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Liu Xiaoyan - - 2012
A novel type of block copolymer has been synthesized. It consists of a linear cationic block and an uncharged bottle-brush block. The non-ionic bottle-brush block contains 45 units long poly(ethylene oxide) side chains. This polymer was synthesized with the intention of creating branched brush layers firmly physisorbed to negatively charged ...
Jiao H - - 2012
Twenty 5-month-old Holstein cattle (10 steers and 10 heifers) were selected from a dairy herd for a 28 day study of enteric methane emissions and energy utilization. The cattle were offered a completely mixed diet with grass silage and concentrates (0.45 and 0.55, DM basis, respectively). They were housed as ...
Kirtley John D - - 2012
Carbon formation or "coking" on solid oxide fuel cell (SOFC) anodes adversely affects performance by blocking catalytic sites and reducing electrochemical activity. Quantifying these effects, however, often requires correlating changes in SOFC electrochemical efficiency measured during operation with results from ex situ measurements performed after the SOFC has been cooled ...
Chittka Alexandra A Wolfson Institute for Biomedical Research and Research Department of Cell and Developmental Biology, University College London, London, WC1E 6BT, United Kingdom. - - 2012
During development of the cerebral cortex, neural stem cells (NSCs) undergo a temporal switch from proliferative (symmetric) to neuron-generating (asymmetric) divisions. We investigated the role of Schwann cell factor 1 (SC1/PRDM4), a member of the PRDM family of transcription factors, in this critical transition. We discovered that SC1 recruits the ...
Mathur Jaideep - - 2012
Cell walls lock each cell in a specific position within the supra-organization of a plant. Despite its fixed location, each cell must be able to sense alterations in its immediate environment and respond rapidly to ensure the optimal functioning, continued growth and development, and eventual long-term survival of the plant. ...
Park Subin - - 2012
Objective:This study used a sample of Korean adolescents to evaluate: (a) associations between problematic internet use and depression, bipolar disorder symptoms and suicidal ideation; and (b) whether mood disorders mediate the relationship between problematic internet use and suicidal ideation.Method:A total of 795 middle and high school students were recruited (538 ...
Hefler Marita - - 2012
The tobacco industry's use of social media sites, such as Facebook, is an emerging area of research; however, this is the first study of the potential for social media to advance tobacco control. This paper presents three case studies of using social media for tobacco control advocacy, demonstrates how social ...
Li Wenjing - - 2012
Purpose: Prelingual deafness has been shown to lead to brain reorganization as demonstrated by functional parameters, but anatomical evidences still remain controversial. The present study investigated hemispheric asymmetry changes in deaf subjects using MRI, hypothesizing auditory-, language- or visual-related regions after early deafness. Methods: Prelingually deaf adolescents (n = 16) ...
Jia Xilai - - 2012
Design and fabrication of effective electrode structure is essential but still challenge for current lithium-ion battery technology. Herein we report the design and fabrication of a class of high-performance robust nanocomposites based on iron oxide spheres and carbon nanotubes (CNTs). An efficient aerosol-spray process combined with vacuum filtration was used ...
Channa Kalavati R - - 2012
Exposure to pesticides places pregnant women and the developing foetus at the highest risk. The objective of this study is to obtain an exposure assessment by investigating levels of pesticides in blood plasma of delivering women. We report on the concentrations of α, β, γ HCH, endosulfan, HCB and the ...
Samuel R S - - 2012
Current AA recommendations for sows are to provide a fixed amount of AA intake throughout gestation; however, the demand for nutrients changes from maternal lean tissue in early gestation (EG) to fetal and mammary growth in late gestation (LG). The objective of this study was to determine the Lys requirement ...
Jacoby Richard P - - 2012
The primary function of mitochondria is respiration, where catabolism of substrates is coupled to ATP synthesis via oxidative phosphorylation. In plants, mitochondrial composition is relatively complex and flexible and has specific pathways to support photosynthetic processes in illuminated leaves. This review begins with outlining current models of mitochondrial composition in ...
Gatz Margaret M Department of Psychology, University of Southern California, Los Angeles, CA, USA. - - 2013
The Study of Dementia in Swedish Twins is a study of dementia in a defined population of twins. The goals included estimating heritability of Alzheimer's disease and identifying risk and protective factors in twin pairs discordant for the disease. The data, including not only diagnoses and age of onset but ...
