Search Results
Results 951 - 1000 of 2099
< 15 16 17 18 19 20 21 22 23 24 25 >
Beckmann Jens - - 2012
The homoleptic 1:1 Lewis pair (LP) complex [MesTe(TeMes(2))]O(3)SCF(3) (1) featuring the cation [MesTe(TeMes(2))](+) (1a) was obtained by the reaction of Mes(2)Te with HO(3)SCF(3). The reaction of 1 with Ph(3)E (E = P, As, Sb, Bi) proceeded with substitution of Mes(2)Te and provided the heteroleptic 1:1 LP complexes [MesTe(EPh(3))]O(3)SCF(3) (2, E ...
Peelen Marius V - - 2012
Interaction with everyday objects requires the representation of conceptual object properties, such as where and how an object is used. What are the neural mechanisms that support this knowledge? While research on semantic dementia has provided evidence for a critical role of the anterior temporal lobes (ATLs) in object knowledge, ...
Liu Yu-Peng - - 2012
Platinum-based chemotherapy is the first-line treatment for non-small cell lung cancer, but recurrence occurs in most patients. Recent evidence suggests that CD133+ cells are the cause of drug resistance and tumor recurrence. However, the correlation between chemotherapy and regulation of CD133+ cells has not been investigated methodically. In this study, ...
Jung Jae-Hoon JH Department of Chemistry, Seoul National University, Seoul 151-742, - - 2012
The timing of flowering is coordinated by a web of gene regulatory networks that integrates developmental and environmental cues in plants. Light and temperature are two major environmental determinants that regulate flowering time. Although prolonged treatment with low nonfreezing temperatures accelerates flowering by stable repression of FLOWERING LOCUS C (FLC), ...
Bedke Jens - - 2012
What's known on the subject? and What does the study add? White blood cell count and C-reactive protein are reliable prognostic RCC Biomarkers.Nevertheless, accepted cut-offs for risk stratifications are missing. Therefore, both parameters were re-evaluated and multivariable analyses revealed an optimal CRP breakpoint at 0.25 mg/dL to be best to stratify ...
Rodrigues Aline Fernanda de Almeida Chaves - - 2012
The exposure of the fetus to a hyperglycemic environment promotes the development of hypertension and renal dysfunction in the offspring at adult age. We evaluated the role of renal nerves in the hypertension and renal changes seen in offspring of diabetic rats. Diabetes was induced in female Wistar rats (streptozotocin ...
Liu Lingjun - - 2012
The reaction of CuCl-catalyzed coupling of thiol ester with organostannane has been theoretically investigated using density functional calculations. This reaction takes place with CuCl as a catalyst, giving the product ketone and an organotin sulfide. The relatively low overall activation barrier calculated (26.0 kcal/mol) supports the experimental fact that this ...
Krause Kim - - 2012
Human activities have drastically increased nitrogen (N) inputs into natural and near-natural terrestrial ecosystems such that critical loads are now being exceeded in many regions of the world. This implies that these ecosystems are shifting from natural N limitation to eutrophication or even N saturation. This process is expected to ...
Regoes Roland R RR Institute of Integrative Biology, ETH Zurich, - - 2013
Many viruses, particularly RNA viruses, mutate at a very high rate per genome per replication. One possible explanation is that high mutation rates are selected to meet the challenge of fluctuating environments, including the host immune response. Alternatively, recent studies argue that viruses evolve under a trade-off between replication speed ...
Jeong Hee-Rok HR Department of Food Science and Technology, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, - - 2012
To investigate neuronal cell protective effects of an ethyl acetate fraction from chestnut inner skin, in vitro assays, including 2',7'-dichlorofluorescein diacetate, 3-[4,5-dimethythiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT), and lactate dehydrogenase (LDH), were performed. Intracellular accumulation of reactive oxygen species resulting from hydrogen peroxide (H(2)O(2)) treatment of PC12 cells was significantly reduced when ...
Wang Sunli - - 2012
TiO(2)-Ag hybrid hollow spheres (about 700 nm in diameter) with a highly uniform morphology and good structural stability were facilely prepared via a one-pot hydrothermal method, using carbon spheres as templates followed by an annealing treatment. Through this route, the as-prepared hybrid hollow spheres preserved the uniformity of the initial ...
- - 2012
Note from the Editors: The author of this issue's Editorial: The coming paradigm shift, has been interviewed in email by China Medical Tribune, before the editorial is published. For the benefit of our readers, we publish the questions and answers together with the Editorials. The Editorial and the Interview will be re-published in Chinese language ...
Daur Nelly - - 2012
We studied how similar postsynaptic responses are maintained in the face of interindividual variability in the number of presynaptic neurons. In the stomatogastric ganglion of the lobster, Homarus americanus, the pyloric (PY) neurons exist in variable numbers across animals. We show that each individual fiber of the stomach muscles innervated ...
