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Hendrickson Sara J SJ Department of Epidemiology, Harvard School of Public Health, Boston, MA, - - 2012
Carotenoids have been hypothesized to reduce the risk of many diseases, but associations with intakes or blood concentrations may arise from other constituents of fruit and vegetables. Use of genetic variation in β-carotene 15,15'-monooxygenase 1 (BCMO1), a key enzyme in provitamin A carotenoid metabolism, as a surrogate for carotenoid exposure ...
Dubinina Galyna G - - 2012
The linear and non-linear optical properties of a series of linear and cross-conjugated platinum(II) acetylide complexes that contain extended p-(phenylene vinylene) chromophores are reported. The complexes exhibit very high femtosecond 2-photon absorption (2PA) cross-section values (σ2 up to 10,000 GM), as measured by nonlinear transmission (NLT) and two-photon excited fluorescence ...
Martínez-Meyer Enrique E Instituto de Biología, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico. - - 2013
Spatial abundance patterns across species' ranges have attracted intense attention in macroecology and biogeography. One key hypothesis has been that abundance declines with geographical distance from the range centre, but tests of this idea have shown that the effect may occur indeed only in a minority of cases. We explore ...
Escalona-Cardoso Gerardo N - - 2012
Abstract Valproic acid (VPA) is a potent inducer of neural tube defects in human and mouse, its teratogenicity is associated with its potential to generation of free radicals and increase oxidative stress. Furthermore, spirulina (SP) has shown pharmacological properties against teratogenicity, which are attributed to its antioxidant potential. Accordingly, the ...
Churchhouse Claire - - 2012
We describe a novel method for inferring the local ancestry of admixed individuals from dense genome-wide single nucleotide polymorphism data. The method, called MULTIMIX, allows multiple source populations, models population linkage disequilibrium between markers and is applicable to datasets in which the sample and source populations are either phased or ...
Jones Helen E - - 2012
Many cells in both the central visual system and other sensory systems exhibit a center surround organization in their receptive field, where the response to a centrally placed stimulus is modified when a surrounding area is also stimulated. This can follow from laterally directed connections in the local circuit at ...
Steensels Deborah - - 2013
Mycobacterium bovis is responsible for a zoonosis originating in cattle. We report a case of a man with vertebral spondylodiscitis caused by Mycobacterium bovis. Diagnosis was complicated because of the lack of IS6110. These strains are rare, but microbiologists should be aware of their existence.
Boase Samuel - - 2012
BACKGROUND: The complex interplay between host, environment, and microbe in the etiopathogenesis of chronic rhinosinusitis (CRS) remains unclear. This study focuses on the host-microbe interaction, specifically the regulation of nitric oxide (NO) and reactive oxygen species (ROS) against the pathogenic organism Staphylococcus aureus (S. aureus). NO and ROS play crucial ...
Gundelach Justin H - - 2013
The di-2-pyridylketone thiosemicarbazone Dp44mT is a metal-chelating compound that has been demonstrated to have potent activity as an anticancer agent. Here we report that it also has a dramatic inhibitory effect on T-cell activation in vitro. We found that 10 nM Dp44mT (IC(50) 3.2 nM) prevented the up-regulation of surface ...
Moladje Donkwe Suzye Mireille - - 2012
The methanol extract of dried fruits of Odyendyea gabonensis afforded one new quassinoid [(-)-odyendanol (1)], one new canthin-6-one alkaloid [9-hydroxy-5-methoxycanthin-6-one (4)], and two new steroids [22E, 24R-stigmasta-5,22-diene-3,7-dione (7) and 22E,24R-stigmast-22-ene-3,7-dione (8)] along with fourteen known compounds. The structures of all compounds were established by analyzing the spectroscopic data. The 13C-NMR ...
Yan Yulan - - 2012
Abstract Type III interferon (IFN-λ) is a novel member of the interferon family, which preferentially promotes antiviral responses from epithelial cells and cooperates with type I IFNs in the clearance of viral infections. However, the effect of mIFN-λ(2) to the LA795 lung adenocarcinoma cell is largely unknown. In this study, ...
Xie Zheng Z Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, USA. - - 2013
General anesthetics produce anesthesia by depressing central nervous system activity. Activation of inhibitory GABA(A) receptors plays a central role in the action of many clinically relevant general anesthetics. Even so, there is growing evidence that anesthetics can act at a presynaptic locus to inhibit neurotransmitter release. Our own data identified ...
