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Results 251 - 300 of 2497
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Pei Chunying - - 2012
Abstract MSH6 (mutS homolog 6), one of the five key mismatch repair (MMR) genes, was found to play an important role in conferring resistance to alkylating agents - temozolomide (TMZ) in malignant glioma. This study aims to investigate whether genetic variations in MSH6 gene are associated with the survival outcomes ...
Shen Yongqing - - 2012
ABSTRACT: BACKGROUND: The histone H3K27 demethylases UTX and JMJD3 are important regulatory factors that modulate gene expression by altering the physical state of chromatin. Previous studies have indicated an abnormal H3K27 methylation status in carcinogenesis. We therefore investigated the expression patterns of UTX and JMJD3 in renal cell carcinoma (RCC) ...
Zhang Ben-Yan - - 2012
Formaldehyde is ubiquitous in the environment. It is known to be a genotoxic substance. We hypothesized that reactive oxygen species (ROS) and lipid peroxidation are involved in formaldehyde-induced genotoxicity in human lung cancer cell lines A549. To test this hypothesis, we investigated the effects of antioxidant on formaldehyde-induced genotoxicity in ...
Ogura M - - 2012
Electrical transport properties of (La(1-x)X(x))MnO(3) (X = Ca, Sr), which exhibits the so-called colossal magnetoresistance (CMR) effect, are investigated in the framework of linear response theory combined with first-principles calculation. The calculation is performed by applying the coherent potential approximation and Kubo-Greenwood formula to the KKR Green's function method. In order to ...
Lee Hee Jung - - 2012
The conjugation of Eu(3+) -doped coordination polymers constructed from Gd(3+) and isophthalic acid (H(2) IPA) with silica particles is investigated for the production of luminescent microspheres. A series of doping ratio-controlled silica@coordination polymer core-shell spheres is easily synthesized by altering the amounts of metal nodes used in the reactions, where ...
Medjakovic Svjetlana - - 2012
Pomegranate is an ancient fruit that is still part of the diet in the Mediterranean area, the Middle East, and India. Health-promoting effects have long been attributed to this fruit. Modern research corroborates the use of pomegranate as a folk remedy for diabetes and metabolic syndrome, and is responsible for ...
Ramseier C A - - 2012
Background and aim Dental professionals need adequate education in tobacco use prevention and cessation skills. The aim of this study was to identify the level of integration of tobacco education in undergraduate curricula of European dental schools.Method In 2009, a total of 197 European dental schools were identified through web-based ...
Ronikier M - - 2012
The arctic-alpine Ranunculus glacialis s. l. is distributed in high-mountain ranges of temperate Europe and in the North, where it displays an extreme disjunction between the North Atlantic Arctic and Beringia. Based on comprehensive sampling and employing plastid and nuclear marker systems, we (i) test whether the European/Beringian disjunction correlates ...
Li Zifu - - 2012
The formation of hierarchical porous protein scaffolds from oil-in-water (o/w) high internal phase emulsions (HIPEs) stabilized by bovine serum albumin (BSA) protein nanoparticles (Pickering HIPE) is reported. The route consists of three principal steps. First, a stable o/w HIPE stabilized by BSA protein nanoparticles is formulated. Next, crosslinking the dispersed ...
Li Hsiao-Juan - - 2012
AIM: To report a study of the effects of protein-energy malnutrition on the functional recovery of older people with hip fracture who participated in an interdisciplinary intervention. BACKGROUND: It is not clear whether protein-energy malnutrition is associated with worse functional outcomes or it affects the interdisciplinary intervention program on the ...
Waki Takamitsu - - 2012
Activation tagging is a powerful tool for discovering novel genes that are not easily identified by loss-of-function (lof) screening due to genetic redundancy or lethality. Although the current activation tagging system, which involves a viral enhancer sequence, has been used for a decade, alternative methods that allow organ- or tissue-specific ...
Palmans H - - 2012
In a recent paper (Bhullar and Watchman 2012 Phys. Med. Biol. 57 273-86), the authors comment on data concerning the effective depth of cylindrical ionization chambers in water for clinical proton beams calculated in a previous paper (Palmans 2006 Phys. Med. Biol. 51 3483-501) and propose different results. They present ...