Kanzaki Ryo - - 2012
Proton-donating and ionization properties of several protic ionic liquids (PILs) made from N-methylimidazole (Mim) and a series of acids (HA) have been assessed by means of potentiometric and calorimetric titrations. With regard to strong acids, bis(trifluoromethanesulfonyl) amide (Tf2NH) and trifluoromethanesulfonic acid (TfOH), it was elucidated that the two equimolar mixtures ...
To Kelvin K W - - 2013
We report a pseudo-outbreak of Tsukamurella due to improperly wrapped scissors used for processing of tissue specimens. A polyphasic approach, involving biochemical, genetic, and metabolomic techniques, was used in the laboratory investigation. This report highlights that early recognition of pseudo-outbreaks is important in preventing unnecessary and incorrect treatment of patients.
Ali Mohammad Javed - - 2012
AIMS: To study the clinical and diagnostic profile of punctal dysgenesis with membranes, to classify and correlate the membranes clinicopathologically and study the outcomes of membranotomy. METHODS: A prospective interventional study involving 55 dysgenetic puncta of 22 consecutive patients seen between July 2008 ansd December 2011. Data collected include demographics, ...
Madakashira Bhavani P BP Department of Zoology, Miami University, Oxford, OH 45056, - - 2012
Most growth factor receptor tyrosine kinases (RTKs) signal through similar intracellular pathways, but they often have divergent biological effects. Therefore, elucidating the mechanism of channeling the intracellular effect of RTK stimulation to facilitate specific biological responses represents a fundamental biological challenge. Lens epithelial cells express numerous RTKs with the ability ...
Barnes Michael D - - 2012
The article provides an overview of efforts to improve public health and health education training and on the potential use of Critical Component Elements (CCEs) for undergraduate health education programs toward more consistent quality assurance across programs. Considered in the context of the Galway Consensus Conference, the authors discuss the ...
Berscheminski Julia - - 2013
PML nuclear bodies (PML NBs), also called ND10, are matrix-bound nuclear structures that have been implicated in a variety of functions, including DNA repair, transcriptional regulation, protein degradation, and tumor suppression. These domains are also known for their potential to mediate an intracellular defense mechanism against many virus types. This ...
Suh Junho - - 2012
We report the results of back-action evading experiments utilizing a tightly coupled electro-mechanical system formed by a radio-frequency micromechanical resonator parametrically coupled to a NbTiN superconducting microwave resonator. Due to excess dissipation in the microwave resonator, we observe a parametric instability induced by a thermal shift of the mechanical resonance ...
Krkosek Martin M Department of Zoology, University of Otago, Dunedin, New Zealand. - - 2013
Parasites may have large effects on host population dynamics, marine fisheries and conservation, but a clear elucidation of their impact is limited by a lack of ecosystem-scale experimental data. We conducted a meta-analysis of replicated manipulative field experiments concerning the influence of parasitism by crustaceans on the marine survival of ...
Liu Nick W NW Urologic Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, - - 2013
Previous studies have shown that ischemia alters gene expression in normal and malignant tissues. There are no studies that evaluated effects of ischemia in renal tumors. This study examines the impact of ischemia and tissue procurement conditions on RNA integrity and gene expression in renal cell carcinoma. Ten renal tumors ...
Montaño Sherwin P - - 2012
Studies of bacteriophage Mu transposition paved the way for understanding retroviral integration and V(D)J recombination as well as many other DNA transposition reactions. Here we report the structure of the Mu transpososome--Mu transposase (MuA) in complex with bacteriophage DNA ends and target DNA--determined from data that extend anisotropically to 5.2 Å, ...
Xu Qing-Wen - - 2012
Tumor-specific antigens (TSA) are central elements in the immune control of cancers. To systematically explore the TSA genome, we developed a computational technology called heterogeneous expression profile analysis (HEPA), which can identify genes relatively uniquely expressed in cancer cells in contrast to normal somatic tissues. Rating human genes by their ...
Semmler Alexander - - 2012
OBJECTIVES: The objective of this preliminary study was to explore long-term changes in neurobehavioral parameters, brain morphology and electroencephalography of sepsis patients who received intensive care compared to non-septic intensive care unit (ICU) patients. METHODS: Two-centre follow-up study 6-24 months after discharge from hospital using published norms and existing databases ...
Das Utpal - - 2012
An organocatalytic asymmetric synthesis of spironitrocyclopropanes has been demonstrated starting from 2-arylidene-1,3-indandiones and bromonitroalkanes catalyzed by a cinchona-derived bifunctional organocatalyst. The products were obtained with excellent enantioselectivities, diastereoselectivities and with good yields.
