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Thakkar Santosh V - - 2012
A molecular understanding of excipient effects on the interrelationship(s) between dynamics and conformational stability of proteins, such as monoclonal antibodies (mAbs), can be important for their pharmaceutical development. The current study examines stabilizing and destabilizing effects of excipients on the conformational stability and local dynamics of distinct solvent-exposed regions within ...
Visnes Håvard - - 2012
BACKGROUND: The 'jumper's knee paradox', where symptomatic athletes appear to perform better in a counter movement jump (CMJ) compared to asymptomatic controls in previous case-control studies is not fully understood. AIM: The aim was to examine the relationship between jumping ability and change of jumping ability as potential risk factors ...
Piao Yongjun - - 2012
MOTIVATION: Gene selection for cancer classification is one of the most important topics in the biomedical field. However, microarray data poses a severe challenge for computational techniques. We need dimension reduction techniques that identify a small set of genes to achieve better learning performance. From the perspective of machine learning, ...
Pavri Behzad B - - 2012
BACKGROUND: -We evaluated the viability of I(Kur) as a target for maintenance of sinus rhythm in patients with a history of atrial fibrillation through the testing of MK-0448, a novel I(Kur) inhibitor. METHODS AND RESULTS: -In vitro MK-0448 studies demonstrated strong inhibition of I(Kur) with minimal off-target activity. In vivo ...
Xiang Xia - - 2012
Droplet methods have been successfully applied in DNA hybridization analysis and protein-protein interaction. Existing assay methods implemented in droplet platforms are severely limited by expensive and high-maintenance equipment. As a convenient detection method, colorimetry provides a new path for microscale assay since it can enhance assay efficiency and simplify the ...
Zhang Lian Ying - - 2012
Unique DNA-promoted Pd nanocrystals on carbon nanotubes (Pd/DNA-CNTs) are synthesized for the first time, in which through its regularly arranged PO(4) (3-) groups on the sugar-phosphate backbone, DNA directs the growth of ultrasmall Pd nanocrytals with an average size of 3.4 nm uniformly distributed on CNTs. The Pd/DNA-CNT catalyst shows much ...
Sauvageau Janelle - - 2012
In this study, the role of lipoteichoic acid (LTA) anchors in the activation of the innate immune response was investigated through the chemical synthesis of a series of LTA derivatives and the determination of their ability to induce NO production in bone marrow-derived macrophages (BMM). To this end, an efficient ...
Muzychenko D A - - 2012
The formation of a novel surface reconstruction upon Co deposition on freshly cleaved Ge(111)2 × 1 surfaces is studied by means of scanning tunneling microscopy (STM) at 4.5 K. Previously we demonstrated that at this low substrate temperature the deposited Co atoms remain immobile after they become embedded underneath the Ge(111)2 × 1 surface. We ...
Yuki Michiko - - 2012
Purposes:(a) To measure the urinary excretion of antineoplastic drugs of three patients during 48 h after the administration of cyclophosphamide (two patients) and 5-fluorouracil (one patient). (b) To evaluate environmental contamination with antineoplastic drugs via excreta of patients in the home setting. (c) To evaluate exposure of family members to antineoplastic ...
Wu Yinuo - - 2012
A C-H arylation with aryl chloride is made viable through a transition-metal-free approach. In the presence of a simple diol associating with KOt-Bu, various phenanthridine derivatives can be conveniently accessed. In particular, only 10 mol % of simple and inexpensive ethylene glycol is required for this protocol. These results represent ...
Bayir A - - 2012
The aim of this study was to examine the effects of ubiquinone (CoQ10) on heart tissue and erythrocytes in acute organophosphate poisoning (AOP). A total of 20 rabbits were divided into three groups: sham (n = 8), pralidoxime (PAM) + atropine (n = 6), and CoQ10 + PAM + atropine (n = 6). Blood samples were taken from each test subject to ...
Aoun Samar M - - 2012
This project implemented and evaluated two models of care for terminally ill people living alone at home: installing personal alarms (PA) and providing extra care aide (CA) support. The primary aim was to assess the feasibility of using a randomised controlled trial (RCT) approach with this group. A secondary aim ...
Zhong Yun-Shi - - 2012
Abstract Objectives: Brunner's adenoma is a rare benign tumor of the duodenum. The traditional management option was close follow-up and surgical tumor resection. With the development of endoscopy devices and techniques, endoscopic resection is considered an alternative treatment option. However, whether small lesions require treatment has been controversial. We planned ...
