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Results 651 - 700 of 2099
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Lim Jinhwan J Department of Medicine, University of California, Irvine, CA, - - 2013
Polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene (BaP) are ubiquitous environmental pollutants found in tobacco smoke, air pollution, and grilled foods. Prenatal exposure to BaP causes premature reproductive senescence in mice, and other PAHs are transplacental ovarian carcinogens. Glutathione (GSH) is critical for detoxification of the reactive metabolites of PAHs. ...
Kurzwernhart Andrea - - 2012
Ru(II)(arene) complexes have been shown to be promising anticancer agents, capable of overcoming major drawbacks of currently used chemotherapeutics. We have synthesized Ru(II)(η(6)-arene) compounds carrying bioactive flavonol ligands with the aim to obtain multi-targeted anticancer agents. In order to validate this concept, studies on the mode of action of the ...
Choi Inchul - - 2012
The trophectoderm epithelium is the first differentiated cell layer to arise during mammalian development. Blastocyst formation requires the proper expression and localization of tight junction, polarity, ion gradient and H(2)O channel proteins in the outer cell membranes. However, the underlying transcriptional mechanisms that control their expression are largely unknown. Here, ...
Boscari Alexandre - - 2013
Medicago truncatula is one of the most studied model plants. Nevertheless, the genome of this legume remains incompletely determined. We used RNA-Seq to characterize the transcriptome during the early organogenesis of the nodule and during its functioning. We detected 37,333 expressed transcription units; to our knowledge, 1,670 had never been ...
Hopps Sarah - - 2012
Introduction:Cetuximab is a chimeric mouse-human (30:70) IgG1 monoclonal antibody that competitively inhibits the binding of epidermal growth factor. Cetuximab is generally well tolerated; however, hypersensitivity infusion reactions have been reported. The incidence at the University of Oklahoma was currently unknown, though anecdotally high. The purpose of this study was to ...
Zoja Carla - - 2013
Bardoxolone methyl is an antioxidant inflammation modulator acting through induction of Keap1-Nrf2 pathway. Results from a recent phase IIb clinical trial reported that bardoxolone methyl was associated with improvement in the estimated glomerular filtration rate in patients with advanced chronic kidney disease and Type 2 diabetes. However, increases in albuminuria, ...
Berger Lisa - - 2012
BACKGROUND: Acamprosate has been found to enhance rates of complete abstinence and to increase percent days abstinent (PDA) from alcohol relative to placebo treatment. As most U.S. clinical trials of acamprosate have been conducted in alcohol and other drug specialty clinics, there is a need to examine the efficacy of ...
Guo Hao-Bo - - 2012
Benzoic acid (BA) derivatives of environmental relevance exhibit various photophysical and photochemical characteristics. Here, time-dependent density functional theory (TDDFT) is used to calculate photoexcitations of eight selected BAs and the results are compared with UV spectra determined experimentally. High-level gas phase EOM-CCSD calculations and experimental aqueous phase spectra were used ...
Manzari-Tavakoli Asma - - 2012
Context: Otostegia persica Boiss (Lamiaceae) contains antioxidant agents and is used in traditional medicine for treatment of diabetes mellitus complications. Objectives: The acute antihyperglycemic, antilipid peroxidation, and insulin secretory activities of methanol extract of O. persica aerial parts were investigated. Materials and methods: The extract [200, 300, 400 mg/kg body weight ...
Domingo M Soledad MS Museum of Paleontology, University of Michigan, 1109 Geddes Avenue, Ann Arbor, MI 48109, USA. - - 2013
The exceptional fossil sites of Cerro de los Batallones (Madrid Basin, Spain) contain abundant remains of Late Miocene mammals. From these fossil assemblages, we have inferred diet, resource partitioning and habitat of three sympatric carnivorous mammals based on stable isotopes. The carnivorans include three apex predators: two sabre-toothed cats (Felidae) ...
Somogyi Bálint - - 2012
Molecule-sized fluorescent emitters are much sought-after to probe biomolecules in living cells. We demonstrate here by time-dependent density functional calculations that the experimentally achievable 1-2 nm sized silicon carbide nanocrystals can emit light in the near-infrared region after introducing appropriate color centers in them. These near-infrared luminescent silicon carbide nanocrystals ...
Dahmer Tabitha - - 2012
Abstract The triterpene chikusetsusaponin IVa was isolated from the fruit of Ilex paraguariensis. Using biochemical and pharmacological methods, we demonstrated that chikusetsusaponin IVa (1) prolongs the recalcification time, prothrombin time, activated partial thromboplastin time, and thrombin time of normal human plasma in a dose-dependent manner, (2) inhibits the amidolytic activity ...
