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Oliva Anthony A AA Jr The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, - - 2012
Traumatic brain injury (TBI) results in significant inflammation which contributes to the evolving pathology. Previously, we have demonstrated that cyclic AMP (cAMP), a molecule involved in inflammation, is down-regulated after TBI. To determine the mechanism by which cAMP is down-regulated after TBI, we determined whether TBI induces changes in phosphodiesterase ...
Zeigler-Hill Virgil - - 2012
The purpose of the present study was to examine whether the association between explicit self-esteem and relationship outcomes was moderated by implicit self-esteem. This was accomplished by asking 210 undergraduates who were currently involved in romantic relationships to complete measures of their explicit self-esteem, implicit self-esteem, mate retention strategies, and ...
Humphries Linda - - 2012
: The purpose of this study was to test an evidence-based procedure of drawing blood samples for coagulation testing from heparinized peripherally inserted central catheter (PICC) by comparing results with blood drawn from venipuncture (VP). : A prospective, quasi-experimental design using purposive sampling was used. : The setting was a ...
Kavanaugh Barbara E - - 2012
Our goal in the present study was to investigate the prevalence and correlates of genital warts in a population of female sex workers in Mombasa, Kenya. Because of the high prevalence of human immunodeficiency virus type 1 (HIV-1) in this population, we were particularly interested in the association between HIV-1 ...
Liu Wenli - - 2012
The ability to identify stop consonants from brief onset spectra was compared between a group of Chinese children with phonological dyslexia (the PD group, with a mean age of 10 years 4 months) and a group of chronological age-matched control children. The linguistic context, which included vowels and speakers, and ...
Lopez-Chavez Ariel - - 2012
The Eastern Cooperative Oncology Group (ECOG) 4599 study showed a significant survival benefit with the use of bevacizumab (BV) in combination with carboplatin and paclitaxel (CP) in comparison with CP chemotherapy alone in patients with previously untreated advanced, metastatic or recurrent non-small-cell lung cancer (NSCLC). Such results were achieved using ...
McDonald Oliver G - - 2012
Studies of cell lines and of animal models of pancreatic cancer have raised a number of provocative questions about the nature and origins of human pancreatic cancer and have provided several leads into exciting new approaches for the treatment of this deadly cancer. In addition, clinicians with little or no ...
Land Michael F - - 2012
Structures which bend light and so form images are present in all the major phyla. Lenses with a graded refractive index, and hence reduced spherical aberration, evolved in the vertebrates, arthropods, annelid worms, and several times in the molluscs. Even cubozoan jellyfish have lens eyes. In some vertebrate eyes, multiple ...
Zhang Li - - 2012
We developed and evaluated a fully automated 3-dimensional (3D) method for segmentation of the choroidal vessels, and quantification of choroidal vasculature thickness and choriocapillaris-equivalent thickness of the macula, and evaluated repeat variability in normal subjects using standard clinically available spectral domain optical coherence tomography (SD-OCT). A total of 24 normal ...
Routledge Clay - - 2012
According to terror management theory (TMT; Greenberg, Pyszczynski, 1986), self-esteem protects people from anxiety associated with the knowledge of certain mortality. A number of studies provide evidence consistent with this assertion, but no studies have experimentally examined the effect of threatened self-esteem on death-anxiety. In the current study, self-esteem was ...
Qi Mei - - 2012
Recurrent gene fusions have been thought to play a central role in leukemias, lymphomas, and sarcomas, but they have been neglected in carcinomas, largely because of technical limitations of cytogenetics. In the past few years, an increasing number of recurrent gene fusions have been recognized in epithelial cancers. The majority ...
Dåderman Anna M - - 2012
Previous neuropsychiatric studies suggest a relationship between reading disability and cognitive impulsivity. This relationship is not entirely explained by the high comorbidity between reading disability and attention deficit hyperactivity disorder (ADHD), as children with a co-occurrence of these disorders tend to be more impulsive than those with ADHD only. Other ...
Al-Subu Awni - - 2012
: We assessed the accuracy of esophageal endoscopic features in children with eosinophilic esophagitis (EoE) living in rural communities in West Virginia. : Specific esophageal endoscopic features for EoE disease have been identified in children and adults. In the published reports, the sensitivity of these features ranged between 19% and ...