Neu Rebecca C - - 2012
Reactions of the perfluoroarylboranes RB(C(6)F(5))(2) (R = C(6)F(5), Ph, Cl, OC(6)F(5)) with Me(3)SiCH(N(2)), (C(6)F(5))CH(N(2)) or Ph(2)C(N(2)) yield (C(6)F(5))(2)B(Me(3)SiCH(C(6)F(5))) , (C(6)F(5))B(Me(3)SiCH(C(6)F(5)))(2), (C(6)F(5))B(Me(3)SiCH(C(6)F(5)))(Me(3)SiCH(C(6)H(5))) , (C(6)F(5))(2)B(CH(C(6)F(5))(2)) , ClB(C(6)F(5))(Ph(2)C(C(6)F(5))) and (C(6)F(5)O)B(C(6)F(5))(Me(3)SiCH(C(6)F(5))) as a result of single or double insertion of a Me(3)SiCH, C(6)F(5)CH or Ph(2)C fragment into a B-C bond of the respective borane. ...
Pelikan Richard C - - 2012
Nonsyndromic orofacial clefts are common birth defects whose etiology is influenced by complex genetic and environmental factors and gene-environment interactions. Although these risk factors are not yet fully elucidated, it is known that alterations in transforming growth factor-beta (TGFβ) signaling can cause craniofacial abnormalities, including cleft palate, in mammals. To ...
Rauck Richard - - 2012
OBJECTIVES: The Prometra® Programmable Pump System (Flowonix Medical, Inc., Mt. Olive, NJ, USA) is designed for continuous intrathecal administration of morphine sulfate to treat chronic intractable pain. As a follow-up to a previous report on acute six-month data, this study evaluated the efficacy of treatment at one year and the ...
Prasad Vani - - 2012
Reconstruction of large soft tissue defects of the back is a challenging problem. Large defects of the back were reconstructed with multiple random pattern or local pedicled muscle (and skin graft) or musculocutaneous flaps. The clinical use of perforator flaps has demonstrated that harvesting of flaps on a single perforator ...
Wang Tie - - 2012
This manuscript reports a shape-controlled synthesis of colloidal superparticles from iron-oxide nanocubes. Our results show that the formation of superparticles is under thermodynamic control and their shape is determined by Gibbs free energy minimization. The resulting superparticles adopted a simple cubic superlattice structure, and their shape can be tuned between ...
Rijsdijk M - - 2012
BACKGROUND: High efficacy of intrathecal methylprednisolone acetate (MPA) with lidocaine has been reported in a large patient group suffering from intractable postherpetic neuralgia (PHN). Because the treatment effect was never independently confirmed and there are ongoing safety concerns, intrathecal MPA did not become standard care for intractable PHN. We report ...
Suh Dong-Hye - - 2012
ABSTRACT Background: Striae distensae (striae alba) is a challenging cosmetic problem for which various treatment modalities have been applied. However, the treatment of striae distensae has not been satisfactory. Objectives: This study was done to evaluate the effectiveness and the safety of enhanced penetration of platelet rich plasma with ultrasound ...
Donaldson Phillip - - 2012
One of the most widely used tasks in the spatial memory literature is the judgement of relative direction (JRD) test. The present investigation examined the hypothesis that standard JRD task demands bias spatial recall. In two experiments, participants' recall of small-scale layouts as measured by standard JRD tests (in which ...
Masuda Masaharu - - 2012
AIMS: In patients with paroxysmal atrial fibrillation (AF), the P-wave signal-averaged electrocardiogram often demonstrates a low-amplitude potential at the terminal part of filtered P-wave (atrial late potential: A(LP)), which would originate from delayed pulmonary vein (PV) potentials. The aim of this study was to investigate the impact of PV isolation ...
Yoshimura Tomoyuki - - 2012
β-Lactams with contiguous tetra- and trisubstituted carbon centers were prepared in a highly enantioselective manner through 4-exo-trig cyclization of axially chiral enolates generated from readily available α-amino acids. Use of a weak base (metal carbonate) in a protic solvent (EtOH) is the key to the smooth production of β-lactams. Use ...
Breinbauer Hayo A - - 2012
OBJECTIVES/HYPOTHESIS: Our goal was to assess the impact of personal music players, earphones, and music styles on output, the subject's preferred listening levels, and outline recommendations for the prevention of music-induced hearing loss. STUDY DESIGN: Experimental study. Personal music players' output capabilities and volunteers' preferred output levels were assessed in ...
