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Results 601 - 650 of 2501
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Thanapal Mohana Raj - - 2012
BACKGROUND: Although laparoscopic surgeries are associated with reduced surgical stress response and shortened post-operative recovery, intense pain and high analgesia requirements in the immediate post-operative period are often the chief complaints. AIM: The aim of this study was to evaluate the effect of pre-emptive intraperitoneal local anaesthetic drugs on post-operative ...
Araújo-Pérez Félix F Division of Gastroenterology and Hepatology, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, - - 2012
There is growing evidence the microbiota of the large bowel may influence the risk of developing colorectal cancer as well as other diseases including type-1 diabetes, inflammatory bowel diseases and irritable bowel syndrome. Current sampling methods to obtain microbial specimens, such as feces and mucosal biopsies, are inconvenient and unappealing ...
Marelli Benedetto - - 2012
None of the replacements proposed in the literature for small-calibre blood vessels (SCBV) fully satisfies the stringent requirements that these grafts have to fulfil. Here, an electrospun silk fibroin tubular construct is hybridized with type I collagen gel to produce a biomimetic SCBV graft with physiologically relevant compliance and burst ...
Ackman James B JB Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, - - 2012
The morphological and functional development of the vertebrate nervous system is initially governed by genetic factors and subsequently refined by neuronal activity. However, fundamental features of the nervous system emerge before sensory experience is possible. Thus, activity-dependent development occurring before the onset of experience must be driven by spontaneous activity, ...
Zhang Lu - - 2012
Angiogenesis plays an important role in many pathological processes. Identification of novel anti-angiogenic agents will provide new insights into the mechanisms for angiogenesis as well as potential lead compounds for developing new drugs. In the present study, a series of resveratrol methylated derivatives have been synthesized and screened. We found ...
Jacquot de Rouville Henri-Pierre - - 2012
A neutral donor-acceptor [2]rotaxane, which has been synthesized using click chemistry, has had its solid-state structure and superstructure elucidated by X-ray crystallography. Both dynamic (1)H NMR spectroscopy and electrochemical investigations have been employed in an attempt to shed light on both geometrical reorganization and redox-switching processes that are occurring or ...
Shao Y-Y - - 2012
Patients enrolled in clinical trials of advanced hepatocellular carcinoma (HCC) are usually required to have good liver reserve and organ function. However, their outcomes are still highly variable. We aimed to examine whether current staging systems can predict the survival of these highly selected patients. Patients from clinical trials involving ...
Núñez-Villanueva Diego - - 2012
A simple method for the synthesis of an azepane quaternary amino acid in enantiopure form is described. Theoretical, NMR, and X-ray studies indicated that this azepane-derived amino acid is an effective stabilizer of 310 helical structures in short peptides.
A Shahin - - 2012
We study aging behavior of aqueous suspension of Laponite as a function of concentration of Laponite, concentration of salt, time elapsed since preparation of suspension (idle time) and temperature by carrying extensive rheological and conductivity experiments. We observe that temporal evolution of elastic modulus, which describes structural build-up and aging, ...
Diao Bo - - 2012
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness, tissue remodeling, and airflow obstruction. The pathogenesis of asthma is only partly understood, and there is an urgent need for improved therapeutic strategies for this disease. The protein-protein interaction (PPI) network has considerable promise as a tool for discovery of ...
Routti Heli - - 2012
The aim of the present study was to investigate how contaminant exposure and reduced food intake affect tissue distribution and biotransformation of halogenated organic contaminants (HOCs) in Arctic seabirds using herring gull (Larus argentatus) as a model species. Herring gull chicks were exposed for 44 d to cod liver oil ...
Martín-Sómer Ana - - 2012
The gas-phase acidity of a series of amine-borane complexes has been investigated through the use of electrospray mass spectrometry (ESI-MS), with the application of the extended Cooks kinetic method, and high-level G4 ab initio calculations. The most significant finding is that typical nitrogen bases, such as aniline, react with BH(3) to ...
Anton Alfonso - - 2012
Purpose:To evaluate visual function with a novel Multichannel Functional Test (ATD). Methods:Design: Prospective and Cross-sectional study. Settings: Multicenter study. Patients: A total of 186 eyes were included: 42 with glaucoma, 14 glaucoma suspects due to optic nerve characteristics, 25 ocular hypertensives and 105 normal eyes. Observation procedures: All performed standard ...
