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Results 551 - 600 of 2097
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Gao Chao - - 2012
We designed and synthesized the three molecular tweezers 1 a-c(4+) containing an electron acceptor 4,4'-bipyridinium (BPY(2+) ) unit in each of the two arms and an (R)-2,2'-dioxy-1,1'-binaphthyl (BIN) unit that plays the role of chiral centre and the hinge of the structure. Each BPY(2+) unit is connected to the BIN hinge ...
Smith Paul J - - 2012
We outline a simple approach involving instrument setup and calibration for the analysis of Hoechst dye 33342-loading in human cell lines for exploring heterogeneity in dye efflux efficiency and the status of side population (SP) A549 lung cancer cells. Dual excitation 488 nm/multiline UV (351-364 nm) flow cytometry was used ...
Baltazar Ludmila de Matos - - 2012
OBJECTIVES: Antimicrobial photodynamic inhibition (aPI) is based on the use of a light source and a photosensitizer to kill pathogens. Little is known about aPI of dermatophytic fungi and its mechanism of action. We aimed to evaluate aPI of Trichophyton rubrum. METHODS: We performed tests using toluidine blue (TBO) as ...
Rozen-Zvi Benaya - - 2012
AIM: Hemoglobin (Hb) variability is associated with poor survival in patients with chronic kidney disease. Association of Hb variability after kidney transplantation with patients' and graft survival has not been adequetly studied. METHODS: This retrospective study used registry data to examine the association between Hb variability in the early post-transplant ...
Albert Anastasia - - 2012
Ambient desorption/ionization mass spectrometry (ADI-MS) is an attractive method for direct analysis with applications in homeland security, forensics, and human health. For example, low temperature plasma probe (LTP) ionization was successfully used to detect e.g. explosives, drugs, and pesticides directly on the target. Despite the fact that the field is ...
Boggara Mohan Babu - - 2012
The location and distribution of ibuprofen, a model nonsteroidal anti-inflammatory drug, in a phospholipid bilayer was examined in molecular detail by a combination of neutron diffraction and computer simulations. In addition to their use as antipyretic, analgesic and anti-inflammatory drugs, such nonsteroidal anti-inflammatory drugs are used in the treatment of ...
Zhong Mei-Jin - - 2012
An efficient approach for the synthesis of tetrasubstituted cyclopentadienes through Pd-catalyzed reactions of (Z)-2-en-4-yn acetates with substituted indoles was developed. This methodology has the advantages of broad scope, simple conditions and easily accessible starting materials.
Donahoo Ryan - - 2012
A comprehensive analysis of 175 Xanthomonas axonopodis pv. dieffenbachiae strains isolated from ten Araceae hosts was done to identify pathogen variation. The strains were subjected to repetitive extragenic palindromic sequence polymerase chain reaction (Rep-PCR) and four major phylogenetic clusters were generated. A subset of forty strains isolated from Anthurium, Dieffenbachia, ...
Zhang Shuzhen - - 2012
The development and progression of chronic complications in diabetic patients, such as retinopathy, nephropathy, neuropathy, cataracts, and stroke, are related to the activation and/or overexpression of aldose reductase (ALR2), which is a member of the aldo-keto reductase superfamily. A structure-activity relationship study focused on the C7 position of 1,2,4-benzothiadiazine-1,1-dioxide derivatives ...
Krasemann Susanne - - 2012
Prion diseases are fatal neurodegenerative disorders. An important step in disease pathophysiology is the conversion of cellular PrPC to disease-associated misfolded conformers, summarized as PrPSc. These misfolded PrP variants are a common component of prion infectivity and detectable in diseased brain and lymphoreticular organs such as spleen. In the latter, ...
Imbiriba Luis Aureliano - - 2012
It is well established that the mental simulation of actions involves visual and/or somato-motor representations of those imagined actions. In order to investigate if the total absence of vision affects the brain activity associated to the retrieval of motor representations, we recorded the readiness potential (RP), a marker of motor ...
Foroughinia F - - 2012
OBJECTIVE: This study sought to investigate the effect of omega-3 polyunsaturated fatty acids (PUFAs) on cardiac biomarkers, CK-MB and troponin I, in patients undergoing PCI. BACKGROUND: Restenosis remains as a major long-term complication following percutaneous coronary intervention (PCI). It appears that there is strong relationship between post-PCI creatinin kinase MB ...