Jackson Dana L - - 2013
Foamy viruses are retroviruses whose Pol protein is synthesized without Gag from a spliced mRNA. Unlike orthoretroviruses, reverse transcription occurs during viral assembly, leading to DNA-containing virions. When prototype foamy virus Pol is expressed as an orthoretroviral-like Gag-Pol fusion protein, reverse transcription also occurs late in viral replication, as measured ...
Fergusson Jennifer - - 2012
There is concern in many developed countries that school students are turning away from science. However, students may be choosing not to study science and dismissing the possibility of a scientific career because, in the junior secondary years, they gain a false view of science and the work of scientists. ...
Zollman Kevin J S KJ Department of Philosophy, Carnegie Mellon University, Pittsburgh, PA 15213-3890, USA. - - 2013
Costly signalling theory has become a common explanation for honest communication when interests conflict. In this paper, we provide an alternative explanation for partially honest communication that does not require significant signal costs. We show that this alternative is at least as plausible as traditional costly signalling, and we suggest ...
Schreiver C - - 2012
OBJECTIVE: This cross-sectional observational cohort study was designed to investigate i) whether glycaemic variability in paediatric patients with type 1 diabetes is lower in those using an insulin pump (CSII) compared to those using multiple daily insulin injections (MDI) and ii) whether urinary F(2) -isoprostanes and/or urinary prostaglandin F(2α) excretion ...
Ryan Charles J - - 2012
PURPOSE: To evaluate the efficacy, safety, biomarkers, and pharmacokinetics of rilotumumab, a fully human, monoclonal antibody against hepatocyte growth factor (HGF)/scatter factor, combined with mitoxantrone and prednisone (MP) in patients with castration-resistant prostate cancer (CRPC). EXPERIMENTAL DESIGN: This double-blinded phase 2 study randomized (1:1:1) patients with progressive, taxane-refractory CRPC to ...
Lurati Buse Giovanna A L GA Department of Anesthesia and Intensive Care Medicine, University Hospital Basel, Spitalstrasse 21, CH-4031 Basel, Switzerland. - - 2012
Volatile anesthetics provide myocardial preconditioning in coronary surgery patients. We hypothesized that sevoflurane compared with propofol reduces the incidence of myocardial ischemia in patients undergoing major noncardiac surgery. We enrolled 385 patients at cardiovascular risk in 3 centers. Patients were randomized to maintenance of anesthesia with sevoflurane or propofol. We ...
Sanchez Tim - - 2012
With remarkable precision and reproducibility, cells orchestrate the cooperative action of thousands of nanometre-sized molecular motors to carry out mechanical tasks at much larger length scales, such as cell motility, division and replication. Besides their biological importance, such inherently non-equilibrium processes suggest approaches for developing biomimetic active materials from microscopic ...
Lamichhaney Sangeet - - 2012
The Atlantic herring (Clupea harengus), one of the most abundant marine fishes in the world, has historically been a critical food source in Northern Europe. It is one of the few marine species that can reproduce throughout the brackish salinity gradient of the Baltic Sea. Previous studies based on few ...
Foss Cristina - - 2012
In spite of commercially available products, the complete and sustained repair of damaged articular cartilage still presents various challenges. Amongst biomaterials proposed for cartilage repair, silk fibroin (SF) has been recently proposed as a material template for porous scaffolds cultured with chondrocytes and investigated in static and dynamic conditions. In ...
Wang Yan-Ying - - 2012
Abstract MicroRNAs are closely linked to tumor metastasis and let-7a may play a role in inhibiting the proliferation, invasion, and metastasis of lung cancer. In vitro, we aim to observe the impact of let-7a on the proliferation and invasion of the nonsmall cell lung cancer cell line 95D by constructing ...
Meng Li L CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, - - 2013
Numerous unique properties of carbon nanotubes make them attractive for applications in neurobiology such as drug delivery, tissue regeneration, and as scaffolds for neuronal growth. In this study, the critical roles of the length of multiwall carbon nanotubes (MWCNTs) on a neuronal-like model cell line PC12 cells are investiaged. Incubation ...
Miller Dori J - - 2012
The first two weeks of neonatal life constitute a critical period for estrogen receptor-alpha (ESR1)-dependent uterine adenogenesis in the pig. A relaxin receptor (RXFP1)-mediated, lactocrine-driven mechanism was proposed to explain how nursing could regulate endometrial ESR1 and related gene expression events associated with adenogenesis in the porcine neonate during this ...
