adequate cirrhotic liver biopsy size have not been established for quantitative fibrosis measurements (collagen proportionate area: ...
Sutton Matt - - 2012
Pay-for-performance programs are being adopted internationally despite little evidence that they improve patient outcomes. In 2008, a program called Advancing Quality, based on the Hospital Quality Incentive Demonstration in the United States, was introduced in all National Health Service (NHS) hospitals in the northwest region of England (population, 6.8 million). ...
Dudvarski Zoran - - 2012
Recent studies have evidenced that nasal polyposis (NP) may lead to significant limitations in physical, emotional and social aspects of life of the affected patients. The study is aimed to investigate the influence of asthma on quality of life (QoL), intensity of symptoms, endoscopic and computerized tomography (CT) sinus findings ...
Lambidis Constantinos - - 2012
The superiority of autogenous fistulae in patients with end-stage renal disease, performing hemodialysis, is well established and largely accepted. However, in case that superficial veins in the upper arm are not available for fistula construction, brachial vein transposition may be a viable alternative prior to graft placement. This transposition could ...
Li Jingguo - - 2012
Herein, we synthesize a coumarin-substituted diacetylene monomer (CODA) and report the novel photo-controlled reversible assembly and disassembly behavior of the polymerized CODA (PCODA) vesicles. The photo-triggered dimerization and cleavage reactions of the coumarin groups within the surface of the adjacent PCODA vesicles can be utilized as the driving force to ...
Ruggiero Simona - - 2012
Introduction. To the average consumer, "cosmetics" are not considered to cause damage to human health under normal conditions of use. Thus, cosmetic "safety" does not require any particular attention to the possibility that cosmetics may result in a toxic exposure, especially for children. Poison Control Centres (PCCs) provide specialized and ...
de la Rosa Xavier - - 2012
PURPOSE: Stroke induces strong expression of the 72-kDa heat-shock protein (HSP-70) in the ischaemic brain, and neuronal expression of HSP-70 is associated with the ischaemic penumbra. The aim of this study was to image induction of Hsp-70 gene expression in vivo after brain ischaemia using reporter mice. METHODS: A genomic ...
Li Wei - - 2012
Temporal analytical techniques to track nanoparticles in live cell would provide rich information to well understand the biologic properties of nanoparticles in molecular level. Significant advances in fluorescence microscopy techniques with high temporal and spatial resolution allow single nanoparticles to label biomolecules, ions, and microstructures in live cells, which will ...
Jacob Heike - - 2012
Emotional communication uses verbal and nonverbal means. In case of conflicting signals, nonverbal information is assumed to have a stronger impact. It is unclear, however, whether perceptual nonverbal dominance varies between individuals and whether it is linked to emotional intelligence. Using audiovisual stimulus material comprising verbal and nonverbal emotional cues ...
Rhodes Allison J - - 2012
Here, we report a method for synthesis of cylindrical copolypeptide brushes via N-carboxyanhydride polymerization utilizing a new tandem catalysis approach that allows preparation of brushes with controlled segment lengths in a straightforward, one-pot procedure requiring no intermediate isolation or purification steps. To obtain high density brush copolypeptides, we used a ...
Howard David L - - 2012
To assess physician attitude towards making oral contraceptives available over the counter in the United States (US). We assessed physician attitudes towards a transition from prescription only to over-the-counter availability (rx-OTC) for oral contraceptive pills by disseminating an electronic survey directed primarily to residents training in Obstetrics and Gynecology (OBGYN) ...
Runquist Ryan Briscoe - - 2012
A plant species immigrating into a community may experience a rarity disadvantage due to competition for the services of pollinators. These negative reproductive interactions have the potential to lead to competitive displacement or exclusion of a species from a site. In this study, we used one- and two-species arrays of ...
Creveling J R - - 2012
Palaeomagnetic studies of Palaeoproterozoic to Cretaceous rocks propose a suite of large and relatively rapid (tens of degrees over 10 to 100 million years) excursions of the rotation pole relative to the surface geography, or true polar wander (TPW). These excursions may be linked in an oscillatory, approximately coaxial succession ...
Tsuboi Nobuo - - 2012
BACKGROUND: Studies have suggested that obesity-related glomerulopathy (ORG) is one of the important disease entities leading to end-stage renal disease. However, information is limited regarding the clinical features and renal outcomes of Japanese ORG patients. METHODS: Among the patients whose renal biopsy was performed at our institute during the past ...
Qu Fei - - 2012
Ag nanoclusters functioned by hyperbranched polyethyleneimine have been developed as a new fluorescent and colorimetric platform for sensitive and selective recognition of halide ions (e.g., Cl-, Br-, and I-). The recognition mechanism is based on the unique reactions between halide ions and the silver atoms. In particular, halide-induced oxidative etching ...
Palermo Francesco A - - 2012
Aloes are now considered a very interesting source of bioactive compounds among which phytosterols should play a major role. The present study is an attempt to investigate the hypocholesterolemic activity of Aloe vera associated with its impact on the reproductive status of juvenile goldfish. Therefore, the short- and long-term effects ...
Sumby Krista M - - 2012
AIM: To clone and characterise two related intracellular esterases from Oenococcus oeni and Lactobacillus hilgardii under wine-like conditions. METHODS AND RESULTS: The published genome sequences for O. oeni and Lb. hilgardii were used to identify, clone and purify putative esterase genes from these species designated EstCOo8 and EstC34 respectively. Both ...
Wang Hui - - 2012
Glycoproteins derived from Hansenula polymorpha can not be used for therapeutic purposes due to their high-mannose type asparagine-linked (N-linked) glycans, which result in immune reactions and poor pharmacokinetic behaviors in human body. Previously, we reported that the trimannosyl core N-linked glycans (Man(3)GlcNAc(2)) intermediate can be generated in endoplasmic reticulum in ...
Vallianou Natalia G - - 2012
BACKGROUND: Neck circumference, beyond a measure of obesity, is a unique fat depot with increasing significance. This study aimed to investigate the association between neck circumference and biomarkers, indicators of cardiovascular risk. METHODS: During 2009, 490 volunteers (46 ± 16 years, 40% males) were consecutively enrolled to the study (participation rate 85%). Biochemical ...
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