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Results 201 - 250 of 2497
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Worrell Brady T - - 2012
A good exchange: 5-Iodo-1,2,3-triazoles undergo facile substitution reactions with fluoride salts, thus providing ready access to 5-fluorotriazoles. The latter can be further elaborated with various nucleophiles to furnish fully substituted 1,2,3-triazole compounds.
Hickey Noelene - - 2012
AIM: To report a study that investigated the career development, aspirations, and choices of undergraduate students and graduates of nursing double degree programmes. BACKGROUND: Over one-third of Australian undergraduate nursing students study by double degree mode. Their career destinations will have an impact on the availability of graduates in a ...
Chalkias Athanasios - - 2012
To the Editor: We have read with great interest the excellent article by Wold et al. which has been published in the latest issue of Acta Physiologica (Wold et al. 2012). The authors concluded that the cardiac contractile dysfunction after rewarming is explained not only by the aggravation of calcium ...
Andersson Jonas - - 2012
Radiation dosimetry of highly modulated dose distributions requires a detector with a high spatial resolution. Liquid filled ionization chambers (LICs) have the potential to become a valuable tool for the characterization of such radiation fields. However, the effect of an increased recombination of the charge carriers, as compared to using ...
Wagenaar Alfred F - - 2012
Objectives: Changes in employment contracts may impact the quality of working life, job insecurity, health and work-related attitudes. We examined the validity of two partly competing theoretical approaches. Based upon a segmentation approach, we expected no change in scores among stable trajectories, whereas upward trajectories were expected to be for ...
Brenner M K - - 2012
Cellular therapies for cancer are showing increasing efficacy but their introduction as a 'standard of care' for these disorders is hampered by technical, regulatory and financial concerns. This review identifies some of the major problems and suggests potential solutions.Cancer Gene Therapy advance online publication, 12 October 2012; doi:10.1038/cgt.2012.74.
Alam Anwar - - 2012
Abstract Addition of poly-dispersed acid functionalized Single-walled Carbon Nanotubes (AF-SWCNTs) significantly suppressed allo-immune cytotoxic T cell (CTL) response generated in a mixed lymphocyte reaction (MLR) between spleen cells from C57Bl/6 (H-2b) and BALB/c (H-2d) mice. AF-SWCNTs treatment also decreased the expression CD69 expression, enhanced apoptotic response in T cells and ...
Ohuchi Hideo - - 2012
Background: Maternal New York Heart Association (NYHA) class is associated with pregnancy outcome in women with congenital heart disease (WCHD), but objective predictive criteria of exercise capacity have not been established. Methods and Results: A total of 33 WCHD (age, 28±5 years; NYHA class, 1.3±0.6) who had undergone cardiopulmonary exercise testing (CPX) ...
Chime Salome Amarachi - - 2012
Objective: To formulate sustained-release diclofenac potassium-loaded solid lipid microparticles (SLMs) based on solidified reverse micellar solution (SRMS) and to evaluate the in vitro and in vivo properties. Methods: SRMS consisting of mixtures of Phospholipon® 90H and Softisan® 154 were used to formulate diclofenac potassium-loaded SLMs. Characterization based on the particle size and ...
Schure R - - 2012
BACKGROUND AND OBJECTIVE: Human subjects affected by inflammatory diseases, such as periodontitis, may be at increased risk for the development of cardiovascular diseases and calcification of atheromas; however, the potential mechanisms have not been defined. Alpha-2-Heremans Schmid glycoprotein (fetuin A) is an abundant serum glycoprotein of ~49 kDa that inhibits ectopic ...
Seo Hwi Won - - 2012
This study was to compare the degree of cell-mediated immunity induced by three commercial Mycoplasma hyopneumoniae bacterins using interferon-γ (IFN-γ) measurements, lymphocyte stimulation assays, and delayed-type hypersensitivity tests. Serum IFN-γ levels were significantly elevated in all four vaccinated pig groups at 21 days post-vaccination (P<0.05). Lymphocytes isolated 21 days post-vaccination ...
Schmitt V - - 2012
Bismuth sodium titanate (Bi(0.5)Na(0.5))TiO(3) (BNT) is considered to be one of the most promising lead-free alternatives to piezoelectric lead zirconate titanate (PZT). However, the effect of dopants on the material has so far received little attention from an atomic point of view. In this study we investigated the effects of ...
