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Results 251 - 300 of 5599
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Lee Chun Fan - - 2012
PURPOSE: To compare the measurement precision and related properties between the 5-level EuroQoL Group's 5-dimension (EQ-5D-5L) questionnaire and the Functional Assessment of Cancer Therapy-Breast (FACT-B) questionnaire in assessing breast cancer patients. METHODS: An observational study of 269 Singaporean breast cancer patients. To compare discriminative ability and responsiveness, the effect sizes ...
Estevez M-Carmen - - 2012
A highly sensitive and specific SPR-based competitive immunoassay for the detection of Thiabendazole (TBZ) has been developed. An indirect format where a TBZ-protein conjugate is immobilized onto gold surfaces has been selected. Under the optimal conditions, a LOD of 0.67 nM (0.13 μg L(-1)) and an IC(50) of 3.2 nM ...
Kim Yeong-Hoon - - 2012
The present study was designed to evaluate the association of serum calcium (Ca) and magnesium (Mg) levels with heart rate variability (HRV). One hundred and sixteen adult women were recruited in this cross-sectional study. Serum Ca and Mg levels were measured, and HRV in each time and frequency domain was ...
Mamlouk Soulafa - - 2012
Low levels of oxygen or hypoxia is often an obstacle in health, particularly in pathological disorders like cancer. The main family of transcription factors responsible for cell survival and adaptation under strenuous conditions of hypoxia are the 'Hypoxia-Inducible Factors' (HIFs). Together with Prolyl hydroxylases (PHDs), HIFs regulates tumor angiogenesis, proliferation, ...
Müller A-C - - 2012
BACKGROUND AND PURPOSE: This study reports on the treatment techniques, toxicity, and outcome of pelvic intensity-modulated radiotherapy (IMRT) for lymph node-positive prostate cancer (LNPPC, T1-4, c/pN1 cM0). PATIENTS AND METHODS: Pelvic IMRT to 45-50.4 Gy was applied in 39 cases either after previous surgery of involved lymph nodes (n = 18) or with a ...
Cervantes-Paz Braulio - - 2012
Raw and heat-processed Jalapeño peppers (green and red) were evaluated for their pigments profile and antioxidant capacity. Sixty seven pigments were separated and characterized by HPLC-DAD-MS, including carotenoids (isomers and esters), chlorophylls, and pheophytins. The distinctive characteristics of this pepper genotype were the presence of antheraxanthin monoesters, zeaxanthin monoesters, mutatoxanthin ...
Guo Hong-Guang - - 2012
Photochemical degradation of fluoroquinolone ciprofloxacin (CIP) in water by UV and UV/H(2)O(2) were investigated. The degradation rate of CIP was affected by pH, H(2)O(2) dosage, as well as the presence of other inorganic components. The optimized pH value and H(2)O(2) concentration were 7.0 and 5 mM. Carbonate and nitrate both impeded ...
Yan Hai-Tao - - 2012
BACKGROUND: Glutamate homeostasis plays a critical role in mediating the addiction-related behaviors. Therefore, preventing the disruption or reestablishing of it is a novel strategy for the treatment of addiction. Glutamate transporters are responsible for clearing extracellular glutamate and maintaining glutamate homeostasis. Our previous work demonstrated that aquaporin-4 (AQP4) deficiency attenuated ...
Guo Qinfeng - - 2012
The genetic variation across a species' range is an important factor in speciation and conservation, yet searching for general patterns and underlying causes remains challenging. While the majority of comparisons between central and marginal populations have revealed a general central-marginal (C-M) decline in genetic diversity, others show no clear pattern. ...
Borges G S - - 2012
BACKGROUND: The role of extracellular signal-regulated kinases (ERKs) in nociception has been explored in the last years. While in spinal cord their activation is frequently correlated with pain or acute noxious stimuli, supraspinally, this association is not so evident and remains unclear. This study aims to evaluate ERK1/2 activation in ...
Cheng Yi-Chuan - - 2012
The schizophrenia susceptibility gene, Rgs4, is one of the most intensively studied regulators of G-protein signaling members, well known to be fundamental in regulating neurotransmission. However, little is known about its role in the developing nervous system. We have isolated zebrafish rgs4 and shown that it is transcribed in the ...
Cárdenas-Jirón Gloria I - - 2012
In this work we investigated the outside binding mode between a cationic porphyrin and a nucleotide pair of DNA, adenine-thymine and guanine-cytosine, in a supramolecular assembly. We used two structural models (semi-extended, extended) that differ in the size of porphyrin, two kinds of theoretical methods: a three layer ONIOM (B3LYP/6-31G(d)/PM3/UFF), ...
