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Results 701 - 750 of 2098
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Maucher Fuquay Jennifer - - 2012
Domoic acid (DA) causes neurological effects in multiple species upon exposure, including status epilepticus in pregnant sea lions and an epileptic disease state that commonly develops in juveniles. This study aims to define brain toxicokinetic parameters in the pregnant rat in the larger context of maternal-fetal toxin transfer. Specifically, Sprague-Dawley ...
Bandekar Amey - - 2012
We investigated the feasibility and efficacy of a drug delivery strategy to vascularized cancer that combines targeting selectivity with high uptake by targeted cells and high bioexposure of cells to delivered chemotherapeutics. Targeted lipid vesicles composed of pH responsive membranes were designed to reversibly form phase-separated lipid domains which are ...
Beckmann Jens - - 2012
The homoleptic 1:1 Lewis pair (LP) complex [MesTe(TeMes(2))]O(3)SCF(3) (1) featuring the cation [MesTe(TeMes(2))](+) (1a) was obtained by the reaction of Mes(2)Te with HO(3)SCF(3). The reaction of 1 with Ph(3)E (E = P, As, Sb, Bi) proceeded with substitution of Mes(2)Te and provided the heteroleptic 1:1 LP complexes [MesTe(EPh(3))]O(3)SCF(3) (2, E ...
Thorneloe Kevin S - - 2012
Pulmonary edema resulting from high pulmonary venous pressure (PVP) is a major cause of morbidity and mortality in heart failure (HF) patients, but current treatment options demonstrate substantial limitations. Recent evidence from rodent lungs suggests that PVP-induced edema is driven by activation of pulmonary capillary endothelial transient receptor potential vanilloid ...
Brennan Fiona P - - 2012
An understanding of the survival capacity of Escherichia coli in soil is critical for the evaluation of its role as a faecal indicator. Recent reports that E. coli can become long-term residents in maritime temperate soils have raised the question of how the organism survives and competes for niche space ...
Subramanian Deepak N - - 2012
BACKGROUND: severity assessment in community-acquired pneumonia (CAP) is important as it is associated with significant mortality. In this study, we compared a previously suggested severity assessment rule for CAP- SOAR (systolic blood pressure, oxygenation, age and respiratory rate)- against the CURB-65 criteria. METHODS: we conducted a prospective study in three ...
Fujita Hirofumi - - 2012
Compartmentalization is essential for a brain area to be involved in different functions through topographic afferent and efferent connections that reflect this organization. The adult cerebellar cortex is compartmentalized into longitudinal stripes, in which Purkinje cells (PCs) have compartment-specific molecular expression profiles. How these compartments form during development is generally ...
Zhao Feng - - 2012
AIMS: To evaluate the screening test ability of UF-1000i combination with AX-4280 for major pathological urinary formed elements and to establish screening rules suitable for our laboratory. METHODS: A total of 2220 cases of urine samples were collected from out-patients and inpatients. The sample tests were finished within 4 h ...
Zeng Gaofeng - - 2012
Pincers do the trick: The conversion of ethanol to ethyl acetate and hydrogen was achieved using a pincer-Ru catalyst in a Pd-Ag membrane reactor. Near quantitative conversions and yields could be achieved without the need for acid or base promoters or hydrogen acceptors.
Reisacher William R - - 2012
BACKGROUND: It has been previously demonstrated that local, antigen-specific immunoglobulin E (IgE) can be detected using a standard in vitro assay of lysed epithelial cells in saline, harvested via nasal mucosal brush biopsy (MBB). However, compared to surgical biopsy or serum, smaller amounts of IgE are harvested using MBB, making ...
Lin Fanyu - - 2012
Twenty one immediate-early (IE) genes of white spot syndrome virus (WSSV) have been identified so far. However, the transcriptional regulation of WSSV IE genes remains largely unknown. In this report, the 5' flanking regions of eighteen WSSV IE genes were cloned and eight functional promoter regions were identified. WSSV IE ...
Stéphanie Demoulin - - 2012
Human pDCs represent a rare population of circulating cells characterized by a rapid and massive TLR-dependent secretion of type I IFN in response to pathogenic agents or danger signals. Through their capacity to bring together innate and adaptive immunity and to secrete soluble factors controlling cancer development, these cells could ...