Tsuruoka Tohru - - 2012
Quantized conductance was observed in a cation-migration-based resistive switching memory cell with a simple metal-insulator-metal (MIM) structure using a thin Ta(2)O(5) layer. The observed conductance changes are attributed to the formation and dissolution of a metal filament with an atomic point contact of different integer multiples in the Ta(2)O(5) layer. ...
Koo Ng N K F - - 2012
Background: Predicting which chronic rhinosinusitis patients have nasal obstruction due to reversible mucosal inflammation could prevent unnecessary surgery. Aim: To investigate whether the change in nasal peak inspiratory flow following maximal decongestion (i.e. mucosal reversibility) at first visit predicts the response to topical steroids in chronic rhinosinusitis patients, as measured ...
Zheng Xiuwen X Department of Biostatistics, University of Washington, Seattle, WA 98195-7232, USA. - - 2012
Genome-wide association studies are widely used to investigate the genetic basis of diseases and traits, but they pose many computational challenges. We developed gdsfmt and SNPRelate (R packages for multi-core symmetric multiprocessing computer architectures) to accelerate two key computations on SNP data: principal component analysis (PCA) and relatedness analysis using ...
Kinsey Debbie - - 2012
Foster care is a complex setting in which to provide therapeutic interventions due to the high rates of difficulty, poor outcomes and high numbers of professionals and carers involved. This systematic review aims to examine interventions that have been empirically assessed in foster care. Thirty papers describing 20 interventions were ...
Simi Massimiliano - - 2012
Background. The magnetic surgical camera is an emerging technology having the potential to improve visualization without taking up port site space. However, tilting the point of view downward/upward can be done only by constantly applying a pressure on the abdomen. This study aims to test the hypothesis that the novel ...
Kim J H - - 2012
We reviewed retrospectively seven patients with Apert acrosyndactyly and measured the size of the capitate ossification centre relative to that of the hamate and determined the relative position of the middle finger metacarpal relative to the ring finger metacarpal. We then compared those parameters in 197 normal children. In all ...
Huang Jung-Chen - - 2012
The Salton Sea in California is an important habitat for fish and waterfowl. Its ecosystem is threatened due to diminishing water supplies and increasing salinity. An alternative source of water to support species conservation habitat may be obtained from local rivers (e.g., Alamo or New Rivers), provided that a wetland ...
Boutorine Yury I YI Département de Biochimie, Université de Montréal, Montréal, Quebec H3C 3J7, - - 2012
Analysis of available RNA crystal structures has allowed us to identify a new family of RNA arrangements that we call double twist-joints, or DTJs. Each DTJ is composed of a double helix that contains two bulges incorporated into different strands and separated from each other by 2 or 3 bp. ...
Farren Conor K - - 2012
AIMS: To investigate the prognostic factors that determine 2-year outcomes in a group of alcohol-dependent patients with depression or bipolar disorder who were treated in an intensive 4-week inpatient programme. METHODS: This was a longitudinal study of an inpatient treatment cohort of dual affective disorder and alcohol-dependent patients, in Dublin, ...
Klee Andreas - - 2012
Microemulsions with magnetic properties were formed by employing a magnetic room temperature ionic liquid (MRTIL) as polar phase, cyclohexane as oil, and an appropriate mixture of ionic surfactant and decanol as a cosurfactant. By means of small-angle neutron scattering (SANS) and electric conductivity the microemulsion structure could be confirmed, where ...
Feng Yancong - - 2012
In this work, the dispersive and conductive properties of polymer nanocomposites are investigated simultaneously using the molecular dynamic simulation method. Four factors influencing the dispersion and conductivity are concerned, including polymer-nanoparticle interaction, nanoparticles with grafted chains, cross-linking of polymer chains and blending of polymer. It is shown that the variation ...
Koyanagi Takashi - - 2012
Aromatic amino acid decarboxylases (AADCs) are found in various organisms and play distinct physiological roles. AADCs from higher eukaryotes have been well studied because they are involved in the synthesis of biologically important molecules such as neurotransmitters and alkaloids. In contrast, bacterial AADCs have received less attention because of the ...
Alharfi Ibrahim - - 2012
Acquired hypernatremia in hospitalized patients is often associated with poorer outcomes. Our aim was to evaluate the relationship between acquired hypernatremia and outcome in children with severe traumatic brain injury (sTBI). We performed a retrospective cohort study of all severely injured trauma patients (Injury Severity Score≥12) with sTBI (GCS≤8 and ...
