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Luk N M - - 2012
Background  Topical immunotherapy has recently been found useful in the treatment of chronic and extensive Alopecia Areata (AA). Objective  To evaluate the efficacy and safety of diphenylcyclopropenone (DPCP) use among Chinese patients with steroid resistant and extensive AA in our institute. Methods  The medical records of 31 Chinese patients treated ...
Ma Yadi - - 2012
The interaction of indigo carmine (IC) with calf thymus DNA in physiological buffer (pH 7.4), using ethidium bromide (EB) dye as a fluorescence probe, was investigated by UV-vis absorption, fluorescence and circular dichroism (CD) spectroscopy, coupled with viscosity measurements and DNA melting studies. Hypochromicity of the absorption spectra of IC ...
Ma Averil A Department of Medicine, University of California, San Francisco, California 94143-0451, USA. - - 2012
A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts multiple intracellular signalling cascades. Recent studies in three general areas have converged to highlight the clinical and biological importance of A20. First, human genetic studies have strongly linked polymorphisms and mutations in the gene encoding A20 to ...
Bonacucina Giulia - - 2012
Context: Mixtures made of oil, water and surfactants give rise to a wide range of structure with different characteristics and phase manifestations. Objective: Aim of this paper is to build up and understand the phase diagram of a model ternary system (Water, Polysorbate 80 and isopropyl myristate) by the use ...
Laffleur Flavia - - 2012
The objective of this study was to evaluate the biodegradability of thiolated chitosans in comparison to unmodified chitosan. Mediated by carbodiimide, thioglycolic acid (TGA) and mercaptonicotinic acid (MNA) were covalently attached to chitosan via formation an amide bond. Applying two different concentrations of carbodiimide 50 and 100 mM, two chitosan TGA ...
Coffinier Yannick - - 2012
In this paper, we report on the functionalization of silicon nanostructured (NanoSi) surface with an organic layer of nitrilotriacetic acid (NTA) and its subsequent use as an affinity surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) interface for histidine-tagged peptide enrichment and mass spectrometry analysis. The NTA terminal groups are immobilized onto ...
Reznik Nikita - - 2012
Droplets of liquid perfluorocarbon (PFC) are under study as the next generation of contrast agents for ultrasound (US). These droplets can be selectively vaporized into echogenic gas bubbles in situ by externally applied US, with numerous applications to diagnosis and therapy. However, little is known about the mechanisms of droplet ...
Lee Hyeongjin - - 2012
A new cell-printed scaffold consisting of poly(ϵ-caprolactone) (PCL) and cell-embedded alginate struts is designed. The PCL and alginate struts are stacked in an interdigitated pattern in successive layers to acquire a three-dimensional (3D) shape. The hybrid scaffold exhibits a two-phase structure consisting of cell (MC3T3-E1)-laden alginate struts able to support ...
Morón María Carmen - - 2012
Water plays a fundamental function in life and technology. To gain a deeper knowledge to the problem of the hydration of biomolecules, the dynamics of water around an 89-residue protein of interest in molecular recognition, cancer cell research and amyloid fibrils investigations is analyzed. The biomolecule is the ribonuclease inhibitor ...
Zhu Shi-Dan - - 2012
It is important to understand the eco-physiological characters of plants when exploring mechanisms underlying species substitution in the process of plant succession. In the present study, we selected 34 woody species from different stages of secondary succession in subtropical forests of southern China, and measured their hydraulic conductivity, gas exchange ...
Skog Amanda - - 2012
OBJECTIVE: To define factors influencing neurodevelopment in children with and without complete congenital heart block (CHB) born to mothers with Ro/SSA autoantibodies. PATIENTS AND METHODS: Medical records of a population-based cohort of siblings with (n=60) and without (n=54) CHB born 1974-2009 to anti-Ro/SSA positive mothers were retrieved from children primary ...
Maslanka Tomasz - - 2012
The aim of the undertaken research was to determine whether Foxp3(+)CD25(+)CD8(+) cells exist in cattle and whether Foxp3 expression in CD8(+) T cells is correlated with the intensity of CD25 expression. It has been found that 0.66 and 2.36% of CD8(+) cells on average showed high and low expression of ...
Massie Crystal L - - 2012
Abstract Stimulus-response curves (SRC) provide information about the neurophysiological strength of corticospinal connections. The method for measuring and/or drawing meaningful conclusions of SRCs has not been well-established in the stroke population. This study sought to characterize the use of an abbreviated SRC in stroke by comparing two data collection and ...
