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Fu Limin - - 2012
SUMMARY: CD-HIT is a widely used program for clustering biological sequences to reduce sequence redundancy and improve the performance of other sequence analyses. In response to the rapid increase in the amount of sequencing data produced by the next generation sequencing technologies, we have developed a new CD-HIT program accelerated ...
Wang Yizhong Y The Center for Animal Experiment and ABSL-3 Laboratory, Wuhan University, Wuhan, People's Republic of - - 2013
Retinoic acid inducible gene-I (RIG-I) is critical in the activation of the type I IFN-dependent antiviral innate immune response to hepatitis C virus (HCV) infection. We examined whether hepatic stellate cells (HSC; LX-2) possess a functional RIG-I signaling pathway and produce antiviral factors that can inhibit HCV. We showed that ...
Collier Daniel M DM Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, - - 2012
A growing body of evidence suggests that the extracellular domain of the epithelial Na(+) channel (ENaC) functions as a sensor that fine tunes channel activity in response to changes in the extracellular environment. We previously found that acidic pH increases the activity of human ENaC, which results from a decrease ...
Fung Kim Yc - - 2012
Butyrate and its analogues have long been investigated as potential chemotherapeutic agents. Our previous structure-activity relationship studies of butyrate analogues revealed that 4-benzoylbutyrate had comparable in vitro effects to butyrate when used to treat HT29 and HCT116 colorectal cancer cell lines. The aim of this study was to identify potential ...
Buschmann Johanna - - 2012
Tendon rupture repair is a surgical field where improvements are still required due to problems such as repeat ruptures, adhesion formation and joint stiffness. In the current study, a reversibly expandable and contractible electrospun tube based on a biocompatible and biodegradable polymer was implanted around a transected and conventionally sutured ...
Signes-Pastor Antonio J AJ Dept. de Tecnología Agroalimentaria, Grupo de Calidad y Seguridad Alimentaria, Univ. Miguel Hernández, Carretera de Beniel, km 3.2, 03312-Orihuela, Alicante, - - 2012
Rice can easily accumulate arsenic (As) into its grain and is known to be the highest As-containing cereal. In addition, the As burden in rice may increase during its processing (such as when cooking using As-polluted water). The health risk posed by the presence of As in cooked rice depends ...
Mustanoja S - - 2012
BACKGROUND AND PURPOSE: There are little data on the etiology of multiple brain infarcts (MBI) and their impact on clinical outcome in young patients. METHODS: We studied 548 MRI-imaged patients (15-49 years) with a first-ever ischaemic stroke. Ischaemic lesions were categorized into three groups: single lesions, MBI in one or >1 ...
Inaba Yoshimi - - 2012
Purpose:We show that a novel fragile X-related epigenetic element 2 FMR1 methylation test can be used along with a test for sex-determining region Y (SRY) to provide the option of combined fragile X syndrome and sex chromosome aneuploidy newborn screening.Methods:Fragile X-related epigenetic element 2, SRY, and FMR1 CGG repeat analyses ...
Cimini Annamaria - - 2012
Peroxiredoxins are ubiquitous proteins that recently attracted major interests in view of the strict correlation observed in several cell lines and/or tissues between different levels of their expression and the increased capacity of cells to survive in different pathophysiological conditions. They are recently considered as the most important enzymes regulating ...
Venegoni Ivan - - 2012
Polymer light-emitting diodes (PLEDs) have attracted growing interest in recent years for their potential use in displays and lighting fields. Nevertheless, PLED devices have some disadvantages in terms of low optoelectronic efficiency, high cost, short lifetimes and low thermal stability, which limit their final applications. Huge efforts have been made ...
Koltai Hinanit H Institute of Plant Sciences, Agricultural Research Organization (ARO), the Volcani Center, Bet Dagan 50250, Israel. - - 2013
Strigolactones (SLs) - a group of plant hormones and their derivatives - have been found to play a role in the regulation of root development, in addition to their role in suppression of lateral shoot branching: they alter root architecture and affect root-hair elongation, and SL signalling is necessary for ...
Martin Keith R - - 2012
Abstract Consumption of polyphenol-rich fruits, for example, tart cherries, is associated with a lower risk of cardiovascular disease and cancer. This is due, in large part, to the diverse myriad bioactive agents, that is, polyphenol anthocyanins, present in fruits. Anthocyanin-rich tart cherries purportedly modulate numerous cellular processes associated with oncogenesis ...
Dieckmann K-P - - 2012
miRNAs are small noncoding RNA molecules that can be released into body fluids. Germ cell tumours (GCTs) overexpress miRNAs of the miR-371-3 cluster. Thus, serum levels of these miRNAs may correlate with tumour load. miRNAs of the miR-371-3 cluster were quantified in cubital vein blood samples of 20 GCT patients ...