Bamias A - - 2012
BackgroundThe combinations of methotrexate, vinblastine, Adriamycin, cisplatin (Pharmanell, Athens, Greece) (MVAC) or gemcitabine, cisplatin (GC) represent the standard treatment of advanced urothelial cancer (UC). Dose-dense (DD)-MVAC has achieved longer progression-free survival (PFS) than the conventional MVAC. However, the role of GC intensification has not been studied. We conducted a randomized, ...
Hamed Refaat B - - 2012
Covering: up to May 2012The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via modification of fermented intermediates, with important exceptions being the carbapenems and aztreonam. ...
Bochem Andrea E - - 2012
AimsLow HDL-C is a potent risk factor for cardiovascular disease (CVD). Yet, mutations in ABCA1, a major determinant of circulating HDL-C levels, were previously not associated with CVD risk in cohort studies. To study the consequences of low plasma levels of high-density lipoprotein cholesterol (HDL-C) due to ATP-binding cassette transporter A1 ...
Sun Haoran - - 2012
The photostability of aromatic compounds in the presence of air is significantly improved through perfluoroalkylation of the corresponding aromatic cores and use of polyfluorinated solvents despite higher O(2) concentration in polyfluorinated solvents than in hydrocarbon solvents.
Romano A - - 2012
BackgroundA combination of bortezomib (1.3 mg/m(2)), melphalan (5 mg/m(2)), and dexamethasone (40 mg) (BMD), with all three drugs given as a contemporary intravenous administration, was retrospectively evaluated.Patients and MethodsFifty previously treated (median 2 previous lines) patients with myeloma (33 relapsed and 17 refractory) were assessed. The first 19 patients were treated with a ...
Tang Li - - 2012
A dual-modal imaging probe based on size-controlled silica nanoconjugates was synthesized for targeted imaging of lymph nodes by means of both PET and near infrared fluorescence techniques. 20 nm nanoconjugates functionalized with an aptamer (green triangles) that targets 4T1 breast cancer cells improved the detection efficiency of sentinel lymph nodes ...
Semmler Alexander - - 2012
OBJECTIVES: The objective of this preliminary study was to explore long-term changes in neurobehavioral parameters, brain morphology and electroencephalography of sepsis patients who received intensive care compared to non-septic intensive care unit (ICU) patients. METHODS: Two-centre follow-up study 6-24 months after discharge from hospital using published norms and existing databases ...
Das Utpal - - 2012
An organocatalytic asymmetric synthesis of spironitrocyclopropanes has been demonstrated starting from 2-arylidene-1,3-indandiones and bromonitroalkanes catalyzed by a cinchona-derived bifunctional organocatalyst. The products were obtained with excellent enantioselectivities, diastereoselectivities and with good yields.
Wong Jordan R - - 2012
BACKGROUND:No studies exist regarding the value of pharmacist interventions using rapid identification of coagulase-negative staphylococci (CoNS) by rapid polymerase chain reaction (rPCR) from blood cultures.OBJECTIVE:To evaluate the impact of interventions by infectious diseases pharmacists (ID PharmDs) on blood cultures positive for CoNS using rPCR and assess the duration of antistaphylococcal ...
Tyritzis Stavros I - - 2012
Abstract We are celebrating the 10th anniversary of robot-assisted laparoscopic radical cystectomy (RARC) with urinary diversion (UD), and it seems that this operation is successfully following the footsteps of robot-assisted laparoscopic radical prostatectomy. Until now, approximately 1000 RARCs have been recorded; of them, only 102 were performed totally intracorporeally with ...
Gibson Andrew - - 2012
BACKGROUND: Fruit and vegetable (FV) intake, which is often low in older people, is associated with reduced chronic disease risk. OBJECTIVE: We determined whether increased FV intake improves measures of immune function. DESIGN: We conducted a randomized controlled trial (The Ageing and Dietary Intervention Trial) in 83 healthy volunteers aged ...
van Angelen Annelies A - - 2012
BackgroundCisplatin is an effective anti-neoplastic drug, but its clinical use is limited due to dose-dependent nephrotoxicity. The majority of cisplatin-treated patients develop hypomagnesaemia, often associated with a reduced glomerular filtration rate (GFR), polyuria and other electrolyte disturbances. The aim of this study is to unravel the molecular mechanism responsible for ...
Zhang Wen-Juan - - 2012
MLAA-34 is a novel acute monocytic leukemia (M5)-associated antigen (MLAA) that plays a role in the apoptosis of U937 cells. However, the expression and molecular mechanism of MLAA-34 in U937 cells remain largely unclear. Here, we utilized three strategies to gain insight into the expression and molecular functions of MLAA-34 ...
