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Zhao Qianyi - - 2012
Osmium hydrido vinylidene 1 shows diverse cyclization reactivity with activated terminal alkynes. Treatment of 1 with HCCCOR' (R'=OEt and Me) gave osmafurans 3 a and 3 b via osmium alkenyl/vinylidenes 2 a and 2 b. In addition, 1 reacted with HCCCH(OH)CCH to yield osmabenzene 4, in which the alkynol acted as a C(5) fragment ...
Igawa Kazunobu - - 2012
Asymmetric silanes: A synthesis of nonracemic alkenylhydrosilanes has been developed based on the desymmetrization of a dihydrosilane through alkenylation with an alkyne using an asymmetric catalyst. The alkenylhydrosilane product can be used as a versatile chiral building block for other functionalized nonracemic silanes through the stereoselective conversion of its hydride ...
Aljarilla Ana - - 2012
Two new organic dyes incorporating triphenylamine as a donor and oligothienylenevinylene as a bridge have been synthesized. The new dyes cover the entire visible region and have a power conversion of up to 6.25%.
Jim Kin K - - 2012
ABSTRACT OBJECTIVE: To evaluate the occurrence, treatment, and outcome of subdural empyema complicating community-acquired bacterial meningitis in adults. METHODS: Case series from a prospective nationwide cohort study from Dutch hospitals from 2006 to 2011. RESULTS: Subdural empyema was diagnosed in 28 of 1,034 episodes (2.7%), and was present on admission ...
Bastakoti Bishnu Prasad - - 2012
Here we report a new method of synthesizing one-dimensional metal oxide nanotubes (MoO(3)) via thermal mesostructural transition of spherical micelle templates. This nanotube formation is realized by entanglement of adjacent spherical core-shell nanoparticles templated from block copolymer micelles.
Boffetta P - - 2012
BackgroundThe use of biological-based markers of exposure, intermediate effect, outcome, and susceptibility has become standard practice in cancer epidemiology, which has contributed to identification of several carcinogenic agents. Nevertheless, with the exception of biological agents, this contribution, in terms of providing sufficiently strong evidence as required by the International Agency ...
Jameson Gayle S - - 2012
PURPOSE: This study was designed to establish the maximum-tolerated dose (MTD) and to evaluate tolerability, pharmacokinetics, and antitumor activity of etirinotecan pegol. EXPERIMENTAL DESIGN: Patients with refractory solid malignancies were enrolled and assigned to escalating-dose cohorts. Patients received one infusion of etirinotecan pegol weekly × 3 every 4 weeks (w×3q4w), ...
Ren Guodong - - 2012
MicroRNAs (miRNAs) are key regulators of gene expression and play critical roles in modulating metabolism, development and physiology in animals and plants. miRNA levels are transcriptionally and post-transcriptionally controlled for their proper function. Recent studies have shown that RNA-binding proteins play important roles in producing miRNAs by affecting the accurate ...
Rutter Abigail V - - 2012
Our previous studies have shown that both lung cancer cells and non-malignant lung cells release acetaldehyde in vitro. However, data from other laboratories have produced conflicting results. Furthermore, all these studies have been carried out in 2D models which are less physiological cell growth systems when compared to 3D models. ...
Palfreeman Adrian - - 2012
OBJECTIVES: The 2008 UK National Guidelines for HIV testing recommended HIV testing should be offered to all general medical admissions aged 16-60 years in high prevalence areas, and that this should be evaluated to ensure this was effective in diagnosing previously undiagnosed HIV. METHODS: HIV testing was introduced as a ...
Boterashvili Meital - - 2012
To mix or not to mix: Integrated (left) and segregated (right) assemblies were obtained upon treating functionalized γ-Fe(2) O(3) nanoparticles (NPs) with AuNPs. Their binary nature is controlled by the capping layer of the γ-Fe(2) O(3) NPs and the AuNP initial aggregation state. The segregated assembly formation is induced by ...
Ovcharenko Victor I - - 2012
The reaction of copper(II) hexafluoroacetylacetonate [Cu(hfac)(2)] with the stable nitronyl nitroxide 2-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (L(a)) resulted in a paired heterospin complex [[Cu(hfac)(2)](3)(μ-O,N-L(a))(2)][Cu(hfac)(2)(O-L(a))(2)]. The crystals of the compound were found to be capable of a reversible single-crystal-to-single-crystal (SC-SC) transformation initiated by the variation of temperature. At room temperature, the molecular structure of [[Cu(hfac)(2)](3)(μ-O,N-L(a))(2)][Cu(hfac)(2)(O-L(a))(2)] ...