De Padova Irene Paola - - 2012
The synthesis of silicene, graphene-like silicon, has generated very strong interest. Here, we reveal the growth of high aspect ratio, perfectly straight and aligned silicon nanoribbons, exhibiting pyramidal cross section. They are multi-stacks of silicene and show in angle-resolved photoemission cone-like dispersion of their π and π* bands, at the ...
Santra Soumava S Department of Pharmaceutical Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48202, - - 2012
To further explore the basic structural motifs (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine and (2S,4R,5R)-2-benzhydryl-5-(benzylamino)tetrahydro-2H-pyran-4-ol, developed by our research group, for monoamine transport inhibition, we designed and synthesized various structurally altered analogues. The new compounds were tested for their affinities for the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET) in ...
Karbowiak Miroslaw - - 2012
Absorption emission and excitation spectra are measured and analyzed to achieve assignments of energy levels for 4fN ions in Ba2YCl7:RE3+ (RE = Pr, Nd, Tb, Dy, Ho, Er, and Tm) crystals. The experimental energy levels were analyzed in terms of the usual free-ion parameters and the crystal field (CF) ones, ...
Haldar Krishna Kanta - - 2012
We design well-defined metal-semiconductor nanostructures using thiol-functionalized CdTe quantum dots (QDs)/quantum rods (QRs) with bovine serum albumin (BSA) protein-conjugated Au nanoparticles (NPs)/nanorods (NRs) in aqueous solution. The main focus of this article is to address the impacts of size and shape on the photophysical properties, including radiative and nonradiative decay ...
Okada Youji Y Department of Analytical Chemistry, Faculty of Health Sciences, Kyorin University, 426 Miyashita-cho, Hachioji, Tokyo 192-8508, - - 2012
We examined the free radical scavenging activity of Sasa veitchii extract (Hoshi's Striped Bamboo Extract(®), HSBE), well known in folk medicine as an efficient drug and antioxidant in detail. To evaluate the free radical scavenging activity of HSBE, its reactivity as hydrogen atom donor toward the 1, 1-diphenyl-2-picrylhydrazyl has been ...
Touchon Marie - - 2012
Clustered, regularly interspaced, short palindromic repeats (CRISPRs) are implicated in the defence against foreign DNA in various archaea and bacterial species. They have also been associated with slower spread of antibiotic resistance. However, experimental and evolutionary studies raise doubts about the role of CRISPRs as a sort of immune system ...
Adrian Julie Ann Luiz - - 2012
The nutrient composition of common guava, Psidium guajava L., and strawberry guava (waiwi), Psidium cattleianum var. lucidum, tree parts and fruits was determined during three seasons for six locations in Hawaii to assess guava as a potential feed for cattle. All guava plant parts were higher (p < 0.001) in ...
Kunishima Munetaka - - 2012
The reaction of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) with various nitrogen-containing compounds, particularly tertiary amines (tert-amines), has been studied for the preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts [DMT-Am(s)]. DMT-Ams derived from aliphatic tert-amines exhibited activity for the dehydrocondensation between a carboxylic acid and an amine to form an amide in a model reaction. Based on ...
Lee Haeok - - 2012
Purpose: The purpose of this article is to explain the evolution of a situation-specific theory developed to enhance understanding of health-related behaviors of Korean Americans (KAs) who have or are at risk for a chronic hepatitis B virus (HBV) infection. Organizing Construct: The situation-specific theory evolved from an integration of ...
da Silva Maria Stella Peccin - - 2012
ABSTRACT The purpose of this study was to evaluate the influence of helium-neon laser on skin injury in rabbits. For this purpose, fifteen New Zealand rabbits underwent bilateral skin damage in leg. Helium-neon laser light, at a fluence of 6 J/cm(2) and wavelength of 632.8 nm was applied on the ...
Alkjaer Tine - - 2012
This study investigated the function of the cruciate ligaments during a forward lunge movement. The mechanical roles of the anterior and posterior cruciate ligament (ACL, PCL) during sagittal plane movements, such as forward lunging, are unclear. A forward lunge movement contains a knee joint flexion and extension that is controlled ...
Yang Fanghong - - 2012
We exploited the synthesis of near-infrared (NIR) emitting ternary-alloyed CdTeSe and quaternary-alloyed CdZnTeSe quantum dots (QDs) with rod and tetrapod morphologies, which have tunable emission in the NIR electromagnetic spectrum. The morphologies of the QDs depended strongly on their growth kinetics, probably due to the coordinating ligands used in the ...
Das Priyadip - - 2012
In this work, we have rationally designed and synthesized two new reagents (L(1) and L(2) ), each bearing a pendant aldehyde functionality. This aldehyde group can take part in cyclization reactions with β- or γ-amino thiols to yield the corresponding thiazolidine and thiazinane derivatives, respectively. The intramolecular charge-transfer (ICT) bands ...
