Search Results
Results 851 - 900 of 2099
< 13 14 15 16 17 18 19 20 21 22 23 >
Olin Jacqueline L - - 2012
OBJECTIVE:To review the clinical trials, pharmacologic characteristics, safety, and efficacy of the elvitegravir/cobicistat/emtricitabine/tenofovir single tablet formulation (Stribild).DATA SOURCES:Literature searches were performed in MEDLINE (1948-September 2012) and PubMed (1966-September 2012) using the search terms GS-9137, elvitegravir, GS 9350, cobicistat, quad pill, Stribild, and integrase inhibitors. Abstracts from HIV/AIDS conferences were reviewed.STUDY ...
Kim Mi Young MY Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, - - 2013
The major inducible 70-kDa heat shock protein (hsp70) is host protective in a mouse model of measles virus (MeV) brain infection. Transgenic constitutive expression of hsp70 in neurons, the primary target of MeV infection, abrogates neurovirulence in neonatal H-2(d) congenic C57BL/6 mice. A significant level of protection is retained after ...
Khil Laura - - 2012
Background:Change in headache diagnoses over time within the same individual is not well studied in the adult population. In this study, we prospectively examined the individual variation of migraine and tension-type headache (TTH) diagnoses over time.Methods:As part of the epidemiological Deutsche Migräne und Kopfschmerzgesellschaft (DMKG) headache study, 1312 participants were ...
Grzechnik Katarzyna - - 2012
Matrix isolation spectroscopy has been combined with ab initio calculations to characterize the 1:1 complexes of H(2) O(2) with OCS and CS(2) . The infrared spectra of the argon and nitrogen matrices doped with H(2) O(2) and OCS or CS(2) have been measured and analyzed. The geometries of the complexes ...
Adamowicz Piotr - - 2012
A death caused by a new designer drug, 4-methylmethcathinone (mephedrone), is reported. Eight small plastic bags containing white powder were found in the jacket of a young dead male. Spot tests conducted by the police officer indicated the presence of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in the powders. Laboratory routine screening analyses of ...
Improta Roberto - - 2012
We here report a fully quantum mechanical study of the main photochemical and photophysical decay routes in aqueous solution of Thymine deoxy-dinucleotide (TpT- and TpTNa) and of its analogue locked in C3-endo puckering, characterizing five different representative backbone conformers and discussing the chemical physical effects modulating the yield of the ...
Roy Xavier - - 2012
Making contact to a quantum dot: Single quantum-dot electronic circuits are fabricated by wiring atomically precise metal chalcogenide clusters with conjugated molecular connectors. These wired clusters can couple electronically to nanoscale electrodes and be tuned to control the charge-transfer characteristics.
Schuster Antje - - 2013
To assess efficacy and safety of a new dry powder formulation of inhaled colistimethate sodium in patients with cystic fibrosis (CF) aged ≥6 years with chronic Pseudomonas aeruginosa lung infection. A prospective, centrally randomised, phase III, open-label study in patients with stable CF aged ≥6 years with chronic P aeruginosa ...
Valentin-Hansen Louise L Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, the Panum Institute, Copenhagen, - - 2012
In seven-transmembrane (7TM), G protein-coupled receptors, highly conserved residues function as microswitches, which alternate between different conformations and interaction partners in an extended allosteric interface between the transmembrane segments performing the large scale conformational changes upon receptor activation. Computational analysis using x-ray structures of the β(2)-adrenergic receptor demonstrated that PheVI:09 ...
Vanbiervliet G - - 2012
Background and study aims: Uncovered self-expanding metal stents offer effective relief for colonic obstruction. The aim of this study was to determine the effectiveness of fully covered self-expanding metal stents (FCSEMSs) in the treatment of benign colonic strictures.Patients and methods: All patients presenting with a symptomatic benign colonic stricture (occlusion ...
Akhtar Tariq A - - 2012
cis-Prenyltransferases (CPTs) are predicted to be involved in the synthesis of long-chain polyisoprenoids, all with >5 isoprene (C5) units. Recently, we identified a short-chain CPT, neryl diphosphate synthase (NDPS1), in tomato (Solanum lycopersicum). Here, we searched the tomato genome and identified and characterized its entire CPT gene family, which is ...
Misas-Villamil Johana C - - 2012
Vacuolar Processing Enzymes (VPEs) are important cysteine proteases implicated in maturation of e.g. seed storage proteins and involved in programmed cell death during plant-microbe interactions and development. Here, we introduce a specific, cell-permeable, activity-based probe for VPEs. This probe is highly specific for all four Arabidopsis VPEs and labeling is ...
