Search Results
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Burton Neil J - - 2012
OBJECTIVES: To compare osteotomy orientation relative to the sagittal and transverse planes of the tibia, and cis cortical damage for tibial plateau leveling osteotomy (TPLO) performed with the following aids: (1) Synthes TPLO jig and saw guide, (2) Slocum TPLO jig with ancillary Kirschner wires (SlocumK), and (3) Slocum jig ...
Rossini Giada - - 2012
West Nile virus (WNV) is currently circulating in several European countries and over the past decades, concomitant with enhanced surveillance studies and improved diagnostic capabilities, an increase in the geographical distribution and in the number of cases in Europe has been documented. In Italy, in 2011, 14 human cases of ...
Chan Cynthia Y - - 2012
OBJECTIVE:To determine whether thiazides have a chronic antihypertensive effect, in the absence of diuresis, in patients with severe renal disease (creatinine clearance <30 mL/min) or in those receiving dialysis.DATA SOURCES:A search was performed in PubMed, CENTRAL, and International Pharmaceutical Abstracts, using MeSH terms and/or key words. MeSH terms included kidney ...
Konermann Lars - - 2012
Electrospray ionization (ESI) generates intact gas phase ions from analytes in solution for mass spectrometric investigations. ESI can proceed via different mechanisms. Low molecular weight analytes follow the ion evaporation model (IEM), whereas the charged residue model (CRM) applies to large globular species. A chain ejection model (CEM) has been ...
Jiménez Josefina - - 2012
A divergent approach was used for the synthesis of dendritic structures based on a cyclotriphosphazene core with 12 or 24 hydroxyl groups, by starting from [N(3) P(3) (OC(6) H(4) OH-4)(6) ] and using an acetal-protected 2,2-di(hydroxymethyl)propionic anhydride as the acylating agent. Hydroxyl groups in these first- and second-generation dendrimers, G1-(OH)(12) ...
Danielsson Anna - - 2012
Abstract Purpose: The aim of this study was to identify gene expression profiles distinguishing alpha-particle (211)At and (60)Co irradiation. Materials and methods: Gene expression microarray profiling was performed using total RNA from confluent human fibroblasts 5 hours after exposure to (211)At labeled Trastuzumab monoclonal antibody (0.25, 0.5, and 1 Gy) ...
Kielstein Jan T - - 2012
BackgroundExtracorporeal membrane oxygenation (ECMO) is increasingly used in the intensive care unit (ICU) setting to improve gas exchange in patients with acute respiratory distress syndrome as well as in patients pre- and post-heart and lung transplantation. In this clinical setting, acute kidney injury (AKI) is frequently observed. So far, it ...
Ziadi Asraa - - 2012
A formal γ-alkynylation of ketones via Pd-catalyzed C-C bond-cleavage is presented. The method allows for the coupling of tert-cyclobutanols and bromoacetylenes, giving access to versatile alkynes that are beyond reach otherwise.
Tang San-Yuan - - 2012
We investigated the effect of casticin on apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). We found that casticin potentiated TRAIL-induced apoptosis in human colon cancer cells. Casticin downregulated cell survival proteins including Bcl-xL, Bcl-2, survivin, XIAP and cFLIP, and induced death receptor 5 (DR5), but had no effect ...
Ozawa Takeaki - - 2012
Recent progress of bioanalytical techniques has accelerated the deep understanding of cellular states and development of novel drugs as well as medical diagnosis. Particularly, small organic molecules, quantum dots, and genetically encoded optical probes have revolutionized imaging and analysis of intracellular molecular networks during the past decade. The emphasis of ...
Zurwerra Didier - - 2012
A new total synthesis of the marine macrolide (-)-zampanolide (1) and the structurally and stereochemically related non-natural levorotatory enantiomer of (+)-dactylolide (2), that is, ent-2, has been developed. The synthesis features a high-yielding, selective intramolecular Horner-Wadsworth-Emmons (HWE) reaction to close the 20-membered macrolactone ring of 1 and ent-2. The β-keto ...
Kim Beom-Su - - 2012
Scaffolds can be used for tissue engineering because they can serve as templates for cell adhesion and proliferation for tissue repair. In this study, chitosan/hydroxyapatite (CS/HAp) composites were prepared by coprecipitation synthesis. Then, CS and CS/HAp fabrics were prepared by wet spinning. CS fibers with a diameter of 15 ± ...
