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Results 401 - 450 of 3014
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Yamaguchi Tomoko - - 2012
Mast cells play important roles in the pathogenesis of allergic diseases. They are generally classified into two phenotypically distinct populations: connective tissue-type mast cells (CTMCs) and mucosal-type mast cells (MMCs). The number of mast cells that can be obtained from tissues is limited, making it difficult to study the function ...
Eby Charles - - 2012
After a decade of clinical investigation, pharmacogenetic-guided initial dosing of warfarin is at a crossroads. Genotypes for two single nucleotide polymorphisms (SNPs) in the cytochrome P 450 2C9 gene, affecting warfarin metabolism, and one SNP in vitamin K reductase complex 1 gene, affecting warfarin sensitivity, account for approximately 30% of ...
Elsaid Naba - - 2012
Purpose: To explore the potential of an amphiphilic chitosan derivative to facilitate the transscleral delivery of rapamycin, a potential multi-therapeutic agent with poor water solubility. Methods: The amphiphilic chitosan derivative, O-octanoyl-chitosan-polyethylene glycol (OChiPEG) graft copolymer, was analysed using Fourier-transform infrared spectroscopy (FT-IR). OChiPEG micelles were prepared via the thin film ...
Ittermann Till - - 2012
Background: Hypothyroidism may be a risk factor for obesity, because metabolic rates tend to be decreased in this disorder. Currently it is under debate whether smoking may modify the association between hypothyroidism and obesity. Against this background the aims of our study were to investigate whether there is an association ...
Liu Xiaoyan - - 2012
A novel type of block copolymer has been synthesized. It consists of a linear cationic block and an uncharged bottle-brush block. The non-ionic bottle-brush block contains 45 units long poly(ethylene oxide) side chains. This polymer was synthesized with the intention of creating branched brush layers firmly physisorbed to negatively charged ...
Jiao H - - 2012
Twenty 5-month-old Holstein cattle (10 steers and 10 heifers) were selected from a dairy herd for a 28 day study of enteric methane emissions and energy utilization. The cattle were offered a completely mixed diet with grass silage and concentrates (0.45 and 0.55, DM basis, respectively). They were housed as ...
Kirtley John D - - 2012
Carbon formation or "coking" on solid oxide fuel cell (SOFC) anodes adversely affects performance by blocking catalytic sites and reducing electrochemical activity. Quantifying these effects, however, often requires correlating changes in SOFC electrochemical efficiency measured during operation with results from ex situ measurements performed after the SOFC has been cooled ...
Camarero L - - 2012
Recent findings indicate that increased atmospheric deposition of nitrogen of human origin has caused changes in the pattern of ecological nutrient limitation in lakes in the northern hemisphere. An increase in the nitrogen to phosphorus ratio, and hence a shift from pristine nitrogen limitation to human-induced phosphorus limitation of phytoplankton ...
Drutel Anne - - 2012
The thyroid is the organ with the highest selenium content per gram of tissue because it expresses specific selenoproteins. Since the discovery of myxoedematous cretinism and thyroid destruction following selenium repletion in iodine- and selenium-deficient children, data on links between thyroid metabolism and selenium have multiplied. Although very minor amounts ...
Fargier Guillaume - - 2012
The nonreceptor Syk kinase is detected in epithelial cells, where it acts as a tumor suppressor, in addition to its well-established role in immunoreceptor-based signal transduction in hematopoietic cells. Thus, several carcinomas and melanomas have subnormal concentrations of Syk. Although Syk is mainly localized at the plasma membrane, it is ...
Elam Capt Amanda L - - 2012
We report a neonate who presented at birth with multiple, scattered, white macerated plaques. Punch biopsy confirmed epidermal nevi. At 3 months of age the patient presented with infantile spasms and, after full evaluation, was diagnosed with tuberous sclerosis complex (TSC). We suggest that physicians consider TSC in a neonate with ...
Napoline J W - - 2012
A tris(phosphino)amide-ligated Zr-Co heterobimetallic complex has been shown to activate N-H bonds of hydrazine derivatives via a proton-coupled electron transfer process. Such reactivity is highly unusual for an early metal such as Zr, but is promoted by the adjacent redox active Co atom.
Benhamou Laila - - 2012
The complexation of Fe(SO(3)CF(3))(2) to the series of fluoro α-substituted tris-(2-aminomethylpyridyl)amine tripods F(1-3)TPA yields the triflato F(1-3)TPAFe(SO(3)CF(3))(2) complexes which have firstly been characterized in solution. As expected, bis-acetonitrile charged species are present in CH(3)CN, and neutral bis-triflato complexes in CH(2)Cl(2). The X-ray diffraction analyses of F(1)TPAFe(SO(3)CF(3))(2) and F(2)TPAFe(SO(3)CF(3))(2) crystallized from ...