Kawahara Ryoko - - 2012
Going into reverse: An efficient and versatile catalytic system for the dehydrogenative oxidation of alcohols under extremely mild conditions is developed using a Cp*Ir complex with bipyridonate ligand as catalyst (see scheme, Cp*=pentamethylcyclopentadienyl). Reversible and repetitive transformation between 2-propanol and acetone by catalytic dehydrogenation-hydrogenation is also achieved.
Okamoto Curtis T - - 2012
This Editorial Focus highlights the findings of Yui, et al., in this issue, on the basolateral targeting and microtubule dependent targeting of aquaporin-2 water channels.
Liu J J JJ Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. - - 2013
This is the first prospective cohort analysis on the association between vitamin D and endometrial cancer incorporating time-varying predicted plasma 25-hydroxyvitamin D [25(OH)D]. The prospective cohort analysis of predicted 25(OH)D and total dietary vitamin D intake used the Cox proportional hazards model, and involved 644 incident endometrial cancer events from ...
Tai Davina J - - 2012
BackgroundMaintenance of central blood volume (CBV) is essential for hemodynamic stability during hemodialysis (HD), though preservation of CBV is poorly understood. Pneumatic compression devices (PCDs) during HD may help maintain CBV.MethodsWe performed a randomized, crossover trial to determine the effect of PCDs on CBV during HD. Patients underwent two consecutive ...
Nakajima Takayuki - - 2012
Reactions of M(OAc)(2)·4H(2)O (M = Ni, Co) with 3-[benzyl(2-hydroxyethyl)amino]-1-propanol (H(2)L) in the presence of pyridine or triethylamine afforded novel homometallic icosanuclear wheel-shaped complexes [M(20)L(4)(HL)(4)(OAc)(28)] (M = Ni (1), Co (2)), which consist of a central M(II)(12) single-stranded, nearly planar loop with four peripheral [M(2)(HL)(OAc)(2)] fragments attached in an S(4) symmetrical ...
Borisovska Maria - - 2012
Trans-soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) complexes formed between the SNARE motifs of synaptobrevin II, SNAP-25, and syntaxin play an essential role in Ca(2+)-regulated exocytosis. Apart from the well studied interactions of the SNARE domains, little is known about the functional relevance of other evolutionarily conserved structures in ...
Lavine Laura Corley - - 2012
The insulin signaling pathway is the primary signaling pathway coupling growth with nutritional condition in all animals. Sensitivity to circulating levels of insulin has been shown to regulate the growth of specific traits in a dose-dependent manner in response to environmental conditions in a diversity of insect species. Alternative phenotypes ...
Huang Haohao - - 2012
The presence of a polyelectrolyte in a colloidal dispersion affects the interaction between colloidal particles through electrostatic and bridging interactions. In this paper, using a self-consistent field approach, a simple theory is developed which allows to calculate the bridging force between two plates and two colloidal particles. The present approach ...
Caserta Sergio - - 2012
Pattern formation under the action of flow is a subject of considerable scientific interest with applications going from microfluidics to granular materials. Here, we present a systematic investigation of shear-induced banding in confined biphasic liquid-liquid systems, i.e., formation of alternating regions of high and low volume fraction of droplets in ...
Lee Jung Ok JO Department of Anatomy, Korea University College of Medicine, Seoul 136-705, - - 2012
Metformin is a leading oral anti-diabetes mellitus medication and is known to stimulate GLUT4 translocation. However, the mechanism by which metformin acts is still largely unknown. Here, we showed that short time treatment with metformin rapidly increased phosphorylation of Cbl in an AMP-activated protein kinase (AMPK)-dependent fashion in 3T3-L1 preadipocytes. ...
Gijsbers Esther F - - 2012
Three homosexual men from a proven homosexual HIV-1 transmission cluster revealed large variation in their clinical course of infection. To evaluate the effect of viral evolution of the same viral variant in these three patients, we analyzed the sequence variation in the capsid protein and determined the impact of the ...
M Doody Catriona - - 2012
AIM AND OBJECTIVES: To explore the experiences of registered intellectual disability nurses caring for the older person with intellectual disability. BACKGROUND: Increased longevity for the older person with intellectual disability is relatively a new phenomenon with social and medical factors having significantly increased the lifespan. The ageing population of people ...
Poupin Nathalie - - 2012
Fractional synthesis rates (FSR) of tissue proteins (P) are usually measured using labeled amino acid (AA) tracer methods over short periods of time under acute, particular conditions. In this work, we developed a new isotopic approach, by combining the long-term and non-steady-state 15N labeling of AA and P tissue fractions ...
