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Underhill Gregory H - - 2012
Efforts in the interdisciplinary field of bioengineering have led to innovative methods for investigating the complexities of cell responses in vitro. These approaches have emphasized the reduction of complex multicomponent cellular microenvironments into distinct individual signals as a means to both (a) better construct mimics of in vivo microenvironments and ...
Mallarino Ricardo - - 2012
One of the chief aims of modern biology is to understand the causes and mechanisms of morphological evolution. Multicellular animals display a stunning diversity of shapes and sizes of their bodies and individual suborganismal structures, much of it important to their survival. What is the most efficient way to study ...
Boyd Chelsea D - - 2012
The second messenger bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) has emerged as a broadly conserved intracellular signaling molecule. This soluble molecule is important for controlling biofilm formation, adhesion, motility, virulence, and cell morphogenesis in diverse bacterial species. But how is the typical bacterial cell able to coordinate the actions of upward ...
Rizo Josep - - 2012
Neurotransmitter release is governed by proteins that have homo-logs in most types of intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the SNARE proteins syntaxin-1, synaptobrevin/VAMP, and SNAP-25. The SNAREs initiate fusion by forming tight SNARE complexes that bring the vesicle and plasma membranes together. SNARE maintenance in a ...
Szundi Istvan I Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, United - - 2012
Cytochrome c oxidase from Rhodobacter sphaeroides is frequently used to model the more complex mitochondrial enzyme. The O(2) reduction in both enzymes is generally described by a unidirectional mechanism involving the sequential formation of the ferrous-oxy complex (compound A), the P(R) state, the oxyferryl F form, and the oxidized state. ...
Cahill Katharine J - - 2013
Polar bimolecular reactions often begin as charge-transfer complexes and may proceed with a high degree of electron transfer character. Frontier molecular orbital (FMO) theory is predicated in part on this concept. We have developed an electron transfer model (ETM) in which we systematically transfer one electron between reactants and then ...
Bohman Keith D - - 2012
Mucin-producing tumors of the prostate include both primary and secondary tumors with mucinous differentiation or features involving the prostate gland. These tumors are relatively rare and have variable prognostic and therapeutic implications. Primary mucinous (colloid) adenocarcinoma of the prostate is defined as prostatic adenocarcinoma with mucinous differentiation involving 25% or ...
Tajbakhsh Zahra - - 2012
To compare and evaluate the agreement between keratometry readings using three devices: the Pentacam HR, the Orbscan IIz, and the TMS-4 topographer. In this prospective comparative study, 115 eyes from 115 healthy refractive surgery candidates were sequentially examined using three devices. Fourier analysis was used to evaluate corneal astigmatism in ...
Jehle Alayna - - 2012
Apologies are important in social interactions. Study 1 investigated participants' reactions after being insulted by a confederate and receiving no apology, a voluntary apology, a coerced apology with consequences (i.e., explicitly coerced apology), or a coerced apology without consequences (i.e., implicitly coerced apology). Receiving any apology produced more positive perceptions ...
Beltrán-Becerra K J - - 2012
Fabry disease (FD) is a rare X-linked genetic lysosomal storage disease caused by a deficiency of the enzyme α-galactosidase A, that produces accumulation of globotriaosylceramide. There is a multisystemic involvement, including renal, cardiac, eye, and nervous system manifestations. AIM: To perform a descriptive analysis of the ophthalmological manifestations in Mexican ...
Hunt Jennifer L - - 2012
In 2008, the Joint Commission created 2 new hospital standards that revolve around competency assessment of credentialed and privileged healthcare practitioners. These are called Ongoing Professional Practice Evaluation (OPPE) and Focused Professional Practice Evaluation (FPPE). As many pathologists work as members of a hospital medical staff, either through primary employment ...
Poteat V Paul - - 2012
Among 342 white college students, we examined the effects of social dominance orientation (SDO), right-wing authoritarianism (RWA), and racial color-blindness on modern racism attitudes. Structural equation modeling was used to test the indirect effects of SDO and RWA on modern racism attitudes through color-blind racial attitudes. We found strong indirect ...