Everett Roger D RD MRC-University of Glasgow Centre for Virus Research 8, Glasgow, Scotland. - - 2013
Herpes simplex virus 1 (HSV-1) immediate-early protein ICP0 is required for efficient lytic infection and productive reactivation from latency and induces derepression of quiescent viral genomes. Despite being unrelated at the sequence level, ICP0 and human cytomegalovirus proteins IE1 and pp71 share some functional similarities in their abilities to counteract ...
Cheatham Carol L CL Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 28081, USA. - - 2012
Choline is essential for fetal brain development, and it is not known whether a typical American diet contains enough choline to ensure optimal brain development. The study was undertaken to determine whether supplementing pregnant women with phosphatidylcholine (the main dietary source of choline) improves the cognitive abilities of their offspring. ...
Nikula Raisa R Allan Wilson Centre for Molecular Ecology and Evolution, Department of Zoology, University of Otago, Dunedin, New Zealand. - - 2013
Dispersal by passive oceanic rafting is considered important for the assembly of biotic communities on islands. However, not much is known about levels of population genetic connectivity maintained by rafting over transoceanic distances. We assess the evolutionary impact of kelp-rafting by estimating population genetic differentiation in three kelp-associated invertebrate species ...
Nahon Pierre - - 2012
PURPOSE: Metabolomics depicts metabolic changes in biological systems using a multiparametric analysis technique. This study assessed the metabolomic profiles of serum, obtained by proton NMR spectroscopy, from cirrhotic patients with and without hepatocellular carcinoma (HCC). EXPERIMENTAL DESIGN: The study included 154 consecutive patients with compensated biopsy-proven alcoholic cirrhosis. Among these, ...
Chen Hongman - - 2012
To determine the role played by the Wnt/β-catenin signaling pathway in the development of endometrial cancer (EC), we examined the expression of Wnt10a and Wnt10b in EC tissues and the correlation between their expression. Furthermore, the associations between these two proteins and the clinicopathological characteristics and prognosis of EC were ...
Bertrand Arthur - - 2012
The contribution of supramolecular chemistry to polymer science opens new perspectives for the design of polymer materials exhibiting valuable properties and easier processability due to the dynamic nature of non-covalent interactions. Hydrogen bonding polymers can be used as supramolecular units for yielding larger assemblies that possess attractive features, arising from ...
Furl Nicholas - - 2012
Humans adeptly use visual motion to recognize socially relevant facial information. The macaque provides a model visual system for studying neural coding of expression movements, as its superior temporal sulcus (STS) possesses brain areas selective for faces and areas sensitive to visual motion. We used functional magnetic resonance imaging and ...
Kamar Rita - - 2013
The Bacillus cereus pathogenic spectrum ranges from strains used as probiotics to human-lethal strains. However, prediction of the pathogenic potential of a strain remains difficult. Here, we show that food poisoning and clinical strains can be differentiated from harmless strains on the basis of host colonization phenotypes.
Ferreira José A B - - 2012
Nucleophilic addition of water and of methanol to 3,6-diamino-2,4,5,7-tetrabromo-9-[2-(methoxycarbonyl) phenyl]-9H-xanthen-9-ylium, 4BrR123, yields, respectively, xanthyl, 2-(3,6-diamino-2,4,5,7-tetrabromo-9-hydroxy-9H-xanthen-9-yl) benzoate, HO4BrR123 and, xanthyl, 2-(3,6-diamino-2,4,5,7-tetrabromo-9-methoxy-9H-xanthen-9-yl) benzoate, MeO4BrR123. The novel experimental results are addressed theoretically. The Linear Free Energy Relationship, LFER, Second Order Perturbation Theory analysis of the Natural Bond Orbital, NBO, and Quantum Theory of ...
Whitfield John B JB Queensland Institute of Medical Research, Brisbane, Queensland, Australia. - - 2013
Alcohol consumption has multiple biochemical consequences. Only a few of these are useful as diagnostic markers, but many reflect potentially harmful or beneficial effects of alcohol. Average consumption of 2 to 4 drinks per day is associated with lower overall or cardiovascular mortality risk than either lower or higher intake. ...
Kornecki Katherine P - - 2012
A new mixed-valent Rh(2)(II,III) dimer, [Rh(2)(espn)(2)Cl] (espn(2-) = α,α,α',α'-tetramethyl-1,3-benzenedipropanamidate), is reported. This compound readily dissociates Cl(-) at low concentrations in solution to form the active [Rh(2)(espn)(2)](+) catalyst, which performs intramolecular C-H amination with TONs > 1400. This work expands the scope of Rh(2)(II,III) dimers to nitrenoid chemistry.
