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Wilbrink Maarten Hotse - - 2012
A previously identified sterol catabolic gene cluster is widely dispersed among actinobacteria, enabling them to degrade and grow on naturally occurring sterols. We investigated the physiological roles of various genes by targeted inactivation in mutant RG32 of Rhodococcus rhodochrous, which selectively degrades sterol side chains. The ltp3 and ltp4 deletion ...
Biedermann Peter H W - - 2012
Insect fungus gardens consist of a community of interacting microbes that can have either beneficial or detrimental effects to the farmers. In contrast to fungus-farming ants and termites, the fungal communities of ambrosia beetles and the effects of particular fungal species on the farmers are largely unknown. Here we used ...
Schlich Karsten - - 2012
The widespread use of silver nanoparticles (Ag-NPs), for example, in textiles and cleaning products, means that they are likely to reach the environment via biosolids or the effluent from wastewater treatment plants. The aim of the present study was to determine the ecotoxicity of Ag-NPs in the earthworm reproduction test ...
Hassan Mohammad Q MQ Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, - - 2012
MicroRNAs (miRNAs) negatively and post-transcriptionally regulate expression of multiple target genes to support anabolic pathways for bone formation. Here, we show that miR-218 is induced during osteoblast differentiation and has potent osteogenic properties. miR-218 promotes commitment and differentiation of bone marrow stromal cells by activating a positive Wnt signaling loop. ...
Gutiérrez-Mercado Yanet K - - 2012
It has been demonstrated that the exposure of biological systems to magnetic fields (MFs) can produce several beneficial effects: tissue recovery in chronic wounds, re-establishment of blood circulation after tissue ischemia or in necrotic tissues, improvement after epileptic episodes, angiogenesis, etc. In the current study, the effects of extremely low ...
Botezatu Andreea - - 2012
  2,5-Dimethyl-3-methoxypyrazine (DMMP) has been recently identified in both Coccinellidae-tainted (by either Coccinella septempunctata or Harmonia axyridis beetles) and untainted wines; however, little is known regarding its impact on wine aroma and flavor. The aims of this study were to obtain an accurate estimate of both the ortho- and retronasal ...
Seo Keumyoung - - 2012
The change in the atomic nitrogen concentration on a semiconducting nanowire's surface and the consequent changes in the electrical characteristics of a nanowire transistor were investigated by exposing In(2)O(3) nanowires to nitrogen (N(2)) plasma. After plasma was applied at N(2) flow rates of 20, 40, and 70 sccm with a fixed ...
Coupland V H VH King's College London, Thames Cancer Registry, 1st Floor Capital House, 42, Weston Street, London SE1 3QD, UK. - - 2012
This study investigated the variation in incidence of all, and six subgroups of, oesophageal and gastric cancer between ethnic groups. Data on all oesophageal and gastric cancer patients diagnosed between 2001 and 2007 in England were analysed. Self-assigned ethnicity from the Hospital Episode Statistics dataset was used. Male and female ...
Portaccio E - - 2012
BACKGROUND AND PURPOSE: The development of treatment strategies for cognitive impairment in multiple sclerosis (MS) is still in its infancy. The objective of this prospective, non-randomized, pilot study was to assess the possible efficacy of treatment with natalizumab in comparison with interferon beta (IFNB) in a group of relapsing-remitting (RR) ...
Thompson Hayley S - - 2012
Low use of BRCA counseling and testing services among black women has been reported in several studies, even though such services may play an important role in reducing racial disparities in breast cancer. Surprisingly, little is known about the extent to which black women at high risk for BRCA mutations ...
Ding San-Yuan - - 2012
Covalent organic frameworks (COFs) represent an exciting new type of porous organic materials, which are ingeniously constructed with organic building units via strong covalent bonds. The well-defined crystalline porous structures together with tailored functionalities have offered the COF materials superior potential in diverse applications, such as gas storage, adsorption, optoelectricity, ...
Lee Jin - - 2012
One of the immunosuppressive responses when hepatocellular carcinoma (HCC) develops in mammals is defective proliferation in the spleen. The objective of this study was to investigate the protective effect of the Styrax japonica Siebold et al. Zuccarini (SJSZ) glycoprotein on the proliferation of splenocytes induced by diethlynitrosamine (DEN). To assess ...
