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Ukeh Donald A - - 2012
The maize weevil, Sitophilus zeamais, is an economically important pest of stored grains in tropical and subtropical regions of the world. The behavioral responses of adult S. zeamais to volatile organic compounds (VOCs) from maize seeds, Zea mays, were studied to identify semiochemicals used in host location and provide potential ...
Gonzalez-Moreno Olga - - 2012
Studies about parasitization by Cryptosporidium in great apes have been scarce and mostly conducted in captivity. The present study reports the presence of Cryptosporidium sp. in wild chimpanzees (Pan troglodytes) from Ugalla, western Tanzania. Ugalla is one of the driest, most open, and seasonal habitats inhabited by chimpanzees. Cryptosporidium sp. ...
Gyllenberg A - - 2012
The major histocompatibility complex class II transactivator (CIITA) gene (16p13) has been reported to associate with susceptibility to multiple sclerosis, rheumatoid arthritis and myocardial infarction, recently also to celiac disease at genome-wide level. However, attempts to replicate association have been inconclusive. Previously, we have observed linkage to the CIITA region ...
Waider Jonas - - 2012
While tryptophan hydroxylase-2 (Tph2) null mutant (Tph2 (-/-)) mice are completely deficient in brain serotonin (5-HT) synthesis, the formation of serotonergic neurons and pathfinding of their projections are not impaired. However, 5-HT deficiency, during development and in the adult, might affect morphological and functional parameters of other neural systems. To ...
Alpan Oral - - 2012
To the Editor: In the study by Burks et al. (July 19 issue),(1) 22 of 40 patients (55%) passed the oral food challenge of 5 g of egg-white powder after 10 months of oral immunotherapy with egg-white powder. However, in the study by Burks et al., no oral food challenge ...
Afef Nasraoui Hajaji - - 2012
This study explored the natural variability of Arabidopsis thaliana to find out its response to ammonium availability and characterize the tolerance capacity to cadmic stress under low, average or high nitrogen supplies. Growth was determined by different morphological traits and metabolic enzymes. Plant growth was inhibited by cadmium at low ...
Hamedi Mahiar - - 2012
Aqueous self-assembly of DNA and molecular electronic materials can lead to the creation of innumerable copies of identical devices, and inherently programmed complex nanocircuits. Here self-assembly of a water soluble and highly conducting polymer PEDOT-S with DNA in aqueous conditions is shown. Orientation and assembly of the conducting DNA/PEDOT-S complex ...
Carreras Elena - - 2012
OBJECTIVES: To describe the outcome of patients with twin-to-twin transfusion syndrome and cervical length ≤ 25 mm, treated with laser and an Arabin cervical pessary. METHODS: Retrospective analysis of a consecutive series of all cases with severe twin-to-twin transfusion syndrome who underwent laser surgery: a group with cervical length above 25 mm (group A) ...
Maitani Yoshie - - 2012
Pheochromocytomas are highly angiogenic neuroendocrine tumors. The side effects of treatment with cytotoxic agents frequently outweigh the benefits. Neuroendocrine tumors are highly angiogenic, dependent on vascular endothelial growth factor and receptor (VEGFR) activation. Sunitinib has antitumor and antiangiogenic activities that target VEGFRs. We investigated the antitumor activity of liposomal sunitinib ...
King Stephen D W - - 2012
PURPOSE: A growing body of research documents the harmful effects of religious/spiritual (R/S) struggle (e.g., feeling abandoned or punished by God) among patients with a wide variety of diagnoses. Documented effects include poorer quality of life, greater emotional distress, poorer recovery, and increased disability. This study reports the use of ...
Ringer Simone K - - 2012
Objective  To compare xylazine and romifidine constant rate infusion (CRI) protocols regarding degree of sedation, and effects on postural instability (PI), ataxia during motion (A) and reaction to different stimuli. Study design  Blinded randomized experimental cross-over study. Animals  Ten adult horses. Methods  Degree of sedation was assessed by head height ...
Ema Makoto - - 2012
Context: Widespread production and use of nanomaterials have caused the release of increasing amounts of nanomaterials into the environment. The introduction of novel materials into industry requires safety evaluations as well as an understanding of the impact of the nanomaterials on human health, because the unique properties and size of ...
Liu Dongyue - - 2012
As an efficient reactive oxygen species-scavenging enzyme, superoxide dismutase (SOD) has been shown to inhibit tumor growth and interfere with motility and invasiveness of cancer cells. In this study, the molecular mechanisms of cell cycle arrest when S180 tumor cells were exposed to high levels of SOD were investigated. Here, ...
