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Wallander Michelle L ML ARUP Institute for Clinical and Experimental Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, - - 2013
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Clinical behavior is best predicted by size and mitotic count (risk index). KIT and platelet-derived growth factor receptor α (PDGFRA) mutations have therapeutic and prognostic value but few other prognostically significant molecular markers have been identified. ...
Lykou Evdoxia E General Hospital of Athens G. Gennimatas, Athens G. Gennimatas, - - 2013
Patients with neurodegenerative disease show distinct patterns of personality change, some of which may be traced to focal neurological damage, whereas others may be mediated by cultural reactions to functional impairment. Although such changes are early and pervasive in behavioral variant frontotemporal dementia (bvFTD), and milder changes are seen in ...
Goertz Christine M CM Palmer Center for Chiropractic Research, Davenport, IA 52803, USA. - - 2013
Randomized controlled trial. To assess changes in pain levels and physical functioning in response to standard medical care (SMC) versus SMC plus chiropractic manipulative therapy (CMT) for the treatment of low back pain (LBP) among 18 to 35-year-old active-duty military personnel. LBP is common, costly, and a significant cause of ...
Ellman M B MB Department of Biochemistry, Section of Rheumatology, Rush University Medical Center, Chicago, Illinois 60612, - - 2013
Osteoarthritis (OA) and degenerative disc disease (DDD) are similar diseases involving the breakdown of cartilage tissue, and a better understanding of the underlying biochemical processes involved in cartilage degeneration may allow for the development of novel biologic therapies aimed at slowing the disease process. Three members of the fibroblast growth ...
Slee Joshua B JB Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, - - 2013
Vascular endothelial cells and their actin microfilaments align in the direction of fluid shear stress (FSS) in vitro and in vivo. To determine whether cofilin, an actin severing protein, is required in this process, the levels of phospho-cofilin (serine-3) were evaluated in cells exposed to FSS. Phospho-cofilin levels decreased in ...
Lipstein Ellen A - - 2013
The aim of the study was to describe parents' experiences and the information used when making decisions about tumor necrosis factor-α inhibitor (TNFαi) treatment. We interviewed parents of children with Crohn disease (CD) or juvenile idiopathic arthritis who had experience deciding about TNFαi treatment. Interview questions focused on information used ...
Mackenzie Ruth M RM Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, - - 2013
The aim of the present study was to determine whether the endothelial dysfunction associated with CAD (coronary artery disease) and T2D (Type 2 diabetes mellitus) is concomitant with elevated mtROS (mitochondrial reactive oxygen species) production in the endothelium and establish if this, in turn, regulates the activity of endothelial AMPK ...
Sanfilippo Jennifer L JL Departments of Biomedical Engineering and Athletics University of Wisconsin-Madison, Madison, WI, - - 2013
Hamstring strain reinjury rates can reach 30% within the initial 2 wk after return to sport (RTS). Incomplete recovery of strength may be a contributing factor. However, relative strength of the injured and unaffected limbs at RTS is currently unknown.The purpose was to characterize hamstring strength and morphology at the ...
Swenson David M DM Grand Rapids Medical Education Partners, Grand Rapids, MI, - - 2013
U.S. high school athletes sustain millions of injuries annually. Detailed patterns of knee injuries, among the most costly sports injuries, remain largely unknown. We hypothesize that patterns of knee injuries in U.S. high school sports differ by sport and sex. U.S. high school sports-related injury data were collected for 20 ...
Borsook David D Department of Anesthesia and Perioperative and Pain Medicine, Boston Childrens Hospital, Harvard Medical School, Boston, MA 02115, USA. - - 2013
Nerve damage takes place during surgery. As a consequence, significant numbers (10%-40%) of patients experience chronic neuropathic pain termed surgically induced neuropathic pain (SNPP). The initiating surgery and nerve damage set off a cascade of events that includes both pain and an inflammatory response, resulting in "peripheral and central sensitization," ...
Bothe Nina N Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Charité Campus Mitte, Berlin, - - 2013
Physical activity activates brain regions and transmitter systems that represent the reward system (i.e., the ventral striatum [VS] and dopamine). To date, the effect of training status and acute exercise on reward processing has not been investigated systematically in humans. To address this issue, we examined highly trained (HT) physically ...