Poteat V Paul - - 2012
Among 342 white college students, we examined the effects of social dominance orientation (SDO), right-wing authoritarianism (RWA), and racial color-blindness on modern racism attitudes. Structural equation modeling was used to test the indirect effects of SDO and RWA on modern racism attitudes through color-blind racial attitudes. We found strong indirect ...
Pan Billy X - - 2012
Leber's hereditary optic neuropathy (LHON), a mitochondrial disease, has clinical manifestations that reflect the initial preferential involvement of the papillomacular bundle (PMB). The present study seeks to predict the order of axonal loss in LHON optic nerves using the Nerve Fiber Layer Stress Index (NFL-S(I)), which is a novel mathematical ...
Moharram Fatma Abd-Elkader - - 2012
Objectives  The aim of this study was to investigate a new flavone triglycoside, together with eleven phenolic metabolites from 80% aqueous methanol extract of S. splendens leaves (AME) and assessment of its hypoglycemic and antiinflammatory activities along with in vitro antioxidant effect. Methods  The phenolic composition of S. splendens leaves was analyzed ...
Carbone David P - - 2012
We investigated the predictive and prognostic effects of VeriStrat, a serum or plasma-based assay, on response and survival in a subset of patients enrolled on the NCIC Clinical Trials Group, BR.21 phase III trial of erlotinib versus placebo in previously treated advanced non-small-cell lung cancer patients. Pretreatment plasma samples were ...
Stathi Sofia - - 2012
Research has demonstrated widespread negative attitudes held toward people with mental health problems. Our study investigated whether a new prejudice reduction technique, imagined intergroup contact (Crisp & Turner, 2009), could combat stigma against people with mental illness, and the mediating processes through which it may exert this beneficial effect. We ...
Barras Jamie J Department of Informatics, King's College, Strand, London WC2R 2LS, London, United Kingdom. - - 2012
The performance of rectangular radio frequency (RF) coils capable of being used to detect nuclear quadrupole resonance (NQR) signals from blister packs of medicines has been compared. The performance of a fixed-pitch RF coil was compared with that from two variable-pitch coils, one based on a design in the literature ...
Metwally Abdelkader A - - 2012
Nonviral siRNA vectors prepared by the direct mixing of siRNA and mixtures of an asymmetric N(4),N(9)-diacyl spermine conjugate, N(4)-linoleoyl-N(9)-oleoyl-1,12-diamino-4,9-diazadodecane (LinOS), with either cholesterol or DOPE, at various molar ratios of the neutral lipids, are reported. The effects of varying the lipid formulation and changing the N/P charge ratio on the ...
Givens Richard S RS Department of Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, 5010 Malott Hall, Lawrence, Kansas 66045, United States. - - 2013
Using model (R)-2-acetyl-2-phenyl acetate esters of (S)- or (R)-α-substituted-p-hydroxybutyrophenones (S,R)-12a and (R,R)-12b, we have shown that a highly efficient photo-Favorskii rearrangement proceeds through a series of intermediates to form racemic rearrangement products. The stereogenic methine on the photoproduct, rac-2-(p-hydroxyphenyl)propanoic acid (rac-9), is formed by closure of a phenoxy-allyloxy intermediate 17 ...
Yin Jie - - 2012
On page 5441, Karen K. Gleason, Mary C. Boyce, and co-workers demonstrate a deterministic method to obtain orderly herringbone patterns through buckling of a stiff thin film deposited by chemical vapor deposition on a compliant substrate. Controlling the stretching and releasing of the sample enables tuning the features of the ...
Lim Kok Seong - - 2012
Guanine is a major target for oxidation in DNA, with 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) as a major product. 8-oxodG is itself significantly more susceptible to oxidation than guanine, with the resulting damage consisting of more than 10 different products. This complexity has hampered efforts to understand the determinants of biologically relevant DNA ...
Schaller Ruth A - - 2012
The first demonstrated example of a regulatory function for a bacterial hemerythrin (Bhr) domain is reported. Bhrs have a characteristic sequence motif providing ligand residues for a type of non-heme diiron site that is known to bind O(2) and undergo autoxidation. The amino acid sequence encoded by the VC1216 gene ...
Senger Nicholas A NA Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California 94132, United - - 2012
The "element effect" in nucleophilic aromatic substitution reactions (S(N)Ar) is characterized by the leaving group order, F > NO(2) > Cl ≈ Br > I, in activated aryl halides. Multiple causes for this result have been proposed. Experimental evidence shows that the element effect order in the reaction of piperidine ...