Bell David C - - 2012
Advances in DNA sequencing, based on fluorescent microscopy, have transformed many areas of biological research. However, only relatively short molecules can be sequenced by these technologies. Dramatic improvements in genomic research will require accurate sequencing of long (>10,000 base-pairs), intact DNA molecules. Our approach directly visualizes the sequence of DNA ...
Lahijani Maryam Shams - - 2012
Effects of extremely low-frequency magnetic fields (ELF-MFs) on the histopathology, histomorphometry, ultrastructural changes (transmission electron microscope, TEM), apoptosis and alkaline phosphatase (ALP) activities in the spleens of preincubated white leghorn chicken embryo were investigated. Ninety fertilized eggs were divided into six groups as control (n = 15), sham (n = 15) and four experimental ...
Groesser L - - 2012
Epidermal nevi (EN) are classified into organoid and non-organoid subtypes.(1) The most frequent organoid EN type is the sebaceous nevus, while the keratinocytic EN represents the most common non-organoid EN. We have previously reported a peculiar EN variant termed "nevus marginatus".
Randel R D - - 2012
The influence of nutrition on puberty in beef heifers is complex and under neuroendocrine control. The stores of body fat in mammals are a determinant of the onset and maintenance of puberty. Body fat stores are greater in heifers with greater residual feed intake than in their more efficient herdmates. ...
Petherick J C - - 2012
The welfare outcomes for Bos indicus cattle (100 heifers and 50 cows) spayed by either the dropped ovary technique (DOT) or ovariectomy via flank laparotomy (FL) were compared with cattle subjected to physical restraint (C), restraint by electroimmobilization in conjunction with physical restraint (EIM), and physical restraint and mock AI ...
Börnhorst Claudia - - 2012
OBJECTIVE: Measurement errors in dietary data lead to attenuated estimates of associations between dietary exposures and health outcomes. The present study aimed to compare and evaluate different approaches of handling implausible reports by exemplary analysis of the association between dietary intakes (total energy, soft drinks, fruits/vegetables) and overweight/obesity in children. ...
Fan Jinchen - - 2012
Aramid macroscale fibers, also called Kevlar fibers, exhibit extremely high mechanical performance. Previous studies have demonstrated that bulk aramid macroscale fibers can be effectively split into aramid nanofibers (ANFs) by dissolution in dimethylsulfoxide (DMSO) in the presence of potassium hydroxide (KOH). In this paper, we first introduced the ANFs into ...
Salvador Jorge A R - - 2012
Covering: up to December 2011This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, sources, and general biological effects of the main classes of naturally occurring pentacyclic triterpenoids ...
Singh Dependra Narayan - - 2012
BACKGROUND AND OBJECTIVE: Intraoperative parathyroid hormone (IOPTH) kinetics and therefore the efficacy of IOPTH utilization as a predictor of cure are likely to be affected by baseline IOPTH levels, vitamin D deficiency and parathyroid weight. PATIENTS AND METHODS: Consecutive subjects with primary hyperparathyroidism (PHPT, n=51) undergoing parathyroidectomy with IOPTH monitoring ...
Moravec Frantisek - - 2012
Abstract A new nematode species, Rhabdochona (Rhabdochona) hypsibarbi n. sp. (Rhabdochonidae), is described from the intestine of the freshwater cyprinid fish Hypsibarbus wetmorei (Smith) in the Mekong River, Nakhon Phanom Province, northeast Thailand. It is mainly characterized by medium-sized, bifurcate deirids, the presence of 14 anterior prostomal teeth and of ...
Richardson Amanda - - 2012
OBJECTIVE: As the third most popular website in the world, messages embedded in the video-sharing site, YouTube, have the potential to influence tobacco-related attitudes, beliefs and behaviours. Despite the growing number of videos depicting little cigars/cigarillos (LCCs), there has been no examination of the portrayal of these products on YouTube. ...
Yoon Hun-Young - - 2012
We report here the clinical presentation and successful surgical management of synovial hemangioma accompanied by cruciate ligament injury in a dog. Surgical correction of cruciate ligament injury was performed after removing torn cruciate ligaments, synovial mass and masses attached to the ligaments and distal femoral articular cartilage. At 10 months, ...
Zhuang Chunlin - - 2012
The p53-MDM2 interaction has been approved to be a valuable target to develop effective antitumor agents. Novel p53-MDM2 inhibitors bearing pyrrolidone scaffolds were successfully identified by structure-based design. The nanomolar inhibitor 5 possessed good p53-MDM2 inhibitory activity (Ki = 780 nM) due to its hydrophobic and hydrogen bonding interactions with ...
