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Results 351 - 400 of 2501
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Singh Birdavinder - - 2012
This study investigates the beneficial role of lisinopril, an angiotensin converting enzyme inhibitor (ACEI) and telmisartan, an angiotensin receptor blocker (ARB), in intracerebroventricular (i.c.v.) streptozotocin (STZ) induced dementia of Alzheimer's disease (AD) type in mice. This study also aimed to explore the role of PPAR-γ in lisinopril and telmisartan mediated ...
DÄ…bkowska Maria - - 2012
Adsorption of human serum albumin (HSA) on mica from 0.15 M, NaCl solutions and various pH was studied using in situ streaming potential measurements, AFM imaging and XPS. Results obtained by streaming potential were consistent with AFM measurements and theoretical predictions based on the random sequential adsorption model. This allowed ...
Oi Maya M Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, - - 2013
Effective preselection of sex has been accomplished in several species of livestock and also in humans using the flow cytometric sperm sorting method. A guaranteed high sorting accuracy is a key prerequisite for the widespread use of sperm sexing. The standard validation method is flow cytometric remeasurement of the DNA ...
Sasaki Hisako - - 2012
Two new prenylated flavonoids (1, 4) and two new prenylated C-methyl-flavonoids (6, 7), together with four known flavonoids (2, 3, 5, 8), were isolated from the roots of Desmodium caudatum. The structures of the new compounds were elucidated by extensive spectroscopic analyses including 1D-, 2D-NMR and MS. The antifungal activities ...
Kennedy Carrie H - - 2012
Little data exist regarding the acute assessment of blast concussion and the course of recovery in the combat zone, as most research has examined service members long after they have returned home. This manuscript examined a case series of 377 service members seen for acute concussion evaluation following medical evacuation ...
Enoch Steven - - 2012
This study outlines how mechanistic organic chemistry related to covalent bond formation can be used to rationalise the ability of low molecular weight chemicals to cause respiratory sensitisation. The results of an analysis of 104 chemicals which have been reported to cause respiratory sensitisation in humans showed that most of ...
Sun Jing - - 2012
Background: Myopia is an important cause of correctable visual impairment worldwide. Both genetic and environmental factors contribute to its development. The population of Chinese university students consists of about 30 million young people characterized by academic excellence and similar ages. To date, little is known about their refractive status. Methods: ...
Jahn Reinhard - - 2012
Calcium-dependent exocytosis of synaptic vesicles mediates the release of neurotransmitters. Important proteins in this process have been identified such as the SNAREs, synaptotagmins, complexins, Munc18 and Munc13. Structural and functional studies have yielded a wealth of information about the physiological role of these proteins. However, it has been surprisingly difficult ...
Christiansen Erik - - 2012
Objective:To estimate the Danish epidemiological long-term incidence rates for suicide attempts in the general population of children and adolescents, and to analyze the impact from single and multiple risk factors on the risk of suicide attempts.Method:We used longitudinal register data from a total cohort of all individuals born between 1983 ...
Okello Francis Ogojo - - 2012
Poverty and limited availability of health facilities are major barriers to health care in resource-poor countries. For people living with HIV (PLHIV), these factors are compounded by social stigma and decreased mobility, making delivery of public health services a greater challenge. In 2003, the international development organization FHI (formerly known ...
Hetherington Lh - - 2012
Idiopathic environmental intolerance (IEI) is a medically unexplained disorder characterised by a wide variety of unspecific symptoms in different organ systems and attributed to nontoxic concentrations of chemicals and other environmental factors that are tolerated by the majority of individuals. Both exposure to chemicals and behavioural conditioning are considered as ...
Raghavan Vijay - - 2012
The sodium salts of amino acids with hydrophobic fluorenyl methyloxy carbonyl (FMOC) group and short alkyl side chains are found, to have surfactant properties. This was ascertained first through visual observation of concentration dependent solution behavior, and then confirmed by tensiometry measurements. The critical micelle concentrations (CMCs) for the sodium ...
Kuo W Y - - 2012
Iron superoxide dismutases (FeSODs; FSDs) are primary antioxidant enzymes in Arabidopsis thaliana chloroplasts. The stromal FSD1 conferred the only detectable FeSOD activity, whereas the thylakoid membrane- and nucleoid-co-localized FSD2 and FSD3 double mutant showed arrested chloroplast development. FeSOD requires cofactor Fe for its activity, but its mechanism of activation is ...