McCord F - - 2012
Although more people are retaining increasing numbers of their natural teeth into older ages, approximately 30-40% of persons over the age of 75 years in Western countries are edentulous. The causes and significance of tooth loss vary widely among individuals and cultures, and missing teeth may be replaced by a ...
Mosca E - - 2012
Climate is one of the most important drivers of local adaptation in forest tree species. Standing levels of genetic diversity and structure within and among natural populations of forest trees are determined by the interplay between climatic heterogeneity and the balance between selection and gene flow. To investigate this interplay, ...
Ishizuka Tomohito - - 2012
Anesthetic and cardio-respiratory effects of medetomidine, lidocaine, butorphanol and propofol total intravenous anesthesia (MLBP-TIVA) were evaluated in horses undergoing an experimental surgery. Ten horses were pre-medicated with an intravenous injection (IV) of medetomidine (5 μg/kg) and butorphanol (20 μg/kg). Anesthesia was induced by administration of 1% propofol (3 mg/kg, IV) ...
Mettenleiter Thomas C - - 2012
Herpesvirus capsids are assembled in the nucleus of infected cells whereas final maturation occurs in the cytosol. To access the final maturation compartment, intranuclear capsids have to cross the nuclear envelope which represents a formidable barrier. They do so by budding at the inner nuclear membrane, thereby forming a primary ...
Gao Xue - - 2012
This paper describes a novel, simple method for the highly sensitive and selective detection of thrombin using fibrinogen (Fib) and CuInS(2) quantum dots (QDs) as biosensing probes. Water-soluble near-infrared CuInS(2) QDs capped by mercaptopropionic acid (MPA) were directly synthesized by a hydrothermal method. Addition of fibrinogen to the CuInS(2) QDs ...
Zakas Christina - - 2012
In many species, alternative developmental pathways lead to the production of two distinct phenotypes, promoting the evolution of morphological novelty and diversification. Offspring type in marine invertebrates influences transport time by ocean currents, which dictate dispersal potential and gene flow, and thus has sweeping evolutionary effects on the potential for ...
Chang Yung-Huang - - 2012
A three-dimensional Ni foam deposited with graphene layers on surfaces is used as a conducting solid support to load MoS(x) catalysts for electrocatalytic hydrogen evolution. The graphene sheets grown on Ni foams provide robust protection and efficiently increase the stability in acid. The superior performance of hydrogen evolution is attributed ...
Jang Tae-Won - - 2012
Objectives: This study aimed to investigate changes in the smoking rate among Korean adults from 1998-2009 by gender and occupational groups. Methods: Using the data from the first (1998), second (2001), third (2005) and fourth (2009) waves of the Korean National Health and Nutrition Examination Survey (KNHANES), we examined men ...
Intartaglia Romuald - - 2012
Ultra small silicon nanoparticles (Si-NPs) with narrow size distribution are prepared in a one step process by UV picosecond laser ablation of silicon bulk in liquid. Characterization by electron microscopy and absorption spectroscopy proves Si-NPs generation with an average size of 2 nm resulting from an in situ photofragmentation effect. ...
Li X - - 2012
BACKGROUND AND OBJECTIVE: Adipocyte fatty acid-binding protein (A-FABP) is expressed in adipocytes, macrophages and microvascular endothelial cells, and it plays a central role in inflammation, atherosclerosis and metabolic responses. This pilot study investigated the effect of nonsurgical periodontal therapy on the serum levels of A-FABP in subjects with chronic periodontitis. ...
Hagemeister Fredrick B - - 2012
Observation until the development of symptoms, or 'watch and wait', has long been a proposed management technique for patients with indolent lymphomas. However, investigators have found that there may be differences in outcomes for various patient groups according to histopathology, clinical features of the disease, biologic factors as yet to ...
Pantic Igor - - 2012
Despite recent advances in hematopoietic tissue research, effects of aging on hematopoietic erythroid precursor (EP) cells are unclear. In this article we present results suggesting that chromatin textural entropy of EP cells in mouse spleen increases with age, while chromatin homogeneity decreases. The experiment was conducted on a total of ...
Saeheng Suwadee - - 2012
Background: To investigate the relationship between dermatopharmacokinetic (DPK) tape stripping from in vitro and in vivo using 1% terbinafine hydrochloride topical cream as the model formulation. Methodology: In vitro and in vivo tape strippings were conducted on separated pig ear skin used as a biological membrane for franz diffusion cell ...