Prod'hom Sylvain - - 2012
INTRODUCTION: Quitting smoking is associated with weight gain, which may threaten motivation to engage or sustain a quit attempt. The pattern of weight gained by smokers treated according to smoking cessation guidelines has been poorly described. We aimed to determine the weight gained after smoking cessation and its predictors, by ...
Floyd Brice E - - 2012
Autophagy is a macromolecular degradation pathway by which cells recycle their contents as a developmental process, housekeeping mechanism, and response to environmental stress. In plants, autophagy involves the sequestration of cargo to be degraded, transport to the cell vacuole in a double-membrane bound autophagosome, and subsequent degradation by lytic enzymes. ...
Glinianaia Svetlana V - - 2012
The population-based Northern Survey of Twin and Multiple Pregnancy (NorSTAMP, formerly the Multiple Pregnancy Register) has collected data since 1998 on all multiple pregnancies in North of England (UK) from the earliest point of ascertainment in pregnancy. This paper updates recent developments to the NorSTAMP and presents some early mortality ...
Baeg Kang-Jun - - 2012
We report here the development of high-performance p- and n-channel organic field-effect transistors (OFETs) and complementary circuits using inkjet-printed semiconducting layers and high-k polymer dielectric blends of poly(vinylidenefluoride-trifluoroethylene) (P(VDF-TrFE)) and poly(methyl methacrylate) (PMMA). Inkjet-printed p-type polymer semiconductors containing alkyl-substituted thienylenevinylene (TV) and dodecylthiophene (PC12TV12T) and n-type poly{[N,N9-bis(2-octyldodecyl)-naphthalene-1,4,5,8-bis(dicarboximide)-2,6-diyl]-alt-5,59-(2,29-bithiophene)} (P(NDI2OD-T2)) OFETs typically ...
Callini Elsa - - 2012
Hydrogen desorption from borohydrides is often accompanied by the release of diborane. The amount of diborane released as a byproduct during the decomposition of borohydrides scales inversely with the borohydride stability, which in turn depends on the electronegativity of the corresponding cation. We present a model based on the difference ...
Shishkin Oleg V - - 2012
To understand how deuterium and fluorine substituents influence the supramolecular architecture of pyridine N-oxide crystals, the crystal structure of 3-fluoropyridine N-oxide (PNO-3F) was determined and the crystal packing motives of non-deuterated pyridine-N-oxide (PNO), partial-deuterated pyridine-N-oxide (PNO-D) and PNO-3F were analyzed based on ab initio quantum-chemical calculations of the intermolecular interaction ...
Akpinar Deniz - - 2012
The aim of the study was to investigate the effects of extremely low-frequency electric field (ELF EF) on visual evoked potential (VEP), thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), total oxidant status (TOS), and oxidant stress index (OSI). Thirty female Wistar rats, aged 3 months, were divided into ...
Spadafranca Angela - - 2012
Extracts of Phaseolus vulgaris (beans) are known to reduce glycaemia and food intake in rodents and humans. The present study evaluated the effects of a new, standardised and purified P. vulgaris extract (PVE), when employed as a supplement in a mixed balanced meal (60 % carbohydrates, 25 % lipids and 15 % protein), ...
Jacob Gitta A - - 2012
Background: Both emotion regulation and impulsivity are core aspects of borderline personality disorder (BPD) pathology. Although both problems may be combined specifically in BPD, few studies to date have investigated the emotional modulation of impulsivity in BPD. Methods: Women with BPD and matched healthy controls performed go/no-go tasks after induction ...
Rodriguez Isabel - - 2012
Background: The purpose was to analyze the cardiac and renal capillary density and glomerular morphology that result from a chronic excess or deficiency of thyroid hormones in rats.Methods: We performed histopathological, morphometric and immunohistochemical analyses in hypothyroid and hyperthyroid rats to evaluate the density of mesenteric, renal and cardiac vessels ...
Lund Cathrine - - 2012
ABSTRACT: BACKGROUND: Up to date information on poisoning trends is important. This study reports the epidemiology of all hospitalized acute poisonings in Oslo, including mortality, follow-up referrals, and whether the introduction of over-the-counter sales of paracetamol outside pharmacies had an impact on the frequency of poisonings. METHODS: All acute poisonings ...
Mitsui Yozo - - 2012
What's known on the subject? and What does the study add? The process of bladder regeneration with a bladder acellular matrix graft (BAMG) is thought to be accelerated by administration of vascular endothelial growth factor into the host bladder. In the present study, we showed that simultaneous implantation of bilateral ...