Dåderman Anna M - - 2012
Previous neuropsychiatric studies suggest a relationship between reading disability and cognitive impulsivity. This relationship is not entirely explained by the high comorbidity between reading disability and attention deficit hyperactivity disorder (ADHD), as children with a co-occurrence of these disorders tend to be more impulsive than those with ADHD only. Other ...
Keszthelyi Daniel - - 2012
Microscopic colitis (MC) is diagnosed in up to 13% of patients investigated for chronic diarrhea, particularly in middle-aged and elderly patients. Recent studies have suggested an etiological role for various drugs, including nonsteroidal anti-inflammatory drugs and proton pump inhibitors. To ascertain the potential role for drug exposure in the development ...
Gómez de Liaño-Sánchez R - - 2012
OBJECTIVE: To evaluate factors that may decompensate a strabismus or lead to diplopia after refractive surgery. METHODS: Retrospective study of 19 patients, who presented with binocular decompensation after refractive surgery. Mean age at surgery was 38.89 SD 10.26 (27-63) years. Fourteen patients were myopic, 5 hyperopic, and 5 of them ...
Qi Mei - - 2012
Recurrent gene fusions have been thought to play a central role in leukemias, lymphomas, and sarcomas, but they have been neglected in carcinomas, largely because of technical limitations of cytogenetics. In the past few years, an increasing number of recurrent gene fusions have been recognized in epithelial cancers. The majority ...
Mercer David F - - 2012
The role of parenteral lipid emulsions in the treatment of intestinal failure-associated liver disease (IFALD) is both topical and controversial. There is strong evidence supporting plant-based (soy, olive) lipid emulsions as a key cause for IFALD, especially in neonates. As a result, alternate lipid formulations, most notably fish oil emulsions ...
Land Michael F - - 2012
Structures which bend light and so form images are present in all the major phyla. Lenses with a graded refractive index, and hence reduced spherical aberration, evolved in the vertebrates, arthropods, annelid worms, and several times in the molluscs. Even cubozoan jellyfish have lens eyes. In some vertebrate eyes, multiple ...
Piil Karin - - 2012
This article explores the concept of professional identity of Danish nurses working in an expanded practice. The case study explores the experiences of a small group of Danish nurses with a new professional category that reaches into a domain that customarily belonged to physicians. The aim of this case study ...
Ferguson Neil - - 2012
Just world beliefs for students (N = 413) from India and the United Kingdom were measured. The participants then read a scenario about the 2008 terrorist attacks on Mumbai. The participants were then assessed for terrorism distress and offered multiple strategies (revenge and denial) to restore their just world beliefs. ...
Zeigler-Hill Virgil - - 2012
The purpose of the present study was to examine whether the association between explicit self-esteem and relationship outcomes was moderated by implicit self-esteem. This was accomplished by asking 210 undergraduates who were currently involved in romantic relationships to complete measures of their explicit self-esteem, implicit self-esteem, mate retention strategies, and ...
Morales M C - - 2012
PURPOSE: To report the clinical outcomes of cataract surgery (phacoemulsification and intraocular lens implantation) combined with 23-gauge vitrectomy, and to evaluate the effectiveness and safety of this technique. METHODS: A retrospective, consecutive, non-comparative study which included 105 eyes. Phacoemulsification and intraocular lens implantation (in the capsular sac) combined with 23-gauge ...
Humphries Linda - - 2012
: The purpose of this study was to test an evidence-based procedure of drawing blood samples for coagulation testing from heparinized peripherally inserted central catheter (PICC) by comparing results with blood drawn from venipuncture (VP). : A prospective, quasi-experimental design using purposive sampling was used. : The setting was a ...
Malstädt Nadine - - 2012
This study examined supraspan free recall in children with and without spelling impairment. A repeated free recall task involving overt rehearsal and three computer-based adaptive working memory tasks were administered to 54 eight-year-old children. Children without spelling impairments tended to recall more items than did those children with spelling deficits. ...