Chanput Wasaporn - - 2012
Little is known about the polarizing potential of currently used human macrophage cell lines, while a better understanding phenomena can support the prediction of effects in vivo based on in vitro analysis. To test the polarization capability of PMA differentiated-THP-1 macrophages (M0), cells were stimulated with 20 ng ml(-1) IFNγ ...
Banglawala Sarfaraz M - - 2012
BACKGROUND: Nasal packing is routinely used after septoplasty because it is believed to decrease risk of postoperative bleeding, hematomas, and adhesions. Multiple studies have shown, however, that there are numerous complications associated with nasal packing. The purpose of this work was to perform a meta-analysis on the existing literature to ...
Zou Jianli - - 2012
Significant progress has been made during the past decade in preparing nanosheets from a wide range of materials, which are actively pursued for various applications such as energy storage, catalysis, sensing, and membranes. One of the next critical challenges is developing a robust and versatile assembly method which allows construction ...
Dubinina Galyna G - - 2012
The linear and non-linear optical properties of a series of linear and cross-conjugated platinum(II) acetylide complexes that contain extended p-(phenylene vinylene) chromophores are reported. The complexes exhibit very high femtosecond 2-photon absorption (2PA) cross-section values (σ2 up to 10,000 GM), as measured by nonlinear transmission (NLT) and two-photon excited fluorescence ...
Escalona-Cardoso Gerardo N - - 2012
Abstract Valproic acid (VPA) is a potent inducer of neural tube defects in human and mouse, its teratogenicity is associated with its potential to generation of free radicals and increase oxidative stress. Furthermore, spirulina (SP) has shown pharmacological properties against teratogenicity, which are attributed to its antioxidant potential. Accordingly, the ...
Churchhouse Claire - - 2012
We describe a novel method for inferring the local ancestry of admixed individuals from dense genome-wide single nucleotide polymorphism data. The method, called MULTIMIX, allows multiple source populations, models population linkage disequilibrium between markers and is applicable to datasets in which the sample and source populations are either phased or ...
Chen Dexiang - - 2012
A number of product development partnerships are actively developing new vaccines to combat infectious diseases in developing countries. To be effective, the products under development should not only be safe, efficacious, and affordable, but they should also have additional desirable technical attributes, including enhanced stability, efficient packaging, and improved ease ...
Magbanua Mark Jesus M - - 2012
Molecular characterization of circulating tumor cells (CTCs) from blood is technically challenging because cells are rare and difficult to isolate. We developed a novel approach to isolate CTCs from blood via immunomagnetic enrichment followed by fluorescence activated cell sorting (IE/FACS). Isolated CTCs were subjected to genome-wide copy number analysis via ...
Caplan Stacee Lee - - 2012
Increasing evidence demonstrates that modulating the cGMP-dependent protein kinase G (PKG) pathway produces an array of behavioral phenotypes in the fruit fly, Drosophila melanogaster. Altering PKG activity, either genetically via the foraging (for) gene or using pharmacology, modifies tolerance to acute abiotic stresses such as hyperthermia and hypoxia. PKG signaling ...
Metrot Julien - - 2012
BACKGROUND: . Better understanding of how bimanual coordination changes over the first weeks of recovery after stroke is required to address the potential utility for bimanual rehabilitation. Three-dimensional kinematic analysis can provide quantitative assessment of unimanual and bimanual movements. OBJECTIVE: . To assess the natural evolution of reaching kinematics during ...
Scapa Victor I - - 2012
BACKGROUND: Nasal polyps in patients with cystic fibrosis (CF) are believed to be phenotypically different than polyps affecting non-CF patients. The aim of this study was to investigate differences in cell cycle regulatory mechanisms between these 2 groups. In this prospective study at a tertiary care academic medical center, multiple ...
Meador Mary Ann B - - 2012
The dielectric properties and loss tangents of low-density polyimide aerogels have been characterized at various frequencies. Relative dielectric constants as low as 1.16 were measured for polyimide aerogels made from 2,2'-dimethylbenzidine (DMBZ) and biphenyl 3,3',4,4'-tetracarbozylic dianhydride (BPDA) cross-linked with 1,3,5-triaminophenoxybenzene (TAB). This formulation was used as the substrate to fabricate ...
Kawashima Saki - - 2012
A number of studies have suggested a correlation between a decreased incidence in infectious diseases and an increased incidence of allergic diseases, including asthma. Although several pathogen-derived products have been shown to possess therapeutic potential for allergic diseases, it remains largely unknown whether β-glucan, a cell wall component of a ...
