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Hyman Steven E - - 2012
Drug discovery is at a near standstill for treating psychiatric disorders such as schizophrenia, bipolar disorder, depression, and common forms of autism. Despite high prevalence and unmet medical need, major pharmaceutical companies are deemphasizing or exiting psychiatry, thus removing significant capacity from efforts to discover new medicines. In this Commentary, ...
Yan Nan - - 2012
Objective: Previous studies of English-speaking esophageal (SE) and tracheoesophageal (TE) speakers revealed a significantly lower voice fundamental frequency (F0) than normal laryngeal (NL) speakers. Studies of SE and TE speakers of a tone language, however, indicated discrepant findings. Tonal SE and TE speakers could produce comparable or even higher F0 ...
Yin Guodong - - 2012
An efficient synthesis of novel functionalized 2-aryl-4-(indol-3-yl)-4H-chromenes has been developed, in the presence of a catalytic amount of iodine, from easily available starting materials, 2-hydroxychalcone derivatives. Indole, substituted indoles and 7-azaindole are suitable for this transformation. The possible domino Michael addition-intramolecular cyclization reaction mechanism is proposed.
Me Dorsaf D - - 2012
AIM: The aim is to develop an appropriate formulation of the deleterious rhizobacterium Pseudomonas trivialis X33d and to evaluate its effectiveness to reduce brome growth. METHODS AND RESULTS: Two formulations of P. trivialis X33d, a semolina-kaolin granular formulation (Pesta) and talc-kaolin powder, were prepared and their effectiveness in reducing brome ...
Singhal Tarun - - 2012
The aim of this study was to compare the grading and prognostic value of l-[methyl-(11)C]-methionine ((11)C-MET) PET in glioma patients with (18)F-FDG PET and contrast-enhanced MRI. METHODS: Patients (n = 102) with histopathologically confirmed gliomas were followed up for an average of 34.6 ± 3.8 mo after PET. The median ...
Buddingh K Tim - - 2012
BACKGROUND: There is resistance to routine intraoperative cholangiography (IOC) during cholecystectomy because it prolongs surgery and may be experienced as cumbersome. An alternative instrument may help to reduce these drawbacks and lower the threshold for IOC. This trial compared the Kumar cannulation technique to the more commonly used Olsen clamp ...
McMahon Brandon J - - 2012
It is well recognized that cancer patients have an increased risk of thrombosis and bleeding. Contributory factors to thrombotic complications include prothrombotic risks carried by many chemotherapeutic agents, type of cancer, stage of cancer, age, and comorbidities. Surgical procedures and the presence of an indwelling vascular device, often used as ...
Ness Rob W RW Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom. - - 2012
The nature of spontaneous mutations, including their rate, distribution across the genome, and fitness consequences, is of central importance to biology. However, the low rate of mutation has made it difficult to study spontaneous mutagenesis, and few studies have directly addressed these questions. Here, we present a direct estimate of ...
Isaksson Ulf - - 2012
BACKGROUND: Violence towards caregivers in the care of older people is a challenge attracting increasing attention in nursing research. However, studies that focus on the approaches caregivers in nursing homes resort to and how they manage everyday care situations involving threats and violent situations are relatively few. AIMS AND OBJECTIVES: ...
Sousa Hugo - - 2012
Human Papillomavirus infection is considered as the main etiological factor of cervical cancer (ICC), although, the role of host genetic factors in ICC susceptibility has been increasing. Immunological response is crucial for the prevention of viral associated diseases. Interleukin 1 receptor antagonist (IL-1RN) is considered to be an important regulator ...
Hyndman Rob J - - 2012
When independence is assumed, forecasts of mortality for subpopulations are almost always divergent in the long term. We propose a method for coherent forecasting of mortality rates for two or more subpopulations, based on functional principal components models of simple and interpretable functions of rates. The product-ratio functional forecasting method ...
Smith Eric E - - 2012
In this issue of Neurology®, Duering et al.(1) present compelling proof-of-principle evidence that small subcortical infarcts have remote consequences on gray matter volume. Using MRI scans acquired before and after an incident subcortical infarct, they were able to show that the appearance of a new subcortical infarct was associated with ...
Kang Ning - - 2012
PURPOSE: To present our surgical techniques for retroperitoneal laparoendoscopic single-site (LESS) pyelopyelostomy for retrocaval ureter and our initial experience with this method in 4 patients. METHODS: From June 2010 to May 2011, 4 patients with retrocaval ureter underwent retroperitoneal LESS pyelopyelostomy with a homemade single-port device and standard straight laparoscopic ...