Sattler Wesley - - 2012
[Tris(2-pyridylthio)methyl]zinc hydride, [κ(3)-Tptm]ZnH, is a multifunctional catalyst that is capable of achieving (i) rapid release of hydrogen by protolytic cleavage of silanes with either water or methanol and (ii) hydrosilylation of aldehydes, ketones, and carbon dioxide. For example, [κ(3)-Tptm]ZnH catalyzes the release of 3 equivalents of H(2) by methanolysis of ...
Kelly A K - - 2012
This study evaluated the effect of residual feed intake (RFI) on the expression of constituent genes of the somatotropic axis in skeletal muscle across 2 diverse dietary regimes. Beef heifers (n = 86; initial BW = 191.8 kg [SD = 37]) fed a low-forage (LF) total mixed ration comprised of ...
Jones Huw B - - 2012
Islets of Langerhans represent a heterogeneous population in insulin resistant and diabetic animals and humans as histological appearances and function vary substantially. Mathematical representation that reflects this morphological diversity will assist in assessment of degeneration and regeneration, enabling comparisons between species, strains, and experimental investigations. Our investigative approach used a ...
Costa Paolo - - 2012
Cerebral vein thrombosis (CVT) is a rare complication of spontaneous intracranial hypotension (SIH). When to suspect a thrombotic disorder during the course of intracranial hypotension is not fully elucidated. A 48-year-old woman was admitted because of SIH with no signs of CVT on neuroimaging. The occurrence of diplopia and blurred ...
Sun Miao - - 2012
Here we tested the hypothesis that excess maternal androgen in late pregnancy reduces placental and fetal growth, increases placental steroidogenesis, and adversely affects glucose and lipid metabolism in adult female offspring. Pregnant Wistar rats were randomly assigned to treatment with testosterone (daily injections of 5 mg free testosterone from gestational ...
Starling Jean - - 2012
Objective:This study aims to describe the clinical course of psychotic disorders, including the premorbid history, symptoms and level of functioning in a group of children and adolescents treated by paediatric mental health services, mainly as inpatients.Method:A sample of 45 children and adolescents with a psychotic disorder (mean age 13.2 years) ...
Liu Lianliang - - 2012
Cardiovascular protective functions of bamboo shoot ACE inhibitory peptide (BSP) from bamboo shoot were evaluated, including anti-hypertensive effect on spontaneously hypertensive rats (SHRs) and anti-hyperlipidemic effect on high-fat diet-induced rats. 30 days anti-hypertensive effects of BSP on SHRs were assayed. Asp-Tyr (10 mg/day kg BW) and BSP (50 mg/day kg ...
Awasthi Niranjan - - 2012
Gemcitabine has limited clinical benefits in pancreatic ductal adenocarcinoma (PDAC). Insulin-like growth factor (IGF) signaling proteins are frequently over-expressed in PDAC. The therapeutic potential of BMS-754807, a small molecule inhibitor of IGF-type 1 receptor (IGF-1R) and insulin receptor (IR), and gemcitabine was evaluated in experimental PDAC. Cell proliferation and protein ...
Martirosyan Varsik - - 2012
In the present work, the frequency-dependent effects of extremely low-frequency electromagnetic field (ELF EMF) on Escherichia coli K-12 growth have been studied. The frequency-dependent effects of ELF EMF have shown that it can either stimulate or inhibit the growth of microbes. However, the mechanism by which the ELF EMF affects ...
Parish J A - - 2012
Five tall fescue [Lolium arundinaceum (Schreb.)] pastures: 'Kentucky-31' with 78.0% of plants infected with ergot alkaloid-producing endophyte (Neotyphodium coenophialum) (KY31 E+); 'Jesup' AR542 endophyte-infected contaminated with 30.3% tall fescue containing ergot alkaloid producing-endophyte (Jesup AR542 E+); 'GA-186' AR584 endophyte-infected contaminated with 11.8% tall fescue containing ergot alkaloid producing-endophyte (AGRFA 140); ...
Troscianko Jolyon - - 2012
Humans are expert tool users, who manipulate objects with dextrous hands and precise visual control. Surprisingly, morphological predispositions, or adaptations, for tool use have rarely been examined in non-human animals. New Caledonian crows Corvus moneduloides use their bills to craft complex tools from sticks, leaves and other materials, before inserting ...
Siddiqui Salman - - 2012
Severe asthma affects 5 to 10% of the asthma population but consumes a disproportionate amount of the global asthma budget (∼50%) due to unscheduled health care utilization in primary care, hospitalizations due to severe exacerbations, and the costs of pharmacotherapy. A key challenge in managing severe asthma is to identify ...
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