Miles Rachael E H - - 2012
We compare and contrast measurements of the mass accommodation coefficient of water on a water surface made using ensemble and single particle techniques under conditions of supersaturation and subsaturation, respectively. In particular, we consider measurements made using an expansion chamber, a continuous flow streamwise thermal gradient cloud condensation nuclei chamber, ...
Fukaya Chikashi - - 2012
OBJECTIVES: Intracranial hemorrhage is a crucial complication of deep brain stimulation (DBS) surgery. The bleeding caused by mechanical tissue injury due to microelectrode and/or DBS electrode lead insertion has been well studied. However, hemorrhage caused by a congenital underlying disease such as vascular malformation has not been examined carefully. MATERIALS ...
Choi Jong-Cheol - - 2012
A new method for the high-throughput study of cell spreading dynamics is devised by multi-step microscopy projection photolithography based on a cell-friendly photoresist. By releasing a large number of rounded cells in single cell arrays and monitoring their spreading dynamics by interference reflection microscopy, a large number of cell spreading ...
Fonseca Nuno A - - 2012
MOTIVATION: A ubiquitous and fundamental step in high-throughput sequencing analysis is the alignment (mapping) of the generated reads to a reference sequence. To accomplish this task numerous software tools have been proposed. Determining the mappers that are most suitable for a specific application is not trivial. RESULTS: This survey focuses ...
Kaplan Kursat Ali - - 2012
  Gastroprotective effects of α-lipoic acid (ALA) against oxidative gastric damage induced by indomethacin (IND) have been investigated. All doses (50, 75, 100, 150, 200, and 300 mg/kg body weight) of ALA reduced the ulcer index with 88.2% to 96.1% inhibition ratio. In biochemical analyses of stomach tissues, ALA administration ...
Sherwinter Danny A - - 2012
The rigid sigmoidoscope is an important tool in a surgeon's armamentarium, yet it has remained essentially unchanged despite poor imaging and the inability to project or record the images. Herein we report our initial experience with a novel introducer built from readily available operating room supplies and designed to convert ...
Byrne Sahara - - 2012
One reason that tobacco-sponsored smoking cessation ads are less effective than those sponsored by public health agencies may be that the persuasive arguments in tobacco-sponsored ads are inherently weaker than arguments made in public health ads. An alternate explanation is that sponsorship disclosure on the face of the ad activates ...
Wills B P D - - 2012
Metacarpal shaft fractures are common injuries that frequently unite with some shortening of the metacarpal. The aim of this study was to determine the effect of metacarpal shortening on digital flexion force. The index metacarpal of six cadaveric upper limbs was incrementally shortened. The flexion force produced at the end ...
Vanneste Sven - - 2012
A double-cone coil with large angled windings has been developed to modulate deeper brain areas such as the anterior cingulate cortex (ACC). Abnormal resting state activity in the pregenual ACC (pgACC), dorsal ACC (dACC) and subgenual ACC (sgACC) has been observed in depression. A patient with medication resistant chronic depression ...
Budec Mirela - - 2012
AIMS: We showed previously that the acute effect of ethanol on intestinal immunoglobulin A (IgA) expression might be mediated by endogenous nitric oxide (NO). To extend these findings, this study was designed to investigate a possible role of neuronal NO synthase (nNOS) in the observed phenomenon, using 7-nitroindazole (7-NI), a ...
Mazziotti Silvio - - 2012
MR of the small bowel is a useful technique for the evaluation of both intraluminal and extraluminal pathologic involvement of the small bowel in patients with Crohn's disease. Crohn's disease is associated with a range of extraintestinal complications that sometimes may be the initial presenting symptoms. Some of these extraintestinal ...
de la Fuente Marta González - - 2012
AIMS: β-adrenergic stimulation has profound influence in the genesis and maintenance of atrial fibrillation (AF). However, the effects of β-adrenoceptors stimulation on repolarizing currents and action potential (AP) characteristics in human atrial myocytes from left (LAA) and right atrial appendages (RAA) obtained from sinus rhythm (SR) and chronic AF (CAF) ...
Zeng Xian-Chun - - 2012
ABBA was reported to be an actin dynamics regulator. However, the molecular mechanism of action of ABBA is still totally obscure. Here we show that ABBA is ubiquitously expressed in all the examined cultured cells. We found that expression of ABBA in NIH3T3 cells promotes cell spreading. ABBA binds to ...