Wong Jordan R - - 2012
BACKGROUND:No studies exist regarding the value of pharmacist interventions using rapid identification of coagulase-negative staphylococci (CoNS) by rapid polymerase chain reaction (rPCR) from blood cultures.OBJECTIVE:To evaluate the impact of interventions by infectious diseases pharmacists (ID PharmDs) on blood cultures positive for CoNS using rPCR and assess the duration of antistaphylococcal ...
Tyritzis Stavros I - - 2012
Abstract We are celebrating the 10th anniversary of robot-assisted laparoscopic radical cystectomy (RARC) with urinary diversion (UD), and it seems that this operation is successfully following the footsteps of robot-assisted laparoscopic radical prostatectomy. Until now, approximately 1000 RARCs have been recorded; of them, only 102 were performed totally intracorporeally with ...
Gibson Andrew - - 2012
BACKGROUND: Fruit and vegetable (FV) intake, which is often low in older people, is associated with reduced chronic disease risk. OBJECTIVE: We determined whether increased FV intake improves measures of immune function. DESIGN: We conducted a randomized controlled trial (The Ageing and Dietary Intervention Trial) in 83 healthy volunteers aged ...
van Angelen Annelies A - - 2012
BackgroundCisplatin is an effective anti-neoplastic drug, but its clinical use is limited due to dose-dependent nephrotoxicity. The majority of cisplatin-treated patients develop hypomagnesaemia, often associated with a reduced glomerular filtration rate (GFR), polyuria and other electrolyte disturbances. The aim of this study is to unravel the molecular mechanism responsible for ...
Zhang Wen-Juan - - 2012
MLAA-34 is a novel acute monocytic leukemia (M5)-associated antigen (MLAA) that plays a role in the apoptosis of U937 cells. However, the expression and molecular mechanism of MLAA-34 in U937 cells remain largely unclear. Here, we utilized three strategies to gain insight into the expression and molecular functions of MLAA-34 ...
Li Dawei D Department of General Surgery, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai, People's Republic of - - 2013
The mammalian Forkhead Box (Fox) transcription factor FOXM1 is implicated in tumorigenesis including mouse intestinal cancer. However, the clinical significance of FOXM1 signaling in human colorectal cancer pathogenesis remains unknown. We investigated FOXM1 expression in 203 cases of primary colon cancer and matched normal colon tissue specimens and explored the ...
Tsen Adam W - - 2012
Graphene, a truly two-dimensional hexagonal lattice of carbon atoms, possesses remarkable properties not seen in any other material, including ultrahigh electron mobility, high tensile strength, and uniform broadband optical absorption. While scientists initially studied its intrinsic properties with small, mechanically exfoliated graphene crystals found randomly, applying this knowledge would require ...
Ghose Kaushik - - 2012
An important question in neuroscience is how the activity from spatially distributed cortical representations is integrated and processed together. In this study, we used a new approach to investigate the integration of distributed cortical activity. We used microstimulation to directly activate pairs of sites in primary visual cortex of rhesus ...
Outterson Kevin - - 2012
Food and Drug Administration (FDA) rules are often forged in crisis. After the 1937 sulfanilamide disaster that killed more than 100 people, Congress passed the Food, Drug, and Cosmetic Act (FDCA), requiring drugs to be safe and properly labeled. In 1962, a requirement was introduced for proof of drug efficacy ...
Panja Anangamohan - - 2012
A new symmetrical tricyanide building block mer-[Fe(bbp)(CN)(3)](2-) [1; bbp = bis(2-benzimidazolyl)pyridine dianion] has been prepared and structurally and magnetically characterized. It forms a new low-spin meridionally capped {Fe(III)L(CN)(3)} fragment with the tridentate bbp ligand. The reaction of 1 with Ni(II) salts in the presence of various ancillary ligands affords several ...
Russell Mike R MR Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, - - 2013
Neuroblastoma is uniquely sensitive to single-agent inhibition of the DNA damage checkpoint kinase Chk1, leading us to examine downstream effectors of this pathway and identify mitotic regulator Wee1 as an additional therapeutic target in this disease. Wee1 was overexpressed in both neuroblastoma cell lines and high-risk patient tumors. Genetic or ...
Kalimuthu Palraj - - 2012
The bacterial xanthine dehydrogenase (XDH) from Rhodobacter capsulatus was immobilized on an edge plane pyrolytic graphite (EPG) electrode to construct a hypoxanthine/xanthine biosensor that functions at physiological pH. Phenazine methosulfate (PMS) was used as a mediator which acts as an artificial electron transfer partner for XDH. The enzyme catalyzes the ...
Bogoch Isaac I - - 2013
In this retrospective cohort study, we demonstrate that PCR-confirmed diagnoses of influenza were made solely by lower respiratory sampling in 6.9% of cases, as traditional upper respiratory tract tests were negative, indeterminate or not performed. Clinical features of these cases are presented. Clinicians should consider lower respiratory tract sampling in ...
