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Milovancevic Milica Pejovic - - 2012
Systemic lupus erythematosus (SLE) is a multisystemic, autoimmune disease of unknown etiology, which affects multiple organ systems, including the central nervous system (CNS). Neuropsychiatric manifestations are seen in 13-75 % of all SLE patients, with equal frequency in children and adults. Despite a high prevalence of psychiatric manifestations, there is no ...
Wanebo Harold J - - 2012
An overview of colorectal cancer discussed (Philip Paty) the good outcome after primary management with local control in 90-95 % of colon and 85 % in rectal cancer patients with major progression to metastases and to death related to hematogenous dissemination. The major disease pathways include the APC, aneuploid pathway involving mutations ...
Ji Yong-Il - - 2012
Thymosin β4 (Tβ4), a small acidic actin binding peptide, is overexpressed in a side population of cancer stem cells and CD133-positive colorectal cancer stem cells. In order to understand the relationship between Tβ4 and CD133, we studied the expression patterns of Tβ4 and CD133 in ovarian cancers. The expression patterns ...
Kuo Yen-Ling - - 2012
Abstract Conclusion: Partial laryngopharyngectomy (PLP) provides acceptable oncologic results and laryngeal preservation rate in selected patients with squamous cell carcinoma of the hypopharynx. Even when local recurrence develops, the chance of successful salvage is still high. Objectives: To evaluate the oncologic results and laryngeal preservation rate in patients with squamous ...
Ramel Maria-Elena - - 2012
A distinct sobemovirus was isolated from diseased Artemisia annua plants grown in experimental culture plots in Switzerland. Electron microscopy performed on extracts of leaf and root samples of a diseased A. annua plant revealed icosahedral-30 nm viral particles. The complete nucleotide sequence of the viral genome was determined. The single positive-strand ...
Ishiyama Mitsutomi - - 2012
Duodenal stenosis due to periduodenal hematoma is a rare condition. Although clinical presentations should vary among causes, symptoms of duodenal stenosis due to periduodenal hematoma commonly include abdominal pain, nausea, or vomiting. We describe three cases of duodenal stenosis due to periduodenal hematoma with similar clinical courses. All patients had ...
Hunter Luke - - 2012
Backbone-fluorinated amino acids exhibit unique conformational behaviour, and have potential utility as components of bioactive shape-controlled peptides. However, methods for the elaboration of backbone-fluorinated amino acids have thus far been limited to solution phase peptide coupling reactions. In this paper, protocols are developed that allow the successful manipulation of backbone-fluorinated ...
Liu Junxia - - 2012
If you've got it, use it: Malic acid is converted into dimethyl malonate by a direct, one-pot process. The process is cyanide- and halide-free. Phosphovanadomolybdates serve as bifunctional catalysts, effecting the oxidative decarboxylation and esterification in a consecutive manner. Oxidative CC bond cleavage first forms hemiacetals. The results serve as ...
Samuelsson Kristian - - 2012
BACKGROUND:There have been numerous studies on anterior cruciate ligament (ACL) reconstruction. Considering the vast number of studies, a quick assessment reveals rather few with a high level of evidence. PURPOSE:The primary aim was to categorize the study type and level of evidence of studies on primary ACL reconstruction by applying ...
Li Lei - - 2012
Polymeric onions: A concept of vesicle fabrication based on nonstoichiometric complexation of a polybase with an amphiphilic ligand bearing a sulfonic acid group is reported. In contrast to conventional polymersomes, the polymer backbones are oriented mainly parallel to the vesicle walls. The vesicles can collapse under UV irradiation because of ...
Lemons Jennifer - - 2012
Despite the intrinsic role religious/spiritual (hereafter, R/S) beliefs have in patient clinical decision-making and crisis coping, there is little research exploring the relationship that exists between clergy (professionals who provide R/S counsel and guidance) and genetic counseling patients. This qualitative, exploratory study was designed to explore Protestant clergy (N = 8) perceptions ...
Szabo Melinda - - 2012
Haplotype tagging SNPs of interleukin-23 receptor gene rs1004819, rs7517847, rs7530511, rs2201841, rs1343151 and rs10889677 were determined in 396 patients with rheumatoid arthritis, 190 patients with Crohn's disease, 206 patients with ankylosing spondylitis and 182 controls. Using regression analysis models the rs1004819, rs2201841, and rs10889677 SNPs were found to confer risk ...