Bejarano-Villafuerte Angela - - 2012
A new chiral nonracemic thiol derived from a popular acidic resolving agent that incorporates a cyclic disubstituted phosphate group (phencyphos) has been prepared in enantiomerically pure form. The stereochemistry and absolute configuration were established by performing a single-crystal X-ray structural analysis of a synthetic intermediate. The thiol compound was used ...
Cui Zining - - 2012
A novel series of 1,3,4-oxadiazole derivatives containing 5-phenyl-2-furan moiety were synthesized from the intermediates diacylhydrazine 3 and acylhydrazone 5 via an efficient approach under microwave irradiation in good yields. Their structures were characterized by IR, 1H NMR, and elemental analysis. The antifungal tests indicated that the title compounds showed in ...
Hosseinzadeh Somayeh - - 2012
Context: For many years it has been known that lead is life-threatening, not only as an air pollutant but also because of it has been associated with several conditions including neurodegenerative disease. Curcumin (the principal curcuminoid found in turmeric) has demonstrated potent antioxidant properties. Objective: We investigated neuroprotective effects of ...
Froehler Michael T - - 2012
A young woman with factor V Leiden thrombophilia presented with headache due to thrombosis of the right transverse sinus (TS) and superior sagittal sinus. Despite appropriate anticoagulation, she experienced worsening headache, progressive neurologic deficits and spontaneous subarachnoid hemorrhage. Endovascular therapy was therefore undertaken. A 6 mm Solitaire FR device was ...
Tsutani Y - - 2012
BackgroundTo select optimal candidates for extrapleural pneumonectomy (EPP), we retrospectively evaluated the usefulness of metabolic response by fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) after neoadjuvant chemotherapy to predict prognosis for patients with resectable malignant pleural mesothelioma (MPM) who underwent EPP in a multicenter study.Patients and methodsWe carried out high-resolution CT (HRCT) ...
Corcione Francesco - - 2012
Abstract Introduction: Laparoscopic total gastrectomy (LTG) is seldom used for gastric cancer because the complex vascularization and lymphatic drainage makes lymphadenectomy and esophagojejunal anastomosis difficult and requires special skills. Our aim was to demonstrate the feasibility and accuracy of LTG in gastric cancer with D2 lymphadenectomy. Material and methods: Eighty-eight ...
Polverino Eva - - 2012
SUMMARY AT A GLANCE: Despite the lack of a clear benefit, systemic corticosteroids are frequently administered in community-acquired-pneumonia. We investigated clinical reasons for steroid prescription and the impact on major outcomes, showing no correlation with mortality or clinical stability independent of severity and cumulative steroid dosage, but an increase in ...
Havlicek Vladimir - - 2012
Recently, a major increase in mass spectrometer installations has occurred in routine clinical microbiology laboratories worldwide. At present, there are hundreds of various instruments sold and the market is still far from being saturated. Although the clinical community still declares it has discovered a "new technology", the first mass spectrometry ...
Mondal Dibakar - - 2012
Important issues in developing hydroxyapatite (HAp)- and titanium (Ti)-based composite biomaterials for orthopedic or dental devices include the dissociation of HAp during fabrication and its influences in the microstructure and biocompatibility of the final composite. During the densification by sintering of HAp/Ti composites, Ti reacts with OH freed from HAp ...
Liu Chao - - 2012
The precise formation of three-dimensional motor circuits is essential for movement control. Within these circuits, motoneurons (MNs) are specified from spinal progenitors by dorsoventral signals and distinct transcriptional programs. Different MN subpopulations have stereotypic cell body positions and show specific spatial axon trajectories. Our knowledge of MN axon outgrowth remains ...
Vizuete María - - 2012
Single- and double-wall carbon nanotubes (CNTs) having dimethylanilino (DMA) units covalently attached to the external graphene wall have been prepared by the reaction of the dimethylaminophenylnitronium ion with the corresponding CNT. The samples have been characterized by Raman and XPS spectroscopies, thermogravimetry, and high-resolution transmission electron microscopy in which the ...
Wiens A J - - 2012
Hyper-redundant mechanisms (HRMs), also known as snake-like robots, are highly adaptable during locomotion on land. Researchers are currently working to extend their capabilities to aquatic environments through biomimetic undulatory propulsion. In addition to increasing the versatility of the system, truly biomimetic swimming could also provide excellent locomotion efficiency. Unfortunately, the ...
