Search Results
Results 501 - 550 of 2098
< 6 7 8 9 10 11 12 13 14 15 16 >
Nayagam Bryony Ariya - - 2012
ABSTRACT: Stem cells have been touted as a potential source of replacement cells for the treatment of severe-to-profoundly deaf individuals, including possible combined therapy with a cochlear implant. The success of such a therapy is dependent on a number of factors, but of critical importance is the functional incorporation of ...
Ostertag Luisa M - - 2013
We examined whether flavan-3-ol-enriched dark chocolate, compared with standard dark and white chocolate, beneficially affects platelet function in healthy subjects, and whether this relates to flavan-3-ol bioavailability. A total of 42 healthy subjects received an acute dose of flavan-3-ol-enriched dark, standard dark or white chocolate, in random order. Blood and ...
Ranade Arati N - - 2012
Usual treatment for Helicobacter pylori-induced peptic ulcer includes a 'triple therapy' consisting of two antibiotics (amoxicillin and clarithromycin) and a proton pump inhibitor (omeprazole). The objective of this project work was defined with a view to retain the drug in stomach for better antiulcer activity and substituting one of the ...
Xue Xiaoyan - - 2013
The treatment of septicemia caused by antibiotic-resistant bacteria is a great challenge in the clinic. Because traditional antibiotics inevitably induce bacterial resistance, which is responsible for many treatment failures, there is an urgent need to develop novel antibiotic drugs. Amino-terminated Poly(amidoamine) dendrimers (PAMAM-NH(2)) are reported to have antibacterial activities. However, ...
Parra-Guillen Zinnia Patricia - - 2013
Interleukin-12 (IL12) is a cytokine with potential applications in the treatment of cancer given the potent immune response that it triggers, in part due to its ability to stimulate expression of interferon-γ (IFNγ). To avoid the toxicity associated with systemic exposure to IL12, a high-capacity adenoviral vector carrying a liver-specific, ...
Burns Daniel - - 2013
Dried blood spots (DBS) technology has been introduced as a microsampling alternative to traditional plasma or serum sampling for pharmacokinetics or toxicokinetics evaluation. The application of DBS has been established for many small molecule drugs at discovery, nonclinical, and clinical stages. However, the application of DBS for large molecule therapeutics ...
Burnett D J - - 2012
The aim of this study was to investigate the effect of processing route (i.e., quench cooling and ball milling) on the surface energy heterogeneity and surface chemistry of indomethacin (IMC). Recently developed inverse gas chromatography (IGC) methodology at finite concentrations was employed to determine the surface energy distributions of crystalline, ...
Zwiech RafaƂ - - 2012
PURPOSE: The study evaluated whether the dual blockade of the renin-angiotensin system may influence the sodium balance in hemodialysis. METHODS: The study involved 148 hemodialysis patients (male 85, female 63), mean age 59.6 ± 12.9 years. Participants were randomly selected to receive either angiotensin-converting enzyme inhibitor (ACEI)-subgroup A-or dual blockade ACEI and angiotensin ...
Hayashi Shinya S Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. - - 2012
Several studies have reported a risk of dislocation in obese patients after total hip arthroplasty. In this study, we evaluated the interaction between obesity and dislocation by kinematic analysis using a navigation system. The intraoperative range of motion (ROM) and postoperative impingement-free ROM were measured in 38 patients, and we ...
Sivanarayana T T Genetics Department, Krishna IVF Clinic, Krishna Nagar, Visakhapatnam, 530 002, Andhra Pradesh, - - 2012
The present study was undertaken to evaluate the effects of morphokinetic abnormalities of human spermatozoa on chromatin packing and DNA integrity and possible beneficial effects of sperm selection in ICSI. Semen samples from 1002 patients were analysed for morphology and motility using CASA. Protamine status and DNA fragmentation were analysed ...