Tran Pamela V - - 2012
The Hedgehog (Hh) signaling pathway plays a fundamental role in development and tissue homeostasis, governing cell proliferation and differentiation, as well as cell fate. Hh signaling is mediated by an intricate network of proteins that have positive and negative roles that work in concert to fine-tune signaling output. Using feedback ...
Tsuruoka Tohru - - 2012
Quantized conductance was observed in a cation-migration-based resistive switching memory cell with a simple metal-insulator-metal (MIM) structure using a thin Ta(2)O(5) layer. The observed conductance changes are attributed to the formation and dissolution of a metal filament with an atomic point contact of different integer multiples in the Ta(2)O(5) layer. ...
Koo Ng N K F - - 2012
Background: Predicting which chronic rhinosinusitis patients have nasal obstruction due to reversible mucosal inflammation could prevent unnecessary surgery. Aim: To investigate whether the change in nasal peak inspiratory flow following maximal decongestion (i.e. mucosal reversibility) at first visit predicts the response to topical steroids in chronic rhinosinusitis patients, as measured ...
Kinsey Debbie - - 2012
Foster care is a complex setting in which to provide therapeutic interventions due to the high rates of difficulty, poor outcomes and high numbers of professionals and carers involved. This systematic review aims to examine interventions that have been empirically assessed in foster care. Thirty papers describing 20 interventions were ...
Simi Massimiliano - - 2012
Background. The magnetic surgical camera is an emerging technology having the potential to improve visualization without taking up port site space. However, tilting the point of view downward/upward can be done only by constantly applying a pressure on the abdomen. This study aims to test the hypothesis that the novel ...
Kim J H - - 2012
We reviewed retrospectively seven patients with Apert acrosyndactyly and measured the size of the capitate ossification centre relative to that of the hamate and determined the relative position of the middle finger metacarpal relative to the ring finger metacarpal. We then compared those parameters in 197 normal children. In all ...
Huang Jung-Chen - - 2012
The Salton Sea in California is an important habitat for fish and waterfowl. Its ecosystem is threatened due to diminishing water supplies and increasing salinity. An alternative source of water to support species conservation habitat may be obtained from local rivers (e.g., Alamo or New Rivers), provided that a wetland ...
Farren Conor K - - 2012
AIMS: To investigate the prognostic factors that determine 2-year outcomes in a group of alcohol-dependent patients with depression or bipolar disorder who were treated in an intensive 4-week inpatient programme. METHODS: This was a longitudinal study of an inpatient treatment cohort of dual affective disorder and alcohol-dependent patients, in Dublin, ...
Klee Andreas - - 2012
Microemulsions with magnetic properties were formed by employing a magnetic room temperature ionic liquid (MRTIL) as polar phase, cyclohexane as oil, and an appropriate mixture of ionic surfactant and decanol as a cosurfactant. By means of small-angle neutron scattering (SANS) and electric conductivity the microemulsion structure could be confirmed, where ...
Feng Yancong - - 2012
In this work, the dispersive and conductive properties of polymer nanocomposites are investigated simultaneously using the molecular dynamic simulation method. Four factors influencing the dispersion and conductivity are concerned, including polymer-nanoparticle interaction, nanoparticles with grafted chains, cross-linking of polymer chains and blending of polymer. It is shown that the variation ...
Rotzler Jürgen - - 2012
The influence of electron donors and electron acceptors of variable strength in the 4 and 4' position of 2 and 2' propyl-bridged axial chiral biphenyl cyclophanes on their atropisomerization process was studied. Estimated free energies ΔG(‡)(T) of the rotation around the central biphenyl bond which were obtained from (1)H-NMR coalescence ...
Witham P J - - 2012
The neutral atom microscope uses a beam of thermal noncharged atoms or molecules to probe an atomic surface with very low interaction energies (<70 meV). Continued optimization of the 'pinhole' neutral atom microscope has improved resolution to 0.35 μm. Recent images are presented demonstrating resolution and the contrast mechanisms identified ...
Nagata Yuuya - - 2012
Poly(quinoxaline-2,3-diyl)s bearing pyrene pendants exhibited solvent-dependent changes of the fluorescence color (blue and green) and the screw-sense selectivity (left-handed and racemic) in chloroform and 1,1,1-trichloroethane, respectively.
M Kager Liesbeth - - 2012
Intravenous administration of activated protein C (APC) inhibits coagulation and inflammation in the lungs of humans and animals. Investigations in rodents demonstrated that direct intrapulmonary delivery of APC also exerts anticoagulant and anti-inflammatory effects. The effect of intrabronchial administration of recombinant human (rh)APC on lipopolysaccharide (LPS)-induced hemostatic and inflammatory alterations ...