Juul Kristian Vinter - - 2012
Aims To estimate the relationship between pharmacokinetics and antidiuretic effect of desmopressin. Methods An investigator-blind, randomized, parallel group study with five dose-groups and one placebo, each consisting of 12 healthy, over-hydrated, non-smoking male subjects 18-55 years of age were infused intravenously over two hours with Placebo, 30, 60, 125, 250 ...
Perrier Aurélie - - 2012
First principle simulations of an extended hexameric molecular switch are reported. The full switching of the system is explained by investigating the nature of the excited states of all possible isomers. A new multi-addressable asymmetric structure is proposed.
Myers Mark G - - 2012
Objectives:Little is currently known about price sensitivity across ethnic groups as well as for non-daily smokers. To address this issue, this study compared perceived price sensitivity across smoking status (daily and non-daily) and within ethnicity (Hispanic and non-Hispanic White) in a recent representative population survey of California smokers. METHODS: This ...
Mavridis Konstantinos - - 2012
INTRODUCTION:The extensive use of prostate-specific antigen as a general prostate cancer biomarker has introduced the hazards of overdiagnosis and overtreatment. Recent studies have revealed the immense biomarker capacity of microRNAs (miRNAs) in prostate cancer. The aim of this study was to analyze the expression pattern of miR-224, a cancer-related miRNA, ...
Bradley Gia M GM Department of Pediatrics and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, - - 2012
Improved nutrition early in life is associated with better pulmonary function for patients with cystic fibrosis (CF). However, nutritional status is poorly correlated with the CFTR genotype. We investigated the extent to which modifier genes influence nutrition in children with CF. BMI data were longitudinally collected from the CF Twin-Sibling ...
Lv Yu-Dan - - 2012
Abstract Objective: The poor sleep quality of epileptic patients may be partly due to the occurrence epileptiform discharges (EDs). We observed the number of interictal discharges in each sleep stage and explored the associations between EDs and sleep phases in epilepsy patients. Methods: Two hundred epileptic patients and 182 healthy ...
Karthikeyan Shanmugam - - 2012
BackgroundMicrofracture is a proven technique to treat articular cartilage defects in the knee. However, there is little evidence in the literature to confirm the ability of microfracture to produce repair tissue in the hip joint.PurposeThe purpose of this study was to report the macroscopic and microscopic appearances of repair tissue ...
Palmer Julie R JR Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA. - - 2013
Most genome-wide association studies (GWAS) have been carried out in European ancestry populations; no risk variants for breast cancer have been identified solely from African ancestry GWAS data. Few GWAS hits have replicated in African ancestry populations. In a nested case-control study of breast cancer in the Black Women's Health ...
Sotomayor Marcos - - 2012
Hearing and balance use hair cells in the inner ear to transform mechanical stimuli into electrical signals. Mechanical force from sound waves or head movements is conveyed to hair-cell transduction channels by tip links, fine filaments formed by two atypical cadherins known as protocadherin 15 and cadherin 23 (refs 4, ...
Colgan Lesley A - - 2012
Serotonin released within the dorsal raphe nucleus (DR) induces feedback inhibition of serotonin neuron activity and consequently regulates mood-controlling serotonin release throughout the forebrain. Serotonin packaged in vesicles is released in response to action potentials by the serotonin neuron soma and terminals, but the potential for release by dendrites is ...
Polverino Eva - - 2012
SUMMARY AT A GLANCE: Despite the lack of a clear benefit, systemic corticosteroids are frequently administered in community-acquired-pneumonia. We investigated clinical reasons for steroid prescription and the impact on major outcomes, showing no correlation with mortality or clinical stability independent of severity and cumulative steroid dosage, but an increase in ...
Havlicek Vladimir - - 2012
Recently, a major increase in mass spectrometer installations has occurred in routine clinical microbiology laboratories worldwide. At present, there are hundreds of various instruments sold and the market is still far from being saturated. Although the clinical community still declares it has discovered a "new technology", the first mass spectrometry ...
Mondal Dibakar - - 2012
Important issues in developing hydroxyapatite (HAp)- and titanium (Ti)-based composite biomaterials for orthopedic or dental devices include the dissociation of HAp during fabrication and its influences in the microstructure and biocompatibility of the final composite. During the densification by sintering of HAp/Ti composites, Ti reacts with OH freed from HAp ...
Buaas F William - - 2012
Adrenal and gonadal steroids are essential for life and reproduction. The orphan nuclear receptor SF1 (NR5A1) has been shown to regulate the expression of enzymes involved in steroid production in vitro. However, the in vivo role of this transcription factor in steroidogenesis has not been elucidated. In this study, we ...