Chimonidou Maria - - 2012
INTRODUCTION:Detection of circulating tumor cells (CTCs) and cell-free DNA (cfDNA) in the peripheral blood of patients with solid tumors has been widely studied for the early detection of metastatic spread. We evaluated whether there was an association between the origin of cfDNA and CTCs. We investigated whether SRY (sex determining ...
Nakamura Mitsunobu - - 2012
The binding and fluorescence properties of complementary RNA sequences attached to different numbers of pyrenes via one carbon linker at the 2'-O-positions have been investigated. Upon hybridization of the pyrene-modified RNA sequences, the modified RNA duplexes with normal thermal stability are formed, and the pyrene arrays are assembled in an ...
Bundhun Ashwini - - 2012
A systematic investigation is carried out using the B3LYP, BLYP, and BHLYP functionals and MP2 level of theory to characterize the low-lying electronic singlet and triplet GeC(2)N(2) isomers. The basis sets used are of double-ζ plus polarization quality with additional s- and p-type diffuse functions, DZP++. Three bent isomers Ge(CN)(2), ...
Camacho-Vanegas Olga - - 2012
Alternative splicing represents a unique post-transcriptional mechanism that increases the complexity of the eukaryotic proteome-generating protein isoforms whose functions can be novel, diverse, and/or even antagonistic when compared to its full-length transcript. The KLF family of genes consists of ≥17 members, which are involved in the regulation of numerous critical ...
van Die M Diana - - 2012
Vitex agnus-castus L. (chaste tree; chasteberry) is a popular herbal treatment, predominantly used for a range of female reproductive conditions in Anglo-American and European practice. The objective of this systematic review was to evaluate the evidence for the efficacy and safety of Vitex extracts from randomised, controlled trials investigating women's ...
Pénalva Clothilde - - 2012
Patj is described as a core component of the Crumbs complex. Along with the other components, Crumbs and Stardust, Patj has been proposed as essential for epithelial polarity. However, no proper in vivo genetic analysis of Patj function has been performed in any organism. We have generated the first null ...
Hasan Kamrul - - 2012
We report the synthesis, X-ray structures, and optoelectronic characterization of two cationic iridium complexes bearing bis[(4-methoxyphenyl)imino]acenaphthene ligands. These complexes exhibited panchromic absorption extending as far as 800 nm, making them of interest for solar-energy-harvesting applications.
Müller Olaf - - 2012
PURPOSE: Methylene blue (MB), which was recently tested in a number of clinical malaria studies in Burkina Faso, is currently investigated for its benefit when added to artemisinin-based combination therapy. Together with a number of other antimalarials, MB is on the list of drugs which potentially induce haemolysis in patients ...
Park Haesuk - - 2012
BACKGROUND:An up-to-date assessment of dipeptidyl peptidase-4 (DPP-4) inhibitors is needed to include newly available data.OBJECTIVE:To assess the efficacy and safety of DPP-4 inhibitors, including sitagliptin, saxagliptin, vildagliptin, and linagliptin, in type 2 diabetes.METHODS:We conducted a search of MEDLINE for randomized controlled trials (RCTs) of DPP-4 inhibitors in type 2 diabetes ...
Price David - - 2012
While the pharmacological management of chronic obstructive pulmonary disease (COPD) has evolved from the drugs used to treat asthma, the treatment models are different and the two diseases require clear differential diagnosis in order to determine the correct therapeutic strategy. In contrast to the almost universal requirement for anti-inflammatory treatment ...
Dingels Carsten - - 2012
The covalent attachment of poly(ethylene glycol) (PEG) to therapeutically active proteins (PEGylation) has become an important method to deal with the pharmacological difficulties of these polypeptides, such as short body-residence times and immunogenicity. However, the derivatives of PEG used for PEGylation lack further functional groups that would allow the addition ...
Gray Bradley - - 2012
OBJECTIVE: To study relationships between clinical skill measures assessed at the beginning of general internists' careers and their career outcomes and practice characteristics. DATA SOURCES: General Internist Community Tracking Study Physician Survey respondents (2000-2001, 2004-2005) linked with residency program evaluations and American Board of Internal Medicine board certification examination score ...
Dhokale Bhausaheb - - 2012
A series of donor-acceptor ferrocenyl substituted BODIPYs have been designed and synthesized via palladium catalyzed Suzuki and Sonogashira coupling reactions. The UV-visible absorption results indicate intramolecular charge transfer from the ferrocene to the BODIPY. The fluorescence quantum yield was drastically reduced, where the ferrocenyl group was directly attached to the ...
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