Ross Matthew S - - 2012
The Canadian oil sands industry stores toxic oil sands process-affected water (OSPW) in large tailings ponds adjacent to the Athabasca River or its tributaries, raising concerns over potential seepage. Naphthenic acids (NAs; CnH2n-ZO2) are toxic components of OSPW, but are also natural components of bitumen and regional groundwaters, and may ...
Raine Gary - - 2012
Many companies nowadays consider schools to be an important setting for marketing to children. However, important concerns can be raised from a health promotion perspective about the potential negative impact of commercial activities on the health and well-being of pupils. As this discussion paper will demonstrate, some commercial activities raise ...
Fajardo Thor V M - - 2012
We previously showed that the movement protein (MP) gene of Alfalfa mosaic virus (AMV) is functionally exchangeable for the cell-to-cell transport of the corresponding genes of Tobacco mosaic virus, Brome mosaic virus, Prunus necrotic ringspot virus, Cucumber mosaic virus and Cowpea mosaic virus. We have analyzed the capacity of the ...
Planell Núria - - 2012
OBJECTIVE: Ulcerative colitis (UC) is a chronic condition characterised by the relapsing inflammation despite previous endoscopic and histological healing. Our objective was to identify the molecular signature associated with UC remission. DESIGN: We performed whole-genome transcriptional analysis of colonic biopsies from patients with histologically active and inactive UC, and non-inflammatory ...
Yanez B - - 2012
BackgroundHealth-related quality-of-life (HRQOL) assessments in research and clinical oncology settings are increasingly important. HRQOL instruments need to be rapid and still maintain the ability to capture the most relevant patient issues in a valid and reliable manner. The current study develops and validates the FACT-G7, a rapid version of the ...
Kersten Judy R - - 2012
The question of what is the ideal anesthetic for patients with cardiovascular disease has been debated for nearly three decades, and similarly to the case for the use of perioperative beta blockers, the answer appears to be increasingly enigmatic. In the current issue of the Journal, Buse et al(1) report ...
Craven Michael - - 2012
Polyoxometalate-phosphazene salt aggregates comprising cyclophosphazene cations are highly efficient catalysts for environmentally benign biphasic oxidations with hydrogen peroxide. These catalysts self-assemble in situ simply by mixing commercial Keggin POMs and readily available phosphazenes.
Boland Rosemarie A - - 2012
BACKGROUND: The aim of this study was to determine if the National Institute of Child Health and Human Development (NICHD) calculator, designed to predict mortality or neurosensory disability in infants 22-25 weeks' gestation, was valid for contemporary Australian infants. METHOD: Outcome data at 2 years of age for 114 infants ...
Lin Youhui - - 2012
A label-free, resettable, and colorimetric logic network has been realized by utilizing thermally regenerable cerium oxide nanoparticles and biocatalytic reactions. Coupling switchable CeO(2) nanoparticles with biocomputing would convert molecular recognition events into colorimetric outputs and make logic gates feasible to reset.
Teicher Martin H - - 2012
ABSTRACT: BACKGROUND: Symptoms of hyperactivity are believed to fade with age leaving ADHD adults mostly inattentive and impulsive. Our aim was to test this assertion using objective measures of hyperactivity, impulsivity and inattention. METHOD: Participants were 40 subjects with ADHD (23M/17F; 35+/-10 yrs) and 60 healthy adults (28M/32F; 29+/-9 yrs) ...
Wang Kai - - 2012
Two series of boronium-cation-based ionic liquids were prepared and fully characterized by (1) H, (13) C, and (11) B NMR and infrared spectroscopy, differential scanning calorimetry (DSC), and elemental analysis. The structure of bis(1-methyl-1H-imidazole-3-yl)dihydroboronium dicyanoborohydride (5 a) was determined by single-crystal X-ray diffraction. The densities of these ionic liquids range from 1.05 ...
Genét Gustav Folmer - - 2012
It remains debated whether traumatic brain injury (TBI) induces a different coagulopathy compared to non-TBI. This study investigated traditional coagulation tests, biomarkers of coagulopathy and endothelial damage in trauma patients with and without TBI. Blood from 80 adult trauma patients were sampled (median of 68 min (IQR 48-88) post-injury) upon ...
de Raedt S - - 2012
The purpose of this study is to gain a better understanding of the changes due to osteoarthritis (OA) occurring in the thumb carpometacarpal (CMC) joint by comparing quantitative geometrical measurements in computed tomography scans of healthy and pathological joints in various stages of OA. The measurements were (1) the subluxation ...