Yu Gilbert - - 2012
The reaction of N(3)(CH(2))(3)Si(OTMS)(3) (TMS = SiMe(3)) with a dialkylammonium having hexynyl group , [FcCH(2)NH(2)CH(2)C(6)H(4)-4-O(CH(2))(4)C[triple bond, length as m-dash]CH]PF(6) (Fc = Fe(C(5)H(4))(C(5)H(5))), in the presence of dibenzo[24]crown-8-ether (DB24C8) and [Cu{Fe(CN)(4)}]PF(6) catalyst yielded the [2]rotaxane containing the dialkylammonium unit terminated by a bulky silyl group. Azides with a silsesquioxane group react ...
Mogelvang Rasmus - - 2012
OBJECTIVE: To evaluate the association of plasma osteoprotegerin (OPG) to hospitalisation for ischaemic heart disease (IHD), ischaemic stroke and all-cause mortality, and the effect of combining plasma OPG and high-sensitivity C-reactive protein (hsCRP). DESIGN: OPG and hsCRP concentrations were measured at baseline in a large Danish prospective community-based population study. ...
Cermak Naomi M - - 2012
BACKGROUND: Protein ingestion after a single bout of resistance-type exercise stimulates net muscle protein accretion during acute postexercise recovery. Consequently, it is generally accepted that protein supplementation is required to maximize the adaptive response of the skeletal muscle to prolonged resistance-type exercise training. However, there is much discrepancy in the ...
Hendriksen Ilse C E IC Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. - - 2013
In malaria-endemic settings, asymptomatic parasitemia complicates the diagnosis of malaria. Histidine-rich protein 2 (HRP2) is produced by Plasmodium falciparum, and its plasma concentration reflects the total body parasite burden. We aimed to define the malaria-attributable fraction of severe febrile illness, using the distributions of plasma P. falciparum HRP2 (PfHRP2) concentrations ...
Jürgens Tim P - - 2012
Introduction:While inhalation of high-flow 100% oxygen is highly effective in cluster headache, studies on its efficacy in migraine are sparse and controversial.Case:We report the case of a 22-year-old patient with an eight-year history of strictly unilateral migraine without aura but cranial autonomic symptoms. She repeatedly responded completely to inhalation of ...
Nesterov Vitaly - - 2012
P-Trityl substituted Li/Cl phosphinidenoid tungsten(0) complex (OC)(5)W{Ph(3)CP(Li/12-crown-4)Cl} (3) was prepared via chlorine/lithium exchange in complex (OC)(5)W{Ph(3)CPCl(2)} (2) using (t)BuLi in the presence of 12-crown-4 in tetrahydrofuran (THF) at low temperature; complex 3 possesses significantly increased thermal stability in contrast to previously reported analogue derivatives. Terminal phosphinidene-like reactivity of 3 was ...
Cavazos-Rehg Patricia A - - 2012
BACKGROUND: Raising cigarette prices through taxation is an important policy approach to reduce smoking. Yet, cigarette price increases may not be equally effective in all subpopulations of smokers. PURPOSE: To examine differing effects of state cigarette price changes with individual changes in smoking among smokers of different intensity levels. METHODS: ...
Scepaniak Jeremiah J - - 2012
Addition of TEMPO to MCl3 (M = Fe, Al) results in the formation of MCl3(eta1-TEMPO) (M = Fe, 1; M= Al, 2). Both 1 and 2 oxidize alcohols to generate ketones or aldehydes, along with the reduced complexes, MCl3(eta1-TEMPOH) (M = Fe, 3; M= Al, 4). Complexes 1-4 have been ...
Ouyang Weiming - - 2012
Regulatory T (T(reg)) cells, characterized by expression of the transcription factor forkhead box P3 (Foxp3), maintain immune homeostasis by suppressing self-destructive immune responses. Foxp3 operates as a late-acting differentiation factor controlling T(reg) cell homeostasis and function, whereas the early T(reg)-cell-lineage commitment is regulated by the Akt kinase and the forkhead ...
Cheng Fansheng - - 2012
A novel gene fragment containing a xylanase was identified from a Holstein cattle rumen metagenomic library. The novel xylanase (Xyln-SH1) belonged to the glycoside hydrolase family 10 (GH10) and exhibited a maximum of 44% identity to the glycoside hydrolase from Clostridium thermocellum ATCC 27405. Xyln-SH1 was heterologously expressed, purified and ...
Zannin Emanuela - - 2012
ABSTRACT: INTRODUCTION: It is well established that during mechanical ventilation of patients with acute respiratory distress syndrome cyclic recruitment/derecruitment and overdistension are potentially injurious for lung tissues. We evaluated whether the forced oscillatory technique (FOT) could be used to guide the ventilator settings in order to minimize cyclic lung recruitment/derecruitment ...
< 15 16 17 18 19 20 21 22 23 24 25 >