Puttabyatappa Muraly - - 2012
A local autocrine/ paracrine role for progesterone is an absolute requirement for corpus luteum formation in primates. Despite this, the mechanism(s) remain obscure, although existing data suggest an anti-apoptotic action to be central. There are a limited number of progestin-regulated gene targets identified in the luteinizing primate follicle, suggesting that ...
Chee Lynette C Y - - 2012
The key roles of RARs and G-CSFR in the regulation of granulopoiesis have been well-documented. In this study, we sought to investigate the interaction between G-CSFR and RARs in myeloid differentiation of adult mice through conditional deletion of RARα or RARγ on a G-CSFR(-/-) background and by pharmacological intervention of ...
Gianfrani Carmen - - 2012
BACKGROUND: Research is intense to find wheat of low or null toxicity for patients with celiac disease (CD). Among candidates, there are diploid wheat species. OBJECTIVE: We compared the immunological properties of 2 lines of diploid monococcum wheat (Triticum monococcum ssp. monococcum), Monlis and ID331, with those of common wheat ...
Morel Adam - - 2012
Chiral ionic liquids (CILs) containing l-prolinate and l-lactate anions and non-chiral quaternary ammonium cations were employed in the palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran with aryl iodides (iodobenzene, 4-iodotoluene, 2-iodoanisole, 4-iodoanisole, 4-iodoacetophenone). In all the reactions 2-aryl-2,3-dihydrofuran () was obtained as the main product with the yield up to ...
Ashikov Angel - - 2012
LARGE (like-glycosyltransferase) and LARGE2 (glycosyltransferase-like 1B, Gyltl1b) are homologous Golgi glycosyltransferases possessing two catalytic domains with homology to members of glycosyltransferase families GT8 and GT49. Mutations in human and mouse Large result in muscular dystrophy due to underglycosylation of dystroglycan. The systemic function of LARGE2 is unknown, but at cellular ...
Borisovska Maria - - 2012
Trans-soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) complexes formed between the SNARE motifs of synaptobrevin II, SNAP-25, and syntaxin play an essential role in Ca(2+)-regulated exocytosis. Apart from the well studied interactions of the SNARE domains, little is known about the functional relevance of other evolutionarily conserved structures in ...
Lavine Laura Corley - - 2012
The insulin signaling pathway is the primary signaling pathway coupling growth with nutritional condition in all animals. Sensitivity to circulating levels of insulin has been shown to regulate the growth of specific traits in a dose-dependent manner in response to environmental conditions in a diversity of insect species. Alternative phenotypes ...
Huang Haohao - - 2012
The presence of a polyelectrolyte in a colloidal dispersion affects the interaction between colloidal particles through electrostatic and bridging interactions. In this paper, using a self-consistent field approach, a simple theory is developed which allows to calculate the bridging force between two plates and two colloidal particles. The present approach ...
Caserta Sergio - - 2012
Pattern formation under the action of flow is a subject of considerable scientific interest with applications going from microfluidics to granular materials. Here, we present a systematic investigation of shear-induced banding in confined biphasic liquid-liquid systems, i.e., formation of alternating regions of high and low volume fraction of droplets in ...
Gijsbers Esther F - - 2012
Three homosexual men from a proven homosexual HIV-1 transmission cluster revealed large variation in their clinical course of infection. To evaluate the effect of viral evolution of the same viral variant in these three patients, we analyzed the sequence variation in the capsid protein and determined the impact of the ...
M Doody Catriona - - 2012
AIM AND OBJECTIVES: To explore the experiences of registered intellectual disability nurses caring for the older person with intellectual disability. BACKGROUND: Increased longevity for the older person with intellectual disability is relatively a new phenomenon with social and medical factors having significantly increased the lifespan. The ageing population of people ...
Poupin Nathalie - - 2012
Fractional synthesis rates (FSR) of tissue proteins (P) are usually measured using labeled amino acid (AA) tracer methods over short periods of time under acute, particular conditions. In this work, we developed a new isotopic approach, by combining the long-term and non-steady-state 15N labeling of AA and P tissue fractions ...
van der Valk Mirthe Emilie - - 2012
OBJECTIVE: The introduction of anti tumour necrosis factor-α (anti-TNFα) therapy might impact healthcare expenditures, but there are limited data regarding the costs of inflammatory bowel diseases (IBD) following the introduction of these drugs. We aimed to assess the healthcare costs and productivity losses in a large cohort of IBD patients. ...