Song Hai - - 2012
Pulmonary neuroendocrine cells (PNECs) are proposed to be the first specialized cell type to appear in the lung, but their ontogeny remains obscure. Although studies of PNECs have suggested their involvement in a number of lung functions, neither their in vivo significance nor the molecular mechanisms underlying them have been ...
Johar Kaid K Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, - - 2012
NRF-1 regulates mediators of neuronal activity and energy generation. NRF-1 transcriptionally regulates Na(+)/K(+)-ATPase subunits α1 and β1. NRF-1 functionally regulates mediators of energy consumption in neurons. NRF-1 mediates the tight coupling of neuronal activity, energy generation, and energy consumption at the molecular level. Energy generation and energy consumption are tightly ...
Jeppsson Fredrik F Innovative Medicines AstraZeneca, CNS and Pain, 15185 Södertälje, - - 2012
β-Site amyloid precursor protein cleaving enzyme1 (BACE1) is one of the key enzymes involved in the processing of the amyloid precursor protein (APP) and formation of amyloid β peptide (Aβ) species. Because cerebral deposition of Aβ species might be critical for the pathogenesis of Alzheimer disease, BACE1 has emerged as ...
Zhu Xinxia X Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, - - 2012
Animals exhibit a rapid and sustained anorexia when fed a diet that is deficient in a single indispensable amino acid (IAA). The chemosensor for IAA deficiency resides within the anterior piriform cortex (APC). Although the cellular and molecular mechanisms by which the APC detects IAA deficiency are well established, the ...
Mukherjee Archana - - 2012
Abstract Non-invasive methods for the assessment of distribution, homing, and retention of stem cells are desired for the successful demonstration of stem cell therapy. Cells labeled with (99m)Tc, (18)F, and (111)In have been reported for tracking the cells in vivo. However, they can be tracked only for a limited time ...
Robinson Christopher W - - 2012
Presenting information to multiple sensory modalities sometimes facilitates and sometimes interferes with processing of this information. Research examining interference effects shows that auditory input often interferes with processing of visual input in young children (i.e., auditory dominance effect), whereas visual input often interferes with auditory processing in adults (i.e., visual ...
Eickholt Jesse J Department of Computer Science, University of Missouri, Columbia, MO 65211, - - 2012
Protein residue-residue contacts continue to play a larger and larger role in protein tertiary structure modeling and evaluation. Yet, while the importance of contact information increases, the performance of sequence-based contact predictors has improved slowly. New approaches and methods are needed to spur further development and progress in the field. ...
Pan Hua H Department of Medicine, Washington University School of Medicine, St. Louis, MO 63108, - - 2013
The emerging demand for programmable functionalization of existing base nanocarriers necessitates development of an efficient approach for cargo loading that avoids nanoparticle redesign for each individual application. Herein, we demonstrate in vivo a postformulation strategy for lipidic nanocarrier functionalization with the use of a linker peptide, which rapidly and stably ...
Waldmann Thomas - - 2012
Investigating the dynamics in an adlayer of the oligopyridine derivative 2-phenyl-4,6-bis(6-(pyridine-2-yl)-4-(pyridine-4-yl)pyridine-2-yl)pyrimidine (2,4'-BTP) on Ag(111) by fast scanning tunneling microscopy (video-STM), we found that rotating 2,4'-BTP adsorbates coexist in a two-dimensional (2D) liquid phase (β-phase) in a dynamic equilibrium with static adsorbate molecules. Furthermore, exchange between an ordered phase (α-phase) and ...
Pinczewska Aleksandra - - 2012
We report the combinatorial preparation and high-throughput screening of a library of modified electrodes designed to catalyse the oxidation of NADH. 60 glassy carbon electrodes were covalently modified with ruthenium (II) or zinc (II) complexes bearing the redox active 1,10-phenanthroline-5,6-dione (phendione) ligand by electrochemical functionalisation using one of four different ...
