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Karthikeyan Shanmugam - - 2012
BackgroundMicrofracture is a proven technique to treat articular cartilage defects in the knee. However, there is little evidence in the literature to confirm the ability of microfracture to produce repair tissue in the hip joint.PurposeThe purpose of this study was to report the macroscopic and microscopic appearances of repair tissue ...
Peelen Marius V - - 2012
Interaction with everyday objects requires the representation of conceptual object properties, such as where and how an object is used. What are the neural mechanisms that support this knowledge? While research on semantic dementia has provided evidence for a critical role of the anterior temporal lobes (ATLs) in object knowledge, ...
Liu Yu-Peng - - 2012
Platinum-based chemotherapy is the first-line treatment for non-small cell lung cancer, but recurrence occurs in most patients. Recent evidence suggests that CD133+ cells are the cause of drug resistance and tumor recurrence. However, the correlation between chemotherapy and regulation of CD133+ cells has not been investigated methodically. In this study, ...
Bedke Jens - - 2012
What's known on the subject? and What does the study add? White blood cell count and C-reactive protein are reliable prognostic RCC Biomarkers.Nevertheless, accepted cut-offs for risk stratifications are missing. Therefore, both parameters were re-evaluated and multivariable analyses revealed an optimal CRP breakpoint at 0.25 mg/dL to be best to stratify ...
Rodrigues Aline Fernanda de Almeida Chaves - - 2012
The exposure of the fetus to a hyperglycemic environment promotes the development of hypertension and renal dysfunction in the offspring at adult age. We evaluated the role of renal nerves in the hypertension and renal changes seen in offspring of diabetic rats. Diabetes was induced in female Wistar rats (streptozotocin ...
Liu Lingjun - - 2012
The reaction of CuCl-catalyzed coupling of thiol ester with organostannane has been theoretically investigated using density functional calculations. This reaction takes place with CuCl as a catalyst, giving the product ketone and an organotin sulfide. The relatively low overall activation barrier calculated (26.0 kcal/mol) supports the experimental fact that this ...
Krause Kim - - 2012
Human activities have drastically increased nitrogen (N) inputs into natural and near-natural terrestrial ecosystems such that critical loads are now being exceeded in many regions of the world. This implies that these ecosystems are shifting from natural N limitation to eutrophication or even N saturation. This process is expected to ...
Wang Sunli - - 2012
TiO(2)-Ag hybrid hollow spheres (about 700 nm in diameter) with a highly uniform morphology and good structural stability were facilely prepared via a one-pot hydrothermal method, using carbon spheres as templates followed by an annealing treatment. Through this route, the as-prepared hybrid hollow spheres preserved the uniformity of the initial ...
- - 2012
Note from the Editors: The author of this issue's Editorial: The coming paradigm shift, has been interviewed in email by China Medical Tribune, before the editorial is published. For the benefit of our readers, we publish the questions and answers together with the Editorials. The Editorial and the Interview will be re-published in Chinese language ...
Kanzaki Ryo - - 2012
Proton-donating and ionization properties of several protic ionic liquids (PILs) made from N-methylimidazole (Mim) and a series of acids (HA) have been assessed by means of potentiometric and calorimetric titrations. With regard to strong acids, bis(trifluoromethanesulfonyl) amide (Tf2NH) and trifluoromethanesulfonic acid (TfOH), it was elucidated that the two equimolar mixtures ...
Ali Mohammad Javed - - 2012
AIMS: To study the clinical and diagnostic profile of punctal dysgenesis with membranes, to classify and correlate the membranes clinicopathologically and study the outcomes of membranotomy. METHODS: A prospective interventional study involving 55 dysgenetic puncta of 22 consecutive patients seen between July 2008 ansd December 2011. Data collected include demographics, ...
Barnes Michael D - - 2012
The article provides an overview of efforts to improve public health and health education training and on the potential use of Critical Component Elements (CCEs) for undergraduate health education programs toward more consistent quality assurance across programs. Considered in the context of the Galway Consensus Conference, the authors discuss the ...
Suh Junho - - 2012
We report the results of back-action evading experiments utilizing a tightly coupled electro-mechanical system formed by a radio-frequency micromechanical resonator parametrically coupled to a NbTiN superconducting microwave resonator. Due to excess dissipation in the microwave resonator, we observe a parametric instability induced by a thermal shift of the mechanical resonance ...
Dambach Donna M - - 2012
Widespread sharing and analysis of clinical trial data and a U.S. government initiative to engineer nonclinical cell-based models that mimic human biological processes have the potential to improve predictions of drug-related adverse events.