Cuartero V - - 2012
The structural, electronic and magnetic properties of TbMn(1-x)Co(x)O(3) (0.1 ≤ x ≤ 0.9) compounds are reported. The samples are isostructural to TbMnO(3) adopting the orthorhombic distorted perovskite structure (Pbnm), except for x = 0.4, 0.5 and 0.6, where an ordered double perovskite structure (P2(1)/n) is found. X-ray absorption spectra at the Mn and Co K edges ...
Amadi Hippolite O - - 2012
An accurate diagnosis of glenohumeral joint (GHJ) instability is essential for an effective surgical intervention. There is presently no known comprehensive algorithm of clinical tests for the confirmation of the functional integrity of glenohumeral ligaments (GHLs). A validated computational GHL strain analyser was applied to a set of GHJ kinematics ...
Via Sara - - 2012
Populations that maintain phenotypic divergence in sympatry typically show a mosaic pattern of genomic divergence, requiring a corresponding mosaic of genomic isolation (reduced gene flow). However, mechanisms that could produce the genomic isolation required for divergence-with-gene-flow have barely been explored, apart from the traditional localized effects of selection and reduced ...
Miles Gareth E - - 2012
There is evidence that knowledge about space will reflect the details of how that space is experienced and how people interact with it. In two experiments we demonstrate that memory for items is spatially structured after their locations were learnt in a desktop virtual environment (DVE). The structure was measured ...
Parker Kathrine - - 2012
Background: We evaluated current oral anticoagulant management at our main dialysis unit and three satellite units against British Haematology Society (BHS) standards. These standards include patients meeting their target INR 60.5 INR units for 60% of the time with an appropriate frequency of monitoring. Methods: Data were collected on anticoagulant ...
Smit P - - 2012
The objective of this paper is to answer the clinical question whether the location of the lesion in an individual patient with actinic keratosis (AK) influences the absolute risk of the development of skin cancer. Between 0.025% and 16% of AK lesions advance towards squamous cell carcinoma per year. It ...
Comakli Veysel - - 2012
Glutathione S-transferase enzyme (GST) (EC 2.5.1.18) was purified from rainbow trout erythrocytes, and some characteristics of the enzyme and effects of some metal ions on enzyme activity were investigated. For this purpose, erythrocyte glutathione S-transferase enzyme which has 16.54 EU/mg protein specific activities was purified 11,026-fold by glutathione-agarose affinity chromatography ...
Kaur Indu Pal - - 2012
Neuropathic pain remains one of the most challenging of all the neurologic diseases and represents a large unmet need of the medical world. It often requires patience on the part of the patient and the physician who must try a variety of different medications on a trial and error basis ...
Unlusoy Meltem Ceylan - - 2012
Numerous compounds have been prepared in order to improve the pharmacological profile of insulinotropic activities. In the present paper, we report the synthesis and the in vitro insulin releasing activity of the 6-methyl-chromonyl-2,4-thiazolidinediones (IIIa-c, IVa-c, Va-c). Compounds IIIb, IIIc, IVa-c, Va and Vc (at lower concentration; 0.001 mg/mL) were able to ...
Zimmerman Mark - - 2012
Zimmerman M, Martinez JH, Young D, Chelminski I, Dalrymple K. Sustained unemployment in psychiatric outpatients with bipolar depression compared to major depressive disorder with comorbid borderline personality disorder. Bipolar Disord 2012: 00: 000-000. © 2012 John Wiley & Sons A/S.Published by Blackwell Publishing Ltd. Objectives:  The morbidity associated with bipolar ...
Huang Mingdong - - 2012
Zinc phthalocyanine (ZnPc) is a promising photosensitizer for photodynamic therapy, but faces some challenges: ZnPc does not dissolve in water and thus require either special formularization of ZnPc, or chemical modification of Pc ring to enhance its bioavailability and photodynamic efficacy. Here, we conjugated mono-substituted ZnPc-COOH with a series of ...
López-Contreras L - - 2012
SUMMARY Protein kinases (PKs) of parasitic protozoa are being evaluated as drug targets. A large number of protein kinases within the protein kinome of Entamoeba histolytica strongly suggest that protein phosphorylation is a key component of pathogenesis regulation by this parasite. PI3 K and Src are kinases previously described in this ...