Cheng Xuefang - - 2012
β-lapachone (β-Lap) is an NAD(P)H: quinone oxidoreductase 1 (NQO1) target antitumor drug candidate in phase II clinical trials. The present study aimed to uncover the metabolic profile, enzyme kinetics, and enzyme isoforms for the metabolism of β-Lap in human liver and intestine in vitro. NQO1-mediated quinone reduction and subsequent glucuronidation ...
Vaquero Mónica - - 2012
Mildly does it: A highly enantioselective catalyst for the hydrogenation of N-aryl imines is described. This catalyst offers practical advantages because it operates under very mild conditions and is based on an Ru complex with a diamine as the sole chiral ligand.
Eiermann W - - 2012
BackgroundWe carried out a prospective clinical study to evaluate the impact of the Recurrence Score (RS) on treatment decisions in early breast cancer (EBC).Patients and methodsA total of 379 eligible women with estrogen receptor positive (ER+), HER2-negative EBC and 0-3 positive lymph nodes were enrolled. Treatment recommendations, patients' decisional conflict, ...
Savage Kevin J - - 2012
When two metal nanostructures are placed nanometres apart, their optically driven free electrons couple electrically across the gap. The resulting plasmons have enhanced optical fields of a specific colour tightly confined inside the gap. Many emerging nanophotonic technologies depend on the careful control of this plasmonic coupling, including optical nanoantennas ...
Mourikis Philippos - - 2012
During organogenesis, a continuum of founder stem cells produces temporally distinct progeny until development is complete. Similarly, in skeletal myogenesis, phenotypically and functionally distinct myoblasts and differentiated cells are generated during development. How this occurs in muscle and other tissues in vertebrates remains largely unclear. We showed previously that committed ...
Zhao Bo - - 2012
Short heptapeptides were identified to function as ubiquitin (UB) mimics that are activated by E1 and form thioester conjugates with E1, E2, and HECT type E3 enzymes. The activities (k(cat)/K(1/2)) of E1 with the UB-mimicking peptides are 130-1,400-fold higher than the equally long peptide with the native C-terminal sequence of ...
Bayani Jane - - 2012
BACKGROUND:Kallikrein-related peptidase 6 (KLK6), a member of the serine protease family of kallikrein (KLK) genes, is dysregulated in ovarian carcinomas (OCa) and its overexpression is associated with poor prognosis. Regulation of its expression is poorly understood and is likely to be influenced by multiple mechanisms. The KLK locus is subject ...
Carvalho-Wells Andrew L - - 2012
BACKGROUND: The response of plasma lipids to dietary fat manipulation is highly heterogeneous, with some indications that APOE genotype may be important. OBJECTIVE: The objective was to use a prospective recruitment approach to determine the effect of dietary fat quantity and composition on both lipid and nonlipid cardiovascular disease biomarkers ...
Martin-Fernandez Inigo - - 2012
Graphene being a zero band gap material hinders the use of its intrinsic form for many applications requiring a moderate band gap, such as field effect transistors and optoelectronic devices. Here we demonstrate a scalable method based on chemical vapor deposition for the direct growth of well-registered graphene nanoribbons on ...
Crook T - - 2012
The Pulvertaft weave has been the standard tendon junction technique used both in tendon transfers and tendon grafts. A limitation of this repair is the sequential failure of stabilizing sutures, rather than the tendon. A novel loop weave is described and compared with the Pulvertaft weave in biomechanical performance. Ovine ...
Yan Lifen - - 2012
Fourier transform infrared spectroscopy (FTIR) was used to observe the photolysis and recombination of a new EPR-silent CO-inhibited form of α-H195Q nitrogenase from Azotobacter vinelandii. Photolysis at 4 K reveals a strong negative IR difference band at $\tilde {\nu}$=1938 cm(-1) , along with a weaker negative feature at 1911 cm(-1) . These bands ...
Penkett Clive S - - 2012
Upon irradiation with UV light, an arenyl dienol was transformed into linear and angular meta photocycloadducts and ortho derived photoadducts. Extended exposure to UV radiation resulted in the formation of other degradation products, which shed light on the chemical processes taking place. One of the linear meta photocycloadducts was thermally ...
Sonar Prashant - - 2012
A fluorenone based alternating copolymer () with a furan based fused aromatic moiety has been designed and synthesized. exhibits a small band gap with a lower HOMO value. Testing this polymer semiconductor as the active layer in organic thin-film transistors results in hole mobilities as high as 0.15 cm(2) V(-1) ...