Wolfe Lynne A LA Undiagnosed Diseases Program, National Institutes of Health, 10 Center DR, MSC 1205, RM# 3-2551, Bethesda, MD 20892, USA. - - 2012
Dolichols, polyisoprene alcohols derived from the mevalonate pathway of cholesterol synthesis, serve as carriers of glycan precursors for the formation of oligosaccharides important in protein glycosylation. Seven autosomal-recessively inherited disorders in the metabolism (synthesis, utilization, recycling) of the dolichols have recently been described, and all are associated with decreased lipid-linked ...
Silva Ernesto - - 2012
Alveolar macrophages (AMs) are important for granuloma formation, which is the histological hallmark in sarcoidosis. Their function as antigen presenting cell in sarcoidosis is also believed to be relevant to the outcome of disease, resulting either in remission or a prolonged chronic inflammation in the lungs.To study alterations in the ...
Khabour Omar F - - 2012
Adiponectin is an adipokine involved in the regulation of body metabolism and immune response. Circulating levels and/or activity of adiponectin were reported to influence susceptibility to several diseases, including type 2 diabetes mellitus, cardiovascular disease, and metabolic syndrome. In this study, serum adiponectin levels and the association of adiponectin gene ...
Goyal Atul A Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, - - 2012
Endorepellin, the angiostatic C-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits angiogenesis by simultaneously binding to the α2β1 integrin and the vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) on endothelial cells. This interaction triggers the down-regulation of both receptors and the concurrent activation of the tyrosine phosphatase SHP-1, ...
Costa Edbhergue V L - - 2012
Magnetic fields (MF) can alter the dynamic behavior of vascular tissue and may have a stimulatory or inhibitory effect on blood vessel growth. Fractal geometry has been used in several studies as a tool to describe the development of blood vascular networks. Due to its self-similarity, irregularity, fractional dimension, and ...
Zarrinpar A - - 2012
Recent research has led to an interest in the role of the gut and liver in type 2 diabetes mellitus (T2DM). To review the role of the gastrointestinal system in glucose homoeostasis, with particular focus on the effects of incretin hormones, hepatic steatosis and bile acids. PubMed and Google Scholar ...
Wan Xiao Chloe XC School of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, - - 2012
Postoperative chemoradiation (CRT) has been shown to be more effective than postoperative radiotherapy (RT) alone in high risk head and neck squamous cell carcinoma (HNSCC) patients. Multimodality therapy is associated with more treatment related-toxicity. In this study, we assessed cervical lymph node histological characteristics to detect prognostic and predictive value ...
Haranath D - - 2012
We present a novel, cost-effective and facile technique, wherein multi-walled carbon nanotubes (CNTs) were used to transform a photoluminescent material to exhibit stable and efficient electroluminescence (EL) at low voltages. As a case study, a commercially available ZnS:Cu phosphor (P-22G having a quantum yield of 65 ± 5%) was combined with a ...
Jayne Christopher - - 2012
Hypoactive Sexual Desire Disorder (HSDD) is a common form of Female Sexual Dysfunction characterized by low sexual desire that causes distress or interpersonal difficulty. This 52-week open-label extension study aimed to assess the safety and tolerability of flibanserin, a postsynaptic 5-HT(1A) agonist/5-HT(2A) antagonist, in women with HSDD. Women with HSDD ...
Sheringham Jessica - - 2013
England has invested in chlamydia screening interventions for young people. It is not known whether young people in poorer socioeconomic circumstances (SEC) are at greater risk of chlamydia and therefore in greater need of screening. To conduct a systematic review examining socioeconomic variations in chlamydia prevalence or positivity in young ...
Sun Yu Y Department of Neurobiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, - - 2012
Parkin is recruited to defective mitochondria to promote degradation by an autophagy mechanism (mitophagy). VDACs specifically interact with Parkin on defective mitochondria and are required for efficient targeting of Parkin to mitochondria and subsequent mitophagy. VDACs recruit Parkin to defective mitochondria. A novel mechanistic aspect of Parkin-dependent mitophagy is proposed ...
Calabrese Ej - - 2012
This article offers a broad assessment of the hormetic dose response and its relevance to biomedical researchers, physicians, the pharmaceutical industry, and public health scientists. This article contains a series of 61 questions followed by relatively brief but referenced responses that provides support for the conclusion that hormesis is a ...