Rabellino Martin - - 2012
Abstract A 59-year-old female presented to our institution with paraparesis caused by medullar compression secondary to multiple myeloma. Spinal cord decompression and transpedicular spine fixation were performed. A month later, the patient complained of sudden pain in her middle back. A CT scan revealed screw impingement on the aortic wall ...
Han Joong Tark - - 2012
Modulation of electronic structures and surface properties of transparent carbon nanotube films is a challenging issue for their application in optoelectronic devices. Here, we report, for the first time, that graphene oxide (GO) nanosheets play the role of a p-doping agent and surface energy modifier of single-walled carbon nanotube (SWCNT)-based ...
Suh Donguk - - 2012
Growth of a cubic nanoparticle was studied by classical molecular dynamics simulation for three seed sizes in nine different supersaturation ratios. Similar to the spherical seed in our previous study, for high supersaturation ratios, a two-stage phenomenon that consists of an initial heterogeneous growth around the seed and homogeneous nucleation ...
Cooper Jeffrey C - - 2012
Humans frequently make real-world decisions based on rapid evaluations of minimal information; for example, should we talk to an attractive stranger at a party? Little is known, however, about how the brain makes rapid evaluations with real and immediate social consequences. To address this question, we scanned participants with functional ...
Beck Alain - - 2012
Here we review the current state of the art in analytical and structural methods used to characterize therapeutic monoclonal antibodies (mAbs) and derivatives. First a general introductive background on immunoglobulins G (IgGs) structures and micro-heterogeneities is presented. Then the review focuses on analytical papers published mainly the last two years. ...
Han Wei - - 2012
Earning their stripes: A hierarchical assembly of micelles composed of an amphiphilic diblock copolymer, poly(styrene)-block-poly(4-vinylpyridine) (PS-b-P4VP), were made by combining controlled evaporative self-assembly of the confined PS-b-P4VP toluene solution in a cylinder-on-Si geometry with spontaneous self-assembly of micelles. This method gave microscopic stripes of nanometer-sized PS-b-P4VP micelles within the stripes.
van Hengel Jolanda J Department for Molecular Biomedical Research, VIB, Ghent University, Technologiepark 927, B-9052  Ghent, - - 2013
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a major cause of juvenile sudden death and is characterized by fibro-fatty replacement of the right ventricle. Mutations in several genes encoding desmosomal proteins have been identified in ARVC. We speculated that αT-catenin, encoded by CTNNA3, might also carry mutations in ARVC patients. Alpha-T-catenin ...
Scheiner Steve - - 2012
Among a wide range of noncovalent interactions, hydrogen (H) bonds are well known for their specific roles in various chemical and biological phenomena. When describing conventional hydrogen bonding, researchers use the notation AH···D (where A refers to the electron acceptor and D to the donor). However, the AH molecule engaged ...
van Woerkum Cees - - 2012
In this paper, we aim to add a new perspective to supporting health-related behavior. We use the everyday-life view to point at the need to focus on the social and practical organization of the concerned behavior. Where most current approaches act disjointedly on clients and the social and physical context, ...
Chen Jingxin J Dept. of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, - - 2013
Epithelial Na(+) channel (ENaC) mutations are associated with several human disorders, underscoring the importance of these channels in human health. Recent human genome sequencing projects have revealed a large number of ENaC gene variations, several of which have been found in individuals with salt-sensitive hypertension, cystic fibrosis, and other disorders. ...
Xie Zhaoyong - - 2012
To compare image noise and radiation dose differences between prospective and retrospective ECG-gated computed tomography (CT) coronary artery imaging with 64-slice spiral CT (64-MSCT) in a paired design. Prospective and retrospective ECG-gated CT coronary angiography was performed among 20 out-patients with suspected coronary artery diseases. If one protocol failed, chose ...
Simioni C - - 2012
Abstract Primary Cytomegalovirus (CMV) infection during pregnancy is the leading infectious cause of congenital neurological disabilities. Diagnosis of maternal primary CMV infection and fetal compromise can be difficult, as well as the fact that most infected child are asymptomatic at birth, which makes binomial CMV and pregnancy challenging. The treatment ...
Gao Xiang - - 2012
In this paper, we describe the development of a novel stable-isotope N-phosphorylation labeling (SIPL) strategy for peptide de novo sequencing and protein quantification base on organic phosphorus chemistry. The labeling reaction could be performed easily and completed within 40 min in a one-pot reaction without additional cleanup procedures. Different with ...