Tsen Adam W - - 2012
Graphene, a truly two-dimensional hexagonal lattice of carbon atoms, possesses remarkable properties not seen in any other material, including ultrahigh electron mobility, high tensile strength, and uniform broadband optical absorption. While scientists initially studied its intrinsic properties with small, mechanically exfoliated graphene crystals found randomly, applying this knowledge would require ...
Adamowicz Piotr - - 2012
A death caused by a new designer drug, 4-methylmethcathinone (mephedrone), is reported. Eight small plastic bags containing white powder were found in the jacket of a young dead male. Spot tests conducted by the police officer indicated the presence of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in the powders. Laboratory routine screening analyses of ...
Improta Roberto - - 2012
We here report a fully quantum mechanical study of the main photochemical and photophysical decay routes in aqueous solution of Thymine deoxy-dinucleotide (TpT- and TpTNa) and of its analogue locked in C3-endo puckering, characterizing five different representative backbone conformers and discussing the chemical physical effects modulating the yield of the ...
Roy Xavier - - 2012
Making contact to a quantum dot: Single quantum-dot electronic circuits are fabricated by wiring atomically precise metal chalcogenide clusters with conjugated molecular connectors. These wired clusters can couple electronically to nanoscale electrodes and be tuned to control the charge-transfer characteristics.
Vanbiervliet G - - 2012
Background and study aims: Uncovered self-expanding metal stents offer effective relief for colonic obstruction. The aim of this study was to determine the effectiveness of fully covered self-expanding metal stents (FCSEMSs) in the treatment of benign colonic strictures.Patients and methods: All patients presenting with a symptomatic benign colonic stricture (occlusion ...
Akhtar Tariq A - - 2012
cis-Prenyltransferases (CPTs) are predicted to be involved in the synthesis of long-chain polyisoprenoids, all with >5 isoprene (C5) units. Recently, we identified a short-chain CPT, neryl diphosphate synthase (NDPS1), in tomato (Solanum lycopersicum). Here, we searched the tomato genome and identified and characterized its entire CPT gene family, which is ...
Misas-Villamil Johana C - - 2012
Vacuolar Processing Enzymes (VPEs) are important cysteine proteases implicated in maturation of e.g. seed storage proteins and involved in programmed cell death during plant-microbe interactions and development. Here, we introduce a specific, cell-permeable, activity-based probe for VPEs. This probe is highly specific for all four Arabidopsis VPEs and labeling is ...
Nahon Pierre - - 2012
PURPOSE: Metabolomics depicts metabolic changes in biological systems using a multiparametric analysis technique. This study assessed the metabolomic profiles of serum, obtained by proton NMR spectroscopy, from cirrhotic patients with and without hepatocellular carcinoma (HCC). EXPERIMENTAL DESIGN: The study included 154 consecutive patients with compensated biopsy-proven alcoholic cirrhosis. Among these, ...
Chen Hongman - - 2012
To determine the role played by the Wnt/β-catenin signaling pathway in the development of endometrial cancer (EC), we examined the expression of Wnt10a and Wnt10b in EC tissues and the correlation between their expression. Furthermore, the associations between these two proteins and the clinicopathological characteristics and prognosis of EC were ...
Bertrand Arthur - - 2012
The contribution of supramolecular chemistry to polymer science opens new perspectives for the design of polymer materials exhibiting valuable properties and easier processability due to the dynamic nature of non-covalent interactions. Hydrogen bonding polymers can be used as supramolecular units for yielding larger assemblies that possess attractive features, arising from ...
Foreman Andrew - - 2012
BACKGROUND: The role that bacterial biofilms might play in recalcitrant forms of chronic rhinosinusitis (CRS) is increasingly being recognized. However, the detection of bacteria existing in this form, using standard culture, is limited by their unique metabolically inactive properties. All current biofilm diagnostic modalities require invasive mucosal biopsies, which limit ...
Hibino Toshihiko - - 2012
The calcium binding proteins S100A8 and S100A9 can dimerize to form calprotectin, the release of which during tissue damage has been implicated in inflammation and metastasis. However, receptor(s) mediating the physiological and pathophysiological effects of this damage-associated 'danger signal' are uncertain. In this study, searching for candidate calprotectin receptors by ...
Wengert Sonja - - 2012
OBJECTIVE: Proinsulin may represent a predictive marker for assessing insulin resistance and reduced ß-cell function. Objective of the present study was to investigate the association between hepatic steatosis, proinsulin and other parameters in a random population-based sample. DESIGN: Cross-sectional study, conducted in south-western Germany. METHODS: Upper abdominal ultrasound examinations were ...