Zhao Daqiu - - 2012
Herbaceous peony (Paeonia lactiflora Pall.) is an important ornamental plant which contains different flower colors. In this paper, eight genes encoding phenylalanine ammonialyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI), flavanone 3-hydroxylase (F3H), flavonoid 3'-hydroxylase (F3'H), dihydroflavonol 4-reductase (DFR), anthocyanidin synthase (ANS), UDP-glucose: flavonoid 3-o-glucosyltransferase (UF3GT) were isolated. Moreover, the ...
Audran Gérard - - 2012
In a recent work ( Org. Lett. 2012 , 14 , 358 ), we showed that the rate constant k(d) of the chemically activated C-ON bond homolysis of alkoxyamines was subject to solvent effects. However, we showed that solvent effects were weak for the nonactivated alkoxyamine 1 (diethyl (1-(tert-butyl(1-(pyridin-4-yl)ethoxy)amino)-2,2-dimethylpropyl)phosphonate) and ...
Larciprete Rosanna - - 2012
Using photoemission spectroscopy techniques, we show that oxygen intercalation is achieved on an extended layer of epitaxial graphene on Ir(111), which results in the "lifting" of the graphene layer and in its decoupling from the metal substrate. The oxygen adsorption below graphene proceeds as on clean Ir(111), giving only a ...
Gushchin Vladimir A - - 2012
ORF6 is a small gene that overlaps the movement and coat protein genes of subgroup 1a tobamoviruses. The ORF6 protein of Ttomato mosaic virus (ToMV), L-ORF6, interacts in vitro with eukaryotic elongation factor 1 alpha (eEF1A), and mutation of the Tobacco mosaic virus (TMV) U1-ORF6 gene reduces the pathogenicity in ...
Chen Jie - - 2012
The results from the published studies on the association between glutathione S-transferases (GST) gene polymorphism and hepatocellular carcinoma (HCC) in Asian population are still conflicting. GSTM1, GSTT1 and GSTP1 are the mainly mutant sites reported at present. This meta-analysis was performed to evaluate the relationship between GST gene polymorphism and ...
Greve B - - 2012
BACKGROUND AND PURPOSE: Radiotherapy constitutes an essential element in the multimodal therapy of Ewing's sarcoma. Compared to other sarcomas, Ewing tumors normally show a good response to radiotherapy. However, there are consistently tumors with a radioresistant phenotype, and the underlying mechanisms are not known in detail. Here we investigated the ...
de Cheveigné Alain - - 2012
Local field potentials (LFP) recorded in the auditory cortex of mammals are known to reveal weakly selective and often multimodal spectrotemporal receptive fields (STRFs), in contrast to spiking activity. This may in part reflect the wider "listening sphere" of LFPs relative to spikes due to the greater current spread at ...
Maharaj Nirvarthi - - 2012
AIMS: Speckle tracking has emerged as a quantitative technique for assessing left ventricular (LV) function. However, no normative data for LV twist using speckle tracking echocardiography (STE) are available in the black population. This study assessed myocardial mechanics by determining LV twist parameters in different age groups using STE, and ...
Flege Christian - - 2012
In-stent restenosis is still an important issue and stent thrombosis is an unresolved risk after coronary intervention. Biodegradable stents would provide initial scaffolding of the stenosed segment and disappear subsequently. The additive manufacturing technology Selective Laser Melting (SLM) enables rapid, parallel, and raw material saving generation of complex 3- dimensional ...
Caraballo Deborah - - 2012
Recent literature describes methods to reduce "preventable" hospital-acquired venous thromboembolism; however, there is a paucity of data on "preventable" bleeding. While risk assessment models exist for both thrombosis and bleeding, these concepts should be differentiated from whether the event was preventable or non-preventable. Here we describe a protocol to identify, ...
Teramura T - - 2012
Background.  High-performance sunscreen protects both healthy consumers and photosensitive patients from strong ultraviolet (UV) exposure. The sun-protection factor (SPF), which indicates the efficacy of UV protection, is determined using a prescribed sunscreen application thickness of 2.0 mg/cm(2) . Therefore, users should apply at least 2.0 mg/cm(2) of sunscreen to obtain the level ...
Zhang Hanwei - - 2012
We report an all-fiberized, high-pulse-energy, high-average-power, Q-switched fiber master oscillator power amplifier (MOPA) oscillated at 1064 nm. The seed source is an acousto-optic Q-switched fiber laser, which is driven by an arbitrary waveform generator. A preamplifier is developed to boost the average power to about 3 W. Finally, we achieved an average ...