Ramkissoon Jugjeet S - - 2012
Abstract Advanced glycation endproducts and oxidative stress contribute to the pathogenesis of diabetic complications. The total phenolic content (TPC), antioxidant, and antiglycation properties of crude ethanolic extracts of 10 common culinary herbs and spices from Mauritius were investigated in vitro. Fluorescence at 370 nm/440 nm was used as an index of albumin ...
Beeckman Delphine S - - 2012
Chlamydiales are obligate intracellular parasites of eukaryotic cells. They can be distinguished from other Gram-negative bacteria through their characteristic developmental cycle, in addition to special biochemical and physical adaptations to subvert the eukaryotic host cell. The host spectrum includes humans and other mammals, fish, birds, reptiles, insects and even amoeba, ...
McConnell George C - - 2012
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for the motor symptoms of Parkinson's disease (PD). The effects of DBS depend strongly on stimulation frequency: high frequencies (>90 Hz) improve motor symptoms, while low frequencies (<50 Hz) are either ineffective or exacerbate symptoms. The neuronal ...
Benitez Alvaro J AJ Respiratory Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, - - 2013
We developed a single-tube multiplex real-time PCR assay capable of simultaneously detecting and discriminating Legionella spp., Legionella pneumophila, and Legionella pneumophila serogroup 1 in primary specimens. Evaluation of 21 clinical specimens and 115 clinical isolates demonstrated this assay to be a rapid, high-throughput diagnostic test with 100% specificity that may ...
Trinh Thi Thanh Van - - 2012
Bioassay-guided fractionation of an extract of leaves of Macaranga kurzii yielded four new compounds, a stilbene (furanokurzin, 1) and three flavonoids (macakurzin A-C, 2-4). Nine known compounds were also isolated (5-13). Their structures were determined by spectroscopic analyses including MS and 2D NMR. The isolates were all evaluated for acetylcholinesterase ...
Konstantinopoulou Eleni - - 2012
BACKGROUND: Behavioral assessment is useful for the diagnosis of frontotemporal lobar degeneration (FTLD). We explored the ability of the Frontal Behavioral Inventory (FBI) to discriminate between patients with distinct subtypes of FTLD and patients with Alzheimer's disease (AD), as well as the influence of demographic variables on FBI scores. METHODS: ...
Gonzalez-Campo Arantzazu - - 2012
A supramolecular strategy is used for oriented positioning of proteins on surfaces. A viologen based guest molecule is attached to the surface, while a naphthol guest moiety is chemoselectively ligated to a yellow fluorescent protein. CB[8] is used to link the proteins onto surfaces through specific charge-transfer interactions between naphthol ...
Lin Ryan Yeh-Yung - - 2012
Dye-sensitized solar cells using nanocrystalline ZnO as the photoanode and a metal-free sensitizer with a benzothiadiazole entity directly connected to the 2-cyanoacrylic acid acceptor exhibited an efficiency (5.18%) higher than those using the TiO(2) photoanode. Use of a hierarchical ZnO back scattering layer further improved the efficiency to 5.82%.
Lipari Michael T - - 2012
Proprotein convertase subtilisin/kexin 9 (PCSK9) regulates plasma LDL cholesterol levels by regulating the degradation of LDL receptors. Another proprotein convertase, furin, cleaves PCSK9 at Arg(218)-Gln(219) in the surface-exposed "218 loop." This cleaved form circulates in blood along with the intact form, albeit at lower concentrations. To gain a better understanding ...
Baker David G DG Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, - - 2013
Toll-like receptor 7 (TLR7) recognizes guanidine-rich viral ssRNA and is an important mediator of peripheral immune responses to several ssRNA viruses. However, the role that TLR7 plays in regulating the innate immune response to ssRNA virus infections in specific organs such as the central nervous system (CNS) is not as ...
Liu Xin - - 2012
Despite its experimental characterization, the detailed geometry and electronic structure of actinide metallofullerene U@C(82) have been rarely studied. We predict that (#5)C(82) and (#8)C(82) are the best cages for the encapsulation of monovalent and tetravalent U (i.e., U(+) and U(4+)), respectively; while (#9)C(82) is the best cage for divalent, trivalent, ...
Balaji Alexandra B - - 2012
Abstract While the disproportionate impact of HIV on young black men who have sex with men (MSM) is well documented, the reasons for this disparity remain less clear. Through in-depth interviews, we explored the role of familial, religious, and community influence on the experiences of young black MSM and identified ...