Loqman Mohamad Y MY Centre for Integrative Physiology, School of Biomedical Sciences, George Square, University of Edinburgh, Edinburgh EH8 9XD, Scotland, - - 2013
Bone lengthening during skeletal growth is driven primarily by the controlled enlargement of growth plate (GP) chondrocytes. The cellular mechanisms are unclear but membrane transporters are probably involved. We investigated the role of the Na(+)/H(+) antiporter (NHE1) and anion exchanger (AE2) in bone lengthening and GP chondrocyte hypertrophy in Sprague-Dawley ...
Suskind David L DL Department of Pediatrics, Seattle Children's Hospital and University of Washington, Seattle, WA 98105, USA. - - 2013
Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation in the absence of a recognized etiology. The primary therapies are medications that possess anti-inflammatory or immunosuppressive effects. Given the high use of complementary alternative medicines in pediatric IBD, a prospective tolerability study of curcumin, an herbal therapy with known ...
Groleau Veronique V Division of Gastroenterology, Hepatology and Nutrition and Division of General Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. - - 2013
Optimal vitamin D status is known to have beneficial health effects and vitamin D supplements are commonly used. It has been suggested that vitamin D supplementation may increase blood lead in children and adults with previous lead exposure. The objective was to determine the safety regarding lead toxicity during 12 ...
Le-Carlson Minou M Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Stanford University Medical Center, Lucile Packard Children's Hospital, Palo Alto, CA, USA. - - 2013
Evidence suggests eosinophils may be acting as antigen-presenting cells (APCs) by presenting antigen to T cells. We investigated the surface proteins of eosinophils and T cells in the esophageal biopsies of patients with eosinophilic esophagitis (EoE), patients with gastroesophageal reflux disease (GERD), and healthy controls (HCs). : Subjects were categorized ...
Sterling Richard K RK Division of Gastroenterology, Hepatology, and Nutrition, Infectious Diseases, Virginia Commonwealth University Health System, Richmond, VA, USA. - - 2013
Abnormal liver enzymes (LEs) are common in those infected with human immunodeficiency virus (HIV). Histologic data on those with abnormal LE without viral hepatitis are lacking. HIV-positive subjects without hepatitis C virus, hepatitis B virus, alcohol abuse, and diabetes mellitus with more than 1 abnormal LE, defined as 1.25 ULN ...
Ruff Laura E LE Division of Biological Sciences and the Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, - - 2013
Particle-based delivery of encapsulated antigens has great potential for improving vaccine constructs. In this study, we show that antigen-loaded, pH-sensitive hydrogel microparticles are taken up and presented by bone marrow-derived dendritic cells (BMDCs) in vitro and are taken up by dendritic cells (DCs) and monocytes in vivo. This uptake is ...
Sikora Magdalena B - - 2012
The effect of donor kidney volume on recipient kidney function has not been fully evaluated. We performed a prospective analysis of 125 consecutive living kidney donor/recipient pairs. Donor kidney volume was calculated from pretransplantation computed tomography angiograms using a three-dimensional computerized volume method. Cortical volume was calculated from arterial phase ...
Wojciechowski David D Kidney Transplant Service, Division of Nephrology, Department of Medicine, University of California-San Francisco, San Francisco, CA 94143, USA. - - 2012
BK polyomavirus (BKV) infection remains a significant cause of nephropathy and graft loss. Fluoroquinolones inhibit BKV replication in vitro, and small studies suggest in vivo benefit. A strategy of fluoroquinolone prophylaxis directed specifically against BKV has not been formally tested against a control group in kidney transplant recipients. We retrospectively ...
Porzionato A - - 2012
Fluoxetine shows controversial lung effects as it prevents pulmonary hypertension in adult rats but exposure during gestation causes pulmonary hypertension in neonatal rats. In the present study, we tested the null hypothesis that the antidepressant drug fluoxetine does not modify the development of bronchopulmonary dysplasia (BPD) in neonatal rats. Experimental ...
Flipsen Peter - - 2012
Reference data for the acoustic vowel space area (VSA) in children and adolescents do not currently appear to be available in a form suitable for normative comparisons. In the current study, individual speaker formant data for the four corner vowels of American English (/i, u, æ, ɑ/) were used to ...
Catalán V - - 2012
Adipose tissue responds dynamically to alterations in nutrient excess through adipocyte hypertrophy and hyperplasia, followed by increased angiogenesis, immune cell infiltration, extracellular matrix (ECM) overproduction, and thus, increased production of proinflammatory adipokines during the progression of chronic inflammation. Adipose tissue remodelling is an ongoing process that is pathologically accelerated in ...