Sartini Stefania - - 2012
Diabetes mellitus is the major risk factor for cardiovascular disorders. Aldose reductase, the rate-limiting enzyme of the polyol pathway, plays a key role in the pathogenesis of diabetic complications. Accordingly, inhibition of this enzyme is emerging as a major therapeutic strategy to treat hyperglycemic-induced cardiovascular pathologies. In this study we ...
Travaglia Alessio - - 2012
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that influences development, maintenance, survival, and synaptic plasticity of central and peripheral nervous systems. Altered BDNF signaling is involved in several neurodegenerative disorders including Alzheimer's disease. Metal ions may influence the BDNF activity and it is well known that the alteration of Cu(2+) ...
Bao Xin - - 2012
Throw the switch: A new strategy for regulating spin crossover (SCO) properties by the control of an active guest molecule is proposed. As a proof of concept, maleic anhydride was incorporated into a microporous {Fe(pyrazine)[Pt(CN)(4) ]} framework material and chemically switched to maleic acid, thus modifying the SCO properties.
van Mierlo Geertje J D - - 2012
The use of recombinant human proteins for the treatment of several diseases has increased considerably during the last decades. A major safety and efficacy issue of biopharmaceuticals is their potential immunogenicity. To prevent immunogenicity, biotechnology-derived proteins are engineered to be as human-like as possible. Immunogenicity is mainly determined in non-human ...
Zinoviev Alexandra - - 2012
Many eukaryotes encode multiple isoforms of the cap-binding translation initiation factor (eIF4E). Leishmania and trypanosomatids encode four paralogs of this protein, but none can complement the eIF4E function in a yeast mutant. A low conservation is observed between the four paralogs, suggesting they assist these organisms survive a multitude of ...
Elias Rosilene M - - 2012
BackgroundIn patients with end-stage renal disease (ESRD), fluid overload may contribute to their high prevalence of obstructive sleep apnea (OSA) by increasing the amount of fluid displaced from the legs into the neck overnight, and possibly compressing the upper airway (UA). Indeed, in ESRD patients, the amount of overnight rostral ...
Xu Jian-Guo - - 2012
Chlorogenic acid is a well-known antioxidant and has more isomers according to the difference in binding location and number of caffeic on quinic acid. In this study, we investigated and compared the profiles of antioxidant and DNA-protective activities of chlorogenic acid isomers including three caffeoylquinic acid isomers (3-O-caffeoylquinic acid, 3-CQA; ...
Ishii Hironori - - 2012
We often have to make risky decisions between alternatives with outcomes that can be better or worse than the outcomes of safer alternatives. Although previous studies have implicated various brain regions in risky decision making, it remains unknown which regions are crucial for balancing whether to take a risk or ...
Lewis Richard A - - 2012
Bond, metal-metal bond: Addition of 2.5 equiv of Li(NCtBu(2) ) to MCl(2) (M=Mn, Fe, and Co), followed by addition of [12]crown-4, results in formation of [Li([12]crown-4)(2) ][M(2) (NCtBu(2) )(5) ] in good yields. These complexes exhibit short M-M distances and strong magnetic communication between metal centers, demonstrating that ketimides are ...
Jia Xiaofei - - 2012
A new class of bidentate phosphoramidite ligands, based on a spiroketal backbone, has been developed for the rhodium-catalyzed hydroformylation reactions. A range of short- and long-chain olefins, were found amenable to the protocol, affording high catalytic activity and excellent regioselectivity for the linear aldehydes. Under the optimized reaction conditions, a ...
Enomoto Masaru - - 2012
Succinct and stereoselective: A high-yielding two-step indole ring installation comprising the Stille cross-coupling and a Pd(II) -mediated oxidative heterocyclization was exploited in a concise total synthesis of paspalinine. The trans-anti-trans CDE fused ring system of the heptacyclic natural product was established highly stereoselectively through hydroxy-directed cyclopropanation and allylic selenoxide rearrangement.
Ginestà Mireia M - - 2012
BACKGROUND: Methylation markers have shown promise in the early diagnosis of pancreatic carcinoma. The aim of this study was to assess the diagnostic utility of hypermethylation status of candidate genes in combination with KRAS mutation detection in the evaluation of pancreatic masses. EXPERIMENTAL DESIGN: Sixty-one fine needle aspirates of pancreatic ...
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