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Results 551 - 600 of 2099
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Samanta Debasis - - 2012
"Click" polymerization reaction has been performed on the functional self-assembled monolayer to incorporate polytriazoles. Ellipsometric and atomic force microscopic studies indicated a high degree of polymerization and fairly dense surface coverage. Band gap calculation revealed the possibility of its use as a semiconducting material.
Rutter Abigail V - - 2012
Our previous studies have shown that both lung cancer cells and non-malignant lung cells release acetaldehyde in vitro. However, data from other laboratories have produced conflicting results. Furthermore, all these studies have been carried out in 2D models which are less physiological cell growth systems when compared to 3D models. ...
Palfreeman Adrian - - 2012
OBJECTIVES: The 2008 UK National Guidelines for HIV testing recommended HIV testing should be offered to all general medical admissions aged 16-60 years in high prevalence areas, and that this should be evaluated to ensure this was effective in diagnosing previously undiagnosed HIV. METHODS: HIV testing was introduced as a ...
Boterashvili Meital - - 2012
To mix or not to mix: Integrated (left) and segregated (right) assemblies were obtained upon treating functionalized γ-Fe(2) O(3) nanoparticles (NPs) with AuNPs. Their binary nature is controlled by the capping layer of the γ-Fe(2) O(3) NPs and the AuNP initial aggregation state. The segregated assembly formation is induced by ...
Goulet Adeline A Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, United - - 2012
Kinesin-5 is required for forming the bipolar spindle during mitosis. Its motor domain, which contains nucleotide and microtubule binding sites and mechanical elements to generate force, has evolved distinct properties for its spindle-based functions. In this study, we report subnanometer resolution cryoelectron microscopy reconstructions of microtubule-bound human kinesin-5 before and ...
Qin Jun - - 2012
ABSTRACT: INTRODUCTION: Sodium ferulate (SF) is a natural component of traditional Chinese herbs. Our previous study shows that SF has a protective effect on osteoarthritis (OA). The objective of this study was to investigate the effect of SF on TNF/TNFR signal transduction pathway of rat OA chondrocytes. METHODS: Primary rat ...
Ravasco Paula - - 2012
In our published randomized trial in colorectal cancer, group 1 (n = 37) received individualized nutritional counseling and education about regular foods, group 2 (n = 37) received dietary supplements and consumed their usual diet of regular foods, and group 3 (n = 37) consumed their usual diet of regular ...
Ovcharenko Victor I - - 2012
The reaction of copper(II) hexafluoroacetylacetonate [Cu(hfac)(2)] with the stable nitronyl nitroxide 2-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (L(a)) resulted in a paired heterospin complex [[Cu(hfac)(2)](3)(μ-O,N-L(a))(2)][Cu(hfac)(2)(O-L(a))(2)]. The crystals of the compound were found to be capable of a reversible single-crystal-to-single-crystal (SC-SC) transformation initiated by the variation of temperature. At room temperature, the molecular structure of [[Cu(hfac)(2)](3)(μ-O,N-L(a))(2)][Cu(hfac)(2)(O-L(a))(2)] ...
Vilberg Kaia L - - 2012
Prior research has identified several regions where neural activity is enhanced when recollection of episodic information is successful. Here, we investigated whether these regions dissociate according to whether recollection-related activity is transient or sustained across the time that recollected information must be maintained before a behavioral judgment. Human subjects studied ...
Parikh Chaitali - - 2012
The protein kinase v-akt murine thymoma viral oncogene homolog (AKT), a key regulator of cell survival and proliferation, is frequently hyperactivated in human cancers. Intramolecular pleckstrin homology (PH) domain-kinase domain (KD) interactions are important in maintaining AKT in an inactive state. AKT activation proceeds after a conformational change that dislodges ...
Edith-Rodriguez Jessica - - 2012
Hypertension and diabetes have been related to noradrenergic system impairment, especially to the response mediated by alpha-1 receptors. The aim of this work was to investigate possible changes in the expression of alpha-1 adrenergic receptors in aorta and carotid arteries of Wistar Kyoto and spontaneously hypertensive rats after 4 weeks ...
Nakayama Takahiro - - 2012
Establishment and maintenance of epigenetic memories are essential for development. Replacement of canonical histone H3 by its variant H3.3 has been implicated in cellular memory. Drosophila sequence-specific DNA-binding protein GAGA factor and a chromatin factor FACT direct H3.3 replacement in conjunction with H3.3-specific chaperone HIRA at chromatin boundaries to counteract ...
