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Results 501 - 550 of 2501
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Zha Xianfeng - - 2012
T-cell immunodeficiency is a common feature in patients with chronic myeloid leukemia (CML), and deficiency in CD3 levels was detected in T cells from these patients, which may represent a characteristic that is related to a lower T cell activation. In this study, we explored the possibility that forced TCRζ ...
Rashikh Azhar A Faculty of Pharmacy, Jamia Hamdard (Hamdard University), - - 2013
Doxorubicin (DXR) is one of the most effective and widely used anthracycline antibiotics. However, its clinical application is hampered by toxic effects in many organs. Nephrotoxicity is one of the major side effects of anthracycline antibiotics. This study was designed to investigate the possible protective effects of aliskiren (a direct ...
Clementoni Matteo Tretti - - 2012
Abstract Background: The concept of fractional delivery modality of the energy with both ablative and non-ablative devices is now well known and accepted as an effective method to attain significant aesthetic improvements on facial aging skin. A new multi-modal fractional ablative CO2 laser that can create, using same scanner/handpiece, deep ...
Arandjic D - - 2012
The purpose of this study was to investigate radiation doses in cerebral perfusion computed tomography (CT) examination. As a part of routine patient monitoring, data were collected on patients in terms of the skin dose and CT dose index (CTDI(vol)) and dose-length product (DLP) values. For the estimation of the ...
Cheng Jing-Jy - - 2012
Two new alkaloids, 2-demethyl-oxypalmatine (1) and 5-ethoxycarbonylsinoracutine (2), were isolated from the rhizomes of Sinomenium acutum, along with thirty-four known compounds. Cytotoxicity of the isolated compounds was examined for the MCF-7, H460, HT-29, and CEM human cancer cell lines. Dauriporphine (16), 6-O-demethylmenisporphine (17), bianfugecine (18), menisporphine (19), and 6-O-demethyldauriporphine (20) ...
Su Xin - - 2012
Two [1,2,3]triazolo[1,5-a]pyridinium salts have been prepared via a novel Cu(ii)-mediated oxidative cyclization reaction. Both water soluble compounds exhibit broad-range fluorescence emission with huge Stokes shifts as well as color tunability.
Radwan Osman - - 2012
The soybean (Glycine max) genome contains 18 members of the 14-3-3 protein family, but little is known about their association with specific phenotypes. Here, we report that the Glyma0529080 Soybean G-box Factor 14-3-3c (SGF14c) and Glyma08g12220 (SGF14l) genes, encoding 14-3-3 proteins, appear to play essential roles in soybean nodulation. Quantitative ...
Prignano Francesca - - 2012
ABSTRACT Introduction: Fractional CO2-laser is considered a preferential method for skin resurfacing, but little is known about the molecular mechanisms whereby treatments working. In the present study we investigated the possible role of apoptosis by the sequential analysis of lesional skin after laser treatment, with special attention to power. Moreover ...
Hayashi K - - 2012
What is known and Objective:  The increasing cost of drug research and development and the decreasing number of new drugs being launched are serious issues for pharmaceutical companies. Biomarkers for predicting drug effectiveness are regarded as useful tools for combating these trends. However, the extent to which these biomarkers actually ...
Salonia Andrea - - 2012
Introduction.  It is common knowledge among researchers that erectile dysfunction (ED) is an important sentinel marker of cardiovascular and overall men's health. Aim.  Determine whether the delay of time between ED onset and seeking medical help (DSH), considered as a proxy of awareness of the importance of ED for overall ...
Renner Julie Nicole - - 2012
Modular proteins have emerged as powerful tools in tissue engineering because both the mechanical and biochemical properties can be precisely controlled through amino acid sequence. Resilin is an attractive candidate for use in modular proteins because it is well-known for having low stiffness, high fatigue-lifetime, and high resilience. However, no ...
Muzychenko D A - - 2012
The formation of a novel surface reconstruction upon Co deposition on freshly cleaved Ge(111)2 × 1 surfaces is studied by means of scanning tunneling microscopy (STM) at 4.5 K. Previously we demonstrated that at this low substrate temperature the deposited Co atoms remain immobile after they become embedded underneath the Ge(111)2 × 1 surface. We ...
Nativ N I NI Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, - - 2012
Macrovesicular steatosis in greater than 30% of hepatocytes is a significant risk factor for primary graft nonfunction due to increased sensitivity to ischemia reperfusion (I/R) injury. The growing prevalence of hepatic steatosis due to the obesity epidemic, in conjunction with an aging population, may negatively impact the availability of suitable ...