Spalding Roy F - - 2012
TransCanada's proposed international crude oil pipeline route over sensitive, relatively pristine, sub-irrigated land underlain by the Ogallala aquifer led to increased scrutiny and eventual rejection of the Keystone XL pipeline. Pipeline routing could be made much more acceptable by adopting risk-managed routes that lessen the potential to adversely impact high-quality ...
Ghosh Santanu - - 2012
An intramolecular-dehydrogenative-coupling (IDC) using "transition-metal-free" oxidation conditions has been achieved to synthesize a variety of 2-oxindoles bearing an all-carbon quaternary stereogenic center at the benzylic position. The methodology involves a one-pot C-alkylation of β-N-arylamido esters (3, 6) with alkyl halides using potassium tert-butoxide concomitant with a dehydrogenative coupling. A radical-mediated ...
Xu Xing-Dong - - 2012
A series of new platinum-acetylide complexes containing ethynyl-pyrene moieties as the main skeleton were synthesized and characterized. The investigation of the absorption and emission spectra of these complexes revealed that the extension of the molecular size with the introduction of different numbered platinum-acetylide fragments can efficiently tune the absorption and ...
Simeček Jakub - - 2012
To assess the influence of Zn(2+) , Cu(2+) , Fe(3+) , Al(3+) , Ti(IV) , and Sn(IV) on incorporation of (68) Ga(3+) into pendant-arm macrocyclic chelators, the (68) Ga labeling of 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), 1,4,7-triazacyclononane-1,4,7-tris[methyl(2-carboxyethyl)phosphinic acid]) (TRAP), and 1,4,7-triazacyclononane-1-[methyl(2-carboxyethyl)phosphinic acid]-4,7-bis[methyl(2-hydroxymethyl)phosphinic acid] (NOPO), as well as their peptide ...
Mähler Johan - - 2012
The bond distances in hydrated arsenic oxyacid species in aqueous solution have been studied by EXAFS spectroscopy and large angle X-ray scattering, LAXS. These results have been compared to structures in the solid state, as found in an extensive survey of available crystal structures. Protonated oxygen atoms can be distinguished ...
Bell Stephen G - - 2012
The cytochrome P450 enzyme CYP199A4, from Rhodopseudomonas palustris HaA2, can efficiently demethylate 4-methoxybenzoic acid. It is also capable of oxidising a range of other related substrates. By investigating substrates with different substituents and ring systems we have been able to show that the carboxylate group and the nature of the ...
Joshi Ravi- - - 2012
Structures, hydrogen bonding and binding energies of H4SeA (A = O, S, Se) dimers and their cation radicals have been studied using DFT-B3LYP, MP2 and CCSD methods with 6-31++G(d,p), cc-pVTZ and aug-cc-pVTZ basis sets. The binding energy (BE) order of the most stable neutral and cationic dimers have been found ...
Filippi Luca - - 2012
Abstract Background: Fluorodeoxygluose (FDG) positron emission/computed tomography (PET/CT) is emerging as a useful tool for the diagnosis of peritoneal carcinomatosis (PC). In this study, we assessed whether dual-time point imaging can improve the accuracy of FDG PET/CT for the diagnosis of PC after colon rectal cancer (CRC). Methods: Thirty-nine patients ...
Pardey Margery C - - 2012
Impulsivity is characteristic of several mental health disorders and is largely mediated by the prefrontal cortex subregions: the medial prefrontal cortex (mPFC) and the orbitofrontal cortex (OFC). Dopamine (DA) and norepinephrine (NE) are known to modulate activity of the prefrontal cortex, however their direct role in impulsive choice is not ...
Jaroentomeechai Thapakorn - - 2012
Novel phthalimide and o-sulfobenzimide-functionalized silsesquioxanes were successfully synthesized via nucleophilic substitution reactions from octakis(3-chloropropyl)octasilsesquioxane. Surprisingly, the formation of deca- and dodecasilsesquioxanes cages was discovered during substitution with phthalimide, but only octasilsesquioxane maintained a cage in the o-sulfobenzimide substitution reaction. Moreover, we report the electronic effect of nitrogen nucleophiles to promote ...
Spetea Mariana - - 2012
Here we report on the design, synthesis, and biological characterization of novel κ opioid (KOP) receptor ligands of diphenethylamines. In opioid receptor binding and functional assays, the N-cyclobutylmethyl substituted derivative 4 (HS665) showed the highest affinity and selectivity for the KOP receptor and KOP agonist potency. Compound 4 inhibited acetic ...