Zhang Sha - - 2012
The mechanism leading to an alteration of heat aggregation of whey protein isolate (WPI) in the presence of pectin was investigated by assessing structural changes of proteins using Raman spectroscopy. WPI solutions were heated without or with pectin at 0.015-0.2 pectin to WPI weight ratios and pH 6.0 to 6.4. ...
Itsekson Alek M - - 2012
The aim of this study was to determine whether women with recurrent pregnancy loss (RPL) and concurrent premenstrual syndrome (PMS) who underwent desensitization with sex hormones had an improved obstetric outcome. This manuscript summarizes a 10 year open label prospective follow up study of 26 women with RPL, aged 25-42 ...
Junges Roger - - 2012
BACKGROUND AND OBJECTIVE: The number of elderly living in long-term care (LTC) institutions has been increasing in many countries. The objective of this study was to evaluate the caregivers' attitudes and considerations regarding oral health and oral health practices in an LTC institution in Porto Alegre, Brazil. MATERIALS AND METHODS: ...
Ilatovskaya Daria V DV Medical College of Wisconsin, Dept. of Physiology, 8701 Watertown Plank Rd., Milwaukee, WI 53226, - - 2013
The epithelial Na(+) channel (ENaC) is a key transporter participating in the fine tuning of Na(+) reabsorption in the nephron. ENaC activity is acutely upregulated by epidermal growth factor (EGF), insulin, and insulin-like growth factor-1 (IGF-1). It was also proposed that reactive oxygen species (ROS) have a stimulatory effect on ...
Dahm Christina C CC Department of Cardiology, Center for Cardiovascular Research, Aarhus University Hospital, Aalborg, Denmark. - - 2012
Fatty acids in blood may be related to the risk of prostate cancer, but epidemiologic evidence is inconsistent. Blood fatty acids are correlated through shared food sources and common endogenous desaturation and elongation pathways. Studies of individual fatty acids cannot take this into account, but pattern analysis can. Treelet transform ...
Eliseeva Irina - - 2012
YB-1 is a multifunctional cold shock domain containing protein that is involved virtually in all DNA- and mRNA-dependent cellular events. Its amount is regulated at the level of both transcription and translation. We showed previously that translation of poly A(-) YB-1 mRNA in vitro is selectively controlled by two proteins, ...
Heaf James Goya - - 2012
IntroductionMost home haemodialysis (HD) modalities are limited to home use since they are based on a single-pass (SP) technique, which requires preparation of large amounts of dialysate. We present a new dialysis method, which requires minimal dialysate volumes, continuously recycled during treatment [multipass HD (MPHD)]. Theoretical calculations suggest that MPHD ...
Jabeen Fahmida - - 2012
Relying on the successful journey of metal oxides in phosphoproteomics, lanthanum oxide is employed for the engineering of an affinity material for phosphopeptide enrichment. The lanthanum oxide is chemically modified on the surface of silica and characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and Fourier transform ...
Sun Li-Ping - - 2012
Chinese propolis (CP) is a natural product collected by honeybees and a health food raw material. Previous studies have shown that CP exhibits a broad spectrum of biological activities including anticancer, antioxidant, antibacterial, anti-inflammatory, and antiviral activities. The focuses of the present study were the standardization of CP and the ...
Burton Neil J - - 2012
OBJECTIVES: To compare osteotomy orientation relative to the sagittal and transverse planes of the tibia, and cis cortical damage for tibial plateau leveling osteotomy (TPLO) performed with the following aids: (1) Synthes TPLO jig and saw guide, (2) Slocum TPLO jig with ancillary Kirschner wires (SlocumK), and (3) Slocum jig ...
Roberts Nicholas J - - 2013
Nodulation in legumes requires the recognition of rhizobially made Nod factors. Genetic studies have revealed that the perception of Nod factors involves LysM domain receptor-like kinases, while biochemical approaches have identified LECTIN NUCLEOTIDE PHOSPHOHYDROLASE (LNP) as a Nod factor-binding protein. Here, we show that antisense inhibition of LNP blocks nodulation ...
Rossini Giada - - 2012
West Nile virus (WNV) is currently circulating in several European countries and over the past decades, concomitant with enhanced surveillance studies and improved diagnostic capabilities, an increase in the geographical distribution and in the number of cases in Europe has been documented. In Italy, in 2011, 14 human cases of ...
Hiraki Linda T LT Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02215, USA. - - 2013
The primary circulating form of vitamin D is 25-hydroxy vitamin D (25(OH)D), a modifiable trait linked with a growing number of chronic diseases. In addition to environmental determinants of 25(OH)D, including dietary sources and skin ultraviolet B (UVB) exposure, twin- and family-based studies suggest that genetics contribute substantially to vitamin ...