Sullivan Lisa M - - 2013
SMARCB1 gene alterations were first described in highly malignant rhabdoid tumors of the kidney, brain (atypical teratoid/rhabdoid tumor) and soft tissue. An increasing number of tumors have now shown loss of SMARCB1 protein expression by immunohistochemistry, including the majority of epithelioid sarcomas. However, investigations of SMARCB1 gene alterations in epithelioid ...
Veen Mario - - 2012
Although it is recognised that a gluten-free diet has many social implications for coeliac disease patients, not much is known about how such patients actually manage these implications in their everyday interactions. This article examines how dietary restrictions are treated by patients and their families. Data from recorded mealtime conversations ...
Sun Xiaolian - - 2012
Dumbbell-like Pt(48) Pd(52) -Fe(3) O(4) nanoparticles are synthesized and functionalized with oleylamine-polyethyleneglycol to serve as an efficient catalyst for H(2) O(2) reduction and tetramethylbenzidine (TMB) oxidation in biological solutions. The Pt(48) Pd(52) -Fe(3) O(4) /TMB kit is even more active than the natural enzyme for H(2) O(2) detection with a ...
Oestreich Kenneth J - - 2012
There is an emerging body of research demonstrating that the co-expression of key lineage-specifying transcription factors, commonly referred to as 'master regulators', affects the functional capabilities and flexibility of CD4(+) T cell subsets. Here, we discuss how the natural co-expression of these lineage-specifying transcription factors has challenged the concept that ...
Christofi Theodoulakis T Department of Bbiological Sciences, University of Cyprus, Nicosia, - - 2013
The gastrointestinal tract is habitable by a variety of microorganisms and it is often a tissue inflicted by inflammation. Much discussion is raised in recent years about the role of microbiota in intestinal inflammation, but their role in intestinal cancer remains unclear. Here we discuss and extent our work on ...
- - 2012
Exercise does not seem to benefit patients with depression who are already receiving 'good standard care'.
Liu Yu - - 2012
A molecular thermodynamic model is developed to examine crowding effect on DNA melting. Each pair of nucleotides in double-stranded DNA and each nucleotide in single-stranded DNA are represented by two types of charged Lennard-Jones segments, respectively. Water molecules are mimicked explicitly as spherical particles, embedded in a dielectric continuum. Crowders ...
Pei Chunying - - 2012
Abstract MSH6 (mutS homolog 6), one of the five key mismatch repair (MMR) genes, was found to play an important role in conferring resistance to alkylating agents - temozolomide (TMZ) in malignant glioma. This study aims to investigate whether genetic variations in MSH6 gene are associated with the survival outcomes ...
Shen Yongqing - - 2012
ABSTRACT: BACKGROUND: The histone H3K27 demethylases UTX and JMJD3 are important regulatory factors that modulate gene expression by altering the physical state of chromatin. Previous studies have indicated an abnormal H3K27 methylation status in carcinogenesis. We therefore investigated the expression patterns of UTX and JMJD3 in renal cell carcinoma (RCC) ...
Zhang Ben-Yan - - 2012
Formaldehyde is ubiquitous in the environment. It is known to be a genotoxic substance. We hypothesized that reactive oxygen species (ROS) and lipid peroxidation are involved in formaldehyde-induced genotoxicity in human lung cancer cell lines A549. To test this hypothesis, we investigated the effects of antioxidant on formaldehyde-induced genotoxicity in ...
Ogura M - - 2012
Electrical transport properties of (La(1-x)X(x))MnO(3) (X = Ca, Sr), which exhibits the so-called colossal magnetoresistance (CMR) effect, are investigated in the framework of linear response theory combined with first-principles calculation. The calculation is performed by applying the coherent potential approximation and Kubo-Greenwood formula to the KKR Green's function method. In order to ...
Lee Hee Jung - - 2012
The conjugation of Eu(3+) -doped coordination polymers constructed from Gd(3+) and isophthalic acid (H(2) IPA) with silica particles is investigated for the production of luminescent microspheres. A series of doping ratio-controlled silica@coordination polymer core-shell spheres is easily synthesized by altering the amounts of metal nodes used in the reactions, where ...
Medjakovic Svjetlana - - 2012
Pomegranate is an ancient fruit that is still part of the diet in the Mediterranean area, the Middle East, and India. Health-promoting effects have long been attributed to this fruit. Modern research corroborates the use of pomegranate as a folk remedy for diabetes and metabolic syndrome, and is responsible for ...