Jakob Philipp - - 2012
BACKGROUND: MicroRNAs are key regulators of angiogenic processes. Administration of angiogenic early outgrowth cells (EOCs) or CD34(+)-cells has been suggested to improve cardiac function after ischemic injury in particular by promoting neovascularization. The present study therefore examines regulation of angiomiRs, microRNAs involved in angiogenesis, in angiogenic-EOCs and circulating CD34(+)-cells from ...
Jasuja Himanshu - - 2012
The practical use of metal-organic frameworks (MOFs) in applications ranging from adsorption separations to controlled storage and release hinges on their stability in humid or aqueous environments. The sensitivity of certain MOFs under humid conditions is well known, but systematic studies of water adsorption properties of MOFs are lacking. This ...
Beck Alain - - 2012
Here we review the current state of the art in analytical and structural methods used to characterize therapeutic monoclonal antibodies (mAbs) and derivatives. First a general introductive background on immunoglobulins G (IgGs) structures and micro-heterogeneities is presented. Then the review focuses on analytical papers published mainly the last two years. ...
Han Wei - - 2012
Earning their stripes: A hierarchical assembly of micelles composed of an amphiphilic diblock copolymer, poly(styrene)-block-poly(4-vinylpyridine) (PS-b-P4VP), were made by combining controlled evaporative self-assembly of the confined PS-b-P4VP toluene solution in a cylinder-on-Si geometry with spontaneous self-assembly of micelles. This method gave microscopic stripes of nanometer-sized PS-b-P4VP micelles within the stripes.
Scheiner Steve - - 2012
Among a wide range of noncovalent interactions, hydrogen (H) bonds are well known for their specific roles in various chemical and biological phenomena. When describing conventional hydrogen bonding, researchers use the notation AH···D (where A refers to the electron acceptor and D to the donor). However, the AH molecule engaged ...
van Woerkum Cees - - 2012
In this paper, we aim to add a new perspective to supporting health-related behavior. We use the everyday-life view to point at the need to focus on the social and practical organization of the concerned behavior. Where most current approaches act disjointedly on clients and the social and physical context, ...
Xie Zhaoyong - - 2012
To compare image noise and radiation dose differences between prospective and retrospective ECG-gated computed tomography (CT) coronary artery imaging with 64-slice spiral CT (64-MSCT) in a paired design. Prospective and retrospective ECG-gated CT coronary angiography was performed among 20 out-patients with suspected coronary artery diseases. If one protocol failed, chose ...
Simioni C - - 2012
Abstract Primary Cytomegalovirus (CMV) infection during pregnancy is the leading infectious cause of congenital neurological disabilities. Diagnosis of maternal primary CMV infection and fetal compromise can be difficult, as well as the fact that most infected child are asymptomatic at birth, which makes binomial CMV and pregnancy challenging. The treatment ...
Gao Xiang - - 2012
In this paper, we describe the development of a novel stable-isotope N-phosphorylation labeling (SIPL) strategy for peptide de novo sequencing and protein quantification base on organic phosphorus chemistry. The labeling reaction could be performed easily and completed within 40 min in a one-pot reaction without additional cleanup procedures. Different with ...
Ramkissoon Jugjeet S - - 2012
Abstract Advanced glycation endproducts and oxidative stress contribute to the pathogenesis of diabetic complications. The total phenolic content (TPC), antioxidant, and antiglycation properties of crude ethanolic extracts of 10 common culinary herbs and spices from Mauritius were investigated in vitro. Fluorescence at 370 nm/440 nm was used as an index of albumin ...
Beeckman Delphine S - - 2012
Chlamydiales are obligate intracellular parasites of eukaryotic cells. They can be distinguished from other Gram-negative bacteria through their characteristic developmental cycle, in addition to special biochemical and physical adaptations to subvert the eukaryotic host cell. The host spectrum includes humans and other mammals, fish, birds, reptiles, insects and even amoeba, ...
Lau Janet T F - - 2012
A novel bis(ferrocenyl chalcone) silicon(iv) phthalocyanine has been prepared in which the disulfide linker can be cleaved by dithiothreitol. The separation of the ferrocenyl quencher and the phthalocyanine core greatly enhances the fluorescence emission, singlet oxygen production and in vitro photocytotoxicity.
Lebrun-Harris Lydie A - - 2012
OBJECTIVE: To examine health status and health care experiences of homeless patients in health centers and to compare them with their nonhomeless counterparts. DATA SOURCES/STUDY SETTING: Nationally representative data from the 2009 Health Center Patient Survey. STUDY DESIGN: Cross-sectional analyses were limited to adults (n = 2,683). We compared sociodemographic characteristics, health ...
