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Results 901 - 950 of 2099
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Lebrun-Harris Lydie A - - 2012
OBJECTIVE: To examine health status and health care experiences of homeless patients in health centers and to compare them with their nonhomeless counterparts. DATA SOURCES/STUDY SETTING: Nationally representative data from the 2009 Health Center Patient Survey. STUDY DESIGN: Cross-sectional analyses were limited to adults (n = 2,683). We compared sociodemographic characteristics, health ...
Monti Manuela - - 2012
The antral compartment in the ovary consists of two populations of oocytes that differ by their ability to resume meiosis and to develop to the blastocyst stage. Still for reasons not entirely clear, antral oocytes termed surrounded nucleolus (SN; 70% of the population of antral oocytes) develop to the blastocyst ...
Beyer Andrea R - - 2013
The mouse mammary tumor virus (MMTV) Gag protein directs the assembly in the cytoplasm of immature viral capsids, which subsequently bud from the plasma membranes of infected cells. MMTV Gag localizes to discrete cytoplasmic foci in mouse mammary epithelial cells, consistent with the formation of cytosolic capsids. Unexpectedly, we also ...
Huang Qian Q Department of Biological Sciences, Marquette University, Milwaukee, WI, 53201, - - 2013
The role of SMA and SMB smooth muscle myosin heavy chain (MHC) isoforms in tonic and phasic contractions was studied in phasic (longitudinal ileum and stomach circular antrum) and tonic (stomach circular fundus) smooth muscle tissues of SMB knockout mice. Knocking out the SMB MHC gene eliminated SMB MHC protein ...
Kumar Sumit - - 2012
In this study, we have investigated the binding motifs between the aromatic side chains of tryptophan and histidine residues in proteins by studying indole...imidazole heterodimer in a supersonic jet. Different spectroscopic techniques including resonant two photon ionization (R2PI), UV-UV hole-burning and resonant ion dip infrared (RIDIR) spectroscopy merged with quantum ...
Liu Di - - 2012
Abstract In eukaryotic cells the endoplasmic reticulum (ER) is a very critical site for synthesis, folding, modification of protein and calcium homeostasis. The ER responds to factors that perturb ER function such as the accumulation of unfolded proteins (ER stress) by activating unfolded protein response (UPR) to relieve the stress. ...
Zech Astrid - - 2012
ABSTRACT: BACKGROUND: Although resistance exercise interventions have been shown to be beneficial in prefrail or frail older adults it remains unclear whether there are residual effects when the training is followed by a period of detraining. The aim of this study was to establish the sustainability of a muscle power ...
Fu Christine T - - 2012
Although clinical and experimental observations indicate that the optic nerve head (ONH) is a major site of axon degeneration in glaucoma, the mechanisms by which local retinal ganglion cell (RGC) axons are injured and damage spreads among axons remain poorly defined. Using a laser-induced ocular hypertension (LIOH) mouse model of ...
Montavon Thomas - - 2012
Copy number variations are genomic structural variants that are frequently associated with human diseases. Among these copy number variations, duplications of DNA segments are often assumed to lead to dosage effects by increasing the copy number of either genes or their regulatory elements. We produced a series of large targeted ...
Akar Serpil - - 2012
AIMS: To evaluate the results of Faden operations on the medial rectus (MR) muscles with or without recession for the treatment of partially accommodative esotropia associated with a high accommodative convergence to accommodation (AC : A) ratio and to determine whether there was a decrease in the effects of posterior ...
Oliveira Fabiana Aparecida Mayrink FA Division of Nephrology, Federal University of Juiz de Fora, Juiz de Fora (UFJF), - - 2012
the purpose of this study was to investigate the effect of low-level laser therapy (LLLT) on chronic kidney disease (CKD) in a model of unilateral ureteral obstruction (UUO). Regardless of the etiology, CKD involves progressive widespread tissue fibrosis, tubular atrophy, and loss of kidney function. This process also occurs in ...
Hooper Michael J - - 2012
Incorporation of global climate change (GCC) effects into assessments of chemical risk and injury requires integrated examinations of chemical and nonchemical stressors. Environmental variables altered by GCC (temperature, precipitation, salinity, pH) can influence the toxicokinetics of chemical absorption, distribution, metabolism, and excretion as well as toxicodynamic interactions between chemicals and ...
Nan Y - - 2012
Icariin (ICA), a major constituent of flavonoids from the Chinese medical herb Epimedium brevicornum Maxim, is found to be protective for male reproductive ability, with the underlying mechanism largely unknown. Our study here investigated the effects of ICA on Sertoli cells, which act as nurse cells for the germ cells ...