Amore Antonella - - 2012
In silico analyses of several laccase promoter sequences have shown the presence of many different responsive elements differentially distributed along the promoter sequences. Analysis of P. ostreatus laccase promoter poxa1b extending around 1400-bp upstream of the start codon showed the presence of several putative response elements, such as ten Metal ...
Fabian Anke - - 2012
Cell migration is crucial for many important physiological and pathophysiological processes ranging from embryogenesis to tumor metastasis. It requires the coordination of mechanical forces generated in different regions of the migrating cell. It has been proposed that stretch-activated, Ca(2+)-permeable channels are involved in mechanosignaling during cell migration. To date, the ...
Takei Yuko - - 2012
BACKGROUND: There are few data on clinicians' perspectives regarding support for children who have a parent who has been diagnosed with breast cancer. The purpose of this study was to survey the attitudes of physicians and nurses regarding the care of children who had a parent diagnosed with breast cancer. ...
Hu Peng - - 2012
Three rare earth-nitronyl nitroxide radical complexes [Ln(tfa)(3)(NIT-BzImH)] (Ln(iii) = Gd , Tb , Dy ; tfa = trifluoroacetylacetonate; NIT-BzImH = 2-(2'-benzimidazolyl)-4,4,5,5-tetramethylimidazolyl-1-oxyl-3-oxide) have been successfully prepared and structurally characterized. X-Ray crystallographic analysis reveals that all three complexes are isomorphous. Their crystal structures consist of mononuclear molecule units in which lanthanide(iii) is ...
Bailey Jacqueline - - 2012
Inflammation and altered autonomic function are diagnostic signs and symptoms of Complex Regional Pain Syndrome. In the acute stages these are commonly at their most florid accompanied by severe pain and reduced function. Understandably this has directed research towards potential peripheral drivers for the causal mechanisms of this condition. In ...
Ross Ian L - - 2012
Primary adrenal insufficiency (PAI) may be less prevalent in South Africa and specifically among blacks. There are a number of possible reasons for this, with under-diagnosis among South African blacks, being the most likely explanation. Deaths from undiagnosed PAI still occur. © 2012 Blackwell Publishing Ltd.
Wu Ke - - 2012
Studies investigating the association between glutathione S-transferase P1 (GSTP1) gene polymorphism and bladder cancer (BC) risk have reported conflicting results. In order to clarify the effect of GSTP1 polymorphism on the BC susceptibility, we conducted an updated system review of published epidemiology studies to provide more precise evidence. We performed ...
Bai Jane Pf - - 2012
Prolonged use of proton pump inhibitors has reportedly caused rare clinically symptomatic hypomagnesemia. A review of literature suggests PPI drugs may impair intestinal magnesium absorption. With the goal of preventing PPI-induced hypomagnesemia, an oral absorption-centric model was developed by referencing literature data. Our modeling with human data reveals that magnesium ...
Rohr Paula - - 2012
Coal is the largest fossil fuel source used for the generation of energy. However, coal extraction and its use constitute important pollution factors; thus, risk characterization and estimation are extremely important for the safety of coal workers and the environment. Candiota is located to the southeast of the state of ...
Cho Dae-Chul - - 2012
BACKGROUND: The purpose of this study was to evaluate the therapeutic effects of combination therapy with curcumin and alendronate on bone remodeling after ovariectomy in rats. METHODS: Eighty female Sprague-Dawley rats underwent either a sham operation (the sham group) or bilateral ovariectomy (OVX). The ovariectomized animals were randomly distributed amongst ...
Chen Yan - - 2012
Apoptosis is now widely recognized as an important part of chronic obstructive pulmonary disease (COPD) pathogenesis. Our previous study demonstrated that a prostacyclin (PGI(2)) analogue (beraprost sodium, BPS) prevented cigarette smoke extract (CSE) induced apoptosis of the pulmonary endothelium in rats. So we determined to clarify the apoptosis of vascular ...
Nascimento D L - - 2012
The ability to discriminate nestmates from non-nestmates in insect societies is essential to protect colonies from conspecific invaders. The acceptance threshold hypothesis predicts that organisms whose recognition systems classify recipients without errors should optimize the balance between acceptance and rejection. In this process, cuticular hydrocarbons play an important role as ...
