Search Results
Results 601 - 650 of 2098
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Edith-Rodriguez Jessica - - 2012
Hypertension and diabetes have been related to noradrenergic system impairment, especially to the response mediated by alpha-1 receptors. The aim of this work was to investigate possible changes in the expression of alpha-1 adrenergic receptors in aorta and carotid arteries of Wistar Kyoto and spontaneously hypertensive rats after 4 weeks ...
Nakayama Takahiro - - 2012
Establishment and maintenance of epigenetic memories are essential for development. Replacement of canonical histone H3 by its variant H3.3 has been implicated in cellular memory. Drosophila sequence-specific DNA-binding protein GAGA factor and a chromatin factor FACT direct H3.3 replacement in conjunction with H3.3-specific chaperone HIRA at chromatin boundaries to counteract ...
Zhang Sha - - 2012
The mechanism leading to an alteration of heat aggregation of whey protein isolate (WPI) in the presence of pectin was investigated by assessing structural changes of proteins using Raman spectroscopy. WPI solutions were heated without or with pectin at 0.015-0.2 pectin to WPI weight ratios and pH 6.0 to 6.4. ...
Itsekson Alek M - - 2012
The aim of this study was to determine whether women with recurrent pregnancy loss (RPL) and concurrent premenstrual syndrome (PMS) who underwent desensitization with sex hormones had an improved obstetric outcome. This manuscript summarizes a 10 year open label prospective follow up study of 26 women with RPL, aged 25-42 ...
Junges Roger - - 2012
BACKGROUND AND OBJECTIVE: The number of elderly living in long-term care (LTC) institutions has been increasing in many countries. The objective of this study was to evaluate the caregivers' attitudes and considerations regarding oral health and oral health practices in an LTC institution in Porto Alegre, Brazil. MATERIALS AND METHODS: ...
Eliseeva Irina - - 2012
YB-1 is a multifunctional cold shock domain containing protein that is involved virtually in all DNA- and mRNA-dependent cellular events. Its amount is regulated at the level of both transcription and translation. We showed previously that translation of poly A(-) YB-1 mRNA in vitro is selectively controlled by two proteins, ...
Jabeen Fahmida - - 2012
Relying on the successful journey of metal oxides in phosphoproteomics, lanthanum oxide is employed for the engineering of an affinity material for phosphopeptide enrichment. The lanthanum oxide is chemically modified on the surface of silica and characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and Fourier transform ...
Pek Jun Wei - - 2012
In Drosophila, Maelstrom is a conserved component of the perinuclear nuage, a germline-unique structure that appears to serve as a site for Piwi-interacting RNA (piRNA) production to repress deleterious transposons. Maelstrom also functions in the nucleus as a transcriptional regulator to repress the expression of microRNA-7, a process that is ...
Gergidis Leonidas N - - 2012
The structural properties of polymer brushes, formed by dendron polymers up to the third generation, were studied by means of Brownian dynamics simulations for the macroscopic state of good solvent. The distributions of polymer units, of the free-ends, of the dendrons centers of mass and of the units of every ...
Li Jie-Yuan - - 2012
Recent studies in normal subjects suggested the callosal motor fibers pass through the posterior body of the corpus callosum (CC) but this has not been tested in patients with callosal infarction. The objective of the study is to define the pathways involved in transcallosal inhibition by examining patients with infarctions ...
Jin Hekun - - 2012
The degradation of basement membranes by tumor cells involves secretion and activation of proteinases, such as the matrix metalloproteinases (MMPs), and results from an imbalance between their inhibitors and activators that are controlled by various growth factors or cytokines, among which TGF-β1 may be the most intriguing. In order to ...
Ma Shao-Gang - - 2012
The potential roles of serum butyrylcholinesterase (BChE) activity and platelet indices in type 1 diabetes (T1D) remain uncertain. We aimed to investigate the correlation among the platelet indices, serum BChE activity, and diabetic ketoacidosis (DKA). Sixty-one T1D patients, 29 patients with DKA, and 30 age- and sex-matched controls were enrolled. ...
Trinh Thi Thanh Van - - 2012
Bioassay-guided fractionation of an extract of leaves of Macaranga kurzii yielded four new compounds, a stilbene (furanokurzin, 1) and three flavonoids (macakurzin A-C, 2-4). Nine known compounds were also isolated (5-13). Their structures were determined by spectroscopic analyses including MS and 2D NMR. The isolates were all evaluated for acetylcholinesterase ...