Vakhshouri Kiarash - - 2012
We have examined the effects of crystallization kinetics of poly(3-hexylthiophene) and poly[2,5-bis(3-hexadecylthiophen-2-yl)thieno(3,2-b)thiophene] on microstructure and charge transport. Rapid crystallization increases the density of tie molecules in polythiophenes. As a consequence, ordered regions are better connected resulting in higher charge carrier mobilities. Our results suggest that controlling the crystallization kinetics might ...
Spofford Christopher M - - 2012
We report the case of a patient requiring gamma ventral capsulotomy (GVC), a neurosurgical intervention to address severe refractory obsessive-compulsive disorder (OCD). GVC involves stereotactic lesions in the ventral anterior limb of the internal capsule and adjacent ventral striatum. This study details the course of an extinction-based behavioral therapy, namely ...
Manousaki Tereza - - 2012
The study of parallel evolution facilitates the discovery of common rules of diversification. Here, we examine the repeated evolution of thick lips in Midas cichlid fishes (the Amphilophus citrinellus species complex)-from two Great Lakes and two crater lakes in Nicaragua-to assess whether similar changes in ecology, phenotypic trophic traits and ...
Schicher N - - 2012
Background  Uveal melanoma is the most common intraocular neoplasm with a high tendency to metastasize predominantly to the liver. Prognostic parameters for progression and overall survival are not well defined. The aim of this study was to assess the value of pretherapeutic serum levels of C-reactive protein (CRP), lactate dehydrogenase, ...
Park Crystal L - - 2012
OBJECTIVE: We investigated predictors of emotional (worry) and cognitive (perceived risk) dimensions of fear of recurrence (FOR) and their relationships with psychological well-being in a sample of young and middle-aged adult cancer survivors. METHODS: Eligible participants were survivors between 18 and 55 years old and diagnosed from 1 to 3 years prior. ...
Cumming Graeme S - - 2012
SUMMARY The relevance of spatial variation in the environment and host communities for parasite community composition is poorly documented, creating a need for additional case studies from which general principles can be developed. Avian malaria in southern African waterfowl has not previously been studied. As a first step towards documenting ...
Seymen Pinar - - 2012
Abstract: Objective. Acute ethanol intoxication has been shown to cause oxidative damage in many organ systems including the brain. Erythropoietin has antioxidant efffects and prevents neuronal damage in the animal model of ischemic brain injury. In this study, we aimed to investigate the effects of darbepoetin alpha, an analogue of ...
Shi Liang - - 2012
Noticeable differences between the vibrational (IR and Raman) spectra of neat H2O and D2O ice Ih are observed experimentally. Here we employ our theoretical mixed quantum/classical approach to investigate these differences. We find reasonable agreement between calculated and experimental line shapes at both high and low temperatures. From understanding the ...
Thuret Rodolphe - - 2012
What's known on the subject? and What does the study add? The European Association of Urology (EAU) guidelines recommend an inguinal lymph node dissection (ILND) in patients with T1G2-3 squamous cell carcinoma of the penis (SCCP). To date, only four series reported the rates of cancer-specific mortality (CSM) after primary ...
Yang Wenlong - - 2012
Brought to light: Ag(2) S-Ag hybrid nanotubes were synthesized by rapid microwave-assisted sulfidation of Ag(2) CO(3) nanorods. The relative amounts of Ag(2) S and Ag in the hybrid structure can be controlled easily by varying the concentration of the sulfur precursor. The optimized Ag(2) S-Ag hybrid structure has superior photocatalytic ...
Thomsen M - - 2012
We report how the three-dimensional structure of subcutaneous injections of soluble insulin can be visualized by x-ray computed tomography using an iodine based contrast agent. The injections investigated are performed ex vivo in porcine adipose tissue. Full tomography scans carried out at a laboratory x-ray source with a total acquisition ...
Cinel Neval A - - 2012
A highly tunable design for obtaining double resonance substrates to be used in surface-enhanced Raman spectroscopy is proposed. Tandem truncated nanocones composed of Au-SiO(2) -Au layers are designed, simulated and fabricated to obtain resonances at laser excitation and Stokes frequencies. Surface-enhanced Raman scattering experiments are conducted to compare the enhancements ...
Blasco-Costa Isabel - - 2012
SUMMARY Physical habitat structure can influence the distribution and abundance of organisms. In rivers, stream drift, a common process originating from the unidirectional water flow, favours the displacement and downstream dispersion of invertebrates. This process could also generate a gradient in infection levels, leading to decreasing numbers of parasites per ...
