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Results 801 - 850 of 2099
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Park Jae-Hyung JH Department of Physiology, Keimyung University School of Medicine, 1095 Dalgubeoldae-Ro, Dalseo-Gu, Daegu, - - 2013
Alcohol toxicity can induce multiple organ dysfunction, including the liver. Gallated catechins (GCs), the components of green tea extract (GTE), have been known to inhibit intestinal lipid absorption. This study was designed to investigate the inhibitory effect of GC on the absorption of the lipid-soluble ethanol in normal mice. In ...
Ganguly Anutosh A Department of Integrative Biology and Pharmacology, University of Texas Medical School, Houston, Texas 77030, - - 2012
Although microtubules have long been implicated in cell locomotion, the mechanism of their involvement remains controversial. Most studies have concluded that microtubules play a positive role by regulating actin polymerization, transporting membrane vesicles to the leading edge, and/or facilitating the turnover of adhesion plaques. Here we used wild-type and mutant ...
Fajardo Thor V M - - 2012
We previously showed that the movement protein (MP) gene of Alfalfa mosaic virus (AMV) is functionally exchangeable for the cell-to-cell transport of the corresponding genes of Tobacco mosaic virus, Brome mosaic virus, Prunus necrotic ringspot virus, Cucumber mosaic virus and Cowpea mosaic virus. We have analyzed the capacity of the ...
Chaudhry Faisal - - 2013
Actin filament severing is critical for the dynamic turnover of cellular actin networks. Cofilin severs filaments, but additional factors may be required to increase severing efficiency in vivo. Srv2/cyclase-associated protein (CAP) is a widely expressed protein with a role in binding and recycling actin monomers ascribed to domains in its ...
Planell Núria - - 2012
OBJECTIVE: Ulcerative colitis (UC) is a chronic condition characterised by the relapsing inflammation despite previous endoscopic and histological healing. Our objective was to identify the molecular signature associated with UC remission. DESIGN: We performed whole-genome transcriptional analysis of colonic biopsies from patients with histologically active and inactive UC, and non-inflammatory ...
McNulty Shannon - - 2013
Hantavirus pulmonary syndrome (HPS) is a severe respiratory disease characterized by pulmonary edema, with fatality rates of 35 to 45%. Disease occurs following infection with pathogenic New World hantaviruses, such as Andes virus (ANDV), which targets lung microvascular endothelial cells. During replication, the virus scavenges 5'-m(7)G caps from cellular mRNA ...
Bressler Jan J Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, - - 2013
To determine whether 4 genetic variants in the fat mass and obesity associated gene (FTO) identified in genome-wide association studies of diabetes and obesity are associated with cognitive change in midlife in the Atherosclerosis Risk in Communities (ARIC) Study. ARIC is a prospective cohort study of the development of atherosclerosis ...
Yanez B - - 2012
BackgroundHealth-related quality-of-life (HRQOL) assessments in research and clinical oncology settings are increasingly important. HRQOL instruments need to be rapid and still maintain the ability to capture the most relevant patient issues in a valid and reliable manner. The current study develops and validates the FACT-G7, a rapid version of the ...
Diamond Jennifer R JR Division of Medical Oncology, Department of Medicine, University of Colorado Cancer Center, Aurora, CO 80045, USA. - - 2013
The Aurora kinases are a family of conserved serine-threonine kinases with key roles in mitotic cell division. As with other promising anticancer targets, patient selection strategies to identify a responsive subtype will likely be required for successful clinical development of Aurora kinase inhibitors. The purpose of this study was to ...
Kersten Judy R - - 2012
The question of what is the ideal anesthetic for patients with cardiovascular disease has been debated for nearly three decades, and similarly to the case for the use of perioperative beta blockers, the answer appears to be increasingly enigmatic. In the current issue of the Journal, Buse et al(1) report ...
Craven Michael - - 2012
Polyoxometalate-phosphazene salt aggregates comprising cyclophosphazene cations are highly efficient catalysts for environmentally benign biphasic oxidations with hydrogen peroxide. These catalysts self-assemble in situ simply by mixing commercial Keggin POMs and readily available phosphazenes.
Watanabe Momoko M Department of Developmental and Cell Biology, School of Biological Sciences, University of California Irvine, Irvine, California 92697-2300, - - 2012
Choroid plexus epithelial cells (CPECs) have essential developmental and homeostatic roles related to the CSF and blood-CSF barrier they produce. Accordingly, CPEC dysfunction has been implicated in many neurological disorders, such as Alzheimer's disease, and transplant studies have provided proof-of-concept for CPEC-based therapies. However, such therapies have been hindered by ...