Macnaughton Jane - - 2012
The idea of the smoking person portrayed in public health has been criticised as being based on too narrow a view of human nature. This article discusses that view: that of a person with a stable core and epiphenomenal 'behaviours' that can be removed by rational persuasion or Pavlovian manipulation, ...
Marini M - - 2012
During development the vertebrate skeleton is the product of deriving cells from distinct embryonic lineages. The craniofacial skeleton is formed by migrating cranial neural crest cells, whereas the axial and limb skeletons are derived from mesodermal cells. The Vascular Endothelial Growth Factors (VEGFs) / receptors (VEGFRs) system plays an important ...
Roy Johanna-Pascale - - 2012
Foreign accent syndrome (FAS) is an acquired neurologic disorder in which an individual suddenly and unintentionally speaks with an accent which is perceived as being different from his/her usual accent. This study presents an acoustic-phonetic description of two Quebec French-speaking cases. The first speaker presents a perceived accent shift to ...
Moreno-Bravo J A - - 2012
The midbrain is a complex structure where different functions are located. This formation is mainly involved in the visual and auditory information process (tectum) and visual movements and motor coordination (tegmentum). Here we display a complete description of midbrain anatomy based on the prosomeric model and of the developmental events ...
Brunanská M - - 2012
Vitellogenesis in the caryophyllidean tapeworm Archigetes sieboldi Leuckart, 1878, from carp Cyprinus carpio L. in Slovakia, has been examined using transmission electron microscopy and cytochemical staining with periodic acid-thiosemicarbazide-silver proteinate (PA-TSC-SP) for glycogen. Vitelline follicles extend in two lateral bands in the medullary parenchyma along both sides of the monozoic ...
- - 2012
Cover: Detection of caveolin-1 protein and morphology of fractionated caveolae in human MSCs. Please see article in this issue by Baker et al., pages 3773-3787.
Gagnon Marilou - - 2012
HIV plasma viral load testing has become more than just a clinical tool to monitor treatment response at the individual level. Increasingly, individual HIV plasma viral load testing is being reported to public health agencies and is used to inform epidemiological surveillance and monitor the presence of the virus collectively ...
Park E-Y - - 2012
Potassium depletion (K⁺-D) induces hypertrophy and hyperplasia of collecting duct cells, and potassium repletion (K⁺-R) induces regression of these changes. The purpose of this study was to examine the time courses of the changes in cellular composition, the origin of intercalated cells (ICs) and the mechanism responsible for these changes. ...
Zampini Laura - - 2012
The present study focussed on a specific type of rare genetic condition: chromosome 14 deletions. Children with this genetic condition often show developmental delays and brain and neurological problems, although the type and severity of symptoms varies depending on the size and location of the deleted genetic material. The specific ...
Cimpean A M - - 2012
Prox1 is a key regulator of lymphatic endothelial cell commitment during embryonic development. No correlations between Prox1 and VEGF-C/VEGFR3 expression in cervical cancer has been done until now. The aim of the present study was to evaluate the peculiarities of Prox1, VEGF-C and VEGFR3 expression during uterine cervix neoplasia progression. ...
Gómez-Torres M J - - 2012
Capacitation is characterized by a hyperactivated pattern of sperm motility. The acquisition of highly motility is present in the early stages of capacitation. Sperm progressive motility is one of the most important parameters for determining the suitability of semen for processing. However, previous studies have shown that some sperm showing ...
Göelzer J G - - 2012
The aim of the present study was to evaluate local and cytotoxicity systemic tissue reaction in the skull of rats using the implantation of disks of poly (lactic L/D-acid) and evaluate its genotoxicity. 25 males Wistar rats were used, 20 animals underwent surgical procedures and had the discs implanted in ...
Schmidt Anna Marie - - 2012
Links between perception and production were investigated for two adult native speakers of Korean who participated in electropalatographic (EPG) treatment designed to teach phonological and articulatory contrasts between English /s/ - /ʃ/, /z/ - /ʤ/, and /l/ - /ɹ/. Participants were successful in learning to produce the English contrasts. Perception ...
Smith S W - - 2012
Chronic Kidney Disease affects approximately 8% of the population and contributes considerably to premature morbidity and mortality. Recently reported studies have highlighted an important role for resident microvascular pericytes in the pathogenesis of kidney fibrosis. Pericytes are emerging as the predominant source of the activated, matrix depositing, stromal cell population ...
Juste Fabiola Staroble - - 2012
The purpose of this study was to investigate the exchange of disfluencies from function words to content words with age in Brazilian Portuguese speakers who do and do not stutter. Ninety stuttering individuals and 90 controls, native speakers of Brazilian Portuguese, were divided into three age groups (children, adolescents and ...