Journo Chloé - - 2013
Permanent activation of the NF-κB pathway by the human T cell leukemia virus type 1 (HTLV-1) Tax (Tax1) viral transactivator is a key event in the process of HTLV-1-induced T lymphocyte immortalization and leukemogenesis. Although encoding a Tax transactivator (Tax2) that activates the canonical NF-κB pathway, HTLV-2 does not cause ...
Wagner Lauren M - - 2013
ICP4 is the major activator of herpes simplex virus (HSV) transcription. Previous studies have defined several regions of ICP4 that are important for viral gene expression, including a DNA binding domain and transactivation domains that are contained in the C-terminal and N-terminal 520 and 274 amino acids, respectively. Here we ...
Stavelin Anne - - 2012
BACKGROUND:An important objective in external quality assessment (EQA) is to evaluate systematic deviations between methods. However, this is not possible when noncommutable control materials are used. The aim of this study was to develop an EQA model that incorporates a method bias evaluation using native patient samples EQA schemes in ...
Greenberg Daniel A DA Department of Integrative Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario, - - 2013
Mammalian hard α-keratins are fibre-reinforced biomaterials that consist of 10 nm intermediate filaments (IFs) embedded in an elastomeric protein matrix. Recent work suggests that the mechanical properties of IFs are highly sensitive to hydration, whereas hard α-keratins such as wool, hair and nail are relatively hydration insensitive. This raises the ...
Zylberberg Maxine M Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, CA 95616, USA. - - 2013
Infection with parasites and pathogens is costly for hosts, causing loss of nutritional resources, reproductive potential, tissue integrity and even life. In response, animals have evolved behavioural and immunological strategies to avoid infection by pathogens and infestation by parasites. Scientists generally study these strategies in isolation from each other; however, ...
Waldron Levi L Department of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, - - 2012
More than 20 million archival tissue samples are stored annually in the United States as formalin-fixed, paraffin-embedded (FFPE) blocks, but RNA degradation during fixation and storage has prevented their use for transcriptional profiling. New and highly sensitive assays for whole-transcriptome microarray analysis of FFPE tissues are now available, but resulting ...
Bianchini Giulio - - 2012
Reversible encapsulation of [Ru(bpy)(3)](2+) within a self-assembled hexameric resorcin[4]arene capsule turns off the photocatalytic aerobic oxidation of an aliphatic sulfide. Upon addition of a competitive cationic guest, the Ru(ii) catalyst is released into solution where its catalytic activity is restored.
Chen Dexiang - - 2012
A number of product development partnerships are actively developing new vaccines to combat infectious diseases in developing countries. To be effective, the products under development should not only be safe, efficacious, and affordable, but they should also have additional desirable technical attributes, including enhanced stability, efficient packaging, and improved ease ...
Blackburn Julie - - 2013
Direct plating of simulated stool specimens on MacConkey agar (MCA) with 10-μg ertapenem, meropenem, and imipenem disks allowed the establishment of optimal zone diameters for the screening of carbapenem-resistant Gram-negative rods (CRGNR) of ≤ 24 mm (ertapenem), ≤ 34 mm (meropenem), and ≤ 32 mm (imipenem).
Magbanua Mark Jesus M MJ Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA 94115, - - 2013
Molecular characterization of circulating tumor cells (CTC) from blood is technically challenging because cells are rare and difficult to isolate. We developed a novel approach to isolate CTCs from blood via immunomagnetic enrichment followed by fluorescence-activated cell sorting (IE-FACS). Isolated CTCs were subjected to genome-wide copy number analysis via array ...
Chatterjee Mallika M Department of Genetics and Developmental Biology, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030-6403, - - 2012
Combinatorial expression of transcription factors forms transcriptional codes to confer neuronal identities and connectivity. However, how these intrinsic factors orchestrate the spatiotemporal expression of guidance molecules to dictate the responsiveness of axons to guidance cues is less understood. Thalamocortical axons (TCAs) represent the major input to the neocortex and modulate ...
Zhang Hai-Sheng HS Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, - - 2012
Paired box (PAX) 2, a transcription factor, plays a critical role in embryogenesis. When aberrantly expressed in adult tissues, it generally exhibits oncogenic properties. However, the underlying mechanisms remain unclear. We reported previously that the expression of PAX2 was up-regulated in human colon cancers. However, the role of PAX2 in ...
Caplan Stacee Lee - - 2012
Increasing evidence demonstrates that modulating the cGMP-dependent protein kinase G (PKG) pathway produces an array of behavioral phenotypes in the fruit fly, Drosophila melanogaster. Altering PKG activity, either genetically via the foraging (for) gene or using pharmacology, modifies tolerance to acute abiotic stresses such as hyperthermia and hypoxia. PKG signaling ...
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