Chan Cynthia Y - - 2012
OBJECTIVE:To determine whether thiazides have a chronic antihypertensive effect, in the absence of diuresis, in patients with severe renal disease (creatinine clearance <30 mL/min) or in those receiving dialysis.DATA SOURCES:A search was performed in PubMed, CENTRAL, and International Pharmaceutical Abstracts, using MeSH terms and/or key words. MeSH terms included kidney ...
Konermann Lars - - 2012
Electrospray ionization (ESI) generates intact gas phase ions from analytes in solution for mass spectrometric investigations. ESI can proceed via different mechanisms. Low molecular weight analytes follow the ion evaporation model (IEM), whereas the charged residue model (CRM) applies to large globular species. A chain ejection model (CEM) has been ...
Jiménez Josefina - - 2012
A divergent approach was used for the synthesis of dendritic structures based on a cyclotriphosphazene core with 12 or 24 hydroxyl groups, by starting from [N(3) P(3) (OC(6) H(4) OH-4)(6) ] and using an acetal-protected 2,2-di(hydroxymethyl)propionic anhydride as the acylating agent. Hydroxyl groups in these first- and second-generation dendrimers, G1-(OH)(12) ...
Townsend M B - - 2013
Despite the eradication of smallpox, orthopoxviruses (OPV) remain public health concerns. Efforts to develop new therapeutics and vaccines for smallpox continue through their evaluation in animal models despite limited understanding of the specific correlates of protective immunity. Recent monkeypox virus challenge studies have established the black-tailed prairie dog (Cynomys ludovicianus) ...
Danielsson Anna - - 2012
Abstract Purpose: The aim of this study was to identify gene expression profiles distinguishing alpha-particle (211)At and (60)Co irradiation. Materials and methods: Gene expression microarray profiling was performed using total RNA from confluent human fibroblasts 5 hours after exposure to (211)At labeled Trastuzumab monoclonal antibody (0.25, 0.5, and 1 Gy) ...
Smolen Josef S - - 2013
In this viewpoint, we summarise three different lines of evidence suggesting that current biological therapies directed at different molecules or cells have similar efficacy in rheumatoid arthritis and target similar populations of patients; therefore, distinct biological effects of targeted therapies may not account for differences in response. Moreover, currently available ...
Bestley Sophie S Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada. - - 2013
A fundamental goal in animal ecology is to quantify how environmental (and other) factors influence individual movement, as this is key to understanding responsiveness of populations to future change. However, quantitative interpretation of individual-based telemetry data is hampered by the complexity of, and error within, these multi-dimensional data. Here, we ...
Kielstein Jan T - - 2012
BackgroundExtracorporeal membrane oxygenation (ECMO) is increasingly used in the intensive care unit (ICU) setting to improve gas exchange in patients with acute respiratory distress syndrome as well as in patients pre- and post-heart and lung transplantation. In this clinical setting, acute kidney injury (AKI) is frequently observed. So far, it ...
Ziadi Asraa - - 2012
A formal γ-alkynylation of ketones via Pd-catalyzed C-C bond-cleavage is presented. The method allows for the coupling of tert-cyclobutanols and bromoacetylenes, giving access to versatile alkynes that are beyond reach otherwise.
Tang San-Yuan - - 2012
We investigated the effect of casticin on apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). We found that casticin potentiated TRAIL-induced apoptosis in human colon cancer cells. Casticin downregulated cell survival proteins including Bcl-xL, Bcl-2, survivin, XIAP and cFLIP, and induced death receptor 5 (DR5), but had no effect ...
Ozawa Takeaki - - 2012
Recent progress of bioanalytical techniques has accelerated the deep understanding of cellular states and development of novel drugs as well as medical diagnosis. Particularly, small organic molecules, quantum dots, and genetically encoded optical probes have revolutionized imaging and analysis of intracellular molecular networks during the past decade. The emphasis of ...
Wang Sen - - 2013
Antigens encoded in the region of difference (RD) of Mycobacterium tuberculosis constitute a potential source of specific immunodiagnostic antigens for distinguishing tuberculosis (TB) infection from BCG vaccination. We evaluated the diagnostic potential of specific T-cell epitopes selected from two immunodominant antigens, Rv1985c and Rv3425, from RD2 and RD11, respectively, on ...
Donahoo Ryan - - 2012
A comprehensive analysis of 175 Xanthomonas axonopodis pv. dieffenbachiae strains isolated from ten Araceae hosts was done to identify pathogen variation. The strains were subjected to repetitive extragenic palindromic sequence polymerase chain reaction (Rep-PCR) and four major phylogenetic clusters were generated. A subset of forty strains isolated from Anthurium, Dieffenbachia, ...