Mahler Benoit - - 2012
We have recently synthesized atomically flat semiconductor colloidal nanoplatelets with quasi 2D geometry. Here, we show that core/shell nanoplatelets can be obtained with a 2D geometry that is conserved. The epitaxial growth of the shell semiconductor is performed at room temperature. We report the detailed synthesis of CdSe/CdS and CdSe/CdZnS ...
Grossman Zachi - - 2012
AIM: To identify physician and visit characteristics affecting adherence to guidelines recommending delayed antibiotic therapy for acute otitis media (AOM). METHODS: We used physician visit data from an Israeli health maintenance organization to identify children ages 0-15 diagnosed with AOM. We defined early antibiotic treatment as purchase, within 3 days ...
Jiménez-Ruiz E - - 2012
SUMMARY Endogenous transplacental transmission (EnTT) of Neospora caninum is the most common route of infection in cattle and occurs as a consequence of a reactivation of N. caninum infection that may lead to abortion or to the birth of congenitally infected calves. The reactivation of N. caninum infection was studied ...
Valadas Jorge S - - 2012
In situations of hypoxia, glutamate excitotoxicity induces neuronal death. The release of extracellular adenosine is also triggered and is accompanied by an increase of the stress mediator, corticotrophin-releasing factor (CRF). Adenosine A(2A) receptors contribute to glutamate excitoxicity and their blockade is effective in stress-induced neuronal deficits, but the involvement of ...
Artini Marco - - 2012
AIMS: The purpose of this study was to evaluate the antimicrobial efficacy of five different proteases belonging to two different families on S. aureus and S. epidermidis strains. METHODS AND RESULTS: We used three serine proteases and two metalloproteases in single species biofilm formation assays and in human cell invasion ...
Veen Mario - - 2012
Although it is recognised that a gluten-free diet has many social implications for coeliac disease patients, not much is known about how such patients actually manage these implications in their everyday interactions. This article examines how dietary restrictions are treated by patients and their families. Data from recorded mealtime conversations ...
Sun Xiaolian - - 2012
Dumbbell-like Pt(48) Pd(52) -Fe(3) O(4) nanoparticles are synthesized and functionalized with oleylamine-polyethyleneglycol to serve as an efficient catalyst for H(2) O(2) reduction and tetramethylbenzidine (TMB) oxidation in biological solutions. The Pt(48) Pd(52) -Fe(3) O(4) /TMB kit is even more active than the natural enzyme for H(2) O(2) detection with a ...
Via Sara - - 2012
Populations that maintain phenotypic divergence in sympatry typically show a mosaic pattern of genomic divergence, requiring a corresponding mosaic of genomic isolation (reduced gene flow). However, mechanisms that could produce the genomic isolation required for divergence-with-gene-flow have barely been explored, apart from the traditional localized effects of selection and reduced ...
Miles Gareth E - - 2012
There is evidence that knowledge about space will reflect the details of how that space is experienced and how people interact with it. In two experiments we demonstrate that memory for items is spatially structured after their locations were learnt in a desktop virtual environment (DVE). The structure was measured ...
Mehretie Solomon - - 2012
An iron(iii) doped zeolite modified glassy carbon electrode was constructed for the determination of pyridine-2-aldoxime methochloride. X-ray diffraction and chemical analysis were utilized to determine the optimum pH and chemical content for doping zeolite. Cyclic voltammetry was used to characterize the modified electrode and study the kinetics of the acid ...
Priddis Holly - - 2012
AIMS: This article presents a meta-ethnographic synthesis of studies on women's experiences of sustaining a third or fourth degree tear during childbirth. BACKGROUND: It has been reported that for women who sustain third or fourth degree perineal tears (severe perineal trauma) some may experience extensive physical and psychological outcomes. DESIGN: ...
Alvarez M - - 2012
The main goal of this work was to develop a methodology for the computed analysis of American College of Radiology (ACR) mammographic phantom images, to be used in a quality control (QC) program of mammographic services. Discrete wavelet transform processing was applied to enhance the quality of images from the ...
Coffinier Yannick - - 2012
In this paper, we report on the functionalization of silicon nanostructured (NanoSi) surface with an organic layer of nitrilotriacetic acid (NTA) and its subsequent use as an affinity surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) interface for histidine-tagged peptide enrichment and mass spectrometry analysis. The NTA terminal groups are immobilized onto ...