Thavendiranathan Paaladinesh - - 2012
Accurate assessment of mitral regurgitation (MR) severity is important for clinical decision making, prognostication, and decisions regarding timing of surgical intervention. The most common method for noninvasive assessment of MR has been with 2-dimensional transthoracic echocardiography, which is often used as a qualitative tool. Several newer noninvasive modalities including 3-dimensional ...
Macheret Fima F Department of Medicine, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York 10065, USA. - - 2012
This study sought to investigate plasma levels of circulating cardiac natriuretic peptides, atrial natriuretic peptide (ANP) and B-type or brain natriuretic peptide (BNP), in the general community, focusing on their relative differences in worsening human hypertension. Although ANP and BNP are well-characterized regulators of blood pressure in humans, little is ...
Madugundu Guru S - - 2012
We have identified a series of modifications of the 2'-deoxyribose moiety of DNA arising from the exposure of isolated and cellular DNA to ionizing radiation. The modifications consist of 2',3'-dideoxyribonucleoside derivatives of T, C, A, and G, as identified by enzymatic digestion and LC-MS/MS. Under dry conditions, the yield of ...
Lipkovich Ilya - - 2012
Assessing dose response from flexible-dose clinical trials is problematic. The true dose effect may be obscured and even reversed in observed data because dose is related to both previous and subsequent outcomes. To remove selection bias, we propose marginal structural models, inverse probability of treatment-weighting (IPTW) methodology. Potential clinical outcomes ...
Simons D - - 2012
Objective The aim of this study was to describe the dental services delivered by the Community Dental Service (CDS) of Tower Hamlets (TH) and City and Hackney (CH) for adult homeless people in 2009-2011, to assess if the service met its planned objectives and to report the outcomes of the ...
Oonishi Yoshihiro - - 2012
Rounding up: A Rh(I) -catalyzed intermolecular cycloaddition of 4-allenals with alkynes has been developed that provides various monocyclic eight-membered rings in good to high yields in a stereoselective manner. In addition, the chirality of the starting allene is transferred in this reaction, thereby giving optically active monocyclic eight-membered ring compounds.
Suárez-Pantiga Samuel - - 2012
Golden touch: N-allenylsulfonamides react with styrene derivatives to furnish chiral cyclobutanes in both high yield and enantioselectivity at -70 °C. Phosphoramidite ligands such as 1 facilitate this asymmetric gold(I)-catalyzed [2+2] cycloaddition. Tf=trifluoromethanesulfonyl.
Vajjah Pavan - - 2012
The T-optimality criterion is used in optimal design to derive designs for model selection. To set up the method, it is required that one of the models is considered to be true. We term this local T-optimality. In this work, we propose a generalisation of T-optimality (termed robust T-optimality) that ...
Keil E E Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University, Universitätsstr. 1, Düsseldorf, - - 2013
Autophagy is a lysosomal degradation pathway important for cellular homeostasis, mammalian development, cancer and immunity. Many molecular components of autophagy have been identified, but little is known about regulatory mechanisms controlling their effector functions. Here, we show that, in contrast to other p38 MAP kinase activators, the growth arrest and ...
Ach Emily E The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, - - 2013
The purpose of this study is to examine whether parental education, socioeconomic status, or family environment moderate the extent of academic achievement deficits in pediatric brain tumor survivors (PBTS) relative to classmate case-controls. PBTS are known to be at risk for cognitive and academic impairment; however, the degree of impairment ...
Sun Shao-Ni - - 2012
Pretreatment is the key to unlock the recalcitrance of lignocellulosic biomass for the productions of biofuels. Ionic liquids pretreatment has drawn increased attention due to its numerous advantages over conventional methods. In this study, corncob was submitted to pretreatments with 1-ethyl-3-methylimadazolium acetate (EMIMAc) or/and H(2)O/DMSO followed by alkaline extraction to ...
Ma Xiang - - 2012
ABSTRACT: This study enzymatically acrylates two flavonoids from bamboo-leaf extracts, isoorientin and isovitexin, with different fatty acids as acyl donors using Candida antarctica lipase B (CALB). The conversion yield ranged from 35% to 80% for fatty acids with different chain lengths. Higher isoorientin and isovitexin conversion yields (>75%) were obtained ...