Hick Aurore - - 2012
Friedreich's ataxia (FRDA) is a recessive neurodegenerative disorder commonly associated with hypertrophic cardiomyopathy. FRDA is due to expanded GAA repeats within the first intron of the gene encoding frataxin, a conserved mitochondrial protein involved in iron-sulfur cluster biosynthesis. This mutation leads to partial gene silencing and substantial reduction of the ...
Zhang Shuzhen - - 2012
The development and progression of chronic complications in diabetic patients, such as retinopathy, nephropathy, neuropathy, cataracts, and stroke, are related to the activation and/or overexpression of aldose reductase (ALR2), which is a member of the aldo-keto reductase superfamily. A structure-activity relationship study focused on the C7 position of 1,2,4-benzothiadiazine-1,1-dioxide derivatives ...
Gagné Donald D Institut National de la Recherche Scientifique-Institut Armand-Frappier, Université du Québec, Laval, Quebec H7V 1B7, - - 2012
Conformational flexibility between structural ensembles is an essential component of enzyme function. Although the broad dynamical landscape of proteins is known to promote a number of functional events on multiple time scales, it is yet unknown whether structural and functional enzyme homologues rely on the same concerted residue motions to ...
Krasemann Susanne - - 2012
Prion diseases are fatal neurodegenerative disorders. An important step in disease pathophysiology is the conversion of cellular PrPC to disease-associated misfolded conformers, summarized as PrPSc. These misfolded PrP variants are a common component of prion infectivity and detectable in diseased brain and lymphoreticular organs such as spleen. In the latter, ...
Imbiriba Luis Aureliano - - 2012
It is well established that the mental simulation of actions involves visual and/or somato-motor representations of those imagined actions. In order to investigate if the total absence of vision affects the brain activity associated to the retrieval of motor representations, we recorded the readiness potential (RP), a marker of motor ...
Foroughinia F - - 2012
OBJECTIVE: This study sought to investigate the effect of omega-3 polyunsaturated fatty acids (PUFAs) on cardiac biomarkers, CK-MB and troponin I, in patients undergoing PCI. BACKGROUND: Restenosis remains as a major long-term complication following percutaneous coronary intervention (PCI). It appears that there is strong relationship between post-PCI creatinin kinase MB ...
Puttabyatappa Muraly - - 2012
A local autocrine/ paracrine role for progesterone is an absolute requirement for corpus luteum formation in primates. Despite this, the mechanism(s) remain obscure, although existing data suggest an anti-apoptotic action to be central. There are a limited number of progestin-regulated gene targets identified in the luteinizing primate follicle, suggesting that ...
Reese Vanessa C - - 2013
In the human hepatoma cell line HepG2, retinoic acid, clofibric acid, and bile acid treatment can only modestly increase hepatitis B virus (HBV) biosynthesis. Utilizing the human embryonic kidney cell line 293T, it was possible to demonstrate that the retinoid X receptor α (RXRα) plus its ligand can support viral ...
Chee Lynette C Y - - 2012
The key roles of RARs and G-CSFR in the regulation of granulopoiesis have been well-documented. In this study, we sought to investigate the interaction between G-CSFR and RARs in myeloid differentiation of adult mice through conditional deletion of RARα or RARγ on a G-CSFR(-/-) background and by pharmacological intervention of ...
Gianfrani Carmen - - 2012
BACKGROUND: Research is intense to find wheat of low or null toxicity for patients with celiac disease (CD). Among candidates, there are diploid wheat species. OBJECTIVE: We compared the immunological properties of 2 lines of diploid monococcum wheat (Triticum monococcum ssp. monococcum), Monlis and ID331, with those of common wheat ...
Morel Adam - - 2012
Chiral ionic liquids (CILs) containing l-prolinate and l-lactate anions and non-chiral quaternary ammonium cations were employed in the palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran with aryl iodides (iodobenzene, 4-iodotoluene, 2-iodoanisole, 4-iodoanisole, 4-iodoacetophenone). In all the reactions 2-aryl-2,3-dihydrofuran () was obtained as the main product with the yield up to ...
Miller Michael J MJ Atmosphere and Ocean Research Institute, The University of Tokyo, Chiba, Kashiwa, Japan. - - 2013
What eel larvae feed on in the surface layer of the ocean has remained mysterious. Gut contents and bulk nitrogen stable isotope studies suggested that these unusual larvae, called leptocephali, feed at a low level in the oceanic food web, whereas other types of evidence have suggested that small zooplankton ...
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