Nowaczyk MaƂgorzata J M - - 2012
Smith-Lemli-Opitz syndrome (SLOS) is a congenital multiple anomaly/intellectual disability syndrome caused by a deficiency of cholesterol synthesis resulting from a deficiency of 7-dehydrocholesterol (7DHC) reductase encoded by DHCR7. SLOS is inherited in an autosomal recessive pattern. It is characterized by prenatal and postnatal growth retardation, microcephaly, a variable degree of ...
Vignozzi Linda - - 2012
Introduction.  The efficacy of phosphodiesterase type 5 inhibitors (PDE5i) in treating lower urinary tract symptoms is supported by the extremely high expression and activity of PDE5 in male bladder. Although bladder function regulation is similar among genders, no data are available on PDE5 expression and activity in female bladder. Aim.  ...
Naïli Houcine - - 2012
A series of double dihydromethylpiperazinediium metallic sulfates [H(2)mpz]M(II)(SO(4))(2)·nH(2)O (mpz = 2-methylpiperazine, C(5)H(12)N(2)) are prepared by slow evaporation using a racemic (R/S)-mpz (for , ) or enantiopure R-mpz (for ), S-mpz (for ) and sulfates of Cu(II) (for ), Fe(II) (for , ), Co(II) (for ) and Zn(II) (for , , ...
Pallet N - - 2012
Adaptive responses to hypoxia, including hypoxia-inducible factor signaling, allow the cell to satisfy its basal metabolic demand and avoid death, but these responses can also be deleterious by promoting inflammation, cell dedifferentiation and fibrogenesis. Therefore, targeting hypoxia constitutes a promising therapeutic avenue. Recombinant human erythropoietin (rhEPO) appeared as a good ...
Kaplan Tony - - 2012
A model of intervention at the interface and for the in-patient phase for adolescents with severe mental health crises was developed to reduce length of stay while maintaining quality of service consonant with the 'recovery model'. The model is described, and discussed in the context of the limited literature on ...
Clemmesen L - - 2012
Purpose: The application of ultrasound-guidance for peripheral venous access is gaining popularity. It is possible to produce a short axis or a long axis sonographic view of the target vessel and apply an out-of-plane or in-plane needle tip approach. Our aim was to present the dynamic needle tip positioning technique ...
Kochanska Grazyna G Department of Psychology, University of Iowa, Iowa City, IA 52242-1407, USA. - - 2013
Research has shown that interactions between young children's temperament and the quality of care they receive predict the emergence of positive and negative socioemotional developmental outcomes. This multimethod study addresses such interactions, using observed and mother-rated measures of difficult temperament, children's committed, self-regulated compliance and externalizing problems, and mothers' responsiveness ...
Thomas Shirley A SA University of Nottingham, Nottingham NG8 1BB, UK. - - 2013
The aim was to evaluate behavioural therapy as a treatment for low mood in people with aphasia. A randomized controlled trial comparing behavioural therapy plus usual care with a usual care control. Potential participants with aphasia after stroke were screened for the presence of low mood. Those who met the ...
Meltzer Ellen C - - 2012
No evidence-based methods exist to identify prescription drug use disorder (PDUD) in primary care (PC) patients prescribed controlled substances. Aberrant drug-related behaviors (ADRBs) are suggested as a proxy. Our objective was to determine whether ADRBs documented in electronic medical records (EMRs) of patients prescribed opioids and benzodiazepines could serve as ...
Leheta Tahra - - 2012
Abstract Background: Rejuvenation of the lower face can be challenging and no single modality can accomplish all its complex events. Patients and methods: This 18 month study included 24 female patients with a primary complaint of lower face aging signs. They were randomly allocated to either group A who received ...
Zerbetto Mirco - - 2012
In this work we address the description of the dynamics of cyclodextrins in relation with nuclear magnetic resonance (NMR) relaxation data collected for hydroxymethyl groups. We define an integrated computational approach based on the definition and parameterization of a stochastic equation able to describe relevant degrees of freedom affecting the ...
Miravitlles Marc - - 2012
The new GOLD update has moved forward the principles of treatment of stable COPD by including the concepts of symptoms and risks into the decision of therapy; however, no mention of the concept of clinical phenotypes was included. It is recognized that COPD is a very heterogeneous disease and not ...
Nocentini Annalaura - - 2012
The codevelopment of delinquent behaviors and depressive symptoms from Grade 9 to 11 was investigated on an Italian sample of 518 adolescents (399 male) after the transition to high school, evaluating the time-invariant effects of past school failure and social failure and the time-varying effects of school achievement and social ...