Lee Hee Jin - - 2012
Colorectal micropapillary carcinoma has recently been reported as an aggressive variant of adenocarcinoma with a high incidence of lymph node metastasis, but has not been well investigated in terms of survival analysis. This study analyzed the clinicopathological characteristics, including survival data, of the patients with micropapillary carcinoma. We hypothesized that ...
Varghese Shinto - - 2012
Three-in-one: A novel distyrylbenzene-based material forms J-type aggregates in single crystals with highly polarized and bright red emission, giving rise to optical gain narrowing, for which different mechanisms (amplified spontaneous emission, laser emission and stimulated resonance Raman scattering) are observed. These are correlated with the favorable intrinsic and macroscopic properties ...
Hoshida Kyoko - - 2012
Background: T-wave alternans based on the modified moving average method (MMA-TWA) and heart rate turbulence (HRT) have been introduced as predictors for cardiac mortality. In this study, we simultaneously recorded MMA-TWA and HRT in patients after myocardial infarction (MI) and designed a prospective observational study. Methods and Results: We prospectively enrolled 313 ...
Ou-Yang Mei-Chen - - 2012
AIM: To determine if expressed breast milk (milk) reduces procedural pain associated with heel lancing in preterm neonates. METHODS: In this placebo-controlled trial, preterm neonates received 5 mL of distilled water as placebo (water, n = 44), 25% glucose water (glucose, n = 39), or milk (n = 40). Heel ...
Archambault Louis - - 2012
The aim of this paper is to generalize and extend the mathematical formalism used with plastic scintillation detectors (PSDs). By doing so, we show the feasibility of multi-point PSD. The new formalism is based on the sole hypothesis that a PSD optical signal is a linear superposition of spectra. Two ...
Lipkovich Ilya - - 2012
Assessing dose response from flexible-dose clinical trials is problematic. The true dose effect may be obscured and even reversed in observed data because dose is related to both previous and subsequent outcomes. To remove selection bias, we propose marginal structural models, inverse probability of treatment-weighting (IPTW) methodology. Potential clinical outcomes ...
Veit Michael - - 2012
Influenza virus is thought to assemble in raft-domains of the plasma membrane, but many of the conclusions were based on (controversial) Triton-extraction experiments. Here we review how sophisticated methods of fluorescence microscopy, such as FPALM, FRET and FRAP, contributed to our understanding of lipid domain association of the viral proteins ...
Sato Hirofumi - - 2012
The valence electronic states of thiophene (TP), 2-thiophenethiol (TT), 2,2'-bithiophene (BTP), and 2,2'-bithiophene-5-thiol (BTT) on Pt(111) were measured by ultraviolet photoemission spectroscopy (UPS) and metastable atom electron spectroscopy (MAES) to elucidate how the local electronic properties at the organic-metal interface are altered by the extent of π-conjugation and substituent effects. ...
Zhang Wenjun - - 2012
Two new polyfluorenes with dipicolylamine (DPA) pendant, PF-TDPA and PF-HDPA, are designed and synthesized by pre- and post-functionalization, respectively. PF-TDPA with a rigid side chain shows a selective fluorescence quenching upon the addition of Cu(2+) in a mixture solution of tetrahydrofuran and 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) buffer. What is more, the ...
Whyte Sophie - - 2012
The National Institute for Health and Clinical Excellence (NICE) invited the manufacturer of bevacizumab (Roche Products) to submit evidence for the clinical and cost effectiveness of this drug for the treatment of patients with metastatic colorectal cancer (mCRC), as part of the Institute's Single Technology Appraisal (STA) process. The School ...
Prado Anselmo Del - - 2012
In this work the activation of transparent PS substrates by chlorosulfonation is described and their distribution in the subsurface region is analyzed. For this purpose XPS, FTIR-ATR and colorimetry have been used. It is shown that the electrophilic aromatic substitution of polystyrene in pure chlorosulfonic acid is extremely quick with ...
Abdulmalic Mohammad A - - 2012
Treatment of the diethyl ester of o-phenylenebis(oxamic acid) (opbaH(2)Et(2), ) with 5/6 equivalent of MeNH(2) in abs. EtOH results in the exclusive formation of the ethyl ester of o-phenylene(N'-methyl oxamide)(oxamic acid) (opooH(3)EtMe, ) in ca. 50% yield. Treatment of with four equivalents of [Me(4)N]OH followed by the addition of Cu(ClO(4))(2)·6H(2)O ...