Konstantinopoulou Eleni - - 2012
BACKGROUND: Behavioral assessment is useful for the diagnosis of frontotemporal lobar degeneration (FTLD). We explored the ability of the Frontal Behavioral Inventory (FBI) to discriminate between patients with distinct subtypes of FTLD and patients with Alzheimer's disease (AD), as well as the influence of demographic variables on FBI scores. METHODS: ...
Gonzalez-Campo Arantzazu - - 2012
A supramolecular strategy is used for oriented positioning of proteins on surfaces. A viologen based guest molecule is attached to the surface, while a naphthol guest moiety is chemoselectively ligated to a yellow fluorescent protein. CB[8] is used to link the proteins onto surfaces through specific charge-transfer interactions between naphthol ...
Lin Ryan Yeh-Yung - - 2012
Dye-sensitized solar cells using nanocrystalline ZnO as the photoanode and a metal-free sensitizer with a benzothiadiazole entity directly connected to the 2-cyanoacrylic acid acceptor exhibited an efficiency (5.18%) higher than those using the TiO(2) photoanode. Use of a hierarchical ZnO back scattering layer further improved the efficiency to 5.82%.
Liu Xin - - 2012
Despite its experimental characterization, the detailed geometry and electronic structure of actinide metallofullerene U@C(82) have been rarely studied. We predict that (#5)C(82) and (#8)C(82) are the best cages for the encapsulation of monovalent and tetravalent U (i.e., U(+) and U(4+)), respectively; while (#9)C(82) is the best cage for divalent, trivalent, ...
Balaji Alexandra B - - 2012
Abstract While the disproportionate impact of HIV on young black men who have sex with men (MSM) is well documented, the reasons for this disparity remain less clear. Through in-depth interviews, we explored the role of familial, religious, and community influence on the experiences of young black MSM and identified ...
Stavelin Anne - - 2012
BACKGROUND:An important objective in external quality assessment (EQA) is to evaluate systematic deviations between methods. However, this is not possible when noncommutable control materials are used. The aim of this study was to develop an EQA model that incorporates a method bias evaluation using native patient samples EQA schemes in ...
Bianchini Giulio - - 2012
Reversible encapsulation of [Ru(bpy)(3)](2+) within a self-assembled hexameric resorcin[4]arene capsule turns off the photocatalytic aerobic oxidation of an aliphatic sulfide. Upon addition of a competitive cationic guest, the Ru(ii) catalyst is released into solution where its catalytic activity is restored.
Drazen Jeffrey M - - 2012
Small pharmacies that produce and package (or repackage) specific drugs for individual patients are an important part of the medical landscape. These so-called compounding pharmacies formulate therapeutic and diagnostic products for physicians in practice and those engaged in research. They make individualized chemotherapeutic agents, noncommercial formulations (e.g., a liquid rather ...
Badoual Cecile - - 2012
Head and neck cancers positive for human papilloma virus (HPV) have a more favorable clinical outcome than HPV-negative cancers, but it is unknown why this is the case. We hypothesized that prognosis was affected by intrinsic features of HPV-infected tumor cells or differences in host immune response. In this study, ...
Olin Jacqueline L - - 2012
OBJECTIVE:To review the clinical trials, pharmacologic characteristics, safety, and efficacy of the elvitegravir/cobicistat/emtricitabine/tenofovir single tablet formulation (Stribild).DATA SOURCES:Literature searches were performed in MEDLINE (1948-September 2012) and PubMed (1966-September 2012) using the search terms GS-9137, elvitegravir, GS 9350, cobicistat, quad pill, Stribild, and integrase inhibitors. Abstracts from HIV/AIDS conferences were reviewed.STUDY ...
Khil Laura - - 2012
Background:Change in headache diagnoses over time within the same individual is not well studied in the adult population. In this study, we prospectively examined the individual variation of migraine and tension-type headache (TTH) diagnoses over time.Methods:As part of the epidemiological Deutsche Migräne und Kopfschmerzgesellschaft (DMKG) headache study, 1312 participants were ...
Grzechnik Katarzyna - - 2012
Matrix isolation spectroscopy has been combined with ab initio calculations to characterize the 1:1 complexes of H(2) O(2) with OCS and CS(2) . The infrared spectra of the argon and nitrogen matrices doped with H(2) O(2) and OCS or CS(2) have been measured and analyzed. The geometries of the complexes ...