Bessinis Dimitrios P - - 2012
Purpose: This study evaluated the level of histamine in the interaction between the environment and the visual system during lifespan development, exploring potential sex differences. Methods: Male and female Wistar rats, reared in standard laboratory or enriched environment cages from birth to pre-puberty or adulthood, were sacrificed during the critical ...
Alegria L D - - 2012
Topological insulators are a new class of materials that support topologically protected electronic surface states. Potential applications of the surface states in low dissipation electronic devices have motivated efforts to create nanoscale samples with large surface-to-volume ratios and highly controlled stoichiometry. Se vacancies in Bi(2)Se(3) give rise to bulk conduction, ...
Hu Youcai Y Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, - - 2012
Four new anthraquinone analogues including galvaquinones A-C (1-3) and an isolation artifact, 5,8-dihydroxy-2,2,4-trimethyl-6-(3-methylbutyl)anthra[9,1-de][1,3]oxazin-7(2H)-one (4), were isolated from a marine-derived Streptomyces spinoverrucosus based on activity in an image-based assay to identify epigenetic modifying compounds. The structures of 1-4 were elucidated by comprehensive NMR and MS spectroscopic analysis. Galvaquinone B (2) was ...
Xia Zhen - - 2012
Both urea and guanidinium chloride (GdmCl) are frequently used as protein denaturants. Given that, proteins generally adopt extended and/or unfolded conformations in either aqueous urea or GdmCl, one might expect that the unfolded protein chains will remain or become further extended due to the addition of another denaturant. However, a ...
Li Haiyan - - 2012
Two dimensional (2D) co-cultures of Human Bone Marrow Stromal Cells (HBMSCs) and Human Umbilical Vein Endothelial cells (HUVECs) stimulate osteoblastic differentiation of HBMSCs, induce the formation of self-assembled network and cell interactions between the two cell types involving many vascular molecules. Because of their strong activities on angiogenesis and tissue ...
Lu Zhongyang - - 2012
Although it has been reported that deficiency of toll-like receptor (TLR)4 is associated with reduced atherosclerosis in atherosclerosis-prone mice and attenuated pro-inflammatory state in diabetic mice, it remains undetermined if treatment with TLR4 antagonist reduces atherosclerosis in non-diabetic or diabetic mice that have TLR4 expression. In this study, we determined ...
Chen Ping P Department of Computer and Mathematical Sciences, University of Houston-Downtown, Houston, Texas, - - 2013
To build an effective co-reference resolution system tailored to the biomedical domain. Experimental materials used in this study were provided by the 2011 i2b2 Natural Language Processing Challenge. The 2011 i2b2 challenge involves co-reference resolution in medical documents. Concept mentions have been annotated in clinical texts, and the mentions that ...
Robertson Bradley D - - 2012
The first asymmetric total synthesis of the marine natural product apratoxin D, a highly potent inhibitor of H-460 human lung cancer cell growth (IC(50) value of 2.6 nM), is described. Asymmetric N-amino cyclic carbamate (ACC) α,α-bisalkylation was utilized to establish the isolated C-37 methyl group with excellent selectivity. Other key ...
Rosenberg Robert Evan - - 2012
Fluorinated organic compounds have become increasingly important in the pharmaceutical and agricultural industries. However, even the simplest aspects of these compounds is still not well understood. For instance, it is an open question as to whether fluoro-organics can form a hydrogen bond. To answer this question, this work compares the ...
Wang Xiaowen - - 2012
We investigated the relative contributions of temperature and a 300 kHz alternating magnetic field (AMF) on magnetic hyperthermia treatment (MHT). Our system consisted of an induction coil, which generated AMF by electric current flow, and a newly developed, temperature-controlled circulating water-jacketed glass bottle placed inside the coil. The AMF generator operated ...
Tajvidi Kameh - - 2012
Noble causes: Cellulose is effectively converted into methanol, propylene, and ethylene glycol over Cu-based catalysts. Overall yields of above 93 %, together with 63 % yield of C(1) -C(3) compounds, can be reached over simple noble-metal-free systems, opening new opportunities for the sustainable and cost-efficient valorization of cellulose.
Lo Chih-Ping - - 2012
High surface area SiO(2)-RuO(2) (SRO) supports with various SiO(2): RuO(2) ratios were synthesized using a wet chemical method. The supports were catalyzed by depositing platinum nanoparticles on their surface. The synthesized materials were characterized by XRD, TEM, BET, and linear sweep voltammetry to study microstructure and properties. The electrochemical stability, ...