Mori Kumiko - - 2012
BACKGROUND:Telomerase is regarded as a good marker for cancer because it is unregulated in most tumor cells compared with normal cells. We evaluated telomerase activity in the lysate of tumor tissue and surrounding cells of oral cancer patients by an electrochemical technique, dubbed the electrochemical telomerase assay (ECTA).METHODS:The assay used ...
Drake Isabel - - 2012
BACKGROUND: Dietary carbohydrates have been implicated in relation to prostate cancer. OBJECTIVE: Our objective was to examine the associations between dietary intakes of carbohydrates, fiber, and their food sources and risk of prostate cancer, overall and by case severity, in the Malmö Diet and Cancer cohort. DESIGN: The analysis included ...
Kobayashi Atsushi - - 2012
BACKGROUND:The early stages of spondylolysis are extremely difficult to diagnose on plain radiography. Although several studies have examined changes in active spondylolysis on magnetic resonance imaging (MRI), no studies to date have determined the onset frequency of active spondylolysis detectable on MRI but occult on plain radiography. Moreover, the clinical ...
Nomura Motonari - - 2012
Hemagglutinating virus of Japan-envelope (HVJ-E) is a drug delivery vector based on inactivated Sendai virus. Recently, anti-tumor activities were found for HVJ-E itself, and clinical trials of HVJ-E for some malignant tumors are now ongoing. We investigated the in vitro and in vivo antitumor effects of HVJ-E against neuroblastoma, which ...
Cullen Alexis E - - 2012
Distributed abnormalities of gray matter (GM) and white matter (WM) volume characterize individuals experiencing their first episode of schizophrenia. Regions of abnormality are present already, albeit less extensively, during the prodromal phase of illness. This study aimed to determine whether putatively at-risk children, aged 9-12 years, who present multiple antecedents ...
Sánchez-Ilárduya María Belén - - 2012
Plasma rich in growth factors (PRGFs) technology is an autologous platelet-rich plasma approach that provides a pool of growth factors and cytokines that have been shown to increase tissue regeneration and accelerate dental implant osseointegration. In this framework, the spatiotemporal release of growth factors and the establishment of a provisional ...
Karanfilov Boris - - 2012
BACKGROUND: Balloon sinus dilation (BSD) is an increasingly used tool in endoscopic sinus surgery (ESS). The tissue-sparing nature of the instrumentation allows for properly selected patients to undergo office-based procedures under local anesthesia. METHODS: This was an Institutional Review Board (IRB)-approved, prospective, 14-center trial. Patients (n = 203) requiring ESS ...
Lima Alison T M - - 2012
Begomoviruses are single-stranded DNA plant viruses which cause serious epidemics in economically important crops worldwide. Non-cultivated plants also harbor many begomoviruses, and it is believed that these hosts may act as reservoirs and as mixing vessels where recombination may occur. Begomoviruses are notoriously recombination-prone, and also display nucleotide substitution rates ...
Kakde Rajendra B - - 2012
The objective of the current study was to develop a validated, specific stability-indicating reversed-phase liquid chromatographic (LC) method for the quantitative determination of escitalopram oxalate and clonazepam and their related substances in bulk drugs and pharmaceutical dosage forms in the presence of degradation products. Forced degradation studies were performed on ...
Fazio E - - 2012
The purpose of this study was to evaluate the effect of prolonged transportation on adrenocorticotropic hormone (ACTH), cortisol, total and free triiodothyronine (T(3), fT(3)) and thyroxine (T(4), fT(4)) concentrations, and functional variables (heart rate (HR), respiratory rate (RR) and rectal temperature (RT)) in calm and temperamental Limousin young beef bulls. ...
Spiotta Alejandro M - - 2012
INTRODUCTION: The use of balloon remodeling allows for the treatment of aneurysms that were previously considered to be poor candidates for coil embolization. The Scepter C (Microvention, Tustin, California, USA) is a novel temporary occlusion balloon system with a dual coaxial lumen catheter. The design accommodates a more steerable 0.014 ...
Sauce Delphine - - 2012
Reduced thymopoiesis and continuous mobilization of naive T cells into the effector-memory pool can lead to severe alterations of the naive T cell compartment. However, maintenance of the naive T cell population is essential to mount effective immune responses. Evidence of homeostatic regulation of naive T cells is currently debated ...