Koerper M A - - 2012
A consensus conference conducted by the Medical and Scientific Advisory Council of the National Hemophilia Foundation was held in New Orleans, LA, on November 11, 2010, to discuss the impediments to conducting clinical research in persons with haemophilia, von Willebrand's disease and rare bleeding disorders. The conference combined presentations providing ...
Reynoso Mauricio Alberto - - 2012
Translation of mRNAs is a key regulatory step that contributes to the coordination and modulation of eukaryotic gene expression during development or adaptation to the environment. mRNA stability or translatability can be regulated by the action of small regulatory RNAs (sRNAs), which control diverse biological processes. Under low nitrogen conditions, ...
Zhang C F - - 2012
Growth hormone-releasing hormone receptor (GHRHR) has important functions in the regulation of the growth hormone axis and the development and proliferation of pituitary somatotropes. Moreover, some mutations in mouse GHRHR can induce the dwarfism. The objective of this paper is to reveal the association of GHRHR with growth traits in ...
Ozkan Fuat - - 2012
Onychomycosis in toenails is a common fungal infection and vascular abnormalities of lower extremities have been thought as one of the predisposing conditions. The aim of this study was to evaluate predisposition effect of venous insufficiency and peripheral arterial disease on toenail onychomycosis. Thirty-three patients with bilateral onychomycosis in toenails ...
Rossini Anna - - 2012
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), delivered as a membrane-bound molecule expressed on the surface of adenovirus-transduced CD34(+) cells (CD34-TRAIL(+)), was analyzed for its apoptotic activity in vitro on 12 breast cancer cell lines representing estrogen receptor-positive, HER2(+) and triple-negative (TN) subtypes and for its effect on tumor growth, vascularization, ...
Burton Tanya - - 2012
Acromegaly is a rare, chronic, and debilitating disease that results from excessive growth hormone production. Clinically, this disease is associated with enlargement of soft tissue, excessive skeletal growth, and increased risk of cardiovascular disease. Acromegaly is often diagnosed late, when a wide range of comorbidities may already be present. First-line ...
Saunders Jessica A Hutter - - 2012
Animal models and clinical studies have linked the innate and adaptive immune system to the pathology of Parkinson's disease (PD). Despite such progress, the specific immune responses that influence disease progression have eluded investigators. Herein, we assessed relationships between T cell phenotype and function with PD progression. Peripheral blood lymphocytes ...
Benzies Karen - - 2012
Parents are the most significant influence on the growth and development of young children. All parents can increase their knowledge of developmental milestones and parenting practices by participating in effective programs that offer information and support. However, there is limited outcome evaluation of programs offering these services. Prevention-focused parenting programs ...
Vicente Joana G - - 2013
Xanthomonas campestris pv. campestris (Xcc) (Pammel) Dowson is a Gram-negative bacterium that causes black rot, the most important disease of vegetable brassica crops worldwide. Intensive molecular investigation of Xcc is gaining momentum and several whole genome sequences are available. Bacteria; Phylum Proteobacteria; Class Gammaproteobacteria; Order Xanthomonadales; Family Xanthomonadacea; Genus Xanthomonas; ...
Braga Daniela Paes Almeida Ferreira DP Fertility-Centro de Fertilização Assistida, Av. Brigadeiro Luis, 4545, São Paulo, SP, 01401-002, - - 2012
To identify the correlation between different cycles, patient factors and blastocyst characteristics. The study included 420 patients undergoing ICSI cycles and 2781 graded blastocysts, which took into account the blastocyst quality. The correlations between the blastocyst parameters and the patient and cycle characteristics were assessed. The blastocyst development was negatively ...
Pass Harvey I HI Department of Cardiothoracic Surgery, New York University Langone Medical Center, New York, NY 10016, USA. - - 2012
New biomarkers are needed to detect pleural mesothelioma at an earlier stage and to individualize treatment strategies. We investigated whether fibulin-3 in plasma and pleural effusions could meet sensitivity and specificity criteria for a robust biomarker. We measured fibulin-3 levels in plasma (from 92 patients with mesothelioma, 136 asbestos-exposed persons ...
Wang Gang G Department of Environmental Systems Science, Institute of Terrestrial Ecosystems, ETH Zurich, Universitaetstrasse, Zurich, - - 2013
Identification of mechanisms that promote and maintain the immense microbial diversity found in soil is a central challenge for contemporary microbial ecology. Quantitative tools for systematic integration of complex biophysical and trophic processes at spatial scales, relevant for individual cell interactions, are essential for making progress. We report a modeling ...