Denys Gerald A - - 2013
Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired and life-threatening infections. Active surveillance programs for MRSA utilize either molecular or culture-based methods. A prospective study was performed to compare the performance of selective and differential chromogenic media, BBL CHROMagar MRSA II (CMRSA II; BD Diagnostics, Sparks, MD), MRSASelect ...
Zhao Qianyi - - 2012
Osmium hydrido vinylidene 1 shows diverse cyclization reactivity with activated terminal alkynes. Treatment of 1 with HCCCOR' (R'=OEt and Me) gave osmafurans 3 a and 3 b via osmium alkenyl/vinylidenes 2 a and 2 b. In addition, 1 reacted with HCCCH(OH)CCH to yield osmabenzene 4, in which the alkynol acted as a C(5) fragment ...
Ruiz Julio C - - 2013
Maintenance of cellular iron homeostasis requires post-transcriptional regulation of iron metabolism genes by iron regulatory protein 2 (IRP2). The hemerythrin-like domain of F-box and leucine-rich repeat protein 5 (FBXL5), an E3 ubiquitin ligase subunit, senses iron and oxygen availability and facilitates IRP2 degradation in iron replete cells. Disruption of the ...
Igawa Kazunobu - - 2012
Asymmetric silanes: A synthesis of nonracemic alkenylhydrosilanes has been developed based on the desymmetrization of a dihydrosilane through alkenylation with an alkyne using an asymmetric catalyst. The alkenylhydrosilane product can be used as a versatile chiral building block for other functionalized nonracemic silanes through the stereoselective conversion of its hydride ...
Aljarilla Ana - - 2012
Two new organic dyes incorporating triphenylamine as a donor and oligothienylenevinylene as a bridge have been synthesized. The new dyes cover the entire visible region and have a power conversion of up to 6.25%.
Mattar Andrew A G AA Department of Psychology, McGill University, Montreal, Quebec, - - 2013
A complex interplay has been demonstrated between motor and sensory systems. We showed recently that motor learning leads to changes in the sensed position of the limb (Ostry DJ, Darainy M, Mattar AA, Wong J, Gribble PL. J Neurosci 30: 5384-5393, 2010). Here, we document further the links between motor ...
Dewulf Evelyne M - - 2012
OBJECTIVE: To highlight the contribution of the gut microbiota to the modulation of host metabolism by dietary inulin-type fructans (ITF prebiotics) in obese women. METHODS: A double blind, placebo controlled, intervention study was performed with 30 obese women treated with ITF prebiotics (inulin/oligofructose 50/50 mix; n=15) or placebo (maltodextrin; n=15) ...
Jim Kin K - - 2012
ABSTRACT OBJECTIVE: To evaluate the occurrence, treatment, and outcome of subdural empyema complicating community-acquired bacterial meningitis in adults. METHODS: Case series from a prospective nationwide cohort study from Dutch hospitals from 2006 to 2011. RESULTS: Subdural empyema was diagnosed in 28 of 1,034 episodes (2.7%), and was present on admission ...
Bastakoti Bishnu Prasad - - 2012
Here we report a new method of synthesizing one-dimensional metal oxide nanotubes (MoO(3)) via thermal mesostructural transition of spherical micelle templates. This nanotube formation is realized by entanglement of adjacent spherical core-shell nanoparticles templated from block copolymer micelles.
Boffetta P - - 2012
BackgroundThe use of biological-based markers of exposure, intermediate effect, outcome, and susceptibility has become standard practice in cancer epidemiology, which has contributed to identification of several carcinogenic agents. Nevertheless, with the exception of biological agents, this contribution, in terms of providing sufficiently strong evidence as required by the International Agency ...
Jameson Gayle S GS Virginia G. Piper Cancer Center at Scottsdale Healthcare (VGPCC)/TGen, Scottsdale, AZ, USA. - - 2013
This study was designed to establish the maximum tolerated dose (MTD) and to evaluate tolerability, pharmacokinetics, and antitumor activity of etirinotecan pegol. Patients with refractory solid malignancies were enrolled and assigned to escalating-dose cohorts. Patients received 1 infusion of etirinotecan pegol weekly 3 times every 4 weeks (w × 3q4w), ...
Ren Guodong - - 2012
MicroRNAs (miRNAs) are key regulators of gene expression and play critical roles in modulating metabolism, development and physiology in animals and plants. miRNA levels are transcriptionally and post-transcriptionally controlled for their proper function. Recent studies have shown that RNA-binding proteins play important roles in producing miRNAs by affecting the accurate ...