Truong Vinh - - 2012
Hydrogels with tunable degradability have potential uses in a range of applications including drug delivery and tissue scaffolds. A series of PEG hydrogels and amphiphilic PEG-PTMC hydrogels were prepared using copper-catalysed Huisgen's 1,3-dipolar cycloaddition, or 'click' chemistry as the coupling chemistry. The fidelity of the coupling chemistry was confirmed using ...
Gouin Todd - - 2012
Multimedia environmental fate models are valuable tools for investigating potential changes associated with global climate change, particularly because thermodynamic forcing on partitioning behavior as well as diffusive and nondiffusive exchange processes are implicitly considered. Similarly, food-web bioaccumulation models are capable of integrating the net effect of changes associated with factors ...
Perlini Stefano - - 2012
To evaluate whether the evolution of compensated pressure overload hypertrophy (POH) to overt heart failure (HF) is better predicted by systolic versus diastolic dysfunction, serial echocardiography was performed 1, 2, 4, 8, and 10 weeks after suprarenal aortic banding in 52 rats. One week after banding, at comparable extent of ...
Chouhy Diego - - 2012
We developed the 'Hanging droplet' long PCR, a generic and highly sensitive strategy to facilitate the identification of new human papillomavirus (HPV) genomes. The novel procedure used for the first time the 'hanging droplet' PCR technique for the amplification of long DNA fragments with generic primers targeting the L1 and ...
Stefaniu Cristina - - 2012
Heads and tails: GPI glycolipid monolayers on the air/liquid interface are characterized by the ordering of entire molecules, as observed by grazing-incidence X-ray diffraction. Strong hydrogen bonding interactions are responsible for ordering of the head groups to form supercells. These forces are likely to be the key to the interactions ...
Manfredi J M - - 2012
Palmar foot pain is frequently treated by steroid injections into the distal interphalangeal joint (DIPJ) in the anticipation that the steroid will diffuse to the navicular bursa and palmar foot structures. The object of this study was to determine if triamcinolone acetonide (TA) would in fact be able to locally ...
Delrosso Lourdes - - 2012
A 66-year-old man with hypertension presented with complaints of excessive daytime sleepiness (Epworth Sleepiness Score 14/24), dyspnea upon exertion, and episodes of noninjurious dream-enacting behavior. He reported tongue biting when sleeping in the right lateral decubitus position. Medications included atenolol 12.5 mg, lovastatin 20 mg, doxazosin 2 mg, amlodipine 5 ...
Hoeben K W J - - 2012
BackgroundWe evaluated which patient factors were associated with treatment tolerance and outcome in elderly colon cancer patients.DesignPopulation-based data from five regions included in the Netherlands Cancer Registry were used. Patients with resected stage III colon cancer aged ≥75 years diagnosed in 1997-2004 who received adjuvant chemotherapy (N = 216) were included as ...
Chan K M John - - 2012
The role of mitral valve repair (MVR) during coronary artery bypass grafting (CABG) in patients with moderate ischemic mitral regurgitation (MR) is uncertain. We conducted a randomized, controlled trial to determine whether repairing the mitral valve during CABG may improve functional capacity and left ventricular reverse remodeling compared with CABG ...
Jones Helen E - - 2012
Many cells in both the central visual system and other sensory systems exhibit a center surround organization in their receptive field, where the response to a centrally placed stimulus is modified when a surrounding area is also stimulated. This can follow from laterally directed connections in the local circuit at ...
Boase Samuel - - 2012
BACKGROUND: The complex interplay between host, environment, and microbe in the etiopathogenesis of chronic rhinosinusitis (CRS) remains unclear. This study focuses on the host-microbe interaction, specifically the regulation of nitric oxide (NO) and reactive oxygen species (ROS) against the pathogenic organism Staphylococcus aureus (S. aureus). NO and ROS play crucial ...
Moladje Donkwe Suzye Mireille - - 2012
The methanol extract of dried fruits of Odyendyea gabonensis afforded one new quassinoid [(-)-odyendanol (1)], one new canthin-6-one alkaloid [9-hydroxy-5-methoxycanthin-6-one (4)], and two new steroids [22E, 24R-stigmasta-5,22-diene-3,7-dione (7) and 22E,24R-stigmast-22-ene-3,7-dione (8)] along with fourteen known compounds. The structures of all compounds were established by analyzing the spectroscopic data. The 13C-NMR ...
Yan Yulan - - 2012
Abstract Type III interferon (IFN-λ) is a novel member of the interferon family, which preferentially promotes antiviral responses from epithelial cells and cooperates with type I IFNs in the clearance of viral infections. However, the effect of mIFN-λ(2) to the LA795 lung adenocarcinoma cell is largely unknown. In this study, ...