Del Rayo Garrido María - - 2012
Immunisation with neural-derived peptides is a promising strategy in models of spinal cord (SC) injury. Recent studies have also demonstrated that the addition of glutathione monoethyl ester (GHSE) to this strategy further improves motor recovery, tissue protection and neuronal survival after SC injury. Since it is realistic to envision that ...
Viana Priscilla - - 2012
Gas ebullition-facilitated transport of metals and polycyclic aromatic hydrocarbons (PAHs) from the sediment to the water column was investigated in 14 urban waterway locations. Gas ebullition ranged from 2-450 mmol m-2 d-1 with a mean (±1 SEM) of 140±90 mmol m-2 d-1 over four seasons at the field sites and ...
Olmos Carmen - - 2012
AimsThe prognosis of patients with infective endocarditis (IE) remains poor despite the great advances in the last decades. One of the factors closely related to mortality is the development of septic shock (SS). The aim of our study was to describe the profile of patients with IE complicated with SS, ...
Yang Chenxi C Department of Chemistry, University of Wisconsin, Madison, WI 53706, - - 2012
α1(V) is an extensively modified collagen chain important in disease. Comprehensive mapping of α1(V) post-translational modifications reveals unexpectedly large numbers of X-position hydroxyprolines in Gly-X-Y amino acid triplets. The unexpected abundance of X-position hydroxyprolines suggests a mechanism for differential modification of collagen properties. Positions, numbers, and occupancy of modified sites ...
Kobayashi Leo - - 2012
BACKGROUND AND OBJECTIVES: Medical simulation and human factors engineering (HFE) may help investigate and improve clinical telemetry systems. Investigators sought to (1) determine the baseline performance characteristics of an Emergency Department (ED) telemetry system implementation at detecting simulated arrhythmias and (2) improve system performance through HFE-based intervention. METHODS: The prospective ...
Suh Dong-Hye - - 2012
Abstract Background: Infraorbital laxity is a common problem that increases with age. Blepharoplasty with lipectomy is a very commonly performed surgical procedure to treat this problem; however, it is invasive and is associated with the potential for reemergence. Therefore, young patients may prefer a non-surgical procedure to a surgical procedure. ...
Cui Yong - - 2012
INTRODUCTION: The presence of cigarette-related cues has been associated with smoking relapse. These cues are believed to activate brain mechanisms underlying emotion, attention, and memory. Electroencephalography (EEG) alpha desynchronization (i.e., reduction in alpha power) has been suggested to index the engagement of these mechanisms. Analyzing EEG alpha desynchronization in response ...
Medina-Bravo Patricia - - 2012
BACKGROUND: Recent evidence suggests that high-density lipoprotein (HDL) physicochemical characteristics and functional capacity may be more important that HDL-C levels in predicting coronary heart disease. There is little data regarding HDL subclasses distribution in youth with type 1 diabetes. OBJECTIVE: To assess the relationships between glycemic control and HDL subclasses ...
Zeeb Martin - - 2012
Formation of new blood and lymphatic vessels is involved in many physiological and pathological processes, including organ and tumor growth, cancer cell metastasis, fluid drainage and lymphedema. Therefore, the ability to manipulate vascularization in a mammalian system is of particular interest to researchers. Here we describe a method for pharmacological ...
Benkhedah Nadia - - 2012
A new method is presented for acquiring 3D biexponential weighted sodium images of the in vivo human brain with up to three times higher signal-to-noise ratio compared with conventional six-step phase-cycling triple-quantum-filtered imaging. To excite and detect multiple-quantum coherences, a three-pulse preparation is used. During the pulse train, two images ...
Bullock Sam - - 2012
A new route to luminescent derivatives of androgenic steroids containing a ketone group in the 3- or 17-position has been developed. Reaction with the fac-Re(CO)(3)Cl complex of 3,3'-diamino-2,2'-bipyridine (complex ) afforded a cyclic aminal product with different steroids. The rate of reaction and yield varies according to the conjugation or ...
Kim Tae-Bum - - 2012
Asthma is a heterogeneous airway disease with various clinical phenotypes. It is crucial to clearly identify clinical phenotypes to achieve better asthma management.We used cluster analysis to classify the clinical groups of 724 asthmatic patients from the Korean Cohort for Reality and Evolution of adult Asthma (COREA), and in 1843 ...
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