Yuki Michiko - - 2012
Purposes:(a) To measure the urinary excretion of antineoplastic drugs of three patients during 48 h after the administration of cyclophosphamide (two patients) and 5-fluorouracil (one patient). (b) To evaluate environmental contamination with antineoplastic drugs via excreta of patients in the home setting. (c) To evaluate exposure of family members to antineoplastic ...
Maslove David M DM Center for Clinical Informatics, Stanford University School of Medicine, Stanford, CA94305, USA. - - 2013
The increasing availability of clinical data from electronic medical records (EMRs) has created opportunities for secondary uses of health information. When used in machine learning classification, many data features must first be transformed by discretization. To evaluate six discretization strategies, both supervised and unsupervised, using EMR data. We classified laboratory ...
Wu Yinuo - - 2012
A C-H arylation with aryl chloride is made viable through a transition-metal-free approach. In the presence of a simple diol associating with KOt-Bu, various phenanthridine derivatives can be conveniently accessed. In particular, only 10 mol % of simple and inexpensive ethylene glycol is required for this protocol. These results represent ...
Das Sudipta S Department of Biological Sciences, Tata Institute of Fundamental Research, 400005 Mumbai, - - 2012
The eukaryotic 60 S-ribosomal stalk consists of P0, P1, and P2 proteins, which associate in a pentameric structure (P1(2)-P0-P2(2)). The Plasmodium falciparum protein P2 (PfP2) appears to play nonribosomal roles. It gets exported to the infected erythrocyte (IE) surface at 30 h post-merozoite invasion (PMI), concomitant with extensive oligomerization. Here ...
Xu Ping P Department of Tea Science, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, - - 2012
The polysaccharides, named puerh tea polysaccharides (PTPS), were isolated from puerh tea. Physicochemical characteristics, hypoglycemic and antioxidant effects of PTPS in alloxan-induced diabetic mice were investigated. PTPS was found to be a kind of acid heteropolysaccharides conjugate, but the physicochemical characteristics of which were different from the polysaccharides from other ...
Bayir A - - 2012
The aim of this study was to examine the effects of ubiquinone (CoQ10) on heart tissue and erythrocytes in acute organophosphate poisoning (AOP). A total of 20 rabbits were divided into three groups: sham (n = 8), pralidoxime (PAM) + atropine (n = 6), and CoQ10 + PAM + atropine (n = 6). Blood samples were taken from each test subject to ...
Aoun Samar M - - 2012
This project implemented and evaluated two models of care for terminally ill people living alone at home: installing personal alarms (PA) and providing extra care aide (CA) support. The primary aim was to assess the feasibility of using a randomised controlled trial (RCT) approach with this group. A secondary aim ...
Zhong Yun-Shi - - 2012
Abstract Objectives: Brunner's adenoma is a rare benign tumor of the duodenum. The traditional management option was close follow-up and surgical tumor resection. With the development of endoscopy devices and techniques, endoscopic resection is considered an alternative treatment option. However, whether small lesions require treatment has been controversial. We planned ...
Neu Rebecca C - - 2012
Reactions of the perfluoroarylboranes RB(C(6)F(5))(2) (R = C(6)F(5), Ph, Cl, OC(6)F(5)) with Me(3)SiCH(N(2)), (C(6)F(5))CH(N(2)) or Ph(2)C(N(2)) yield (C(6)F(5))(2)B(Me(3)SiCH(C(6)F(5))) , (C(6)F(5))B(Me(3)SiCH(C(6)F(5)))(2), (C(6)F(5))B(Me(3)SiCH(C(6)F(5)))(Me(3)SiCH(C(6)H(5))) , (C(6)F(5))(2)B(CH(C(6)F(5))(2)) , ClB(C(6)F(5))(Ph(2)C(C(6)F(5))) and (C(6)F(5)O)B(C(6)F(5))(Me(3)SiCH(C(6)F(5))) as a result of single or double insertion of a Me(3)SiCH, C(6)F(5)CH or Ph(2)C fragment into a B-C bond of the respective borane. ...
Pelikan Richard C - - 2012
Nonsyndromic orofacial clefts are common birth defects whose etiology is influenced by complex genetic and environmental factors and gene-environment interactions. Although these risk factors are not yet fully elucidated, it is known that alterations in transforming growth factor-beta (TGFβ) signaling can cause craniofacial abnormalities, including cleft palate, in mammals. To ...
Gupta Aparna A Division of Gastroenterology & Hepatology, Department of Medicine, Stanford University, Stanford, California, - - 2013
Neuroendocrine (NE) prostate tumors and neuroendocrine differentiation (NED) in prostatic adenocarcinomas have been associated with poor prognosis. In this study, we used the TRAMP mouse model that develops NE prostate tumors to identify key factors that can lead to NED. We have previously reported that NE tumors express the forkhead ...