Kölsch Verena - - 2013
How independent signaling pathways are integrated to holistically control a biological process is not well understood. We have identified Daydreamer (DydA), a new member of the Mig10/RIAM/lamellipodin (MRL) family of adaptor proteins that localizes to the leading edge of the cell. DydA is a putative Ras effector that is required ...
van der Valk Mirthe Emilie - - 2012
OBJECTIVE: The introduction of anti tumour necrosis factor-α (anti-TNFα) therapy might impact healthcare expenditures, but there are limited data regarding the costs of inflammatory bowel diseases (IBD) following the introduction of these drugs. We aimed to assess the healthcare costs and productivity losses in a large cohort of IBD patients. ...
Cheng Xuefang - - 2012
β-lapachone (β-Lap) is an NAD(P)H: quinone oxidoreductase 1 (NQO1) target antitumor drug candidate in phase II clinical trials. The present study aimed to uncover the metabolic profile, enzyme kinetics, and enzyme isoforms for the metabolism of β-Lap in human liver and intestine in vitro. NQO1-mediated quinone reduction and subsequent glucuronidation ...
Vaquero Mónica - - 2012
Mildly does it: A highly enantioselective catalyst for the hydrogenation of N-aryl imines is described. This catalyst offers practical advantages because it operates under very mild conditions and is based on an Ru complex with a diamine as the sole chiral ligand.
Eiermann W - - 2012
BackgroundWe carried out a prospective clinical study to evaluate the impact of the Recurrence Score (RS) on treatment decisions in early breast cancer (EBC).Patients and methodsA total of 379 eligible women with estrogen receptor positive (ER+), HER2-negative EBC and 0-3 positive lymph nodes were enrolled. Treatment recommendations, patients' decisional conflict, ...
Plavicki Jessica J Department of Pharmaceutical Sciences, University of Wisconsin, Madison, Wisconsin 53705-2222, - - 2013
Embryonic exposure to the environmental contaminant and aryl hydrocarbon receptor agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), disrupts cardiac development and function in fish, birds, and mammals. In zebrafish, the temporal window of sensitivity to the cardiotoxic effects of TCDD coincides with epicardium formation. We hypothesized that this TCDD-induced heart failure results from ...
Savage Kevin J - - 2012
When two metal nanostructures are placed nanometres apart, their optically driven free electrons couple electrically across the gap. The resulting plasmons have enhanced optical fields of a specific colour tightly confined inside the gap. Many emerging nanophotonic technologies depend on the careful control of this plasmonic coupling, including optical nanoantennas ...
He Hongbo - - 2012
The level and integrity of glutamate transmission during critical periods of postnatal development plays an important role in the refinement of pyramidal neuron dendritic arbor, synaptic plasticity, and cognition. Presently, it is not clear how excitatory transmission via the two predominant isoforms of the vesicular glutamate transporter (VGLUT1 and VGLUT2) ...
Zurwerra Didier - - 2012
A new total synthesis of the marine macrolide (-)-zampanolide (1) and the structurally and stereochemically related non-natural levorotatory enantiomer of (+)-dactylolide (2), that is, ent-2, has been developed. The synthesis features a high-yielding, selective intramolecular Horner-Wadsworth-Emmons (HWE) reaction to close the 20-membered macrolactone ring of 1 and ent-2. The β-keto ...
Sakano Chieko - - 2013
Whole-genome sequencing of non-H(2)S-producing Salmonella enterica serovar Typhimurium and S. enterica serovar Infantis isolates from poultry meat revealed a nonsense mutation in the phsA thiosulfate reductase gene and carriage of a CMY-2 β-lactamase. The lack of production of H(2)S might lead to the incorrect identification of S. enterica isolates carrying ...
Kim Beom-Su - - 2012
Scaffolds can be used for tissue engineering because they can serve as templates for cell adhesion and proliferation for tissue repair. In this study, chitosan/hydroxyapatite (CS/HAp) composites were prepared by coprecipitation synthesis. Then, CS and CS/HAp fabrics were prepared by wet spinning. CS fibers with a diameter of 15 ± ...
Ross Matthew S - - 2012
The Canadian oil sands industry stores toxic oil sands process-affected water (OSPW) in large tailings ponds adjacent to the Athabasca River or its tributaries, raising concerns over potential seepage. Naphthenic acids (NAs; CnH2n-ZO2) are toxic components of OSPW, but are also natural components of bitumen and regional groundwaters, and may ...
Raine Gary - - 2012
Many companies nowadays consider schools to be an important setting for marketing to children. However, important concerns can be raised from a health promotion perspective about the potential negative impact of commercial activities on the health and well-being of pupils. As this discussion paper will demonstrate, some commercial activities raise ...
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