Egi Hiroyuki - - 2012
Abstract Background: The aim of this study was to determine whether a correlation exists between the HUESAD and both the OSATS checklist and the global rating score. Material and methods: Fourteen participants were recruited, ranging from residents to consultants. The HUESAD measured three different parameters: Visual spatial ability, smoothness and ...
Smolen Josef S - - 2013
In this viewpoint, we summarise three different lines of evidence suggesting that current biological therapies directed at different molecules or cells have similar efficacy in rheumatoid arthritis and target similar populations of patients; therefore, distinct biological effects of targeted therapies may not account for differences in response. Moreover, currently available ...
Sanchez Tim - - 2012
With remarkable precision and reproducibility, cells orchestrate the cooperative action of thousands of nanometre-sized molecular motors to carry out mechanical tasks at much larger length scales, such as cell motility, division and replication. Besides their biological importance, such inherently non-equilibrium processes suggest approaches for developing biomimetic active materials from microscopic ...
Heaf James Goya - - 2012
IntroductionMost home haemodialysis (HD) modalities are limited to home use since they are based on a single-pass (SP) technique, which requires preparation of large amounts of dialysate. We present a new dialysis method, which requires minimal dialysate volumes, continuously recycled during treatment [multipass HD (MPHD)]. Theoretical calculations suggest that MPHD ...
Gundelach Justin H - - 2013
The di-2-pyridylketone thiosemicarbazone Dp44mT is a metal-chelating compound that has been demonstrated to have potent activity as an anticancer agent. Here we report that it also has a dramatic inhibitory effect on T-cell activation in vitro. We found that 10 nM Dp44mT (IC(50) 3.2 nM) prevented the up-regulation of surface ...
Grant Florence M - - 2013
Considerable debate exists as to appropriate perioperative fluid management. Data from several studies suggest that the amount of fluid administered perioperatively influences surgical outcome. Pancreatic resection is a major procedure in which complications are common. We examined 1,030 sequential patients who had undergone pancreatic resection at Memorial Sloan-Kettering Cancer Center. ...
Spoerke Jill M - - 2012
Class 1 phosphatidylinositol 3-kinase (PI3K) plays a major role in cell proliferation and survival in a wide variety of human cancers. Here, we investigated biomarker strategies for PI3K pathway inhibitors in non-small-cell lung cancer (NSCLC). Molecular profiling for candidate PI3K predictive biomarkers was conducted on a collection of NSCLC tumor ...
Qin Jun - - 2012
ABSTRACT: INTRODUCTION: Sodium ferulate (SF) is a natural component of traditional Chinese herbs. Our previous study shows that SF has a protective effect on osteoarthritis (OA). The objective of this study was to investigate the effect of SF on TNF/TNFR signal transduction pathway of rat OA chondrocytes. METHODS: Primary rat ...
Zannin Emanuela - - 2012
ABSTRACT: INTRODUCTION: It is well established that during mechanical ventilation of patients with acute respiratory distress syndrome cyclic recruitment/derecruitment and overdistension are potentially injurious for lung tissues. We evaluated whether the forced oscillatory technique (FOT) could be used to guide the ventilator settings in order to minimize cyclic lung recruitment/derecruitment ...
Hick Aurore - - 2012
Friedreich's ataxia (FRDA) is a recessive neurodegenerative disorder commonly associated with hypertrophic cardiomyopathy. FRDA is due to expanded GAA repeats within the first intron of the gene encoding frataxin, a conserved mitochondrial protein involved in iron-sulfur cluster biosynthesis. This mutation leads to partial gene silencing and substantial reduction of the ...
Montaño Sherwin P - - 2012
Studies of bacteriophage Mu transposition paved the way for understanding retroviral integration and V(D)J recombination as well as many other DNA transposition reactions. Here we report the structure of the Mu transpososome--Mu transposase (MuA) in complex with bacteriophage DNA ends and target DNA--determined from data that extend anisotropically to 5.2 Å, ...
Buaas F William - - 2012
Adrenal and gonadal steroids are essential for life and reproduction. The orphan nuclear receptor SF1 (NR5A1) has been shown to regulate the expression of enzymes involved in steroid production in vitro. However, the in vivo role of this transcription factor in steroidogenesis has not been elucidated. In this study, we ...
Gelbart Michael A - - 2012
Tissue morphogenesis is the process in which coordinated movements and shape changes of large numbers of cells form tissues, organs, and the internal body structure. Understanding morphogenetic movements requires precise measurements of whole-cell shape changes over time. Tissue folding and invagination are thought to be facilitated by apical constriction, but ...
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