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Sato Kengo - - 2012
MOTIVATION: It is well known that the accuracy of RNA secondary structure prediction from a single sequence is limited, and thus a comparative approach that predicts a common secondary structure from aligned sequences is a better choice if homologous sequences with reliable alignments are available. However, correct secondary structure information ...
Kaur Sarabjeet - - 2012
Previous studies have reported an enhancement of central cholinergic signal cascade by shilajit. For the present study, it was hypothesized that parasympathomimetic effect of shilajit accounting for relaxation of rat corpus cavernosum may be one of the major mechanisms attributing to its traditional role as an aphrodisiac. To test this ...
He Yuxiang - - 2012
The objective of this study was to evaluate the clinical effect of endovascular treatment on postoperative blood pressure (BP) control and kidney function of hypertensive patients with renal artery stenosis (RAS). Between January 2004 and December 2011, RAS was diagnosed in 120 renal arteries from 115 hypertensive patients. Preoperative and ...
Jeong Jae Kwan JK College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, South - - 2013
This study examined the use of PGF(2α) and estradiol benzoate (EB) either with or without GnRH to synchronize estrus in dairy cows for timed artificial insemination (TAI) under field conditions. First, Holstein dairy cows with a corpus luteum (CL) received 500 μg cloprostenol and were then randomly allocated to three ...
Dolejska Monika - - 2012
OBJECTIVES: The aim of the study was to characterize a collection of Escherichia coli and Salmonella harbouring qnr and bla(CTX-M-1) genes on IncN plasmids isolated from humans, food-producing, companion and wild animals, and the environment from six European countries. METHODS: Nineteen IncN plasmids were compared using restriction fragment length polymorphism ...
Gutierrez Junkal - - 2012
A bacterial cellulose mat was used as a template for the fabrication of conductive photoswitchable hybrid nanopaper by the incorporation of sol-gel synthesized vanadium nanoparticles. The resulting nanopaper, prepared through a green pathway, was able to photoinduce a reversible color change. Conductive properties at the nano- and macroscales were confirmed ...
Verucchi Roberto - - 2012
Silicon carbide (SiC) has unique chemical, physical and mechanical properties. A factor strongly limiting SiC based technologies is the high temperatures synthesis. In this work we provide unprece-dented experimental and theoretical evidence of 3C-SiC epitaxy on Silicon at room temperature by using a buckmin-sterfullerene (C60) supersonic beam. Chemical processes, such ...
Russo Arthur C - - 2012
Operation Enduring Freedom and Operation Iraqi Freedom combat veterans given definite diagnoses of mild Traumatic Brain Injury (TBI) during the Veteran Health Administration (VHA) Comprehensive TBI evaluation and reporting no post-deployment head injury were examined to assess (a) consistency of self-reported memory impairment and (b) symptom validity test (SVT) performance ...
Morrison Stewart - - 2012
BACKGROUND: There is no consensus with regard to optimum prophylactic antibiotic regimen in orthopaedic fracture surgery. OBJECTIVE: A systematic review and meta-analysis were performed to determine if multiple-dose perioperative antibiotic prophylaxis is more effective than a single preoperative dose in the prevention of surgical wound infection in patients undergoing operative ...
Niechwiej-Szwedo Ewa - - 2012
Background: We have shown previously that anisometropic amblyopia affects the programming and execution of saccades. The aim of the current paper is to investigate the impact of strabismic amblyopia on saccade performance. Methods: Fourteen adults with strabismic amblyopia, 13 adults with strabismus without amblyopia, and 14 visually-normal adults performed saccades ...
Slater Alex W AW Molecular Bioinformatics Laboratory, Millennium Institute on Immunology and Immunotherapy, Portugal 49, Santiago, CP 8330025, - - 2013
Pairwise alignment of protein structures is a fundamental task in structural bioinformatics. There are numerous computer programs in the public domain that produce alignments for a given pair of protein structures, but the results obtained by the various programs generally differ substantially. Hence, in the application of such programs the ...
Lucena Greice M R S - - 2012
Previous studies from our group have indicated important biological properties of the ethanolic extract and isolated compounds from the bulbs of Cipura paludosa (Iridaceae), a native plant widely distributed in northern Brazil, including antioxidant, neuroprotective and antinociceptive activities. In the present study, the effects of the ethanolic extract and its ...