Chen Bing - - 2012
The self-imaging phenomena in multimode Bragg reflection waveguides (BRWs) have been predicted and investigated by using the plane-wave expansion method and the finite-difference time-domain method. A compact wavelength splitter based on self-imaging principles in BRWs is presented, and its transmission characteristics are investigated by using the finite-difference time-domain method. Calculated ...
Dyck Miriam - - 2012
While impairments in emotion recognition are consistently reported in schizophrenia, there is some debate on the experience of emotion. Only few studies investigated neural correlates of emotional experience in schizophrenia. The present functional magnetic resonance imaging (fMRI) study compared a standard visual mood induction paradigm with an audiovisual method aimed ...
Dogra Shivani - - 2012
The authors report an 18-mo-old girl who presented with features of incomplete Kawasaki disease and was refractory to intravenous immunoglobulin and infliximab treatment. She subsequently responded to pulse intravenous methylprednisolone therapy. The diagnostic dilemma arose after 2 mo when she developed clinical features suggestive of systemic onset juvenile idiopathic arthritis. Since ...
Caballero Fernando - - 2012
K(+) acquisition by Arabidopsis roots is mainly mediated by the high-affinity K(+) transporter AtHAK5 and the inward-rectifier K(+) channel AtAKT1. This model is probably universal to plants. Mutant plants lacking these two systems (athak5,atakt1) take up K(+) and grow when the external K(+) concentration is above a certain level, indicating ...
Nakagawa Saori - - 2012
Micafungin is an echinocandin antifungal agent that is important for treating candidiasis in emergency and intensive care medicine; however, current methods for measuring micafungin plasma levels are lengthy and complicated. We report a simple quantitative method using column-switching high-performance liquid chromatography (HPLC) for determining micafungin in human plasma samples. Human ...
Eckenhoff William T - - 2012
Kinetic and mechanistic studies of atom transfer radical addition (ATRA) catalyzed by copper complexes with tris(2-pyridylmethyl)amine (TPMA) ligand were reported. In solution, the halide anions were found to strongly coordinate to [Cu(I)(TPMA)](+) cations, as confirmed by kinetic, cyclic voltammetry, and conductivity measurements. The equilibrium constant for atom transfer (K(ATRA) = ...
Rishal Ida - - 2012
Automated analyses of neuronal morphology are important for quantifying connectivity and circuitry in vivo, as well as in high content imaging of primary neuron cultures. The currently available tools for quantification of neuronal morphology are either highly expensive commercial packages or cannot provide automated image quantifications at single cell resolution. ...
Wu Zhong - - 2012
Immune thrombocytopenia (ITP) is an autoimmune disorder described as autoantibody-mediated platelet deterioration. Platelets with affiliated IgG are targeted for exploitation by Fc receptor-mediated phagocytic cellular material within the reticuloendothelial system. The objective of this research is to investigate the relationship between the appearance of FC gamma receptors (FCGR) IIB and ...
Parvez Khaled - - 2012
The high cost of platinum based electrocatalysts for the oxygen reduction reaction (ORR) has hindered the practical application of fuel cells. Thanks to its unique chemical and structural properties, nitrogen doped graphene (NG) is among the most promising metal-free catalysts for replacing platinum. In this work, we have developed a ...
Kitson Alex P - - 2012
Docosahexaenoic acid (DHA, 22:6n-3) is higher in the blood and tissues of females relative to males, but the underlying mechanism is not clear. The present study examined the expression of enzymes involved in the biosynthesis of DHA from short-chain n-3 polyunsaturated fatty acids in male and female rats (n = ...
Chung J-W - - 2012
Klinefelter's syndrome, which is characterized by small testes, gynecomastia, hypogonadism, and infertility, is the most common cause of primary testicular failure, and commonly has an XXY karyotype. Deep vein thrombosis and thomboembolic events are a rare occurrence in these patients. Although the exact mechanism is not completely understood, it is ...
Grant Clare F J - - 2012
ABSTRACT: Understanding the mechanisms that maintain protective antibody levels after immunisation is important for vaccine design. In this study, we have determined the kinetics of plasma and memory B cells detectable in the blood of cattle immunised with model T-dependent or T-independent antigens. Immunisation with the T-D antigen resulted in ...
Frakt Austin B - - 2012
By virtue of the Supreme Court's decision on the constitutionality of the Patient Protection and Affordable Care Act, states may reject the law's expansion of Medicaid without losing all Medicaid funding from the federal government. The Court's ruling potentially permits a range of Medicaid options for states, including some that ...