Pieper H H - - 2012
The surface morphology of CeO(2)(111) single crystals and silicon supported ceria films is investigated by non-contact atomic force microscopy (NC-AFM) and Kelvin probe force microscopy (KPFM) for various annealing conditions. Annealing bulk samples at 1100 K results in small terraces with rounded ledges and steps with predominantly one O-Ce-O triple layer ...
Givaja Gonzalo - - 2012
Herein, we report the isolation of new heterobimetallic complexes [Ni(0.6) Pd(1.4) (EtCS(2) )(4) ] (1), [NiPt(EtCS(2) )(4) ] (2) and [Pd(0.4) Pt(1.6) (EtCS(2) )(4) ] (3), which were constructed by using transmetallation procedures. Subsequent oxidation with iodine furnished the MM'X monodimensional chains [Ni(0.6) Pt(1.4) (EtCS(2) )(4) I] (4) and [Ni(0.1) ...
El-Sayed Hany A - - 2012
Highly ordered dimpled Ta (DT) nanotemplates, prepared by electrochemical anodization of Ta, were recently reported to be ideally suited for the fabrication of a Au nanoparticle (NP) array using a Au thin film dewetting method. Here, we provide guidance and understanding of the effect of the DT fabrication and Au ...
Son Kyung Hun - - 2012
In this review, the evaluation methods for the screening of depigmenting substrates were investigated. For this purpose, the evaluation method of tyrosinase, a key-enzyme of melanin biosynthesis, is most frequently used, but evaluating methods based on the regulation of cellular signal transfer factors, or the inhibition of melanosome transfer have ...
Li Tingting - - 2012
The reactivity of the cubane-type rare-earth methylidene complex [Cp'Lu(μ(3) -CH(2) )](4) (1, Cp'=C(5) Me(4) SiMe(3) ) with various unsaturated electrophiles was investigated. The reaction of 1 with CO (1 atm) at room temperature gave the bis(ketene dianion)/dimethylidene complex [Cp'(4) Lu(4) (μ(3) -CH(2) )(2) (μ(3) ,η(2) -O-CCH(2) )(2) ] (2) in 86 % ...
Kritchenkov Andreii S - - 2012
Palladium(II)-coordinated NCR(1) (R(1) = Et (1), NMe(2) (2), Ph (3)) species react smoothly with acyclic nitrones such as the ketonitrones Ph(2)C═N(O)R(4) (R(4) = p-MeC(6)H(4) (4), p-ClC(6)H(4) (5)) and the aldonitrone p-MeC(6)H(4)CH═N(O)Me (6) in the corresponding nitrile media. This reaction proceeds as a consecutive two-step intermolecular cycloaddition to give the mono- ...
Li Wei W Department of Computer Science and Engineering, University of California, Riverside, Riverside CA 92507, USA. - - 2012
RNA-Seq uses the high-throughput sequencing technology to identify and quantify transcriptome at an unprecedented high resolution and low cost. However, RNA-Seq reads are usually not uniformly distributed and biases in RNA-Seq data post great challenges in many applications including transcriptome assembly and the expression level estimation of genes or isoforms. ...
Safdar Zeenat - - 2012
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling that limits the ability of the pulmonary vascular bed to withstand the physiological changes of pregnancy. Historically, pregnancy in PAH carries a high risk to the parturient. Normal pulmonary vasculature can withstand the hemodynamic and physiological changes associated with pregnancy ...
Galmés Jeroni - - 2012
In a previous study, important acclimation to water stress was observed in the Ramellet tomato cultivar (TR) from the Balearic Islands, related to an increase in the water use efficiency through modifications in both stomatal (g(s) ) and mesophyll conductances (g(m) ). In the present work, the comparison of physiological ...
Arai Yonbon - - 2012
Controlling the adsorption behavior of bulk-phase self-assembling dye molecules at solid/liquid interfaces is of importance for application to various devices. Herein, we report an unexpected phenomenon on the adsorption behaviors of bulk J-aggregating water-soluble porphyrin diacids. A comparative study on the adsorption amounts of J-aggregated meso-tetrakis(4-sulfonatophenyl)porphyrin diacid from freshly prepared ...
Raphael Shyni - - 2012
A new aromatic carboxylate ligand, 4-[4-(9H-carbazol-9-yl)butoxy]benzoic acid (HL), has been synthesized by the replacement of the hydroxyl hydrogen of 4-hydroxy benzoic acid with a 9-butyl-9H-carbazole moiety. The anion derived from HL has been used for the support of a series of lanthanide coordination compounds [Ln = Eu (), Gd () ...
Morath Ute - - 2012
Objective  To develop an ultrasound-guided technique for retrobulbar nerve block in horses, and to compare the distribution of three different volumes of injected contrast medium (CM) (4, 8 and 12 mL), with the hypothesis that successful placement of the needle within the retractor bulbi muscle cone would lead to the most ...
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