Aragon Anthony D AD UNM Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, - - 2012
A population of Saccharomyces cerevisiae was cultured for approximately 450 generations in the presence of high glucose to select for genetic variants that grew optimally under these conditions. Using the parental strain BY4741 as the starting population, an evolved culture was obtained after aerobic growth in a high glucose medium ...
Jones Bernard L BL Nuclear/Radiological Engineering and Medical Physics Programs, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0405, - - 2012
This report presents the first experimental demonstration, to our knowledge, of benchtop polychromatic cone-beam x-ray fluorescence computed tomography (XFCT) for a simultaneous determination of the spatial distribution and amount of gold nanoparticles (GNPs) within small-animal-sized objects. The current benchtop experimental setup successfully produced XFCT images accurately showing the regions containing ...
Walder Kathryn K KK Department of Biology, Grinnell College, Grinnell, IA 50112, - - 2013
Immunohistochemical studies previously revealed the presence of the peptide transmitter N-acetylaspartylglutamate (NAAG) in spinal motor neurons, axons and presumptive neuromuscular junctions (NMJs). At synapses in the central nervous system, NAAG has been shown to activate the type 3 metabotropic glutamate receptor (mGluR3) and is inactivated by an extracellular peptidase, glutamate ...
Zanotti-Fregonara Paolo P Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, - - 2013
Two allosteric modulators of the group I metabotropic glutamate receptors (mGluR1 and mGluR5) were evaluated as positron emission tomography (PET) radioligands for mGluR1. LY2428703, a full mGluR1 antagonist (IC(50) 8.9 nM) and partial mGluR5 antagonist (IC(50) 118 nM), and LSN2606428, a full mGluR1 and mGluR5 antagonist (IC(50) 35.3 nM and ...
Kamali Saeed S Department of Chemistry, University of California, Davis, 95616, - - 2013
Nuclear inelastic scattering of (57)Fe labeled [NiFe] hydrogenase is shown to give information on different states of the enzyme. It was thus possible to detect and assign Fe-CO and Fe-CN bending and stretching vibrations of the active site outside the spectral range of the Fe-S cluster normal modes.
Malyszko Jolanta - - 2012
BACKGROUND: Chronic kidney disease is almost always accompanied by anaemia. Erythropoietin-stimulating agents (ESA) can increase haemoglobin concentration and thus reduce the frequency of anaemia-related complications including the cardiovascular events. AIM: The aim of the study was to collect prospective data on 12-month standard ESA therapy used in haemodialyzed patients in ...
Li Lei L Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, - - 2013
Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low-grade malignant neoplasm. To our knowledge, SPN with prominent atypical multinucleated giant tumour cells (MNGTCs) has not yet been reported. We identified four cases of SPN with prominent atypical MNGTCs in a cohort of 62 cases of SPN (6.5%). The ...
Shellmer Diana A DA Department of Pediatric Transplant Surgery, School of Medicine University of Pittsburgh, Pittsburgh, PA, USA. - - 2013
In this cross-sectional study, we compared levels of adaptive functioning and examined potential correlates of adaptive functioning in 18 pediatric intestine (ITX) and 22 liver (LTX) recipients transplanted between June 2003 and March 2009. Family caregivers completed the ABAS-II scale and provided socio-demographic information regarding recipients' age at transplantation, gender, ...
Grant Jeff J Department of Physiology and Biophysics, University of Miami, Miller School of Medicine, Rm 5133 Rosenstiel, 1600 NW 10th Avenue, Miami, FL 33136, - - 2013
Increasing evidence suggests that trabecular meshwork (TM) cells participate in the regulation of intraocular pressure by controlling the rate of filtration of the aqueous humor. Ionic conductances that regulate cell volume and shape have been suggested to play an important role in TM cell volume regulation. Here, we compared ionic ...