Schreiver C - - 2012
OBJECTIVE: This cross-sectional observational cohort study was designed to investigate i) whether glycaemic variability in paediatric patients with type 1 diabetes is lower in those using an insulin pump (CSII) compared to those using multiple daily insulin injections (MDI) and ii) whether urinary F(2) -isoprostanes and/or urinary prostaglandin F(2α) excretion ...
Ryan Charles J - - 2012
PURPOSE: To evaluate the efficacy, safety, biomarkers, and pharmacokinetics of rilotumumab, a fully human, monoclonal antibody against hepatocyte growth factor (HGF)/scatter factor, combined with mitoxantrone and prednisone (MP) in patients with castration-resistant prostate cancer (CRPC). EXPERIMENTAL DESIGN: This double-blinded phase 2 study randomized (1:1:1) patients with progressive, taxane-refractory CRPC to ...
Tseng Wan-Ting - - 2012
The transection of the inferior alveolar nerve (IANx) produces allodynia in the whisker pad (V2 division) of rats. Ectopic discharges from injured trigeminal ganglion (TG) neurons and thalamocortical reorganization are possible contributors to the sensitization of uninjured V2 primary and CNS neurons. To test which factor is more important, TG ...
Nakajima Mitsunari - - 2012
The neural crest is a unique structure in vertebrates. Wnt1-cre and Wnt1-GAL4 double transgenic (dTg) mice have been used in a variety of studies concerning neural crest cell lineages in which the Cre/loxP or GAL4/UAS system was applied. Here, we show psychiatric disorder-related behavioral abnormalities and histologic alterations in a ...
Scott Ian A - - 2012
Minimising the harm from inappropriate prescribing in older populations is a major urgent concern for modern healthcare systems. In everyday encounters between prescribers and patients, opportunities should be taken to identify patients at high risk of harm from polypharmacy and reappraise their need for specific drugs. Attempts to reconcile life ...
Condie Allison G - - 2012
Myelination is a fundamental biological process in the vertebrate nervous system. Damage to or malformation of myelin can lead to various neurological diseases; for example, demyelination in the spinal cord is a major cause of paralysis of patients suffering from multiple sclerosis and related diseases. The ability to directly track ...
Petersen Tue Hvass - - 2012
Neurophysiological markers of the central control of gait in children with cerebral palsy (CP) are used to assess developmental response to therapy. Here we measure the central common drive to a leg muscle in children with CP. We recorded EMGs from the Tibialis Anterior (TA) muscle of 40 children with ...
Motti Elena - - 2012
o-Biaryl carbaldeydes and ketones are obtained through the one-pot reaction of o-aryl iodides with o-bromobenzyl alcohols under the catalytic action of Pd and norbornene, in the presence of a base. The same reaction can also give dibenzopyrans by Pd and norbornene catalysis with a different termination, leading to C-O ring ...
Tamiya A - - 2012
BackgroundThis study was designed to determine the recommended dose of carboplatin-pemetrexed in elderly (≥75 years old), chemotherapy-naive patients with advanced nonsquamous nonsmall-cell lung cancer (NSCLC).Patients and methodsPatients received escalated doses of carboplatin and pemetrexed every 3 weeks for four cycles. Patients with an objective response and stable disease continued pemetrexed ...
Caprile Laura - - 2012
We report the results of a synchrotron-based high-resolution XPS study of the interaction of l-cysteine (Cys) with well-characterized colloidal gold nanoparticles (NPs, typical size 3-4 nm), which were pre-deposited on highly oriented pyrolytic graphite and then brought into contact with the aqueous solution of Cys by drop-casting. By comparison with ...
Felser Andrea - - 2012
Dronedarone is a new antiarrhythmic drug with an amiodarone-like benzofuran structure. Shortly after its introduction, dronedarone became implicated in causing severe liver injury. Amiodarone is a well-known mitochondrial toxicant.The aim of our study was to investigate mechanisms of hepatotoxicity of dronedarone in vitro and to compare them with amiodarone. We ...
Zuhl Micah - - 2012
Gastrointestinal distress, such as diarrhoea, cramping, vomiting, nausea and gastric pain are common among athletes during training and competition. The mechanisms that cause these symptoms are not fully understood. The stress of heat and oxidative damage during exercise causes disruption to intestinal epithelial cell tight junction proteins resulting in increased ...
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