Tavalaee M - - 2012
Integrity of the sperm membrane, of which phosphatidyl serine (PS) plays a central role, is essential for fertilization. The externalisation of PS (EPS) occurs during capacitation and the acrosome reaction. EPS, from the inner to the outer membrane, is considered as a sign of early apoptosis. Therefore, EPS may have ...
Sacristán R Del Pozo - - 2012
The efficacy of chlortetracycline (CTC) in-feed medication to treat pigs with clinical respiratory disease was investigated in a farrow-to-finish pig herd infected with Mycoplasma hyopneumoniae, and with clinical respiratory disease in growing pigs. In total, 533 pigs were included. The animals were vaccinated against M hyopneumoniae and porcine circovirus type ...
Romilly Cédric - - 2012
The endoribonuclease III (RNase III) belongs to the enzyme family known to process double-stranded RNAs. Staphylococcus aureus RNase III was shown to regulate, in concert with the quorum sensing induced RNAIII, the degradation of several mRNAs encoding virulence factors and the transcriptional repressor of toxins Rot. Two of the mRNA-RNAIII ...
Anthimidou Eleni - - 2012
Abstract The antibacterial activity of 31 Greek and Cypriot honeys against Staphylococcus aureus and Pseudomonas aeruginosa was initially screened using an agar-well diffusion assay in comparison with manuka honey. The minimum inhibitory concentration (MIC) was determined in broth using a spectrophotometric-based assay. The MIC of treated honeys with catalase or ...
Hean Sarah - - 2012
Theory is essential to understand our interprofessional educational (IPE) practice. As a discipline, IPE has moved from being widely atheoretical to having a plethora of theories imported from the psychosocial disciplines that have utility to understand, articulate and improve IPE practice and evaluation. This paper proposes that when taking this ...
Hou Zhihui - - 2012
Hydrogen sulfide (H(2) S) is a newly-discovered signaling molecule in plants and has caused increasing attention in recent years, but its function in stomatal movement is unclear. In plants, H(2) S is synthesized via cysteine degradation catalyzed by D-/L-cysteine desulfhydrase (D-/L-CDes). AtD-/L-CDes::GUS transgenic Arabidopsis thaliana plants were generated and used ...
Guarnieri Daniela - - 2012
Many therapeutic drugs are excluded from entering the brain due to their lack of transport through the blood-brain barrier (BBB). The development of new strategies for enhancing drug delivery to the brain is of great importance in diagnostics and therapeutics of central nervous diseases. To overcome this problem, a viral ...
Cersosimo Robert J - - 2012
OBJECTIVE:To review the activity of 3 new agents approved for the management of advanced castration-resistant prostate cancer (CRPC): sipuleucel-T, cabazitaxel, and abiraterone acetate.DATA SOURCES:Literature was accessed through MEDLINE (1977-June 2012) and abstracts from the American Society of Clinical Oncology (2000-2012) using the terms castration-resistant and hormone-refractory prostate cancer, sipuleucel-T, cabazitaxel, ...
Naidoo Yuresh - - 2012
BACKGROUND: The purpose of this level 4, retrospective cohort study was to detail the outcomes of primary, revision, and endoscopic modified Lothrop procedure (EMLP) (Draf III) frontal sinus surgery and evaluate whether risk factors would help determine which patients would benefit from which procedures. METHODS: The study used a retrospective ...
Gazdhar Amiq - - 2012
Background Inefficient alveolar wound repair contributes to the development of pulmonary fibrosis. Hepatocyte growth factor (HGF) is a potent growth factor for alveolar type II epithelial cells (AECII) and may improve repair and reduce fibrosis. We studied if targeted gene transfer of HGF specifically to AEC II cells improves lung ...
Madu Anthony Emeka - - 2012
Abstract Rare inheritable conditions may present without warning in the neonatal period and thus lead curious staff to institute expansive clinical investigations. Non-ketotic hyperglycaemia (NKH) in a normal fully grown male infant following an essentially eventful pregnancy associated with unrelated condition provoked much clinical curiosity. NKH should therefore be included ...
Ramachandran E N - - 2012
Abstract Purpose: To study, characterize and compare chromosome aberrations and karyotype anomalies among newborns from high (> 1.5 mGy/y) and normal (≤ 1.5 mGy/y) level natural radiation areas of monazite-sand bearing southwest coast of Kerala in India. Materials and methods: Cord blood samples from newborns were collected from selected Government ...
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