Ringlever Linda - - 2012
Objective. To examine the unique contribution of perceptions held by mothers about their children's asthma in relation to the symptoms as reported by their children. Methods. Families with a child diagnosed with asthma participating in a larger smoking prevention study were invited to participate. For all, 89 children (mean age ...
Khan Unab I - - 2012
Introduction. Both asthma and obesity often occur in the same individual. Each increases the risk of cardiovascular disease (CVD) with systemic inflammation and also plays a vital role. We examined the independent and synergistic associations of asthma and obesity with systemic inflammation using high-sensitivity C-reactive protein (hs-CRP) levels in adolescents. ...
Hu Kuan - - 2012
Trans-2-enoyl-CoA reductases (TERs, EC 1.3.1.44), which specifically catalyze the reduction of crotonyl-CoA to butyryl-CoA using NADH as cofactor, have recently been applied in the design of robust synthetic pathways to produce 1-butanol as a biofuel. We report here the characterization of a TER homologue in Clostridium acetobutylicum (CaTER), the structures ...
Bae C H - - 2012
BACKGROUND AND OBJECTIVE: Wingless-type MMTV integration site family (Wnt)/β-catenin signaling plays an essential role in cellular differentiation and matrix formation during skeletal development. However, little is known about its role in tooth-root formation. In a previous study, we found excessive formation of dentin and cementum in mice with constitutive β-catenin ...
Dubayova Tatiana - - 2012
PURPOSE: The present study examines the role of Type D personality, anxiety and depression in quality of life (QoL) in patients with two chronic neurological diseases-Parkinson's disease (PD) and multiple sclerosis (MS). METHODS: This cross-sectional study included 142 PD patients (73 % males; mean age 67.6 ± 9.2 years) and 198 patients with MS ...
Watanabe Yoshinobu - - 2012
BACKGROUND: The rates of nonunion after femoral nailing are currently reported to be 4.1-12.5 %. The purpose of this study was to identify the risk factors of noninfected nonunion after femoral nailing, focusing in particular on the effects of the length of the distal main fragment. METHODS: A case-control study was ...
Trummer A - - 2012
Effects of desmopressin (DDAVP) in platelet disorders and primary haemostasis cannot be attributed solely to the increase in FVIII/VWF (von Willebrand factor), as VWF/FVIII concentrates have no effect in these circumstances. Microparticles (MP) can support haemostasis by expression of phospholipids, tissue factor and VWF on their surface. We hypothesized that ...
Ba Sidy - - 2012
Over the last few decades many attempts have been made to use biocatalysts for the biotransformation of emerging contaminants in environmental matrices. Laccase, a multicopper oxidoreductase enzyme, has shown great potential in oxidizing a large number of phenolic and non-phenolic emerging contaminants. However, laccases and more broadly enzymes in their ...
Wang Fei - - 2012
Activator/Dissociation (Ac/Ds) transposable elements have been used in maize insertional mutagenesis as a complement to Mutator (Mu). In this study, to further improve the efficiency of the Ac/Ds mutagenesis system, we adopted apt1-m1 (Ac) on the long arm of chromosome 9 (9L) as a donor Ac to create an Ac ...
O'Malley Natasha T - - 2012
With a worldwide aging population, the incidence and consequences of geriatric fractures are assuming an increasing importance to health care providers and institutions. Studies have shown that optimal efficient management ensures the best outcome for the patient, at the least cost to the institution. A review of the recent literature ...
Tan Yu-Rong - - 2012
Human respiratory syncytial virus (RSV), a major cause of severe respiratory diseases, constitutes an important risk factor for the development of subsequent asthma. In searching for its mechanism, the present study was designed to screen the interacting proteins of two important nonstructural (NS) proteins in human BECs. The subcellular localization ...
Lindfors P - - 2012
Background  Gut-directed hypnotherapy is an effective treatment option for irritable bowel syndrome (IBS). However, clinical observations suggest that patient satisfaction with hypnotherapy is not always associated with improvement in IBS symptoms. Methods  We evaluated 83 patients with IBS treated with gut-directed hypnotherapy (1 h week(-1) , 12 weeks). After the treatment period, patients ...
Moch H - - 2012
Renal carcinoma biomarkers are of potential interest for the diagnosis of renal tumor subtypes and prediction of prognosis or reponses to targeted therapies. Due to the identification of novel renal tumor subtypes, diagnostic immunohistochemical biomarkers are of increasing importance. However, there is currently not enough clinical evidence to recommend prognostic ...