Lu Shuo S Department of Chemistry and Biochemistry, University of Oklahoma, Stephenson Life Science Research Center, Norman, OK 73019, - - 2012
MacB is a founding member of the Macrolide Exporter family of transporters belonging to the ATP-Binding Cassette superfamily. These proteins are broadly represented in genomes of both Gram-positive and Gram-negative bacteria and are implicated in virulence and protection against antibiotics and peptide toxins. MacB transporter functions together with MacA, a ...
Li Hsiao-Juan - - 2012
AIM: To report a study of the effects of protein-energy malnutrition on the functional recovery of older people with hip fracture who participated in an interdisciplinary intervention. BACKGROUND: It is not clear whether protein-energy malnutrition is associated with worse functional outcomes or it affects the interdisciplinary intervention program on the ...
Waki Takamitsu - - 2012
Activation tagging is a powerful tool for discovering novel genes that are not easily identified by loss-of-function (lof) screening due to genetic redundancy or lethality. Although the current activation tagging system, which involves a viral enhancer sequence, has been used for a decade, alternative methods that allow organ- or tissue-specific ...
Palmans H - - 2012
In a recent paper (Bhullar and Watchman 2012 Phys. Med. Biol. 57 273-86), the authors comment on data concerning the effective depth of cylindrical ionization chambers in water for clinical proton beams calculated in a previous paper (Palmans 2006 Phys. Med. Biol. 51 3483-501) and propose different results. They present ...
Vakhshouri Kiarash - - 2012
We have examined the effects of crystallization kinetics of poly(3-hexylthiophene) and poly[2,5-bis(3-hexadecylthiophen-2-yl)thieno(3,2-b)thiophene] on microstructure and charge transport. Rapid crystallization increases the density of tie molecules in polythiophenes. As a consequence, ordered regions are better connected resulting in higher charge carrier mobilities. Our results suggest that controlling the crystallization kinetics might ...
Spofford Christopher M - - 2012
We report the case of a patient requiring gamma ventral capsulotomy (GVC), a neurosurgical intervention to address severe refractory obsessive-compulsive disorder (OCD). GVC involves stereotactic lesions in the ventral anterior limb of the internal capsule and adjacent ventral striatum. This study details the course of an extinction-based behavioral therapy, namely ...
Hoshida Kyoko - - 2012
Background: T-wave alternans based on the modified moving average method (MMA-TWA) and heart rate turbulence (HRT) have been introduced as predictors for cardiac mortality. In this study, we simultaneously recorded MMA-TWA and HRT in patients after myocardial infarction (MI) and designed a prospective observational study. Methods and Results: We prospectively enrolled 313 ...
Therriault-Proulx François F Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, - - 2012
The goal of this study was to develop a novel multi-point plastic scintillation detector (mPSD) capable of measuring the dose accurately at multiple positions simultaneously using a single optical transmission line. A 2-point mPSD used a band-pass approach that included splitters, color filters and an EMCCD camera. The 3-point mPSD ...
Ou-Yang Mei-Chen - - 2012
AIM: To determine if expressed breast milk (milk) reduces procedural pain associated with heel lancing in preterm neonates. METHODS: In this placebo-controlled trial, preterm neonates received 5 mL of distilled water as placebo (water, n = 44), 25% glucose water (glucose, n = 39), or milk (n = 40). Heel ...
Rørth Pernille - - 2012
Cells can migrate individually or collectively. Collective movement is common during normal development and is also a characteristic of some cancers. This review discusses recent insights into features that are unique to collective cell migration, as well as properties that emerge from these features. The first feature is that cells ...
Terada N - - 2012
Adenosine triphosphate (ATP) is a well-known energy source for muscle contraction. In this study, to visualize localization of ATP, a luciferin-luciferase reaction (LLR) was performed in mouse skeletal muscle with an "in vivo cryotechnique" (IVCT). First, to confirm if ATP molecules could be trapped and detected after glutaraldehyde (GA) treatment, ...
Schure R - - 2012
BACKGROUND AND OBJECTIVE: Human subjects affected by inflammatory diseases, such as periodontitis, may be at increased risk for the development of cardiovascular diseases and calcification of atheromas; however, the potential mechanisms have not been defined. Alpha-2-Heremans Schmid glycoprotein (fetuin A) is an abundant serum glycoprotein of ~49 kDa that inhibits ectopic ...
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