Shah Dhvanit I DI Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, - - 2012
Defects in the availability of haem substrates or the catalytic activity of the terminal enzyme in haem biosynthesis, ferrochelatase (Fech), impair haem synthesis and thus cause human congenital anaemias. The interdependent functions of regulators of mitochondrial homeostasis and enzymes responsible for haem synthesis are largely unknown. To investigate this we ...
Foreman Andrew - - 2012
BACKGROUND: The role that bacterial biofilms might play in recalcitrant forms of chronic rhinosinusitis (CRS) is increasingly being recognized. However, the detection of bacteria existing in this form, using standard culture, is limited by their unique metabolically inactive properties. All current biofilm diagnostic modalities require invasive mucosal biopsies, which limit ...
Hibino Toshihiko - - 2012
The calcium binding proteins S100A8 and S100A9 can dimerize to form calprotectin, the release of which during tissue damage has been implicated in inflammation and metastasis. However, receptor(s) mediating the physiological and pathophysiological effects of this damage-associated 'danger signal' are uncertain. In this study, searching for candidate calprotectin receptors by ...
Wengert Sonja - - 2012
OBJECTIVE: Proinsulin may represent a predictive marker for assessing insulin resistance and reduced ß-cell function. Objective of the present study was to investigate the association between hepatic steatosis, proinsulin and other parameters in a random population-based sample. DESIGN: Cross-sectional study, conducted in south-western Germany. METHODS: Upper abdominal ultrasound examinations were ...
Quiroz Yakeel T YT Psychology Department, Center for Memory and Brain, Boston University, Boston, Massachusetts, - - 2013
Sporadic late-onset Alzheimer's disease (AD) dementia has been associated with a 'signature' of cortical atrophy in paralimbic and heteromodal association regions measured with MRI. To investigate whether a similar pattern of cortical atrophy is present in presymptomatic presenilin 1 E280A mutation carriers an average of 6 years before clinical symptom ...
Sartini Stefania - - 2012
Diabetes mellitus is the major risk factor for cardiovascular disorders. Aldose reductase, the rate-limiting enzyme of the polyol pathway, plays a key role in the pathogenesis of diabetic complications. Accordingly, inhibition of this enzyme is emerging as a major therapeutic strategy to treat hyperglycemic-induced cardiovascular pathologies. In this study we ...
Travaglia Alessio - - 2012
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that influences development, maintenance, survival, and synaptic plasticity of central and peripheral nervous systems. Altered BDNF signaling is involved in several neurodegenerative disorders including Alzheimer's disease. Metal ions may influence the BDNF activity and it is well known that the alteration of Cu(2+) ...
Bao Xin - - 2012
Throw the switch: A new strategy for regulating spin crossover (SCO) properties by the control of an active guest molecule is proposed. As a proof of concept, maleic anhydride was incorporated into a microporous {Fe(pyrazine)[Pt(CN)(4) ]} framework material and chemically switched to maleic acid, thus modifying the SCO properties.
van Mierlo Geertje J D - - 2012
The use of recombinant human proteins for the treatment of several diseases has increased considerably during the last decades. A major safety and efficacy issue of biopharmaceuticals is their potential immunogenicity. To prevent immunogenicity, biotechnology-derived proteins are engineered to be as human-like as possible. Immunogenicity is mainly determined in non-human ...
Sakai Kouji - - 2013
Canine distemper virus (CDV) has recently expanded its host range to nonhuman primates. A large CDV outbreak occurred in rhesus monkeys at a breeding farm in Guangxi Province, China, in 2006, followed by another outbreak in rhesus monkeys at an animal center in Beijing in 2008. In 2008 in Japan, ...
Zinoviev Alexandra - - 2012
Many eukaryotes encode multiple isoforms of the cap-binding translation initiation factor (eIF4E). Leishmania and trypanosomatids encode four paralogs of this protein, but none can complement the eIF4E function in a yeast mutant. A low conservation is observed between the four paralogs, suggesting they assist these organisms survive a multitude of ...
Pettit Benjamin B Department of Zoology, University of Oxford, Oxford, UK. - - 2013
For animals that travel in groups, the directional choices of conspecifics are potentially a rich source of information for spatial learning. In this study, we investigate how the opportunity to follow a locally experienced demonstrator affects route learning by pigeons over repeated homing flights. This test of social influences on ...
Elias Rosilene M - - 2012
BackgroundIn patients with end-stage renal disease (ESRD), fluid overload may contribute to their high prevalence of obstructive sleep apnea (OSA) by increasing the amount of fluid displaced from the legs into the neck overnight, and possibly compressing the upper airway (UA). Indeed, in ESRD patients, the amount of overnight rostral ...