Postema P G - - 2012
We describe a patient with acute heart failure shortly after pacemaker implantation. With the documentation of typical dyskinesia of the apical segments with hyperdynamic contractility of the basal segments and a normal coronary angiogram, pacemaker implantation-induced Takotsubo cardiomyopathy was diagnosed. Supportive care was administered and within several days the patient's ...
Hodges Alastair J - - 2012
The intramolecular nitrone dipolar cycloaddition of in situ-generated nitrones such as compound has been used for the synthesis of cyclic isoxazolidines and . The regioselectivity of the intramolecular cycloaddition depends on the nature of the terminal substituent on the dipolarophile. The influence of the substituent on the regioselectivity of the ...
Alemán García Miguel Á - - 2012
A multicomponent assembly is described resulting in [2] and [3]catenanes using three flexible components and three distinct noncovalent interactions. Despite the possibility of competing side-products, only the desired assemblies are generated and characterized spectroscopically.
Gutiérrez-Venegas Gloria - - 2012
Periodontitis is an inflammatory process of infectious origin that affects the gums and, in severe cases, destroys connective tissue, leading to loss of the dental organ. Gram-negative Porphyromonas gingivalis bacteria are recovered from patients with chronic periodontitis. The polysaccharide obtained from these bacteria induces the expression of interleukin (IL)-1 beta, ...
Wang Jun - - 2012
The use of lymphatic microvessel density (LVD) and pro-lymphangiogenic mediators as prognostic factors for survival in breast cancer remains controversial. We searched the electronic databases PubMed and EMBASE without language restrictions for relevant literature to aggregate the survival results. To be eligible, every study had to include the assessment of ...
Rim Jee-Hyun - - 2012
PURPOSE: To evaluate the diagnostic accuracy of carotid Doppler ultrasonography (CDU) to predict the presence of subclinical coronary atherosclerosis in asymptomatic subjects with a zero coronary calcium score. METHODS: Retrospective study of CDU and coronary CT angiography (CTA) findings in 118 asymptomatic subjects with a zero calcium score. CDU was ...
Gaiser T - - 2012
The introduction of total genome sequencing led to the confirmation that tumors show substantial genetic heterogeneity. This phenomenon, which describes the presence of different genetic cell clones within a tumor also complicates the diagnostics of HER2. This article gives a review of new knowledge on polysomy 17 and genetic tumor ...
Castillo Ulises Jiménez - - 2012
The reactions of acetone, 2,2,2-trifluoroacetone and hexafluoroacetone in methanesulfonic (MSA) and triflic acids (TFSA) with benzene have been studied at M06-2X/6-311+G(d,p) level using cluster-continuum model, where the carbonyl group is explicitly solvated by acid molecules. The introduction of a trifluoromethyl group into the ketone structure reduces the activation energy of ...
Rys Sam - - 2012
Continuous sedation until death (CSD), the act of reducing or removing the consciousness of an incurably ill patient until death, often provokes medical-ethical discussions in the opinion sections of medical and nursing journals. A content analysis of opinion pieces in medical and nursing literature was conducted to examine how clinicians ...
Wang Caiyan - - 2012
The peroxisome proliferator-activated receptor-γ (PPARG) is a member of the nuclear hormone receptor superfamily that has attracted considerable attention as a candidate gene for gestational diabetes mellitus (GDM) based on its function as a key factor involved in the regulation of adipocyte differentiation as well as lipid and glucose metabolism ...
Tonni Gabriele - - 2012
Trisomy 9 is a lethal chromosomal abnormality that rarely progresses beyond the second trimester of pregnancy. Multiple central nervous system anomalies, including bifid choroid plexus, ventriculomegaly, and Dandy-Walker malformation, associated with multicystic dysplastic kidney disease in a trisomy 9 fetus are reported. The prenatal ultrasound diagnosis has been aided by ...
Barrow P J - - 2012
Urological tumours are the third most frequent malignancy in Lynch syndrome after colonic and endometrial cancer. Upper urinary tract tumours are well recognised in Lynch syndrome, but the association with prostate and bladder cancer is controversial. We determined the incidence and cumulative and relative risks of prostate and bladder cancer ...
Abdalsamee Mohamed K - - 2012
In this study, the performance and sequestration specificity of the sawfly Athalia rosae L. (Hymenoptera: Tenthredinidae) reared on two wild Brassica oleracea L. (Brassicaceae) populations (KIM and WIN), which express indole glucosinolates (GSs) in very high concentrations, were investigated. The local and systemic plant responses to larval feeding also were ...
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