Vaishampayan Parag P Biotechnology and Planetary Protection Group, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, - - 2013
The advent of phylogenetic DNA microarrays and high-throughput pyrosequencing technologies has dramatically increased the resolution and accuracy of detection of distinct microbial lineages in mixed microbial assemblages. Despite an expanding array of approaches for detecting microbes in a given sample, rapid and robust means of assessing the differential viability of ...
Wang Zili Z Department of Spine Surgery, General Hospital of Ningxia Medical University, No 804, Shengli Street, Yinchuan 750004, Ningxia, - - 2013
This study aimed to explore the feasibility of ultra-short-course chemotherapy in the treatment of spinal tuberculosis. One hundred and eighty-five patients with confirmed spinal tuberculosis and surgical indication were included. The chemotherapy regimen was 2SHRZ/XHRZ. According to the duration of the chemotherapy, the patients were divided into two groups, the ...
Finkel Omri M OM Department of Plant and Environmental Sciences, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, - - 2013
Photochemical reaction centers and rhodopsins are the only phototrophic mechanisms known to have evolved on Earth. The minimal cost of bearing a rhodopsin-based phototrophic mechanism in comparison to maintaining a photochemical reaction center suggests that rhodopsin is the more abundant of the two. We tested this hypothesis by conducting a ...
Barenius Björn B Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden. - - 2013
Hamstring tendon grafts are a popular choice for anterior cruciate ligament (ACL) reconstruction. Typical morbidity reported after hamstring tendon harvest is muscle weakness in flexion, and whilst still a matter for debate, this morbidity may be greater if the gracilis tendon is harvested in addition to the semitendinosus. This study ...
Lo Bernice B Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, - - 2013
Deleterious mutations in genes involved in the Fas apoptosis pathway lead to Autoimmune Lymphoproliferative Syndrome (ALPS). Demonstration of an apoptosis defect is critical for the diagnosis and study of ALPS. The traditional in vitro apoptosis assay, however, requires a week of experimental procedures. Here, we show that defects in Fas-induced ...
Lee Grace M GM Center for Child Health Care Studies, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA. - - 2012
In October 2008, the Centers for Medicare and Medicaid Services (CMS) discontinued additional payments for certain hospital-acquired conditions that were deemed preventable. The effect of this policy on rates of health care-associated infections is unknown. Using a quasi-experimental design with interrupted time series with comparison series, we examined changes in ...
Jiang Xuan X Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland 21218, - - 2013
DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.
Klementowicz Joanna E JE Department of Surgery, The University of California San Francisco, San Francisco, CA, - - 2012
Infection with soil-transmitted gastrointestinal parasites, such as Trichuris trichiura, affects more than a billion people worldwide, causing significant morbidity and health problems especially in poverty-stricken developing countries. Despite extensive research, the role of the immune system in triggering parasite expulsion is incompletely understood which hinders the development of anti-parasite therapies. ...
Valent Peter P The Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna & Ludwig-Boltzmann Cluster Oncology, Waehringer Guertel 18-20, A-1090 Vienna, Austria. - - 2012
The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and ...
Reynolds Lisa A LA Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, EH9 3JT, - - 2012
Heligmosomoides polygyrus is a natural intestinal parasite of mice, which offers an excellent model of the immunology of gastrointestinal helminth infections of humans and livestock. It is able to establish long-term chronic infections in many strains of mice, exerting potent immunomodulatory effects that dampen both protective immunity and bystander reactions ...
Voříšková Jana J Laboratory of Environmental Microbiology, Institute of Microbiology of the ASCR, v.v.i., Praha 4, Czech Republic. - - 2013
Fungi are considered the primary decomposers of dead plant biomass in terrestrial ecosystems. However, current knowledge regarding the successive changes in fungal communities during litter decomposition is limited. Here we explored the development of the fungal community over 24 months of litter decomposition in a temperate forest with dominant Quercus ...
Kara Emily L EL Civil and Environmental Engineering Department, University of Wisconsin-Madison, Madison, WI 53706, USA. - - 2013
With an unprecedented decade-long time series from a temperate eutrophic lake, we analyzed bacterial and environmental co-occurrence networks to gain insight into seasonal dynamics at the community level. We found that (1) bacterial co-occurrence networks were non-random, (2) season explained the network complexity and (3) co-occurrence network complexity was negatively ...
Su Yu-Hung YH Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, - - 2013
8-Oxoguanine (8-OG) is the major mutagenic base lesion in DNA caused by reactive oxygen species (ROS) and accumulates in both nuclear and mitochondrial DNA (mtDNA). In humans, 8-OG is primarily removed by human 8-OG DNA glycosylase 1 (hOGG1) through the base excision repair (BER) pathway. There are two major hOGG1 ...