Kojima Satoko - - 2012
PROBLEM: Local adaptive cervical regulatory T cells (Tregs) are the most likely direct suppressors of the immune eradication of cervical intraepithelial lesion (CIN). PD-1 expression on T cells induces Tregs. No studies have quantitatively analyzed the Tregs and PD-1+ cells residing in CIN lesions. METHOD OF STUDY: Cervical lymphocytes were ...
Bakobaki Julie - - 2012
BACKGROUND: As part of a broader methodological programme of work around clinical trial monitoring, we wanted to evaluate the existing evidence for the effectiveness of different monitoring techniques. PURPOSE: To identify and evaluate prospective studies of the effectiveness of different monitoring strategies. METHODS: A systematic search of MEDLINE from 1950 ...
Chukwujekwu Jude C - - 2012
Using activity-guided fractionation based on in vitro antibacterial assays, five biflavonoids, among them two new ones, were isolated from the aerial parts of Ormocarpum trichocarpum. The isolated compounds showed MIC values in the range of 4.0 to 136.7 µM against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia and IC50 ...
James D C - - 2012
Interventions for strengthening intrinsic foot muscles may be beneficial for rehabilitation from overuse injuries. In this study the acute effects of high-frequency, low-intensity wide-pulse electrical stimulation (WPS) over an intrinsic muscle on subsequent foot function during walking was assessed in healthy participants. WPS was delivered to the m. abductor hallucis ...
Presiado Itay - - 2012
Steady-state and time-resolved emission techniques were used to study the protolytic processes in the excited-state of dehydroluciferin, a non-bioluminescent product of the firefly enzyme luciferase. We found that the ESPT rate coefficient is only s-1, whereas those of D-luciferin and oxyluciferin are and s-1 respectively. We measured the ESPT rate ...
Nascimento Luana Beatriz Dos Santos - - 2012
Antioxidant compounds protect plants against oxidative stress caused by environmental conditions. Different light qualities, such as UV-A radiation and blue light, have shown positive effects on the production of phenols in plants. Kalanchoe pinnata (Lamarck) Persoon (Crassulaceae) is used for treating wounds and inflammations. Some of these beneficial effects are ...
Camaschella Clara - - 2012
Microcytic hypochromic anaemias are a result of defective iron handling by erythroblasts that decrease the haemoglobin content per red cell. Recent advances in our knowledge of iron metabolism and its homeostasis have led to the discovery of novel inherited anaemias that need to be distinguished from common iron deficiency or ...
Miao Hui-Lai - - 2012
Glypican-3 (GPC3), a membrane-associated heparan sulfate proteoglycan, is frequently upregulated in hepatocellular carcinoma (HCC). Yes-associated protein (YAP) is also found over-expressed in HCC and has been identified as a key effector molecule in Hippo pathway, which could control the organ size in animals through the regulation of cell proliferation and ...
Osuagwu Uchechukwu L - - 2012
Abstract Purpose: To compare the effect of tetracaine 1% on central corneal thickness (CCT) measurements obtained by the ultrasound pachymetry (USP) and Topcon SP-3000P specular microscope. Methods: In the following sequence, SP-3000P before anesthesia, USP before anesthesia, SP-3000P 10 mins after anesthesia, USP 10 mins after anesthesia, CCT measurements were obtained from ...
Zeeb Martin - - 2012
Formation of new blood and lymphatic vessels is involved in many physiological and pathological processes, including organ and tumor growth, cancer cell metastasis, fluid drainage and lymphedema. Therefore, the ability to manipulate vascularization in a mammalian system is of particular interest to researchers. Here we describe a method for pharmacological ...
Benkhedah Nadia - - 2012
A new method is presented for acquiring 3D biexponential weighted sodium images of the in vivo human brain with up to three times higher signal-to-noise ratio compared with conventional six-step phase-cycling triple-quantum-filtered imaging. To excite and detect multiple-quantum coherences, a three-pulse preparation is used. During the pulse train, two images ...
Bullock Sam - - 2012
A new route to luminescent derivatives of androgenic steroids containing a ketone group in the 3- or 17-position has been developed. Reaction with the fac-Re(CO)(3)Cl complex of 3,3'-diamino-2,2'-bipyridine (complex ) afforded a cyclic aminal product with different steroids. The rate of reaction and yield varies according to the conjugation or ...
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