Brennan Kevin - - 2012
Cancer cells display widespread genetic and epigenetic abnormalities, but the contribution to disease risk, particularly in normal tissue before disease, is not yet established. Genome-wide hypomethylation occurs frequently in tumors and may facilitate chromosome instability, aberrant transcription and transposable elements reactivation. Several epidemiologic case-control studies have reported genomic hypomethylation in ...
Xu Jian-Guo - - 2012
Chlorogenic acid is a well-known antioxidant and has more isomers according to the difference in binding location and number of caffeic on quinic acid. In this study, we investigated and compared the profiles of antioxidant and DNA-protective activities of chlorogenic acid isomers including three caffeoylquinic acid isomers (3-O-caffeoylquinic acid, 3-CQA; ...
Quintana Elsa - - 2012
Studies of human cancer metastasis have been limited by a lack of experimental assays in which cancer cells from patients metastasize in vivo in a way that correlates with clinical outcome. This makes it impossible to study intrinsic differences in the metastatic properties of cancers from different patients. We recently ...
Leszczynska Katarzyna K Department of Diagnostic Microbiology, Medical University of Białystok, 15-230 Białystok, - - 2013
We aim to develop antibacterial peptide mimics resistant to protease degradation, with broad-spectrum activity at sites of infection. The bactericidal activities of LL-37, ceragenins CSA-13, CSA-90 and CSA-92 and the spermine-conjugated dexamethasone derivative D2S were evaluated using MIC and MBC measurements. Gingival fibroblast counting, interleukin-8 (IL-8) and lactate dehydrogenase (LDH) ...
Gorski Alexandr - - 2012
Reliable assignment of 55 out of 57 vibrational modes has been achieved for 1H-pyrrolo[3,2-h]quinoline using IR, Raman, and fluorescence spectroscopy combined with quantum-chemical calculations. The experiments provided a data set for assessing the performance of different models/basis sets for predicting the vibrational frequencies, as well as IR and Raman intensities ...
Zhao Min - - 2012
Abstract Serum response factor (SRF) is a transcription factor of the MADS box family. To date, DNA binding sites for SRF [serum response elements (SREs)] have been found in the promoters of approximately 50 different genes known to be involved in the regulation cell proliferation, differentiation, and apoptosis. Recent studies ...
Gaddam Deepika - - 2013
Ire1 is an endoplasmic reticulum (ER) transmembrane protein that senses disturbances in protein folding homeostasis and contributes to a multifaceted response to stress. The nuclease activity of Ire1, in addition to splicing the mRNA encoding the transcription factor Xbp1, mediates mRNA degradation in response to ER stress through a pathway ...
Corona Rosalie - - 2012
Although individuals recognize the importance of knowing their family's health history for their own health, relatively few people (e.g., less than a third in one national survey) collect this type of information. This study examines the rates of family communication about family health history of cancer, and predictors of communication ...
van der Pas R - - 2012
Cushing's syndrome is not only accompanied by an increased prevalence of cardiovascular disease, but also by a hypercoagulable state that is reflected by an increased incidence of venous thromboembolism. Overall, patients with CS have been reported to have a more than tenfold increased risk of developing venous thromboembolism. Moreover, the ...
Stack J Conrad JC Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA 16802, - - 2013
Influenza A viruses (IAVs) cause acute, highly transmissible infections in a wide range of animal species. Understanding how these viruses are transmitted within and between susceptible host populations is critical to the development of effective control strategies. While viral gene sequences have been used to make inferences about IAV transmission ...
Sundberg Kristy A KA Systems Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, - - 2012
Many previous studies have demonstrated that changes in selective attention can alter the response magnitude of visual cortical neurons, but there has been little evidence for attention affecting response latency. Small latency differences, though hard to detect, can potentially be of functional importance, and may also give insight into the ...
Drazen Jeffrey M - - 2012
Small pharmacies that produce and package (or repackage) specific drugs for individual patients are an important part of the medical landscape. These so-called compounding pharmacies formulate therapeutic and diagnostic products for physicians in practice and those engaged in research. They make individualized chemotherapeutic agents, noncommercial formulations (e.g., a liquid rather ...
Badoual Cecile - - 2012
Head and neck cancers positive for human papilloma virus (HPV) have a more favorable clinical outcome than HPV-negative cancers, but it is unknown why this is the case. We hypothesized that prognosis was affected by intrinsic features of HPV-infected tumor cells or differences in host immune response. In this study, ...
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