Mangone Massimiliano M Biomechanics and Movement Analysis Laboratory, Department of Physical Medicine and Rehabilitation, Azienda Policlinico Umberto I, Piazzale Aldo Moro, 5, 00185 Rome, Italy. - - 2013
The aim of the present research is to evaluate the relationship between an X-ray-based method (i.e. the Raimondi method) and rasterstereography in the evaluation of vertebral rotation (VR) in a sample of adolescent idiopathic scoliosis (AIS) patients. A total of 25 patients (9 males; mean age 14 ± 3 years; ...
Cruz Giovanna I GI School of Public Health, University of California, Berkeley, Berkeley, CA, - - 2013
Breast cancer incidence rates have declined among older but not younger women; the latter are more likely to be diagnosed with breast cancers carrying a poor prognosis. Epidemiological evidence supports an increase in breast cancer incidence following pregnancy with risk elevated as much as 10 years post-partum. We investigated the ...
Chen Y Y Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, - - 2013
The clinical features and outcomes of 148 patients with acute myeloid leukemia (AML) and 11q23 chromosomal abnormalities were compared with those of 2640 patients with non-11q23 AML. Patients with t(9;11) ), t(6;11) or other 11q23 balanced translocations (t(11;v)(q23;v)) presented at a younger age and with higher percentage of bone marrow ...
Amendola L L Department of Orthopedics and Traumatology, Spine Surgery, Maggiore Hospital, 'C. A. Pizzardi', Largo Nigrisoli 1, 40100 Bologna, Italy. - - 2013
Our aim is to define the role of embolization in the treatment of aneurysmal bone cyst of the spine in order to include this option in the decision making process. From April 2004 to November 2009, seven patients with primary aneurysmal bone cyst of the mobile spine treated by embolization ...
D'Aco Kristin E KE Division of Genetics, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 777, Rochester, NY 14623, - - 2013
We identified a mitochondrial tRNA mutation (m.586 G > A) in a patient with renal failure and symptoms consistent with a mitochondrial cytopathy. This mutation was of unclear significance due to the absence of consistent reports of linkage to specific disease phenotypes and any data pertaining to its effects on mitochondrial function. ...
MacLean Katherine A KA Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224-6823, USA. - - 2013
Salvinorin A is a kappa opioid agonist and the principal psychoactive constituent of the plant Salvia divinorum, which has increased in popularity as a recreational drug over the past decade. Few human studies have examined salvinorin A. This double-blind, placebo-controlled study evaluated the dose-related effects of inhaled salvinorin A in ...
Sun Yuna Y National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, - - 2012
Nucleocapsid protein (NPs) of negative-sense single-stranded RNA (-ssRNA) viruses function in different stages of viral replication, transcription, and maturation. Structural investigations show that -ssRNA viruses that encode NPs preliminarily serve as structural building blocks that encapsidate and protect the viral genomic RNA and mediate the interaction between genomic RNA and ...
Patterson Natalie L NL Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, - - 2012
Traditionally, macroautophagy (autophagy) is viewed as a pathway of cell survival. Autophagy ensures the elimination of damaged or unwanted cytosolic components and provides a source of cellular nutrients during periods of stress. Interestingly, autophagy can also directly intersect with, and impact, other major pathways of cellular function. Here, we will ...
Overton Timothy G TG University Hospitals Bristol NHS Foundation Trust, Bristol, - - 2012
The birth prevalence of gastroschisis is increasing worldwide, yet little evidence exists concerning the optimal monitoring strategies after diagnosis. The aim of this study was to describe the U.K. prevalence, antenatal management and outcomes of affected pregnancies. Cases were identified throughout the U.K. between October 2006 and September 2007, using ...
de Schepper Evelien I T EI Department of General Practice, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. - - 2013
A possible cause of hip pain is the presence of radiating pain from the higher lumbar spine. Identification of factors associated with hip pain arising from the lumbar spine would aid the physician. The first step in identifying possible factors is to look at the association between hip pain and ...