Hermsen M A - - 2012
BACKGROUND: Research has shown that care staff are not always able to offer quality care. Commercialisation and market forces within the care sector are often pointed to as an explanation for this shortcoming. In the present study, insight is gained into the possible connections between the commercialisation of care, on ...
van der Eijk Anne C - - 2012
AIM: To provide an overview of factors influencing the flow rate in intravenous (IV) therapy for newborns. METHODS: We conducted a review of the literature from 1980 to 2011 in PubMed and Web of Knowledge. Articles focusing on flow-rate variability and possible complications due to flow-rate variability were included. RESULTS: ...
McCord F - - 2012
Although more people are retaining increasing numbers of their natural teeth into older ages, approximately 30-40% of persons over the age of 75 years in Western countries are edentulous. The causes and significance of tooth loss vary widely among individuals and cultures, and missing teeth may be replaced by a ...
Mosca E - - 2012
Climate is one of the most important drivers of local adaptation in forest tree species. Standing levels of genetic diversity and structure within and among natural populations of forest trees are determined by the interplay between climatic heterogeneity and the balance between selection and gene flow. To investigate this interplay, ...
Ishizuka Tomohito - - 2012
Anesthetic and cardio-respiratory effects of medetomidine, lidocaine, butorphanol and propofol total intravenous anesthesia (MLBP-TIVA) were evaluated in horses undergoing an experimental surgery. Ten horses were pre-medicated with an intravenous injection (IV) of medetomidine (5 μg/kg) and butorphanol (20 μg/kg). Anesthesia was induced by administration of 1% propofol (3 mg/kg, IV) ...
Mettenleiter Thomas C - - 2012
Herpesvirus capsids are assembled in the nucleus of infected cells whereas final maturation occurs in the cytosol. To access the final maturation compartment, intranuclear capsids have to cross the nuclear envelope which represents a formidable barrier. They do so by budding at the inner nuclear membrane, thereby forming a primary ...
Chassain Carine - - 2012
Using in vivo (1) H NMR spectroscopy in a mouse model of Parkinson's disease, we previously showed that glutamate concentrations in the dorsal striatum were highest after dopamine denervation associated with an increase in gamma-aminobutyric acid (GABA) and (Gln) glutamine levels. The aim of this study was to determine whether ...
Finocchiaro L M E - - 2012
We present here the updated results after 9 years of the beginning of a trial on canine patients with malignant melanoma. This surgery adjuvant approach combined local suicide gene therapy with a subcutaneous vaccine composed by tumor cells extracts and xenogeneic cells producing human interleukin-2 and granulocyte-macrophage colony-stimulating factor. Toxicity ...
Larsen Jette Schilling - - 2012
Some mothers have to give up breastfeeding even though they want to breastfeed. To give up breastfeeding can be a sensitive issue in a time when breastfeeding is promoted as the healthiest for mother and child. The aim of this study was to describe mothers' experiences after they gave up ...
Kitahara Teruyo - - 2012
Objectives: We herein report a case of cervico-brachial disorder (CBD) due to long-term tactile interpreting. Methods: The patient was interviewed to investigate her past history, occupational history, work conditions and clinical course in detail. The case was diagnosed in accordance with the "Diagnostic Criteria for CBD 2007" established by the ...
Yu Yong - - 2012
A new aggregation-induced emission (AIE) compound 1,2-bis[4-(isothiocyanatomethyl)phenyl]-1,2-diphenylethene () was synthesized for use in SDS-PAGE. The molecule is practically nonemissive in solution but becomes highly emissive after reacting with the amine groups of the proteins by either the prestaining or poststaining method. The sensitivity of achieved in the prestaining method is ...
Härkönen Laura - - 2012
SUMMARY Offspring size and performance in invertebrates often decrease with maternal age or as a response to seasonal environment. In viviparous ectoparasites maternal provision may wholly determine offspring performance outside the host. The viviparous deer ked (Lipoptena cervi), an ectoparasite of cervids, breeds from autumn to spring. We reared deer ...
Wan Xiaohua - - 2012
Background and objectives. The study aimed to compare the α fetoprotein (AFP), total β-human chorionic gonadotropin (hCG), and unconjugated estriol (uE3) levels in the second-trimester triple screening for Down syndrome with different regions, and to analyse the related factors that influenced the screening performance. Materials and methods. The study was ...
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