Alvarez M Angeles - - 2012
The title complexes reacted readily with the methylating agents MeI and CF(3)SO(3)Me, chalcogens (O(2), S(8)) and borane adducts BH(3)·L (L = THF, N(t)Bu(3), PPh(3)) to initially give the corresponding neutral or cationic derivatives of the type [Fe(2)Cp(2){μ-P(E)R}(μ-CO)(CO)(2)](n) (Cp = η(5)-C(5)H(5); n = 0, E = O, S, BH(3); n = ...
Hasan Mohammad R - - 2012
The stability of pathogen-specific DNA or RNA amplification targets in clinical samples following short-term storage at room temperature, 4°C, and -80°C was assessed by real-time PCR. In purified nucleic acid extracts, both DNA and RNA targets were stable for up to 30 days, irrespective of storage temperature. In unextracted samples, ...
Kolli Viswa Kalyan - - 2012
BACKGROUND: Methotrexate is widely used as a chemotherapeutic agent for leukemia and other malignancies. The efficacy of this drug is often limited by mucositis and intestinal injury, which are the major causes of morbidity in children and adults. AIM: The present study investigates whether melatonin, a powerful antioxidant, could have ...
Yoo Hyun - - 2012
Acute sepsis can be induced by cytokines such as TNF-α and biological products such as LPS. All of these agents cause systemic inflammation, which is characterized by hemodynamic shock and liver toxicity. However, the outcomes of different septic shock models were totally opposite in transglutaminase 2 knockout (TGase 2(-/-)) mice. ...
Chan Alissa M - - 2012
Dissolved hexachlororuthenate(IV) effectively catalyzes the photodecomposition of chloroform to hydrogen chloride and phosgene under near-UV (λ > 345 nm) irradiation, whereby RuCl(6) (2-) is not itself photocatalytically active but is photochemically transformed into a species that is active, possibly RuCl(5) (CHCl(3) )-. Conversion to a photoactive species during irradiation is ...
Hamoudi M C - - 2012
Freeze-dried beads made of α-cyclodextrin and soybean oil were reported previously as an efficient system for the oral delivery of lipophilic drugs. In the present study, oven-drying was evaluated as another method for drying beads. Oven-drying was optimised and the properties of the resulting beads were assessed. The behavior of ...
Mesbah S Morteza - - 2012
Cap-and-trade programs have proven to be effective instruments for achieving environmental goals while incurring minimum cost. The nature of the pollutant, however, affects the design of these programs. NOx, an ozone precursor, is a non-uniformly mixed pollutant with a short atmospheric lifetime. NOx cap-and-trade programs in the US are successful ...
Gutmann David H - - 2012
Neurofibromatosis type 1 (NF1) is the most common monogenic disorder in which individuals manifest CNS abnormalities. Affected individuals develop glial neoplasms (optic gliomas, malignant astrocytomas) and neuronal dysfunction (learning disabilities, attention deficits). Nf1 genetically engineered mouse models have revealed the molecular and cellular underpinnings of gliomagenesis, attention deficit, and learning ...
Insel Thomas R - - 2012
There has been a steady retreat by the private sector away from developing medications for mental disorders. This retreat comes just as research is identifying new molecular targets, new clinical targets, and new uses of current treatments that may serve as the basis for the next generation of treatments for ...
Tielemans S M A J SM Division of Human Nutrition, Wageningen University, Wageningen, The - - 2013
The aim of this study was to examine the association of physical activity (PA) with all-cause mortality and incident and prevalent cardiovascular disease (CVD) among patients with type 1 diabetes. The EURODIAB Prospective Complications Study is a cohort including 3,250 male and female patients with type 1 diabetes (mean age ...
Stik Grégoire - - 2013
Gallid herpesvirus 2 (GaHV-2) is an oncogenic herpesvirus that causes T lymphoma in chicken. GaHV-2 encodes a basic leucine zipper (bZIP) protein of the AP-1 family, Meq. Upon formation of homo- or heterodimers with c-Jun, Meq may modulate the expression of viral and cellular genes involved in lymphomagenesis. GaHV-2 also ...
Bozkurt Ahmet - - 2012
PURPOSE: The aim of this study was to investigate the dose rate distribution around (192)Ir wires used as radioactive sources in low-dose-rate brachytherapy applications. MATERIALS AND METHODS: Monte Carlo modeling of a 0.3-mm diameter source and its surrounding water medium was performed for five different wire lengths (1-5 cm) using the ...