Takayanagi Kazuya - - 2012
In this study, quantitative reciprocal-space analyses of magnetic domain structures in magnetic artificial lattices of patterned elements were performed by means of the small-angle electron scattering (SAES) technique. Using a conventional transmission electron microscope with a LaB(6) thermal-emission electron gun, Lorentz deflection due to magnetic moments in patterned elements and ...
Zhu Peng P Department of Maternal and Child Health, Anhui Medical University, and Department of Gynecology and Obstetrics, Hefei Maternal and Child Health Hospital, Hefei, - - 2013
Many perinatal stressors, including high prepregnancy body mass index, preterm birth, and cesarean section, increase the risk for short breastfeeding duration. Few studies, however, have investigated the mechanism in the relationship between perinatal determinants and breastfeeding duration. This study aimed to test the hypothesis that delayed onset of lactation (OL) ...
Martin Graham P - - 2012
In many developed-world countries, there have been efforts to increase the 'leadership capacity' of healthcare professionals, particularly lower-status staff without formal managerial power. Creating frontline 'leaders' is seen as a means of improving the quality of healthcare, but such efforts face considerable challenges in practice. This article reports on a ...
Lopes S C - - 2012
New drug design has been one of the major challenges to combat bacterial resistance over the past decade. Conventional antibiotics act by destroying bacterial cell wall or by blocking biosynthetic pathways necessary for its survival. Unfortunately, there has been a fast increase of multi resistance, to several conventional antibiotics, in ...
Perdriau Sébastien - - 2012
Cardanol, a constituent of cashew nutshell liquid (CNSL), was subjected to transfer hydrogenation catalyzed by RuCl(3) using isopropanol as a reductant. The side chain of cardanol, which is a mixture of a triene, a diene, and a monoene, was selectively reduced to the monoene. Surprisingly, it is the C8C9 double ...
Sarma Satyam S Division of Cardiology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, - - 2013
We evaluated the impact of diabetes mellitus (DM) and diabetic therapy on outcomes in patients with reduced ejection fraction (EF) after hospitalization for heart failure (HF). DM is prevalent in patients hospitalized with HF, yet inconclusive data exist on the post-discharge outcomes of this patient population. Post-hoc analysis was performed ...
Albrecht E E Department of Anaesthesiology, Lausanne University Hospital, Bugnon 46, 1011 Lausanne, - - 2013
Prehospital oligoanalgesia is prevalent among trauma victims, even when the emergency medical services team includes a physician. We investigated if not only patients' characteristics but physicians' practice variations contributed to prehospital oligoanalgesia. Patient records of conscious adult trauma victims transported by our air rescue helicopter service over 10 yr were ...
Weaver Keith E KE Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD USA. - - 2012
The par post-segregational killing locus present on Enterococcus faecalis plasmid pAD1 was the first Type I toxin-antitoxin system described in Gram-positive bacteria. Translation of the 33 amino acid Fst toxin, encoded on RNA I, is suppressed by a 66 nucleotide regulatory RNA, RNA II. RNA I and RNA II are ...
Cosconati Sandro - - 2012
Targeting of DNA secondary structures, such as G-quadruplexes, is now considered an appealing opportunity for drug intervention in anticancer therapy. So far, efforts made in the discovery of chemotypes able to target G-quadruplexes mainly succeeded in the identification of a number of polyaromatic compounds featuring end-stacking binding properties. Against this ...
Chan Tracey Evans - - 2012
Developments in medical technology, healthcare delivery, and commercial interests in medicine have increased both the potential for conflicts of interest on the part of physicians, and doubts over the sufficiency of patient autonomy as a justification for administering innovative therapy. The legal and regulatory treatment of innovative therapy is therefore ...
Zhang Lei - - 2012
Fe2O3 microboxes with hierarchically structured shells have been synthesized by simply annealing Prussian blue (PB) microcubes. By utilizing simultaneous oxidative decomposition of PB microcubes and crystal growth of iron oxide shells, we have demonstrated a scalable synthesis of anisotropic hollow structures with various shell architectures. When evaluated as an anode ...
Mei Qiang - - 2012
ABSTRACT: BACKGROUND: MTHFR 677C>T polymorphism is a genetic alteration in an enzyme involved in folate metabolism, but its effect on host susceptibility to cervical cancer is still uncertain. The aim of this study was to investigate the association between MTHFR 677C>T polymorphism and cervical cancer by performing a meta-analysis. METHODS: ...
Gierhake D D Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, Berlin. - - 2013
To reduce the time from symptom onset to treatment with tissue plasminogen activator (tPA) in ischemic stroke, an ambulance was equipped with a CT scanner. We analyzed process and image quality of CT scanning during the pilot study regarding image quality and safety issues. The pilot study of a stroke ...