Ratajczak M Z MZ Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY, - - 2013
In recent years, solid evidence has accumulated that insulin-like growth factor-1 (IGF-1) and 2 (IGF-2) regulate many biological processes in normal and malignant cells. Recently, more light has been shed on the epigenetic mechanisms regulating expression of genes involved in IGF signaling (IFS) and it has become evident that these ...
Sun Yi Y Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 4424B Medical Science-I, 1301 Catherine Street, Ann Arbor, MI 48109, USA. - - 2013
SAG (Sensitive to Apoptosis Gene), also known as RBX2 (RING box protein 2), ROC2 (Regulator of Cullins 2), or RNF7 (RING Finger Protein 7), was originally cloned in our laboratory as a redox inducible antioxidant protein and later characterized as the second member of the RBX/ROC RING component of the ...
Medici Valentina V Department of Internal Medicine, University of California Davis, Davis, CA 95817, USA. - - 2013
Alcoholic liver disease (ALD) is typically associated with folate deficiency, which is the result of reduced dietary folate intake, intestinal malabsorption, reduced liver uptake and storage, and increased urinary folate excretion. Folate deficiency favors the progression of liver disease through mechanisms that include its effects on methionine metabolism with consequences ...
Ray Bimal K - - 2012
A disintegrin and metalloprotease domain-containing protein 12 (ADAM12) is up-regulated in many human cancers and promotes cancer metastasis. Increased urinary level of ADAM-12 in breast and bladder cancers correlates with the disease progression. However, the mechanism of its induction in cancer remains less understood. Previously, we reported a Z-DNA forming ...
Bings Nicolas Hubert - - 2012
Atomic spectrometry remains one of the most powerful methods for the determination of the elements and their compounds in a wide variety of types of samples and in widely differing concentrations. Innovation in the optical methods being atomic absorption, atomic fluorescence, and atomic emission spectrometry mainly with plasma sources as ...
Yin Zhou - - 2012
Phosphorylation-dependent protein-protein interaction has rarely been targeted in medicinal chemistry. Thymoquinone, a naturally occurring antitumor agent, disrupts pre-phosphorylated substrate recognition by the polo-box domain of polo-like kinase 1, a key mitotic regulator responsible for various carcinogenesis when over-expressed. Here, crystallographic studies reveal that the phosphoserine/phosphothreonine recognition site of the polo-box ...
Lim Ratana - - 2012
Preterm birth is a major determinant of neonatal mortality and morbidity with approximately one third due to pre-labor rupture of membranes. Infection and inflammation have strong causal links to preterm delivery, resulting in the activation of nuclear factor-kappaB (NFKB) and its downstream targets. Human sirtuin (SIRT) 6, which has ADP-ribosyl ...
Kurzwernhart Andrea - - 2012
Ru(II)(arene) complexes have been shown to be promising anticancer agents, capable of overcoming major drawbacks of currently used chemotherapeutics. We have synthesized Ru(II)(η(6)-arene) compounds carrying bioactive flavonol ligands with the aim to obtain multi-targeted anticancer agents. In order to validate this concept, studies on the mode of action of the ...
Choi Inchul - - 2012
The trophectoderm epithelium is the first differentiated cell layer to arise during mammalian development. Blastocyst formation requires the proper expression and localization of tight junction, polarity, ion gradient and H(2)O channel proteins in the outer cell membranes. However, the underlying transcriptional mechanisms that control their expression are largely unknown. Here, ...
Hopps Sarah - - 2012
Introduction:Cetuximab is a chimeric mouse-human (30:70) IgG1 monoclonal antibody that competitively inhibits the binding of epidermal growth factor. Cetuximab is generally well tolerated; however, hypersensitivity infusion reactions have been reported. The incidence at the University of Oklahoma was currently unknown, though anecdotally high. The purpose of this study was to ...