Yang Chia-Wei - - 2012
Abstract This case report describes a 63-year-old man initially diagnosed as having a 2.5-cm gastric adenomatous polyp with low-grade dysplasia. In contrast to using conventional knives for endoscopic submucosal dissection, the standard diathermic snare tip was used as an alternative knife for endoscopic submucosal dissection of the lesion with successful ...
Maeda Yutaka - - 2012
Introducing substituents onto SWNT sidewalls increases their solubility and tunes their properties. Controlling the degree of functionalization is important because the addition of numerous functional groups on the sidewall degrades their intrinsic useful electronic properties. We examined the synthesis and characterization of sidewall-functionalized SWNTs in this study. The functionalized SWNTs ...
Song T-J - - 2012
BACKGROUND AND PURPOSE: Cerebral microbleeds (CMBs) are extravasations of blood from lipohyalinized or amyloid angiopathic cerebral arterioles, and the presence and numbers of CMBs are significantly associated with the development of oral anticoagulation (OA)-related intracranial haemorrhage (ICH). The aim of this study was to investigate whether there is a difference ...
Hyde Melissa K - - 2013
People's decision to join an organ donor registry and have a discussion with family about their organ donation preference increases the likelihood that their family will consent to donation of their organs. This study explores the effectiveness of three interventions compared to a control condition to increase individual consent (registering ...
Cecchini Reena S RS NSABP Biostatistical Center, One Sterling Plaza, Pittsburgh, PA 15213, USA. - - 2012
Mammographic breast density is an established risk factor for breast cancer. However, results are inconclusive regarding its use in risk prediction models. The current study evaluated 13,409 postmenopausal participants in the NSABP Study of Tamoxifen and Raloxifene. A measure of breast density as reported on the entry mammogram report was ...
Kotecha Aachal - - 2012
Purpose: To examine postural stability in glaucoma patients and subjects with no ocular disease. Methods: Twenty four glaucoma (G) and 24 control (C) subjects participated (mean age [standard deviation] G: 65.9 [5.5] years) C: 68.3 [5.2] years). Postural stability was measured using a force balance platform under 4 conditions: eyes ...
Longo Dario Livio - - 2012
PURPOSE: To investigate in vivo possible pH level alterations following an acute renal failure disease using a MRI-CEST pH responsive contrast agent. The impact of functional evolution in different renal compartments over time was also investigated. METHODS: a mouse model of acute kidney injury was obtained by glycerol-induced rhabdomyolysis. pH ...
Franco Bagnoli - - 2012
Abstract Objectives: This study aims to determine whether or not treatment of preterm neonates with PDA using IV ibuprofen can impair renal function and in what range of birth weights and gestational ages the risk of major renal side-effects due to ibuprofen is highest. Methods: 134 preterm newborns with PDA ...
Skinner Jonathan R - - 2012
Roughly two thirds of resuscitated cardiac arrests in children and youth are due to inherited heart diseases. The most commonly implicated are the cardiac ion channelopathies long QT syndrome, CPVT (catecholaminergic polymorphic ventricular tachycardia) and Brugada syndrome. Diagnosis is pivotal to further management of the child if he/she survives, and ...
Verdejo-García Antonio - - 2012
Objective:High doses of opiate substitution pharmacotherapy are associated with greater treatment retention and lower illicit drug consumption, although the neurobiological bases of these benefits are poorly understood. Dysfunction of the anterior cingulate cortex (ACC) is associated with greater addiction severity and mood dysregulation in opiate users, such that the beneficial ...
Delavaran H - - 2012
BACKGROUND: Clinical stroke trials with stem cell-based approaches aiming for trophic actions, modulation of inflammation and neuroprotection are ongoing. However, experimental studies also suggest that neuronal replacement by grafted neural stem cells (NSCs) and possibly by endogenous NSCs from the subventricular zone (SVZ) may restore function in the stroke-damaged striatum. ...
Chen Jing - - 2012
This paper introduces a new approach called double asynchronous orthogonal sample design (DAOSD) to probe intermolecular interactions. Specifically designed concentration series are selected according to the mathematical analysis to generate useful 2D correlated spectra. As a result, the interfering portions are completely removed and a pair of complementary sub-2D asynchronous ...
Roy Mukherjee Tapasi - - 2012
ABSTRACT: BACKGROUND: During the pandemic [Influenza A(H1N1)pdm09] period in 2009-2010, an influenza A (Inf-A) virus with H1N2 subtype (designated as A/Eastern India/N-1289/2009) was detected from a 25 years old male from Mizoram (North-eastern India). OBJECTIVE: To characterize full genome of the H1N2 influenza virus. METHODS: For initial detection of Influenza ...