Routledge Clay - - 2012
According to terror management theory (TMT; Greenberg, Pyszczynski, 1986), self-esteem protects people from anxiety associated with the knowledge of certain mortality. A number of studies provide evidence consistent with this assertion, but no studies have experimentally examined the effect of threatened self-esteem on death-anxiety. In the current study, self-esteem was ...
Moharram Fatma Abd-Elkader - - 2012
Objectives  The aim of this study was to investigate a new flavone triglycoside, together with eleven phenolic metabolites from 80% aqueous methanol extract of S. splendens leaves (AME) and assessment of its hypoglycemic and antiinflammatory activities along with in vitro antioxidant effect. Methods  The phenolic composition of S. splendens leaves was analyzed ...
Caricati Luca - - 2012
In two studies, the effect of instability of social stratification on intergroup behaviour of the intermediate-status group was investigated. In both studies, participants were categorised in the intermediate-status group. In Study 1, perceived instability was measured. Results show that the more social stratification was perceived as stable, the more intermediate-status ...
Cooper Chelsea - - 2012
Future classification systems for melanocytic neoplasms will likely include the integration of molecular aberrations. A number of studies have shown that many gene mutations and chromosomal copy number aberrations may correlate with characteristic clinical and morphologic features for melanocytic neoplasms. This review discusses newly described familial germline mutations such as ...
Chick Katherine - - 2012
: The purpose of this article was to describe a collaborative clinical nurse specialist (CNS) project to enhance the patient education provided by registered nurses across 7 medical nursing units in an acute care hospital. : Electronic data reviews assisted the medical CNSs with identifying a deficit in using appropriate ...
Stathi Sofia - - 2012
Research has demonstrated widespread negative attitudes held toward people with mental health problems. Our study investigated whether a new prejudice reduction technique, imagined intergroup contact (Crisp & Turner, 2009), could combat stigma against people with mental illness, and the mediating processes through which it may exert this beneficial effect. We ...
Liu Wenli - - 2012
The ability to identify stop consonants from brief onset spectra was compared between a group of Chinese children with phonological dyslexia (the PD group, with a mean age of 10 years 4 months) and a group of chronological age-matched control children. The linguistic context, which included vowels and speakers, and ...
Morrison Theresa - - 2012
: Community hospital medical-surgical nurses have a limited understanding of the complexities of preventing central line-associated bloodstream infections (CLABSIs). The purpose of this study was to look at the phenomenon of central line care from a human perspective and to develop an understanding of the lived experience as it relates ...
Zhang Hong - - 2012
This study was designed to examine how the two dimensions of adult attachment styles, attachment anxiety and avoidance, would affect young adults' intentions of self-improvement in response to various regulatory strategies used by a close other (i.e., a romantic partner or best friend). One hundred and eighteen undergraduate students were ...
Di Renzo Gian Carlo - - 2012
Progesterone is an essential hormone in the process of reproduction. It has been extensively studied in the treatment of different gynecological pathologies, as a contraceptive and in assisted reproductive technologies. However, the use of progesterone in the pathophysiology of pregnancy remains controversial. Progesterone, and its synthetic form 17 α-hydroxyprogesterone caproate ...
Richardson Jessica G - - 2012
This study investigated the differential contribution of affect and cognition to behavioral intention formation during pursuit of future health-related goals. Cognitive evaluations, affective evaluations and behavioral intentions were measured for each of 32 health-related behaviors. The timeframes of the cognitive/affective measures and the behavioral intention measure were varied between current ...
Al-Subu Awni - - 2012
: We assessed the accuracy of esophageal endoscopic features in children with eosinophilic esophagitis (EoE) living in rural communities in West Virginia. : Specific esophageal endoscopic features for EoE disease have been identified in children and adults. In the published reports, the sensitivity of these features ranged between 19% and ...
Mete Ozgur - - 2012
The diagnosis of follicular epithelial neoplasms is an area of controversy. We provide our experience with common problems that practising pathologists face when confronted with follicular epithelial proliferations. One of the major issues is the recognition of the diagnostic nuclear features of papillary thyroid carcinoma and reactive cytologic atypia. We ...