Gammon B - - 2012
The large majority of melanocytic lesions can be reliably classified as either benign or malignant based upon morphology alone, but a minority of lesions remains difficult to classify by traditional histologic methods. Recently, a panel of fluorescence in situ hybridization (FISH) probes targeting loci on chromosomes 6 and 11 has ...
Doss A L N - - 2012
Cutaneous infections are a leading cause of hospitalization of diabetic patients. Langerhans cells (LCs) are antigen-presenting cutaneous dendritic cells that protect against infections, and effects of diabetes and aging on these cells are unclear. We examined LCs in footpads of rats with streptozotocin-induced diabetes at 3 months of age following ...
Bishop Justin A JA Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231-2410, - - 2012
Evidence for transcriptional activation of the viral oncoproteins E6 and E7 is regarded as the gold standard for the presence of clinically relevant human papillomavirus (HPV), but detection of E6/E7 mRNA requires RNA extraction and polymerase chain reaction amplification-a challenging technique that is restricted to the research laboratory. The development ...
Raju G - - 2012
Differentiation and structural characterization of positional isomers of non-natural amino acid hybrid peptides by using electrospray ionization tandem mass spectrometry (ESI-MS(n) ) is desirable because of their fundamental importance from the view point of peptide mass spectrometry and also of their increasing importance in the area of research towards biomedical ...
Power John D - - 2012
Amphetamine-like cathinone derivatives have become popular as recreational drugs over the past several years but their identification for forensic purposes is made difficult as they undergo extensive fragmentation under commonly used electron ionization (EI) conditions to afford ambiguous mass spectra. To overcome this, the feasibility of using positive electrospray ionization ...
Cao Yunning - - 2012
The condition of the pyrolysis reactor is very important for obtaining stable, precise hydrogen isotopic ratios using gas chromatography/thermal conversion/isotope ratio mass spectrometry (GC/TC/IRMS). However, few studies of the conditioning process have been conducted, and little is known about the best methods for high-precision hydrogen isotope analysis. We investigated δ(2) ...
Tak Vijay - - 2012
A new analytical method based on liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) is proposed and validated for the identification and quantification of alkyl alkylphosphonic acids (AAPAs) in aqueous matrices. Retrospective detection and identification of degradation products of chemical warfare agents is important as an indicator of possible use of ...
Griffith David R - - 2012
Steroids are potent hormones that are found in many environments. Yet, contributions from synthetic and endogenous sources are largely uncharacterized. The goal of this study was to evaluate whether carbon isotopes could be used to distinguish between synthetic and endogenous steroids in wastewater and other environmental matrices. Estrogens and progestogens ...
Spangenberg Jorge E - - 2012
The choice of containers for storage of aqueous samples between their collection, transport and water hydrogen ((2) H) and oxygen ((18) O) stable isotope analysis is a topic of concern for a wide range of fields in environmental, geological, biomedical, food, and forensic sciences. The transport and separation of water ...
Sevastyanov Vyacheslav S - - 2012
The deuterium/hydrogen (D/H) composition of water and hydrocarbon gases is widely used in geological, environmental and petroleum studies. The aim of this work was to develop a simple reduction zirconium dioxide solid electrolyte reactor (SER) for water decomposition and new methods for measuring hydrogen isotope ratios in water and hydrocarbon ...
Vrbanac J James - - 2012
Herein we describe a generic quantitative method using high-resolution, isotope-dilution (HRID) metabolism of isotope-labeled compounds and apply it to the analysis of drug metabolites (DMs) in human plasma. Metabolites (drug) in Safety Testing (MIST) application was one goal. Testosterone (T) and diclofenac (D) were chosen for mass defect characteristics. T, ...
Svilar Ljubica - - 2012
Azaphilones, belonging to the class of mitorubrins usually produced in Hypoxylon fragiforme, react easily with amino groups, giving amine derivatives, mitorubramines. These secondary metabolites exhibit a wide range of biological activities. Finding new secondary metabolites from fungi is important, and electrospray ionization (ESI) high-resolution mass spectrometry (HRMS) coupled with sequential ...
Kher Ajay A Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, - - 2012
Currently, many transplantation centers do not follow former living kidney donors on a long-term basis. Several potential barriers have been identified to provide this follow-up of former living kidney donors, including concerns that donor insurance will not reimburse transplantation centers or primary care physicians for this care. Here, we report ...
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