Sudha Govindan G Department of Biochemistry, Kongunadu Arts and Science College, Coimbatore 641 029, Tamil Nadu, India. - - 2012
Ripe and unripe exotic pepino fruit were evaluated for antioxidant activity, total phenols, and flavonoid content. The antioxidant potency was investigated by employing various established in vitro systems, such as 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2-2'-azinobis(3-ethylbenthiazoline-6-sulphonic acid (ABTS), hydroxyl radical scavenging, reducing power, ferrous ion chelation, ferric reducing antioxidant power (FRAP), and lipid ...
Ma Xiaoya - - 2012
The nervous system provides a fundamental source of data for understanding the evolutionary relationships between major arthropod groups. Fossil arthropods rarely preserve neural tissue. As a result, inferring sensory and motor attributes of Cambrian taxa has been limited to interpreting external features, such as compound eyes or sensilla decorating appendages, ...
Yoon Doo Sang - - 2012
Subcortical vascular mild cognitive impairment (svMCI), a prodromal stage of subcortical vascular dementia (SVaD), is primarily associated with frontal injuries, whereas amnestic MCI (aMCI) is associated with temporoparietal injuries. Twenty-seven patients with svMCI, 20 with aMCI, 14 with SVaD, and 10 normal controls underwent motor intentional tasks (force initiation, development, ...
Evans John Spencer - - 2012
MOTIVATION: The formation of aragonite mineral in the mollusk shell or pearl nacre requires the participation of a diverse set of proteins that form the mineralized extracellular matrix. Although self-assembly processes have been identified for several nacre proteins, these proteins do not contain known globular protein-protein binding domains. Thus, we ...
Perren Sonja S Jacobs Center for Productive Youth Development, University of Zürich, Switzerland. - - 2013
Evidence indicates that being a victim of bullying or peer aggression has negative short- and long-term consequences. In this study, we investigated the mediating and moderating role of two types of attributional mechanisms (hostile and self-blaming attributions) on children's maladjustment (externalizing and internalizing problems). In total, 478 children participated in ...
Zhou Tian-Biao - - 2012
BACKGROUND: and objective:The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk in IgA nephropathy (IgAN) patients is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and ESRD susceptibility in IgAN patients. METHOD: A predefined literature search ...
Yang Kai - - 2012
Owing to their unique physical and chemical properties, graphene and its derivatives such as graphene oxide (GO), reduced graphene oxide (RGO) and GO-nanocomposites have attracted tremendous interest in many different fields including biomedicine in recent years. With every atom exposed on its surface, single-layered graphene shows ultra-high surface area available ...
Rahman Rubina - - 2012
Cadmium zinc telluride (CdZnTe or CZT) is the leading semiconductor detector for gamma spectroscopy at room temperature. In the present study, a coplanar-grid CZT detector was used for gamma-ray measurements of environmental radioactivity on a contaminated saltmarsh sediment core in comparison with results from a coaxial high-purity germanium detector to ...
Chang Chi-Huang - - 2012
Antrodia cinnamomea has a diversity of therapeutic effects including anticancer properties. Its neuroprotective effect is rarely cited. We hypothesized that due to its high phenol, triterpenoid, and adenosine contents, it might exhibit a potent neuroprotective effect. The PC12 cell model was used to investigate its pharmaceutical effects. Congo red staining ...
Fan Jiangli - - 2012
This tutorial review presents some recent developments in the construction and applications of cassettes based on resonance energy transfer between fluorescent dyes in the visible and infrared region. We focused on the contributions of different connections between the energy donor and acceptor according to the "through-space" and "through-bond" methods, and ...
Van Damme Ilse - - 2012
Recent studies regarding the effect of mood on the DRM (Deese-Roediger-McDermott) illusion have not been able to clearly establish yet whether valence or arousal is most critical in determining susceptibility to false memories, nor what the underlying processes are. In three experiments, both the valence and the level of arousal ...
Gautier Elodie - - 2012
Intermittent hypoxia (IH), the main stimulus of obstructive sleep apnoea (OSA), induces inflammation, leading to early atherosclerosis. Whether the cyclooxygenase (COX) pathway contributes to IH-induced atherosclerosis remains to be determined.We studied the effects of 8 week-IH exposure on COX-pathway gene expression and atherosclerosis, and the influence of COX-1 inhibition by ...
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