Gao Yi Y Psychiatry Neuroimaging Laboratory, Harvard Medical School, Boston, MA 02115, USA. - - 2012
The properties of carbon nanotube (CNT)/polymer composites are strongly dependent on the dispersion and orientation of CNTs in the host matrix. Quantification of the dispersion and orientation of CNTs by means of microstructure observation and image analysis has been demonstrated as a useful way to understand the structure-property relationship of ...
Kaufmann Anke - - 2012
G-protein coupled designer receptors that are specifically activated by designer drugs have been developed. Here, we have analyzed the regulation of gene transcription following activation of Gα(q) -coupled designer receptor (Rα(q) ). Stimulation of human embryonic kidney (HEK) 293 cells expressing Rα(q) with clozapine-N-oxide (CNO), a pharmacologically inert compound, induced ...
Lebbe C - - 2013
The aims of the study were to assess the risk of HHV8 transmission resulting from organ transplantation, and related morbidity in liver, heart and kidney transplant recipients. Donor and recipient serologies were screened between January 1, 2004 and January 1, 2005 using HHV8 indirect immunofluorescence latent assay (latent IFA) and ...
Lee Da Yeon da - - 2012
We identified four anti-inflammatory sulfur-containing compounds from garlic, and their chemical structures were identified as Z- and E-ajoene and oxidized sulfonyl derivatives of ajoene. The sulfur compounds inhibited the production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) and the expression of the pro-inflammatory cytokines tumor necrosis factor-α, interleukin-1β, and ...
Kantola T - - 2012
Inflammation contributes to the pathogenesis of colorectal cancer (CRC), and cytokine levels are altered during colorectal carcinogenesis. The serum levels of 13 cytokines and their relation to clinical and pathological parameters, and systemic inflammatory response (mGPS, CRP and neutrophil-lymphocyte ratio), were analysed from a prospective series of 148 CRC patients ...
Ayuk Sandra M - - 2012
Abstract Background: Collagen type I (Col-I) is a major component of the extracellular matrix and is important in wound healing processes. Several studies have shown that low-intensity laser irradiation (LILI) biostimulates Col-I synthesis both in vitro and in vivo. This study aimed to determine if LILI affects collagen production and ...
Grigoriev Pavel - - 2012
We report analyses of regional trends in overall and cause-specific mortality in Belarus for the period 1990-2007. We explore the respective spatial patterns and attempt to determine the factors responsible for the regional mortality variation. The results show that inter-regional mortality differentials tend to rise, mainly because of the growing ...
Chen Miao - - 2012
Chromium mononitride (CrN) exhibits interesting magnetic, structural, and electronic properties for technological applications. Experimental reports on these properties are often inconsistent owing to differences in the degree of nonstoichiometry in CrN(x) . To date, the preparation of bulk and stoichiometric CrN has been challenging; most products are in the form ...
Chen Hao - - 2012
Using Pt3Fe nanoparticles as an example, a surfactant-free Np-KCl matrix method (Np stands for nanoparticle) is developed for the synthesis of nanoparticles with controlled size and structure. In this method, the Np-KCl assembly is formed in a one-pot reduction in THF at room temperature. KCl is an insoluble by-product of ...
Lee Hyung Min - - 2012
Abstract BACKGROUND: Although ablative fractional laser for the facial photodamaged skin was effective and safe, there have been only limited reports regarding the efficacy and safety of fractional Er:YAG laser treatments for photodamaged facial skin in Asians. OBJECTIVE: Our objective was to assess the efficacy and safety of the Er:YAG ...
Santini A - - 2012
A large database of invasive forest pathogens (IFPs) was developed to investigate the patterns and determinants of invasion in Europe. Detailed taxonomic and biological information on the invasive species was combined with country-specific data on land use, climate, and the time since invasion to identify the determinants of invasiveness, and ...
Jiao Yong - - 2012
Seeing in many colors: Confocal images acquired using fluorescently labeled amyloid β-peptide revealed its efficient internalization by endocytosis into endosomes/lysosomes of human neuronal cells with a small portion reaching mitochondria, inducing marked cellular and mitochondrial reactive oxygen species production.
Rauck Richard - - 2012
OBJECTIVES: The Prometra® Programmable Pump System (Flowonix Medical, Inc., Mt. Olive, NJ, USA) is designed for continuous intrathecal administration of morphine sulfate to treat chronic intractable pain. As a follow-up to a previous report on acute six-month data, this study evaluated the efficacy of treatment at one year and the ...