Sun Wenjuan - - 2012
With the rapid development of China's space industry, the importance of radiation protection is increasingly prominent. To provide relevant dose data, we first developed the Visible Chinese Human adult Female (VCH-F) phantom, and performed further modifications to generate the VCH-F Astronaut (VCH-FA) phantom, incorporating statistical body characteristics data from the ...
Andrews Benjamin T BT Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington 98195-7610, United - - 2012
Terminase enzymes are responsible for the excision of a single genome from a concatemeric precursor (genome maturation) and concomitant packaging of DNA into the capsid shell. Here, we demonstrate that lambda terminase can be purified as a homogeneous "protomer" species, and we present a kinetic analysis of the genome maturation ...
Walker Jacqueline L - - 2012
BACKGROUND: There is a paucity of data concerning the energy requirements (ERs) of preschool-age children with cerebral palsy (CP), the knowledge of which is essential for early nutritional management. OBJECTIVE: We aimed to determine the ERs for preschool-age children with CP in relation to functional ability, motor type, and distribution ...
Kelly Simon - - 2012
Rhizobial surface polysaccharides are required for nodule formation on the roots of at least some legumes but the mechanism(s) by which they act are yet to be determined. As a first step to investigate the function of exopolysaccharide (EPS) in the formation of determinate nodules, we isolated Mesorhizobium loti mutants ...
Olver Mark E - - 2012
The present study is an examination of sex offender treatment outcome in a large national cohort of Canadian Federally incarcerated sex offenders followed up an average of 11.7 years postrelease. A brief actuarial risk scale (BARS), which predicted sexual and violent recidivism, was created for the purposes of the present ...
Ahmad Syed S Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise BRITE, North Carolina Central University, Durham, NC 27707, - - 2013
The kinase MEKK2 (MAP3K2) has recently been implicated in tumor growth and metastasis. Thus, selective inhibition of MEKK2 may be a novel strategy for cancer therapy. To identify inhibitors of MEKK2 kinase activity, we have developed a novel activity assay for MEKK2 based on the discovery that recombinant purified MEKK2 ...
Lebedev Artem - - 2013
The very first microfluidic device used for the production of (18)F-labeled tracers for clinical research is reported along with the first human Positron Emission Tomography scan obtained with a microfluidically produced radiotracer. The system integrates all operations necessary for the transformation of [(18)F]fluoride in irradiated cyclotron target water to a ...
Marlinski Vladimir - - 2012
The thalamic reticular nucleus (RE) provides inhibition to the dorsal thalamus, and forms a crucial interface between thalamocortical and corticothalamic signals. Whereas there has been significant interest in the role of the RE in organizing thalamocortical signaling, information on the activity of the RE in the awake animal is scant. ...
Boland Rosemarie A - - 2012
BACKGROUND: The aim of this study was to determine if the National Institute of Child Health and Human Development (NICHD) calculator, designed to predict mortality or neurosensory disability in infants 22-25 weeks' gestation, was valid for contemporary Australian infants. METHOD: Outcome data at 2 years of age for 114 infants ...
Lin Youhui - - 2012
A label-free, resettable, and colorimetric logic network has been realized by utilizing thermally regenerable cerium oxide nanoparticles and biocatalytic reactions. Coupling switchable CeO(2) nanoparticles with biocomputing would convert molecular recognition events into colorimetric outputs and make logic gates feasible to reset.
Teicher Martin H - - 2012
ABSTRACT: BACKGROUND: Symptoms of hyperactivity are believed to fade with age leaving ADHD adults mostly inattentive and impulsive. Our aim was to test this assertion using objective measures of hyperactivity, impulsivity and inattention. METHOD: Participants were 40 subjects with ADHD (23M/17F; 35+/-10 yrs) and 60 healthy adults (28M/32F; 29+/-9 yrs) ...
Hung Hsin-I HI Center for Cell Death, Injury, and Regeneration, Medical University of South Carolina, Charleston, South Carolina 29425, - - 2013
Photodynamic therapy (PDT) is a promising approach to treat head and neck cancer cells. Here, we investigated whether mitochondrial iron uptake through mitoferrin-2 (Mfrn2) enhanced PDT-induced cell killing. Three human head and neck squamous carcinoma cell lines (UMSCC1, UMSCC14A, and UMSCC22A) were exposed to light and Pc 4, a mitochondria-targeted ...