Wagner Catherine E - - 2012
Although population genomic studies using next generation sequencing (NGS) data are becoming increasingly common, studies focusing on phylogenetic inference using these data are in their infancy. Here, we use NGS data generated from reduced representation genomic libraries of restriction-site-associated DNA (RAD) markers to infer phylogenetic relationships among 16 species of ...
Zhang Lu - - 2012
Multifunctional magnetic/upconversion luminescent mesoparticles, consisting of a Fe(3)O(4) nanoparticle core and a LaF(3):Yb(3+), Er(3+) nanocrystal shell, have been developed using a facile co-precipitation approach. Owing to their excellent superparamagnetic properties, superior T(2)-enhanced magnetic resonance effect and strong upconversion emissions, the as-formed mesoparticles have great potential in diverse medical diagnostics and ...
Maslanka Tomasz - - 2012
The aim of the undertaken research was to determine whether Foxp3(+)CD25(+)CD8(+) cells exist in cattle and whether Foxp3 expression in CD8(+) T cells is correlated with the intensity of CD25 expression. It has been found that 0.66 and 2.36% of CD8(+) cells on average showed high and low expression of ...
Massie Crystal L - - 2012
Abstract Stimulus-response curves (SRC) provide information about the neurophysiological strength of corticospinal connections. The method for measuring and/or drawing meaningful conclusions of SRCs has not been well-established in the stroke population. This study sought to characterize the use of an abbreviated SRC in stroke by comparing two data collection and ...
Cuartero V - - 2012
The structural, electronic and magnetic properties of TbMn(1-x)Co(x)O(3) (0.1 ≤ x ≤ 0.9) compounds are reported. The samples are isostructural to TbMnO(3) adopting the orthorhombic distorted perovskite structure (Pbnm), except for x = 0.4, 0.5 and 0.6, where an ordered double perovskite structure (P2(1)/n) is found. X-ray absorption spectra at the Mn and Co K edges ...
Amadi Hippolite O - - 2012
An accurate diagnosis of glenohumeral joint (GHJ) instability is essential for an effective surgical intervention. There is presently no known comprehensive algorithm of clinical tests for the confirmation of the functional integrity of glenohumeral ligaments (GHLs). A validated computational GHL strain analyser was applied to a set of GHJ kinematics ...
Larson David J - - 2012
The ability to accurately reconstruct original spatial positions of field-evaporated ions emitted from a surface is fundamental to the success of atom probe tomography. As such, a clear understanding of the evolution of specimen shape and the resultant ions' trajectories during field evaporation plays an important role in improving reconstruction ...
Cupera Jakub - - 2012
The aim is to determine how well the rate parameter of the homogeneous model of dissolution can be estimated in dependency on the chosen times to measure the empirical data. The approach is based on the theory of Fisher information. We show that if the probability distribution of the measurement ...
Saboonchi Fredrik - - 2012
BACKGROUND: The syndrome of exhaustion is currently a medical diagnosis in Sweden. The description of the syndrome largely corresponds to the suggested core component of burnout, that is exhaustion. Karolinska Exhaustion Scale (KES) has been constructed to provide specific assessment of exhaustion in clinical and research settings. AIM: The purpose ...
Coutinho Eduardo - - 2012
There is strong evidence of shared acoustic profiles common to the expression of emotions in music and speech, yet relatively limited understanding of the specific psychoacoustic features involved. This study combined a controlled experiment and computational modelling to investigate the perceptual codes associated with the expression of emotion in the ...
Lee Eun Mi - - 2012
We conducted a phase II study of preoperative chemoradiation (CRT) with S-1 plus oxaliplatin in patients with locally advanced rectal cancer. The total radiotherapy dose was 50.4 Gy. Chemotherapy consisted of oxaliplatin 50 mg/m(2) on day 1, 8, 22 and 29, and S-1 80 mg/m(2) /day on day 1-14 and ...
Zhao Yang - - 2012
Graphene lite: A density of (2.1±0.3) mg cm(-3) , the lowest to date for a graphene framework architecture, is achieved by preparing an ultralight, N-doped, 3D graphene framework (see photo of a block of the material balancing on a dandelion). Its adsorption capacity for oils and organic solvents is much higher ...
Liu Yu - - 2012
A molecular thermodynamic model is developed to examine crowding effect on DNA melting. Each pair of nucleotides in double-stranded DNA and each nucleotide in single-stranded DNA are represented by two types of charged Lennard-Jones segments, respectively. Water molecules are mimicked explicitly as spherical particles, embedded in a dielectric continuum. Crowders ...
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