Kallio Johanna - - 2012
Quercetin is a natural flavonoid possessing a number of health beneficial effects. Its bioactivity is restricted by low solubility and sensitivity to oxidative degradation, factors that are often ignored in laboratory studies. We studied the antimicrobial effects of quercetin on Staphylococcus aureus, Escherichia coli and Lactobacillus plantarum at concentrations at ...
Rebelo A - - 2012
Anthropometric characteristics, physical fitness and technical skills of under-19 (U19) soccer players were compared by competitive level (elite, n=95; non-elite, n=85) and playing position (goalkeeper, central defender, fullback, midfield, forward). Fitness tests included 5- and 30-m sprints, agility, squat jump (SJ) and countermovement jump (CMJ), strength and Yo-Yo intermittent endurance ...
Magriples Urania U Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA. - - 2013
To investigate the effect of race, body mass index (BMI), and weight gain on blood pressure in pregnancy and postpartum. Secondary analysis of pregnant women aged 14 to 25 who received prenatal care at a university-affiliated public clinic in New Haven, Connecticut and delivered singleton term infants (n = 418). ...
Blades Megan L - - 2012
Further insight towards the complex association and dissociation events of macromolecules requires the development of a spectroscopic technique that can track individual components, or building blocks of these macromolecules, and the complexes which they form, in real time. 3-color fluorescence cross-correlation spectroscopy (3C-FCCS) has been shown to track assemblies of ...
Choi Jae-Kyung - - 2012
Today, state-of-the-art III-Ns technology has been focused on the growth of c-plane nitrides by metal-organic chemical vapor deposition (MOCVD) using a conventional two-step growth process. Here we show that the use of graphene as a coating layer allows the one-step growth of heteroepitaxial GaN films on sapphire in a MOCVD ...
Group Ashley - - 2012
BACKGROUND: Dermatologists are expected to be experts in the evaluation and treatment of their patient's cosmetic concerns. It has been reported that some dermatology residents do not feel adequately trained in this field. OBJECTIVE: To assess how dermatology residents are being trained in cosmetic dermatology. METHODS: A survey was e-mailed ...
Rakhra Sandeep S SS Department of Cardiac Surgery, Royal Children's Hospital, Melbourne, - - 2013
Late outcomes of repair of coarctation with arch hypoplasia have not yet been described. Hypertension and arch reobstruction frequently occur after standard coarctation repair and thus we sought to determine the long-term results of repair in the subset of patients with arch hypoplasia at a single institution over a 20-year ...
Byun Myung-Woo - - 2012
Abstract Polyphenol-rich foods, such as fruits and vegetables, are protective against cardiovascular diseases, but the mechanisms of the beneficial effects are still unknown. The goal of this research was to clarify actions of procyanidin trimer (C1) in rat aortic endothelial cells (RAECs). Procyanidin C1 at concentrations up to 50 μM was ...
Castro Felipe A - - 2012
ABSTRACT: BACKGROUND: Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies. METHODS: To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation (IL8, NFKBIL, RNASEL, TNF, and VEGFA) in 456 participants with incident ...
Sita-Lumsden A A Department of Medical Oncology, Gestational Trophoblastic Disease Centre, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, - - 2012
Post-molar pregnancy gestational trophoblastic tumours (GTT) have been curable with chemotherapy treatment for over 50 years. Because of the rarity of the diagnosis, detailed structured information on prognosis, treatment escalations and outcome is limited. We have reviewed the demographics, prognostic variables, treatment course and clinical outcomes for the post-mole GTT ...
Cmarik Greg - - 2012
UiO-66 is one of the few known water-stable MOFs that are readily amenable to direct ligand substitution. In this work, UiO-66 has been synthesized with amino-, nitro-, methoxy-, and naphthyl-substituted ligands to impart polar, basic, and hydrophobic characteristics. Pure-component CO2, CH4, N2, and water vapor adsorption isotherms were measured in ...
Stein Evan A - - 2012
BACKGROUND: Heterozygous familial hypercholesterolemia (HeFH) is a common genetic disorder leading to premature coronary artery disease (CAD). Despite statins and additional lipid-lowering therapies, many HeFH patients fail to achieve low-density lipoprotein cholesterol (LDL-C) goals. We evaluated mipomersen, an apolipoprotein B synthesis inhibitor, to further lower LDL-C in HeFH patients with ...