Liu Chao - - 2012
The precise formation of three-dimensional motor circuits is essential for movement control. Within these circuits, motoneurons (MNs) are specified from spinal progenitors by dorsoventral signals and distinct transcriptional programs. Different MN subpopulations have stereotypic cell body positions and show specific spatial axon trajectories. Our knowledge of MN axon outgrowth remains ...
Vizuete María - - 2012
Single- and double-wall carbon nanotubes (CNTs) having dimethylanilino (DMA) units covalently attached to the external graphene wall have been prepared by the reaction of the dimethylaminophenylnitronium ion with the corresponding CNT. The samples have been characterized by Raman and XPS spectroscopies, thermogravimetry, and high-resolution transmission electron microscopy in which the ...
Wilkerson Brent A BA Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina 29425, - - 2012
Sphingosine 1-phosphate (S1P) is a blood-borne lysosphingolipid that acts to promote endothelial cell (EC) barrier function. In plasma, S1P is associated with both high density lipoproteins (HDL) and albumin, but it is not known whether the carriers impart different effects on S1P signaling. Here we establish that HDL-S1P sustains EC ...
Thirumalai Vatsala V Section on Developmental Neurobiology, National Institute of Neurological Disorders and Stroke, Bethesda, MD, - - 2013
Dysfunction in sensorimotor synapses is one of the earliest pathological changes observed in a mouse model [spinal muscular atrophy (SMA)Δ7] of spinal muscular atrophy. Here, we examined the density of proprioceptive and cholinergic synapses on calbindin-immunoreactive interneurons ventral to the lateral motor column. This population includes inhibitory Renshaw interneurons that ...
Wiens A J - - 2012
Hyper-redundant mechanisms (HRMs), also known as snake-like robots, are highly adaptable during locomotion on land. Researchers are currently working to extend their capabilities to aquatic environments through biomimetic undulatory propulsion. In addition to increasing the versatility of the system, truly biomimetic swimming could also provide excellent locomotion efficiency. Unfortunately, the ...
Bebeacua Cecilia - - 2013
Tailed phages are genome delivery machines exhibiting unequaled efficiency acquired over more than 3 billion years of evolution. Siphophages from the P335 and 936 families infect the Gram-positive bacterium Lactococcus lactis using receptor-binding proteins anchored to the host adsorption apparatus (baseplate). Crystallographic and electron microscopy (EM) studies have shed light ...
Chimonidou Maria - - 2012
INTRODUCTION:Detection of circulating tumor cells (CTCs) and cell-free DNA (cfDNA) in the peripheral blood of patients with solid tumors has been widely studied for the early detection of metastatic spread. We evaluated whether there was an association between the origin of cfDNA and CTCs. We investigated whether SRY (sex determining ...
Samelson Elizabeth J EJ Department of Medicine, Harvard Medical School and Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA. - - 2012
Adequate calcium intake is known to protect the skeleton. However, studies that have reported adverse effects of calcium supplementation on vascular events have raised widespread concern. We assessed the association between calcium intake (from diet and supplements) and coronary artery calcification, which is a measure of atherosclerosis that predicts risk ...
Torre A - - 2013
What factors are associated with the presence of areas unexposed to the perfusate after whole ovary perfusion? Over half the ovaries perfused with the metabolic marker methylthiazolyl blue tetrazolium (MTT) were incompletely stained. Incomplete staining was statistically significantly associated with a small ovarian slice surface area, inexperience of the experimenter, ...
Wallecha Anu - - 2013
There is a constant need for improved adjuvants to augment the induction of immune responses against tumor-associated antigens (TAA) during immunotherapy. Previous studies have established that listeriolysin O (LLO), a cholesterol-dependent cytolysin derived from Listeria monocytogenes, exhibits multifaceted effects to boost the stimulation of immune responses to a variety of ...
Fishman Yonatan I - - 2012
The mismatch negativity (MMN) is a preattentive component of the auditory event-related potential that is elicited by a change in a repetitive acoustic pattern. While MMN has been extensively used in human electrophysiological studies of auditory processing, the neural mechanisms and brain regions underlying its generation remain unclear. We investigate ...
Bouazoune Karim - - 2012
Mutations in the CHD7 gene cause human developmental disorders including CHARGE syndrome. Genetic studies in model organisms have further established CHD7 as a central regulator of vertebrate development. Functional analysis of the CHD7 protein has been hampered by its large size. We used a dual-tag system to purify intact recombinant ...
Lau Janet T F - - 2012
A novel bis(ferrocenyl chalcone) silicon(iv) phthalocyanine has been prepared in which the disulfide linker can be cleaved by dithiothreitol. The separation of the ferrocenyl quencher and the phthalocyanine core greatly enhances the fluorescence emission, singlet oxygen production and in vitro photocytotoxicity.
< 13 14 15 16 17 18 19 20 21 22 23 >