Spors Hartwig - - 2012
The olfactory system encodes information about molecules by spatiotemporal patterns of activity across distributed populations of neurons and extracts information from these patterns to control specific behaviors. Recent studies used in vivo recordings, optogenetics, and other methods to analyze the mechanisms by which odor information is encoded and processed in ...
Aucagne Vincent - - 2012
Please release me: A new linker for the temporary tagging of peptides at their N-terminus after solid-phase elongation, and its potential for capture/release purification is demonstrated. This concept is extended to a remarkably efficient self-purifying N-to-C iterative triazole ligation strategy, which is applied to the synthesis of a polypeptide having ...
Naqvi Gohar A - - 2012
BACKGROUND:Ankle syndesmotic injuries are complex and require anatomic reduction and fixation to restore the normal biomechanics of the ankle joint and prevent long-term complications. PURPOSE:The aim of this study is to compare the accuracy and maintenance of syndesmotic reduction using TightRope versus syndesmotic screw fixation. STUDY DESIGN:Cohort study; Level of ...
Natesan Usha - - 2012
The coastal zone is one of the nation's greatest environmental and economic assets. The present research aims at studying the shoreline changes along Vedaranyam coast using conventional and modern techniques including field sampling, remote sensing, and geographical information system (GIS). The study area was divided into three zones. Dynamic Land/Sea ...
Rojas-Cervellera Víctor - - 2012
Recent structural determinations have shown that thiolate-protected gold nanoparticles are not as regular and symmetric as initially thought, but characteristic substructures (staple motifs) are formed on their surface. However, their mechanism of formation, especially the fate of the sulfur protons upon thiol binding, remains one of the most intriguing unanswered ...
Nguyen Stacie - - 2012
Abstract Background: Maternal depression is a common condition among new mothers that can be associated with poor maternal health and negative consequences on infant health. Little research has been conducted to examine maternal depression, especially among military mothers, where unique conditions often exist. Using data from a large military cohort, ...
Carvey Christina E - - 2012
ABSTRACT: BACKGROUND: United States Army Soldiers regularly use dietary supplements (DS) to promote general health, enhance muscle strength, and increase energy, but limited scientific evidence supports the use of many DS for these benefits. This study investigated factors associated with Soldiers' confidence in the efficacy and safety of DS, and ...
Ince I Agah - - 2012
The genome of Chilo iridescent virus (CIV) is known for some time, but knowledge on the transcriptional regulation of viral gene expression is limited. In the current study the temporal expression of fifty-four CIV virion protein genes was investigated by combining drug treatments that inhibit protein or DNA synthesis with ...
Piziorska M - - 2012
PURPOSE: The goal of this work was to prepare and to evaluate an off-line adaptive protocol for prostate teleradiotherapy with kilovoltage cone beam computer tomography (CBCT). PATIENTS AND METHODS: Ten patients with localized prostate carcinoma treated with external beams underwent image-guided radiotherapy. In total, 162 CBCT images were collected. Position of ...
Dingwell Jonathan B JB Department of Kinesiology, University of Texas, Austin, Texas 78712-1415, USA. - - 2013
If humans exploit task redundancies as a general strategy, they should do so even if the redundancy is decoupled from the physical implementation of the task itself. Here, we derived a family of goal functions that explicitly defined infinite possible redundancies between distance (D) and time (T) for unidirectional reaching. ...
van den Bergh Menno R MR Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht, the - - 2012
Nasopharyngeal sampling is used for detecting bacteria commonly involved in upper respiratory tract infections, but it requires training and may not always be well tolerated. We sampled children (n = 66) of ages 0 to 4 years, with rhinorrhea, by using a nasopharyngeal swab, a nasal swab, and nose blowing/wiping ...
van Garsse Leen - - 2012
AIMS: We retrospectively evaluated left atrial (LA) strain and strain rate (SR) before and after undersized mitral ring annuloplasty (UMRA) for chronic ischaemic mitral regurgitation (CIMR) with two-dimensional speckle-tracking echocardiography. METHODS AND RESULTS: Left atrial volumes, LA reservoir, LA conduit, LA contractile phases, and LA ejection fraction (LAEF) were measured ...
Bjursten Henrik - - 2012
PURPOSE: Patients undergoing cardiac surgery often require transfusions of red blood cells, plasma and platelets. These components differ widely in both indications for use and composition. However, from a statistical point of view there is a significant colinearity between the components. This study explores the relation between the transfusion of ...