Prasad Vani - - 2012
Reconstruction of large soft tissue defects of the back is a challenging problem. Large defects of the back were reconstructed with multiple random pattern or local pedicled muscle (and skin graft) or musculocutaneous flaps. The clinical use of perforator flaps has demonstrated that harvesting of flaps on a single perforator ...
Wang Tie - - 2012
This manuscript reports a shape-controlled synthesis of colloidal superparticles from iron-oxide nanocubes. Our results show that the formation of superparticles is under thermodynamic control and their shape is determined by Gibbs free energy minimization. The resulting superparticles adopted a simple cubic superlattice structure, and their shape can be tuned between ...
Rijsdijk M - - 2012
BACKGROUND: High efficacy of intrathecal methylprednisolone acetate (MPA) with lidocaine has been reported in a large patient group suffering from intractable postherpetic neuralgia (PHN). Because the treatment effect was never independently confirmed and there are ongoing safety concerns, intrathecal MPA did not become standard care for intractable PHN. We report ...
Hurdle John F JF Department of Biomedical Informatics, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA. - - 2013
Ascertainment of potential subjects has been a longstanding problem in clinical research. Various methods have been proposed, including using data in electronic health records. However, these methods typically suffer from scaling effects-some methods work well for large cohorts; others work for small cohorts only. We propose a method that provides ...
Suh Dong-Hye - - 2012
ABSTRACT Background: Striae distensae (striae alba) is a challenging cosmetic problem for which various treatment modalities have been applied. However, the treatment of striae distensae has not been satisfactory. Objectives: This study was done to evaluate the effectiveness and the safety of enhanced penetration of platelet rich plasma with ultrasound ...
Donaldson Phillip - - 2012
One of the most widely used tasks in the spatial memory literature is the judgement of relative direction (JRD) test. The present investigation examined the hypothesis that standard JRD task demands bias spatial recall. In two experiments, participants' recall of small-scale layouts as measured by standard JRD tests (in which ...
Masuda Masaharu - - 2012
AIMS: In patients with paroxysmal atrial fibrillation (AF), the P-wave signal-averaged electrocardiogram often demonstrates a low-amplitude potential at the terminal part of filtered P-wave (atrial late potential: A(LP)), which would originate from delayed pulmonary vein (PV) potentials. The aim of this study was to investigate the impact of PV isolation ...
Gao Qing-Han QH College of Food Science and Engineering, Northwest A & F University, YangLing, Shaanxi 712100, PR - - 2012
Ten promising jujubes were analyzed for textural characteristic (hardness), antioxidant activity, sugar, organic acid, and phenolic profiles. Total phenolic content (TP) measured by Folin-Ciocalteu method ranged from 275.6 to 541.8 mg of gallic acid equivalents per 100 g fresh weight (mg GAE/100 g FW). Four sugars (rhamnose, fructose, sucrose, and ...
Bench Anthony J AJ Molecular Malignancy Laboratory and Haemato-Oncology Diagnostic Service, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK. - - 2013
Molecular genetic assays for the detection of the JAK2 V617F (c.1849G>T) and other pathogenetic mutations within JAK2 exon 12 and MPL exon 10 are part of the routine diagnostic workup for patients presenting with erythrocytosis, thrombocytosis or otherwise suspected to have a myeloproliferative neoplasm. A wide choice of techniques are ...
Yoshimura Tomoyuki - - 2012
β-Lactams with contiguous tetra- and trisubstituted carbon centers were prepared in a highly enantioselective manner through 4-exo-trig cyclization of axially chiral enolates generated from readily available α-amino acids. Use of a weak base (metal carbonate) in a protic solvent (EtOH) is the key to the smooth production of β-lactams. Use ...
Breinbauer Hayo A - - 2012
OBJECTIVES/HYPOTHESIS: Our goal was to assess the impact of personal music players, earphones, and music styles on output, the subject's preferred listening levels, and outline recommendations for the prevention of music-induced hearing loss. STUDY DESIGN: Experimental study. Personal music players' output capabilities and volunteers' preferred output levels were assessed in ...
Tran Pamela V - - 2012
The Hedgehog (Hh) signaling pathway plays a fundamental role in development and tissue homeostasis, governing cell proliferation and differentiation, as well as cell fate. Hh signaling is mediated by an intricate network of proteins that have positive and negative roles that work in concert to fine-tune signaling output. Using feedback ...
Lee S W Y - - 2012
BACKGROUND: /st>Aortocaval compression (ACC) can result in haemodynamic disturbances and uteroplacental hypoperfusion in parturients. Its detection is difficult because in most patients, sympathetic compensation results in no signs or symptoms. However, profound hypotension may develop after sympathectomy during regional anaesthesia. In this prospective observational study, we aimed to detect ACC ...
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