Ceccon Stefano - - 2012
Abstract Kinematic analysis of swimming is of interest to improve swimming performances. Although the video recordings of underwater swimmers are commonly used, the available methodologies are rarely precise enough to adequately estimate the three dimensional (3D) joint kinematics. This is mainly due to difficulties in obtaining the required kinematic parameters ...
Qin X-J XJ Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, - - 2012
Transforming growth factor (TGF)-β1 produced in airway epithelia has been suggested as a contributor to the airway remodeling observed in asthma patients. The protein tyrosine phosphatase SHP2 is a demonstrable modulator of TGF-β1 production and thus a potential regulator of airway remodeling. To define the signal event by which SHP2 ...
Bryington Matthew - - 2012
OBJECTIVES: Implant surface topography is a key determinant affecting osteoblastic differentiation and cell-cell signaling of implant-adherent cells. MATERIALS AND METHODS: To assess the early osteoinductive and cell-cell signaling events in adherent cells, commercially pure titanium implants (2.2 × 5 mm) with nanotopography (HF-treated TiO(2) grit-blasted) were compared with micron-scale topography TiO(2) grit-blasted (micron-scale, ...
Chen Run - - 2012
c-Met, the receptor for hepatocyte growth factor (HGF), is cell surface tyrosine kinase that controls cancer cell growth, survival, invasion and metastasis. Post-translational modification, such as glycosylation, plays an essential role in regulating the function of cell surface molecules. Whether glycosylation modification regulates the enzymatic properties of c-Met is unknown. ...
Xydakis Michael S - - 2012
From the ongoing military conflicts in Iraq and Afghanistan, an understanding of the neuroepidemiology of traumatic brain injury (TBI) has emerged as requisite for further advancements in neurocombat casualty care. This study reports population-specific incidence data and investigates TBI identification and grading criteria with emphasis on the role of loss ...
Winger Moritz - - 2012
Human parainfluenza virus type 3 (hPIV-3) is a clinically-significant pathogen and is the causative agent of pneumonia and bronchiolitis in children. In this study the solution dynamics of human parainfluenza type 3 haemagglutinin-neuraminidase (HN) have been investigated. A flexible loop around Asp216 that adopts an open conformation in direct vicinity ...
Hoye Thomas R - - 2012
Arynes (aromatic systems containing, formally, a carbon-carbon triple bond) are among the most versatile of all reactive intermediates in organic chemistry. They can be 'trapped' to give products that are used as pharmaceuticals, agrochemicals, dyes, polymers and other fine chemicals. Here we explore a strategy that unites the de novo ...
Agarwal Manisha M Department of Urology, The University of Michigan School of Medicine, Ann Arbor, Michigan, - - 2013
The recent recommendation of the U.S. Preventive Services Task Force against PSA-based screening for prostate cancer was based, in part, on the lack of demonstrated diagnostic utility of serum PSA values in the low, but detectable range to successfully predict prostate cancer. Though controversial, this recommendation reinforced the critical need ...
Peng Junjie - - 2012
Aim:  the aim of this study was to assess the effect of apical lymph node (APN) metastasis in predicting prognosis in curatively treated node-positive rectal cancer. We also investigated the relationship between APN metastasis and total number of metastatic lymph nodes. Method:  A retrospective study was performed of 510 curatively ...
Thompson Amanda L - - 2012
Introduction.  Research focusing on the long-term sequelae of diagnosis and treatment for childhood cancer suggests that although the majority of survivors are not at increased risk for psychopathology, many experience persistent problems in other domains that greatly affect quality of life (QoL). One such domain is social functioning. To date, ...
Cirstea Ion C - - 2012
Activating somatic and germline mutations of closely related RAS genes (H, K, N) have been found in various types of cancer and in patients with or developmental disorders, respectively. The involvement of the RAS signalling pathways in developmental disorders has recently emerged as one of the most important drivers in ...
Sharpe R Allan - - 2012
This review aimed to compare the predictive value between the untreated reduction in intraocular pressure (IOP) from baseline or placebo measured in early phase clinical trials to phase III and IV results for glaucoma medicines. Published, placebo-controlled, randomised, parallel, single-masked or double-masked clinical trials with at least one phase II, ...
Schröter M-A - - 2012
The direct observation of small oscillating structures with the help of a scanning electron beam is a new approach to study the vibrational dynamics of cantilevers and microelectromechanical systems. In the scanning electron microscope, the conventional signal of secondary electrons (SE, dc part) is separated from the signal response of ...
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