Zhao Yunzhou - - 2012
Based on the fact that hydrogen sulfide (H(2)S) possesses the smallest steric hindrance among thiols and the SH(-) group adds faster to an electron-poor C[double bond, length as m-dash]C double bond, we designed and synthesized a tricyanoethylene-derived colorimetric chemodosimeter for the fast and highly selective assay of H(2)S. Chemodosimeter exhibited ...
Nakamura Takatoshi - - 2012
PURPOSE: This study compared the results of laparoscopic surgery for colon cancer in obese patients with a body-mass index (BMI) of 25 kg/m(2) or higher with those in nonobese patients (BMI <25 kg/m(2)) who were matched for clinicohistopathological factors. METHODS: The oncologic outcomes were compared between 140 patients with a BMI of ...
De─čirmenci Nevbahar Akcar - - 2012
OBJECTIVE: The aim of the study was to evaluate the renal resistive index (RI) and pulsatility index (PI) in patients with pleural effusion (PE). MATERIALS AND METHODS: We studied the mean renal RI and PI in 50 patients with PE and 30 healthy volunteers by Doppler sonography. We grouped effusion ...
Liao Chiao-Chun CC Graduate Institute of Life Sciences; National Defense Medical Center; Taipei, - - 2013
The monocyte/macrophage is critical for regulating immune and antitumor responses. Recombinant capsid protein VP1 (rVP1) of foot-and-mouth disease virus induces apoptosis and inhibits migration/metastasis of cancer cells. Here, we explored the effects of rVP1 on macrophages. Our results showed that rVP1 increased LC3-related autophagosome formation via WIPI1 and WIPI2 in ...
Garcia-Ruiz Pedro J - - 2012
Although task-specific dystonias (TSD) have been described for almost two centuries, few entities have been characterised so variously as TSD. Over time TSD have been described as pure motor phenomena, "neurasthenic" symptoms, occupational hazards akin to repetitive strain, hysterical symptoms and finally… back to pure motor phenomena. A review of ...
Slijkhuis Jessica - - 2012
This article explores the approach of dementia paralytica by psychiatrists in the Netherlands between 1870 and 1920 against the background of international developments. The psychiatric interpretation of this mental and neurological disorder varied depending on the institutional and social context in which it was examined, treated, and discussed by physicians. ...
Chen You-Hsuan - - 2012
Diabetic retinopathy can cause poor vision and blindness. Previous research has shown that high blood glucose weakens retinal capillaries and induces glycoxidation. However, the detailed molecular mechanisms underlying the effects of high blood glucose on development of diabetic retinopathy have yet to be elucidated. In this study, we cultured a ...
Antonova Elena - - 2012
The formation of the antimonato polyoxovanadates [V(14) Sb(8) (C(6) H(15) N(3) )(4) O(42) (H(2) O)]⋅4H(2) O (1), (C(6) H(17) N(3) )(2) [V(15) Sb(6) (C(6) H(15) N(3) )(2) O(42) (H(2) O)]⋅ 2.5H(2) O (2), {C(6) H(15) N(3) }(4) [V(16) Sb(4) O(42) ] 2H(2) O (3) (C(6) H(15) N(3) =1-(2-aminoethyl)piperazine, AEP) has ...
Dolo A - - 2012
Studies performed in Burkina Faso and Mali showed differences in susceptibility to malaria between the Fulani and other sympatric ethnic groups, the Mossi and Dogon. We carried out a longitudinal survey and three cross-sectional studies from 2003 to 2005 in order to assess the prevalence of anemia in Dogon and ...
Jin Hong-Bo - - 2012
We tried to study the possible effects of lipoic acid (LA) on adhesion molecule expression and its underlying mechanism in the prevention and treatment of cardiovascular disorders. Intercellular adhesion molecule-1 (ICAM-1) expression and endothelial nitric oxide synthase (eNOS) activity were determined after endothelial cells were exposed to high glucose in ...
Hannan Jafrul - - 2012
Abstract Background: Recurrent appendicitis with the appendix tip in the subhepatic area and late presentations of perforated appendicitis sometimes test the skills of the surgeon. Because of dense adhesions and distorted anatomy, trying to do retrograde appendectomy or looking for the appendicular artery may lead to troublesome bleeding and injure ...
Hu Hong-Hai - - 2012
Our previous data indicate that the inhibition of L-type calcium channels (LTCCs) might be the cause of post-ischemic neuronal injury and that the activation of LTCCs can give rise to neuroprotection. In the present study, we aimed to profile the intervention window of Bay K8644, an LTCC agonist, and determine ...
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