Auerbach Randy P - - 2012
The goal of the study is to examine whether family conflict generates peer-related stress and subsequent depressive symptoms among adolescents. In addition, in the context of the proposed mediation model, we examine whether negative cognitive styles about the self, cause, and consequences moderate the mediational pathway between peer stress and ...
Beggs C - - 2012
OBJECTIVE: While chronic cerebrospinal venous insufficiency (CCSVI) can be characterized using cervical plethysmography, much remains unknown about the haemodynamics associated with this procedure. The aim of the study was therefore to gain a deeper understanding of the observed haemodynamics. METHOD: Forty healthy controls and 44 CCSVI patients underwent cervical plethysmography, ...
Chan Yuk Cheung YC Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, - - 2012
miR-199a-5p plays a critical role in controlling cardiomyocyte survival. However, its significance in endothelial cell biology remains ambiguous. Here, we report the first evidence that miR-199a-5p negatively regulates angiogenic responses by directly targeting v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets-1). Induction of miR-199a-5p in human dermal microvascular endothelial cells ...
Neil Elsbeth - - 2012
Parental mental distress may pre-date or even precipitate a child's adoption, but adoption can also cause birth family members psychological distress. There is a lack of research that has measured the mental distress of birth relatives in contemporary adoptions, most of which are initiated by the child welfare system. The ...
Ojha S - - 2012
The present study was designed to evaluate the cardioprotective potential of lycopene (LCP) against isoproterenol (ISP)-induced myocardial infarction (MI), by assessing hemodynamic, biochemical and histopathological parameters. Wistar male albino rats were orally administered with LCP (0.5, 1.0 and 1.5 mg/kg) or with vehicle for 30 days, with concurrent subcutaneous injections of ISP ...
Ishigami Shin-Taro - - 2012
A new xenicane diterpenoid, cristaxenicin A (1) has been isolated from the deep sea gorgonian Acanthoprimnoa cristata. The structure of 1 was elucidated on the basis of spectral analysis including NMR and MS. The absolute configuration of 1 was determined on the basis of quantum chemical calculation of CD spectra. ...
Idris Nikmah Salamia - - 2012
Abstract Objectives: This study investigated factors involved in breastfeeding planning of pregnant Asian women. Subjects and Methods: A cross-sectional study was conducted on 207 pregnant women visiting the Budi Kemuliaan Hospital, Jakarta, Indonesia, between June and August 2011. The planned breastfeeding duration and determinants were sought using a standardized self-reported ...
Gatica Rodrigo - - 2012
Diabetes is the major cause of end stage renal disease, and tubular alterations are now considered to participate in the development and progression of diabetic nephropathy (DN). Here, we report for the first time that expression of the insulin receptor (IR) in human kidney is altered during diabetes. We detected ...
Bermel Wolfgang - - 2012
Carbon-13 direct-detection NMR methods have proved to be very useful for the characterization of intrinsically disordered proteins (IDPs). Here we present a suite of experiments in which amino-acid-selective editing blocks are encoded in CACON- and CANCO-type sequences to give (13) C-detected spectra containing correlations arising from a particular type or ...
Thompson Patricia P University of Arizona Cancer Center, 1515 N. Campbell Avenue, Tucson, AZ 85724, - - 2012
COX inhibitors reduce colorectal adenoma recurrence by up to 45% and selenium supplementation may prevent colorectal cancer. Following colonoscopic adenoma resection, 1,600 men and women, ages 40 to 80 years, were randomized to celecoxib (400 mg daily), a selective COX-2 inhibitor, and/or selenium (200 μg daily as selenized yeast), or ...
Mercadante Sebastiano - - 2012
Abstract Objectives: The aim of this prospective, open-label study was to evaluate the efficacy and tolerability of tapentadol (TP) in the management of cancer pain. Methods: A four weeks prospective study was carried out in 50 opioid-naive cancer patients with moderate-severe pain. Each patient initially received twice-daily doses of slow ...
O'Kelly Curtis - - 2012
Single crystal iron nanocubes are produced by simply heating a bilayer film. This surface energy driven growth (SEDG) method exploits the difference in surface energies of the components (γ(Fe) ∼ 2.2 J m(-2) versus γ(Nd) ∼ 0.7 J m(-2)) in the binary alloy Fe-Nd system to produce nanocubes of the higher energy Fe component. The dimensions of the ...