Wang Kai - - 2012
Two series of boronium-cation-based ionic liquids were prepared and fully characterized by (1) H, (13) C, and (11) B NMR and infrared spectroscopy, differential scanning calorimetry (DSC), and elemental analysis. The structure of bis(1-methyl-1H-imidazole-3-yl)dihydroboronium dicyanoborohydride (5 a) was determined by single-crystal X-ray diffraction. The densities of these ionic liquids range from 1.05 ...
Genét Gustav Folmer - - 2012
It remains debated whether traumatic brain injury (TBI) induces a different coagulopathy compared to non-TBI. This study investigated traditional coagulation tests, biomarkers of coagulopathy and endothelial damage in trauma patients with and without TBI. Blood from 80 adult trauma patients were sampled (median of 68 min (IQR 48-88) post-injury) upon ...
Tran Anh T - - 2013
Influenza virus infection results in host cell death and major tissue damage. Specific components of the apoptotic pathway, a signaling cascade that ultimately leads to cell death, are implicated in promoting influenza virus replication. BAD is a cell death regulator that constitutes a critical control point in the intrinsic apoptosis ...
Duggan Christopher C Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. - - 2012
Multiple micronutrients (vitamin B complex and vitamins C and E) were effective at reducing infectious disease morbidity, HIV disease progression, and poor pregnancy outcomes in HIV-infected women. The objective was to evaluate whether direct supplementation of these micronutrients to HIV-exposed infants reduces mortality and morbidity. Infants born to HIV-infected women ...
Roff George G School of Biological Sciences, University of Queensland, St Lucia, Queensland 4072, Australia. - - 2013
The inshore reefs of the Great Barrier Reef (GBR) have undergone significant declines in water quality following European settlement (approx. 1870 AD). However, direct evidence of impacts on coral assemblages is limited by a lack of historical baselines prior to the onset of modern monitoring programmes in the early 1980s. ...
de Raedt S - - 2012
The purpose of this study is to gain a better understanding of the changes due to osteoarthritis (OA) occurring in the thumb carpometacarpal (CMC) joint by comparing quantitative geometrical measurements in computed tomography scans of healthy and pathological joints in various stages of OA. The measurements were (1) the subluxation ...
Jakob Philipp - - 2012
BACKGROUND: MicroRNAs are key regulators of angiogenic processes. Administration of angiogenic early outgrowth cells (EOCs) or CD34(+)-cells has been suggested to improve cardiac function after ischemic injury in particular by promoting neovascularization. The present study therefore examines regulation of angiomiRs, microRNAs involved in angiogenesis, in angiogenic-EOCs and circulating CD34(+)-cells from ...
Watanabe H H Department of Biological Sciences, Asahikawa Medical University, Asahikawa 078-8510, Japan. - - 2013
Is it possible to produce offspring after sperm chromosome screening? It is possible to produce zygotes after examining the genome of individual spermatozoa prior to embryo production. Chromosomal aberrations in gametes are a major cause of pregnancy loss in women treated with assisted reproductive technology. However, to our knowledge, there ...
Jasuja Himanshu - - 2012
The practical use of metal-organic frameworks (MOFs) in applications ranging from adsorption separations to controlled storage and release hinges on their stability in humid or aqueous environments. The sensitivity of certain MOFs under humid conditions is well known, but systematic studies of water adsorption properties of MOFs are lacking. This ...
Higginson Jennifer R JR Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary & Life Sciences, Glasgow Biomedical Research Centre, Glasgow G12 8TA, United - - 2012
Previously, it has been shown that rat Schwann cells (SCs), but not olfactory ensheathing cells (OECs), form a boundary with astrocytes, due to a SC-specific secreted factor. Here, we identify highly sulfated heparan sulfates (HSs) and fibroblast growth factors (FGFs) 1 and 9 as possible determinants of boundary formation induced ...
Kumar V Anil - - 2013
Reports of oxacillin-susceptible mecA-positive Staphylococcus aureus strains are on the rise. Because of their susceptibility to oxacillin and cefoxitin, it is very difficult to detect them by using routine phenotypic methods. We describe two such isolates that were detected by chromogenic medium and confirmed by characterization of the mecA gene ...
Camacho-Vanegas Olga - - 2012
Alternative splicing represents a unique post-transcriptional mechanism that increases the complexity of the eukaryotic proteome-generating protein isoforms whose functions can be novel, diverse, and/or even antagonistic when compared to its full-length transcript. The KLF family of genes consists of ≥17 members, which are involved in the regulation of numerous critical ...
van Die M Diana - - 2012
Vitex agnus-castus L. (chaste tree; chasteberry) is a popular herbal treatment, predominantly used for a range of female reproductive conditions in Anglo-American and European practice. The objective of this systematic review was to evaluate the evidence for the efficacy and safety of Vitex extracts from randomised, controlled trials investigating women's ...