Monti Manuela - - 2012
The antral compartment in the ovary consists of two populations of oocytes that differ by their ability to resume meiosis and to develop to the blastocyst stage. Still for reasons not entirely clear, antral oocytes termed surrounded nucleolus (SN; 70% of the population of antral oocytes) develop to the blastocyst ...
Kumar Sumit - - 2012
In this study, we have investigated the binding motifs between the aromatic side chains of tryptophan and histidine residues in proteins by studying indole...imidazole heterodimer in a supersonic jet. Different spectroscopic techniques including resonant two photon ionization (R2PI), UV-UV hole-burning and resonant ion dip infrared (RIDIR) spectroscopy merged with quantum ...
Liu Di - - 2012
Abstract In eukaryotic cells the endoplasmic reticulum (ER) is a very critical site for synthesis, folding, modification of protein and calcium homeostasis. The ER responds to factors that perturb ER function such as the accumulation of unfolded proteins (ER stress) by activating unfolded protein response (UPR) to relieve the stress. ...
Zech Astrid - - 2012
ABSTRACT: BACKGROUND: Although resistance exercise interventions have been shown to be beneficial in prefrail or frail older adults it remains unclear whether there are residual effects when the training is followed by a period of detraining. The aim of this study was to establish the sustainability of a muscle power ...
Ferreira José A B - - 2012
Nucleophilic addition of water and of methanol to 3,6-diamino-2,4,5,7-tetrabromo-9-[2-(methoxycarbonyl) phenyl]-9H-xanthen-9-ylium, 4BrR123, yields, respectively, xanthyl, 2-(3,6-diamino-2,4,5,7-tetrabromo-9-hydroxy-9H-xanthen-9-yl) benzoate, HO4BrR123 and, xanthyl, 2-(3,6-diamino-2,4,5,7-tetrabromo-9-methoxy-9H-xanthen-9-yl) benzoate, MeO4BrR123. The novel experimental results are addressed theoretically. The Linear Free Energy Relationship, LFER, Second Order Perturbation Theory analysis of the Natural Bond Orbital, NBO, and Quantum Theory of ...
Kornecki Katherine P - - 2012
A new mixed-valent Rh(2)(II,III) dimer, [Rh(2)(espn)(2)Cl] (espn(2-) = α,α,α',α'-tetramethyl-1,3-benzenedipropanamidate), is reported. This compound readily dissociates Cl(-) at low concentrations in solution to form the active [Rh(2)(espn)(2)](+) catalyst, which performs intramolecular C-H amination with TONs > 1400. This work expands the scope of Rh(2)(II,III) dimers to nitrenoid chemistry.
Juul Kristian Vinter - - 2012
Aims To estimate the relationship between pharmacokinetics and antidiuretic effect of desmopressin. Methods An investigator-blind, randomized, parallel group study with five dose-groups and one placebo, each consisting of 12 healthy, over-hydrated, non-smoking male subjects 18-55 years of age were infused intravenously over two hours with Placebo, 30, 60, 125, 250 ...
Perrier Aurélie - - 2012
First principle simulations of an extended hexameric molecular switch are reported. The full switching of the system is explained by investigating the nature of the excited states of all possible isomers. A new multi-addressable asymmetric structure is proposed.
Myers Mark G - - 2012
Objectives:Little is currently known about price sensitivity across ethnic groups as well as for non-daily smokers. To address this issue, this study compared perceived price sensitivity across smoking status (daily and non-daily) and within ethnicity (Hispanic and non-Hispanic White) in a recent representative population survey of California smokers. METHODS: This ...
Mavridis Konstantinos - - 2012
INTRODUCTION:The extensive use of prostate-specific antigen as a general prostate cancer biomarker has introduced the hazards of overdiagnosis and overtreatment. Recent studies have revealed the immense biomarker capacity of microRNAs (miRNAs) in prostate cancer. The aim of this study was to analyze the expression pattern of miR-224, a cancer-related miRNA, ...
Saito Eiji - - 2012
Biomineral coatings have been extensively used to enhance the osteoconductvity of polymeric scaffolds. Numerous porous scaffolds have previously been coated with a bone-like apatite mineral through incubation in simulated body fluid (SBF). However, characterization of the mineral layer formed on scaffolds, including the amount of mineral within the scaffolds, often ...
Lv Yu-Dan - - 2012
Abstract Objective: The poor sleep quality of epileptic patients may be partly due to the occurrence epileptiform discharges (EDs). We observed the number of interictal discharges in each sleep stage and explored the associations between EDs and sleep phases in epilepsy patients. Methods: Two hundred epileptic patients and 182 healthy ...
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