Antunes-Martins Ana A The Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London, - - 2013
Chronic pain represents a major health burden; this maladaptive pain state occurs as a consequence of hypersensitivity within the peripheral and central components of the somatosensory system. High throughput technologies (genomics, transciptomics, lipidomics, and proteomics) are now being applied to tissue derived from pain patients as well as experimental pain ...
Gaffey Kate - - 2012
The p38 Mitogen Activated Protein Kinase (MAPK) pathway is upregulated in COPD. To date dual-labelling to identify cell-type specific presence of phosphorylated (phospho-) p38 MAPK has not been carried out.Phospho-p38 MAPK was quantified in a variety of cell types in the lung tissue of 20 COPD patients, 12 smokers and ...
Ohuma E O EO Kenya Medical Research Institute, Centre for Geographic Medicine Research, Kilifi, Kenya. - - 2012
This study aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infection and the effect of age and infection history on the risk of respiratory syncytial virus disease. A birth cohort of 635 children in Kilifi, Kenya, was ...
Gao Huile - - 2012
The purpose of the investigation was to prepare a new type of nanoparticle, namely lapatinib-incorporated lipoprotein-like nanoparticles (LTNPs), and to evaluate the behavior and anti-glioma effect of LTNPs. LTNPs were prepared and characterized using the Cyro-transmission electron microscope (Cryo-TEM) and Raman scan methods. Cellular uptake and subcellular localization studies were ...
Barzey Victor - - 2012
Abstract Objective: To estimate the cost effectiveness of ipilimumab (3mg/kg) compared with best supportive care (BSC) in pre-treated advanced melanoma patients. Methods: The analysis was based on a US payer perspective and lifetime time horizon. A three-state Markov model was developed representing clinical outcomes, quality of life, and healthcare resource ...
Youmans Katherine L KL Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612, - - 2012
APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with amyloid-β peptide (Aβ) suggest interactions among apoE isoforms and different forms of Aβ accumulation. However, it remains unclear how the APOE genotype affects plaque morphology, intraneuronal Aβ, soluble Aβ42, and oligomeric Aβ (oAβ), particularly in vivo. ...
Yabe John - - 2012
Concentrations of Pb, Cd, and other metals in tissues of 17 free-range and 32 commercial broiler chickens from the Kabwe mining town in Zambia were determined. Mean concentrations of Pb and Cd exceeded maximum levels for human consumption in some organs including muscle (Pb only) in free-range chickens, in contrast ...
Navizet Isabelle - - 2012
A usual strategy in both experimental and theoretical studies on bio- and chemiluminescence is to analyze the fluorescent properties of the bio- and chemiluminescence reaction product. Recent findings in a coelenteramide and Cypridina oxyluciferin model arise a concern on the validity of this procedure, showing that the light emitters in ...
Roos Eira - - 2012
OBJECTIVES: The aims of this study were to examine (i) the association of relative weight with subsequent disability retirement due to any diagnosis and also in two major diagnostic groups (ie, musculoskeletal diseases and mental disorders) and (ii) whether diagnosed diseases, physical and mental functioning, and working conditions explain these ...
Marchesi Irene - - 2012
Cyclin dependent kinase 9 (Cdk9) is a serine-threonine kinase, involved in many cellular processes. The regulatory units of Cdk9 are the T family Cyclins (T1, T2) and Cyclin K. Cyclin T2 has two forms termed Cyclin T2a and Cyclin T2b that arise by an alternative splicing of the primary transcript. ...
Loh Gunnar G German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Gastrointestinal Microbiology, Nuthetal, Germany. - - 2012
Aberrant immune responses toward commensal gut bacteria can result in the onset and perpetuation of inflammatory bowel diseases (IBD). Reduced microbiota diversity in conjunction with lower proportion of Gram positive and higher proportion of Gram negative bacteria than in healthy subjects is frequently reported in IBD patients. In a subset ...
Liu Yajie - - 2012
Epithelial-mesenchymal transition (EMT) is an important mechanism of cardiac fibrosis after myocardial infarction (MI). However, it remains unclear whether Snail1, an important regulator of EMT, is involved in cardiac fibrosis. In this study, we explored the expression patterns of Snail1 and a cardiac fibrosis marker-periostin-after MI in mice and then ...
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