Berger Lisa - - 2012
BACKGROUND: Acamprosate has been found to enhance rates of complete abstinence and to increase percent days abstinent (PDA) from alcohol relative to placebo treatment. As most U.S. clinical trials of acamprosate have been conducted in alcohol and other drug specialty clinics, there is a need to examine the efficacy of ...
Guo Hao-Bo - - 2012
Benzoic acid (BA) derivatives of environmental relevance exhibit various photophysical and photochemical characteristics. Here, time-dependent density functional theory (TDDFT) is used to calculate photoexcitations of eight selected BAs and the results are compared with UV spectra determined experimentally. High-level gas phase EOM-CCSD calculations and experimental aqueous phase spectra were used ...
Manzari-Tavakoli Asma - - 2012
Context: Otostegia persica Boiss (Lamiaceae) contains antioxidant agents and is used in traditional medicine for treatment of diabetes mellitus complications. Objectives: The acute antihyperglycemic, antilipid peroxidation, and insulin secretory activities of methanol extract of O. persica aerial parts were investigated. Materials and methods: The extract [200, 300, 400 mg/kg body weight ...
Somogyi Bálint - - 2012
Molecule-sized fluorescent emitters are much sought-after to probe biomolecules in living cells. We demonstrate here by time-dependent density functional calculations that the experimentally achievable 1-2 nm sized silicon carbide nanocrystals can emit light in the near-infrared region after introducing appropriate color centers in them. These near-infrared luminescent silicon carbide nanocrystals ...
Dahmer Tabitha - - 2012
Abstract The triterpene chikusetsusaponin IVa was isolated from the fruit of Ilex paraguariensis. Using biochemical and pharmacological methods, we demonstrated that chikusetsusaponin IVa (1) prolongs the recalcification time, prothrombin time, activated partial thromboplastin time, and thrombin time of normal human plasma in a dose-dependent manner, (2) inhibits the amidolytic activity ...
Rabellino Martin - - 2012
Abstract A 59-year-old female presented to our institution with paraparesis caused by medullar compression secondary to multiple myeloma. Spinal cord decompression and transpedicular spine fixation were performed. A month later, the patient complained of sudden pain in her middle back. A CT scan revealed screw impingement on the aortic wall ...
Han Joong Tark - - 2012
Modulation of electronic structures and surface properties of transparent carbon nanotube films is a challenging issue for their application in optoelectronic devices. Here, we report, for the first time, that graphene oxide (GO) nanosheets play the role of a p-doping agent and surface energy modifier of single-walled carbon nanotube (SWCNT)-based ...
Suh Donguk - - 2012
Growth of a cubic nanoparticle was studied by classical molecular dynamics simulation for three seed sizes in nine different supersaturation ratios. Similar to the spherical seed in our previous study, for high supersaturation ratios, a two-stage phenomenon that consists of an initial heterogeneous growth around the seed and homogeneous nucleation ...
Jiang Jing - - 2012
Although the human brain may have evolutionarily adapted to face-to-face communication, other modes of communication, e.g., telephone and e-mail, increasingly dominate our modern daily life. This study examined the neural difference between face-to-face communication and other types of communication by simultaneously measuring two brains using a hyperscanning approach. The results ...
Gao Chao - - 2012
We designed and synthesized the three molecular tweezers 1 a-c(4+) containing an electron acceptor 4,4'-bipyridinium (BPY(2+) ) unit in each of the two arms and an (R)-2,2'-dioxy-1,1'-binaphthyl (BIN) unit that plays the role of chiral centre and the hinge of the structure. Each BPY(2+) unit is connected to the BIN hinge ...
Smith Paul J - - 2012
We outline a simple approach involving instrument setup and calibration for the analysis of Hoechst dye 33342-loading in human cell lines for exploring heterogeneity in dye efflux efficiency and the status of side population (SP) A549 lung cancer cells. Dual excitation 488 nm/multiline UV (351-364 nm) flow cytometry was used ...
< 6 7 8 9 10 11 12 13 14 15 16 >