Hollen Patricia J PJ University of Virginia, Charlottesville, VA 22903-3387, USA. - - 2013
Appropriate utilization of treatment is a goal for all patients undergoing cancer treatment. Proper treatment maximizes benefit and limits exposure to unnecessary measures. This report describes findings of the feasibility and acceptability of implementing a short, clinic-based decision aid and presents an in-depth clinical profile of the participants. This descriptive ...
Jacobs Leonie C LC Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The - - 2013
Natural variation in human skin pigmentation is primarily due to genetic causes rooted in recent evolutionary history. Genetic variants associated with human skin pigmentation confer risk of skin cancer and may provide useful information in forensic investigations. Almost all previous gene-mapping studies of human skin pigmentation were based on categorical ...
Loksztejn Anna A Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina 27708, USA. - - 2012
Direct visualization of co-translational folding of nascent polypeptide chains is challenging. Here we present, for the first time, AFM images of large protein constructs based on the membrane binding domain of ankyrin-R, complexed with the ribosome. The characteristic "horse-shoe" shape of ankyrin-R emerging from the ribosome was captured.
Tang Liansheng Larry LL Department of Statistics, George Mason University, Fairfax, VA 22030, USA. - - 2013
We propose efficient nonparametric statistics to compare medical imaging modalities in multi-reader multi-test data and to compare markers in longitudinal ROC data. The proposed methods are based on the weighted area under the ROC curve, which includes the area under the curve and the partial area under the curve as ...
Mahadevan Daruka D Arizona Cancer Center, Tucson, AZ, USA, - - 2013
UNBS5162 is a novel naphthalimide that binds to DNA by intercalation and suppresses CXCL chemokine elaboration. A Phase I study of UNBS5162 was conducted to establish pharmacokinetics (PK), maximum tolerated dose (MTD), dose-limiting toxicity, safety and anti-tumor activity in patients with advanced solid tumors or lymphoma. UNBS5162 was administered in ...
Soesbe Todd C TC Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, - - 2013
Paramagnetic chemical exchange saturation transfer (PARACEST) complexes are exogenous contrast agents that have great potential to further extend the functional and molecular imaging capabilities of magnetic resonance. As a result of the presence of a central paramagnetic lanthanide ion (Ln(3+) ≠ La(3+) , Gd(3+) , Lu(3+) ) within the chelate, ...
López-Guimerà Gemma G Dept. of Clinical and Health Psychology, Universitat Autònoma de Barcelona, Bellaterra Cerdanyola del Vallès, Barcelona, Spain. - - 2013
The aim of the current study was to examine and compare dieting and unhealthy weight-control behaviours (UWCB) in population-based samples in two large urban areas in Spain (Barcelona) and in the USA (Twin Cities of Minneapolis and St. Paul, Minnesota). Additionally, use of UWCB across weight categories was explored in ...
Insel Thomas R - - 2012
There has been a steady retreat by the private sector away from developing medications for mental disorders. This retreat comes just as research is identifying new molecular targets, new clinical targets, and new uses of current treatments that may serve as the basis for the next generation of treatments for ...
Bozkurt Ahmet - - 2012
PURPOSE: The aim of this study was to investigate the dose rate distribution around (192)Ir wires used as radioactive sources in low-dose-rate brachytherapy applications. MATERIALS AND METHODS: Monte Carlo modeling of a 0.3-mm diameter source and its surrounding water medium was performed for five different wire lengths (1-5 cm) using the ...
Aucagne Vincent - - 2012
Please release me: A new linker for the temporary tagging of peptides at their N-terminus after solid-phase elongation, and its potential for capture/release purification is demonstrated. This concept is extended to a remarkably efficient self-purifying N-to-C iterative triazole ligation strategy, which is applied to the synthesis of a polypeptide having ...
Naqvi Gohar A - - 2012
BACKGROUND:Ankle syndesmotic injuries are complex and require anatomic reduction and fixation to restore the normal biomechanics of the ankle joint and prevent long-term complications. PURPOSE:The aim of this study is to compare the accuracy and maintenance of syndesmotic reduction using TightRope versus syndesmotic screw fixation. STUDY DESIGN:Cohort study; Level of ...
Natesan Usha - - 2012
The coastal zone is one of the nation's greatest environmental and economic assets. The present research aims at studying the shoreline changes along Vedaranyam coast using conventional and modern techniques including field sampling, remote sensing, and geographical information system (GIS). The study area was divided into three zones. Dynamic Land/Sea ...
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