Ng Alison - - 2012
Eye cosmetics usage is commonplace and whilst some products such as eyeliner are applied with close proximity to the ocular surface, there is little knowledge of the short- and long-term ocular effects of eye cosmetic formulations. This study aimed to investigate the use of eye cosmetics and identify any relationships ...
Kuo Chung-Mou - - 2012
: Endoscopic papillary balloon dilation (EPBD) is a therapeutic procedure for extraction of bile duct stones. : To evaluate the therapeutic outcomes, postoperative complications, and associated risk factors of EPBD in patients with bile duct stones. : A total of 298 patients with bile duct stones were treated with EPBD. ...
Ordóñez Nelson G - - 2012
PAX2 is a member of the PAX family of transcription factors that, together with PAX8, is involved in the regulation of the organogenesis of the kidney and the Müllerian system. Recent investigations have demonstrated that, among tumors, PAX2 is commonly expressed in epithelial tumors of the kidney and female genital ...
Vinogradskiy Yevgeniy - - 2012
The lung radiosensitivity of the most sensitive patients limits doses that can be given to the majority of lung cancer patients. The purpose of the current study was to illustrate the concept of personalizing prescription dose by performing a retrospective study in which the prescription is determined using an individualized ...
Lopez-Chavez Ariel - - 2012
The Eastern Cooperative Oncology Group (ECOG) 4599 study showed a significant survival benefit with the use of bevacizumab (BV) in combination with carboplatin and paclitaxel (CP) in comparison with CP chemotherapy alone in patients with previously untreated advanced, metastatic or recurrent non-small-cell lung cancer (NSCLC). Such results were achieved using ...
Good William V - - 2012
Although cortical visual impairment (CVI) is the leading cause of bilateral vision impairment in children in Western countries, little is known about the effects of CVI on visual function. The aim of this study was to compare visual evoked potential measures of contrast sensitivity and grating acuity in children with ...
Zhang Li - - 2012
We developed and evaluated a fully automated 3-dimensional (3D) method for segmentation of the choroidal vessels, and quantification of choroidal vasculature thickness and choriocapillaris-equivalent thickness of the macula, and evaluated repeat variability in normal subjects using standard clinically available spectral domain optical coherence tomography (SD-OCT). A total of 24 normal ...
Pan Billy X - - 2012
Leber's hereditary optic neuropathy (LHON), a mitochondrial disease, has clinical manifestations that reflect the initial preferential involvement of the papillomacular bundle (PMB). The present study seeks to predict the order of axonal loss in LHON optic nerves using the Nerve Fiber Layer Stress Index (NFL-S(I)), which is a novel mathematical ...
Carbone David P - - 2012
We investigated the predictive and prognostic effects of VeriStrat, a serum or plasma-based assay, on response and survival in a subset of patients enrolled on the NCIC Clinical Trials Group, BR.21 phase III trial of erlotinib versus placebo in previously treated advanced non-small-cell lung cancer patients. Pretreatment plasma samples were ...
Gosline Sara J C - - 2012
The rapid development of high throughput biotechnologies has led to an onslaught of data describing genetic perturbations and changes in mRNA and protein levels in the cell. Because each assay provides a one-dimensional snapshot of active signaling pathways, it has become desirable to perform multiple assays (e.g. mRNA expression and ...
Kavanaugh Barbara E - - 2012
Our goal in the present study was to investigate the prevalence and correlates of genital warts in a population of female sex workers in Mombasa, Kenya. Because of the high prevalence of human immunodeficiency virus type 1 (HIV-1) in this population, we were particularly interested in the association between HIV-1 ...
Labby Zacariah E - - 2012
Response-assessment metrics play an important role in clinical trials and routine patient management. For patients with malignant pleural mesothelioma (MPM), the standard for response assessment is image-based measurements of tumor thickness made according to the modified RECIST (Response Evaluation Criteria in Solid Tumors) protocol. To classify tumor response, changes in ...
McDonald Oliver G - - 2012
Studies of cell lines and of animal models of pancreatic cancer have raised a number of provocative questions about the nature and origins of human pancreatic cancer and have provided several leads into exciting new approaches for the treatment of this deadly cancer. In addition, clinicians with little or no ...
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