Pénalva Clothilde - - 2012
Patj is described as a core component of the Crumbs complex. Along with the other components, Crumbs and Stardust, Patj has been proposed as essential for epithelial polarity. However, no proper in vivo genetic analysis of Patj function has been performed in any organism. We have generated the first null ...
Hasan Kamrul - - 2012
We report the synthesis, X-ray structures, and optoelectronic characterization of two cationic iridium complexes bearing bis[(4-methoxyphenyl)imino]acenaphthene ligands. These complexes exhibited panchromic absorption extending as far as 800 nm, making them of interest for solar-energy-harvesting applications.
Müller Olaf - - 2012
PURPOSE: Methylene blue (MB), which was recently tested in a number of clinical malaria studies in Burkina Faso, is currently investigated for its benefit when added to artemisinin-based combination therapy. Together with a number of other antimalarials, MB is on the list of drugs which potentially induce haemolysis in patients ...
Park Haesuk - - 2012
BACKGROUND:An up-to-date assessment of dipeptidyl peptidase-4 (DPP-4) inhibitors is needed to include newly available data.OBJECTIVE:To assess the efficacy and safety of DPP-4 inhibitors, including sitagliptin, saxagliptin, vildagliptin, and linagliptin, in type 2 diabetes.METHODS:We conducted a search of MEDLINE for randomized controlled trials (RCTs) of DPP-4 inhibitors in type 2 diabetes ...
Price David - - 2012
While the pharmacological management of chronic obstructive pulmonary disease (COPD) has evolved from the drugs used to treat asthma, the treatment models are different and the two diseases require clear differential diagnosis in order to determine the correct therapeutic strategy. In contrast to the almost universal requirement for anti-inflammatory treatment ...
Dingels Carsten - - 2012
The covalent attachment of poly(ethylene glycol) (PEG) to therapeutically active proteins (PEGylation) has become an important method to deal with the pharmacological difficulties of these polypeptides, such as short body-residence times and immunogenicity. However, the derivatives of PEG used for PEGylation lack further functional groups that would allow the addition ...
Reinson Tormi - - 2013
We have previously demonstrated that the human papillomavirus (HPV) genome replicates effectively in U2OS cells after transfection using electroporation. The transient extrachromosomal replication, stable maintenance, and late amplification of the viral genome could be studied for high- and low-risk mucosal and cutaneous papillomaviruses. Recent findings indicate that the cellular DNA ...
Gray Bradley - - 2012
OBJECTIVE: To study relationships between clinical skill measures assessed at the beginning of general internists' careers and their career outcomes and practice characteristics. DATA SOURCES: General Internist Community Tracking Study Physician Survey respondents (2000-2001, 2004-2005) linked with residency program evaluations and American Board of Internal Medicine board certification examination score ...
Lamba Shakti S Department of Anthropology, University College London, 14 Taviton Street, London WC1H 0BW, UK. - - 2013
Conceptions of fairness vary across the world. Identifying the drivers of this variation is key to understanding the selection pressures and mechanisms that lead to the evolution of fairness in humans. Individuals' varying fairness preferences are widely assumed to represent cultural norms. However, this assumption has not previously been tested. ...
Dhokale Bhausaheb - - 2012
A series of donor-acceptor ferrocenyl substituted BODIPYs have been designed and synthesized via palladium catalyzed Suzuki and Sonogashira coupling reactions. The UV-visible absorption results indicate intramolecular charge transfer from the ferrocene to the BODIPY. The fluorescence quantum yield was drastically reduced, where the ferrocenyl group was directly attached to the ...
Maucher Fuquay Jennifer - - 2012
Domoic acid (DA) causes neurological effects in multiple species upon exposure, including status epilepticus in pregnant sea lions and an epileptic disease state that commonly develops in juveniles. This study aims to define brain toxicokinetic parameters in the pregnant rat in the larger context of maternal-fetal toxin transfer. Specifically, Sprague-Dawley ...
Bandekar Amey - - 2012
We investigated the feasibility and efficacy of a drug delivery strategy to vascularized cancer that combines targeting selectivity with high uptake by targeted cells and high bioexposure of cells to delivered chemotherapeutics. Targeted lipid vesicles composed of pH responsive membranes were designed to reversibly form phase-separated lipid domains which are ...
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