Nguyen Le Hoa - - 2012
In this paper, we address the control problem of bifurcations in the Morris-Lecar (ML) neuron model. With the use of a dynamic state-feedback control, two Hopf bifurcation points in the ML neuron model with Type II excitability can be relocated to new desired locations simultaneously. Also, with the proposed control ...
Oswal Dhawal P - - 2012
Sarin is a toxic organophosphorus (OP) nerve agent that has been reported to cause long-term alterations in behavioral and neuropsychological processes. The present study was designed to investigate the effect of low dose sarin exposure on the monoamine neurotransmitter systems in various brain regions of mice. The rationale was to ...
Yan Biao - - 2012
The shortage of freshwater resource in many countries leads to a shift to develop aquaculture in brackish water and sea water. Tilapias are euryhaline that can thrive from freshwater to full sea water. They and their hybrids are the best candidate species for cultivation in brackish habitats. Thus, understanding their ...
Braun M G - - 2012
We report on a retrospective study of 16 rheumatoid arthritis (RA) patients with reduction in size of pulmonary and peripheral rheumatoid nodules following treatment with rituximab (RTX). The 8 female and 8 male patients had an average disease duration of 12.2 years, 88 % were anti-CCP positive and 94 % seropositive. Prior ...
Metz-Flamant C - - 2012
Leukemia is one of the earliest cancer effects observed after acute exposure to relatively high doses of ionizing radiation. Leukemia mortality after external exposure at low doses and low-dose rates has been investigated at the French Atomic Energy Commission (CEA) and Nuclear Fuel Company (AREVA NC) after an additional follow-up ...
Nazir Shahid - - 2012
Chlorophyll biosynthesis is catalyzed by two multi subunit enzymes; a light-dependent and a light-independent protochlorophyllide oxidoreductase. The light-independent enzyme consists of three subunits (ChlL, ChlN and ChlB) in photosynthetic bacteria and plastids in which the chlB gene encodes the major subunit that catalyzes the reduction of protochlorophyllide to chlorophyllide. We ...
Zhang Yan - - 2012
Transcription factors regulate gene expression by binding to specific DNA sequences within the regulatory regions of genes, and have become potential targets in clinical diagnosis and drug development. However, traditional approaches for the detection of transcription factors are usually laborious and time-consuming with a low sensitivity. Here, we develop an ...
Zhao Yadong - - 2012
This study investigates the resonant effects in nonlinear photon absorption in femtosecond laser ablation of Nd-doped silicate glass (Nd:glass). During the femtosecond laser ablation process, the resonant ablation threshold fluence is decreased by up to 40% compared with that of ordinary ablation. However, it is found that the resonant effect ...
Kudsi Omar Yusef - - 2012
BACKGROUND: It has been hypothesized that alcohol metabolism is altered after weight-loss surgery (WLS), with a few studies suggesting a high prevalence of postoperative problem drinking. However, many of these studies were methodologically limited by lack of preoperative alcohol use data, high loss to follow-up, and/or nonsystematic ascertainment of alcohol ...
Andersen E S - - 2012
Variations in bladder position, shape and volume cause uncertainties in the doses delivered to this organ during a course of radiotherapy for pelvic tumors. The purpose of this study was to evaluate the potential of dose accumulation based on repeat imaging and deformable image registration (DIR) to improve the accuracy ...
Pina M Fatima - - 2012
Paroxetine hydrochloride (HCl) is an anti-depressant drug, reported to exist in the anhydrous form (Form II) and as a stable hemihydrate (Form I). In this study, we investigate the hydration behaviour of paroxetine HCl Form II with a view to understanding both the nature of the interaction with water and ...
Han Rongfei - - 2012
The epithelial-mesenchymal transition (EMT) is a fundamental process governing morphogenesis in multicellular organisms and has recently been implicated in promoting carcinoma invasion and metastasis. Besides their therapeutic effects, accumulating evidences suggest that chemotherapeutic agents also induced EMT and enhanced the malignancy of treated cancer cells; however, the mechanism(s) still remains ...
McDonald S D - - 2012
AIMS: Compared with women with uncomplicated pregnancies, women with a history of pre-eclampsia have two to five times the risk of cardiovascular disease. It is not known whether this risk is related to albuminuria, a known cardiovascular risk factor that is part of the definition of pre-eclampsia and that often ...
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