Reznik Nikita - - 2012
Droplets of liquid perfluorocarbon (PFC) are under study as the next generation of contrast agents for ultrasound (US). These droplets can be selectively vaporized into echogenic gas bubbles in situ by externally applied US, with numerous applications to diagnosis and therapy. However, little is known about the mechanisms of droplet ...
Lee Hyeongjin - - 2012
A new cell-printed scaffold consisting of poly(ϵ-caprolactone) (PCL) and cell-embedded alginate struts is designed. The PCL and alginate struts are stacked in an interdigitated pattern in successive layers to acquire a three-dimensional (3D) shape. The hybrid scaffold exhibits a two-phase structure consisting of cell (MC3T3-E1)-laden alginate struts able to support ...
Alves Hm - - 2012
This study aimed to evaluate various concentrations of egg yolk (5, 10, or 20%) in combination with different concentrations of glycerol (3% or 6%) added to a Tris-based extender on the post-thaw characteristics of sperm obtained from Tayassu tajacu. For this purpose, semen from 10 sexually male mature collared peccaries ...
Thompson J M - - 2012
AIMS: To investigate the presence of methicillin-resistant Staphylococcus aureus (MRSA) in untreated hospital wastewaters (UHWW), their transmission into the receiving sewage treatment plant (STP) and survival through the STP treatment. METHODS AND RESULTS: Over 8 consecutive weeks of sampling we isolated 224 S. aureus strains from UHWW-1, UHWW-2 and its ...
Mughal M Akhlaq - - 2012
Hydralazine hydrochloride is an antihypertensive used alone or in combination with isosorbide nitrate for the treatment of congestive heart failure. Since control of blood pressure should be continuous, sustained release delivery of this drug is considered therapeutically beneficial. Core beads for oral administration of this drug were prepared by extrusion-spheronization. ...
Liu Fuqiang - - 2013
Common variations in the gene with no-lysine kinase 1 (WNK1) are associated with hypertension, but because of gene-environment interaction, it is difficult to fully identify the genetic contribution of WNK1 gene polymorphism to blood pressure (BP) variability. The aim of this study was to identify the effect of common WNK1 ...
Yan Jia - - 2012
In marine oxygen minimum zones (OMZs), ammonia-oxidizing archaea (AOA) rather than marine ammonia-oxidizing bacteria (AOB) may provide nitrite to anaerobic ammonium-oxidizing (anammox) bacteria. Here we demonstrate the cooperation between marine anammox bacteria and nitrifiers in a laboratory-scale model system under oxygen limitation. A bioreactor containing 'Candidatus Scalindua profunda' marine anammox ...
Bryant Daniel M - - 2012
To assess global and regional brain matter variations associated with XYY syndrome by comparison with Klinefelter syndrome and typical development. We used two conceptually distinct voxel-based magnetic resonance imaging methods to examine brain structure in young males with XYY syndrome: (1) volumetric comparison to assess global grey and white matter ...
Oestreich Kenneth J - - 2012
There is an emerging body of research demonstrating that the co-expression of key lineage-specifying transcription factors, commonly referred to as 'master regulators', affects the functional capabilities and flexibility of CD4(+) T cell subsets. Here, we discuss how the natural co-expression of these lineage-specifying transcription factors has challenged the concept that ...
Suresh P S - - 2013
A highly sensitive and rapid bioanalytical method has been developed and validated for the estimation of indomethacin in rat plasma with liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the positive-ion mode. The assay procedure involves a simple liquid-liquid extraction of indomethacin and phenacetin (internal standard, IS) ...
Shultz Leonard D - - 2012
Significant advances in our understanding of the in vivo functions of human cells and tissues and the human immune system have resulted from the development of 'humanized' mouse strains that are based on severely immunodeficient mice with mutations in the interleukin-2 receptor common γ-chain locus. These mouse strains support the ...
Enriquez G F - - 2013
The discrete typing units (DTUs) of Trypanosoma cruzi that infect domestic dogs and cats have rarely been studied. With this purpose we conducted a cross-sectional xenodiagnostic survey of dog and cat populations residing in 2 infested rural villages in Pampa del Indio, in the humid Argentine Chaco. Parasites were isolated ...
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