Rosenblum Jeremy J Division of Pediatric Hematology/Oncology, Children's Hospital at Montefiore, Bronx, NY 10467, USA. - - 2013
Febrile neutropenia is a common reason for the hospitalization of pediatric oncology patients. The initiation of antibiotics and the overall decline in rates of bacteremia, would predict a low yield of detection of bacteremia in repeated blood cultures. Despite little evidence supporting the utility of serial cultures, repeat culturing with ...
Wang J T - - 2012
Background: This study aimed to compare recurrence and survival in patients undergoing either selective neck dissection or modified radical neck dissection to treat metastatic cutaneous head and neck squamous cell carcinoma to the cervical lymph nodes (levels I-V) only. Methods: Twenty-eight year, retrospective analysis of a prospectively maintained database from ...
Sharma Sumeet - - 2012
AimsEnd-stage renal disease (ESRD) patients have an excess cardiovascular risk, above that predicted by traditional risk factor models. Prothrombotic status may contribute to this increased risk. Global thrombotic status assessment, including measurement of occlusion time (OT) and thrombolytic status, may identify vulnerable patients. Our aim was to assess overall thrombotic ...
Binulal N S - - 2012
Nanofibrous semi-synthetic polymeric nanocomposite scaffolds were engineered by incorporating a maximum of 15 wt% biopolymeric gelatin nanoparticles (nGs) into the synthetic polymer poly([Formula: see text]-caprolactone) (PCL) prior to electrospinning. The effect of nGs in altering the physico-chemical properties, cell material interaction and biodegradability of the scaffolds was evaluated. Experimental results showed ...
Carter Frances A - - 2012
Objective:To evaluate the suitability and acceptability of computerised cognitive behaviour therapy (CCBT).Method:Participants were patients who had been referred to a secondary care service in the usual manner, and then offered participation in a randomised controlled trial comparing the efficacy of CCBT with a control condition (waitlist) for patients with a ...
Rodriguez-Mateos Ana - - 2012
Growing evidence suggests that intake of flavonoid-containing foods may exert cardiovascular benefits in human subjects. We have investigated the effects of a 10-week blueberry (BB) supplementation on blood pressure (BP) and vascular reactivity in rats fed a high-fat/high-cholesterol diet, known to induce endothelial dysfunction. Rats were randomly assigned to follow ...
Reginskaya Irina - - 2012
The mechanism which leads to a dielectric barrier electrospray (DB-ES) was investigated by measurements of the electrical current. It comprises several components, namely the displacement current, currents which are initiated by electromagnetic transmission, an ion current inside the capillary which is responsible for the built-up of the potential at the ...
Pal T T Departments of Cancer Epidemiology, Biostatistics, Anatomic Pathology and Experimental Therapeutics, Moffitt Cancer Center, MRC-CANCONT, 12902 Magnolia Drive, Tampa, FL 33612, USA. - - 2012
Mutations in genes for hereditary non-polyposis colorectal cancer (HNPCC) in ovarian cancer patients remains poorly defined. We sought to estimate the frequency and characteristics of HNPCC gene mutations in a population-based sample of women with epithelial ovarian cancer. The analysis included 1893 women with epithelial ovarian cancer ascertained from three ...
Lee Young Bok - - 2012
Background  The aim of this study was to evaluate whether Fas (CD95) and Fas ligand (FasL) immunoreactivity in cutaneous squamous cell carcinoma (SCC) are correlated with grade of tumor differentiation. Methods  A total of 31 cutaneous SCC specimens excised during 1997-2004 were collected from the four branch hospitals of the ...
Laurberg Jens R - - 2012
What's known on the subject? and What does the study add? Several studies have shown that defects in DNA-damage response are associated with good survival after chemotherapy and radiotherapy. Furthermore, loss of cell cycle regulators may be prognostic indicators of poor survival after cystectomy. However, the potential clinical impact of ...
Marshall Lewis A - - 2012
Preparation of raw, untreated biological samples remains a major challenge in microfluidics. We present a novel microfluidic device based on the integration of printed circuit boards and an isotachophoresis assay for sample preparation of nucleic acids from biological samples. The device has integrated resistive heaters and temperature sensors as well ...
Harding Rosie - - 2012
This paper explores the legal position of the off-label prescription of antipsychotic medications to people with dementia who experience behavioural and psychological symptoms of dementia (BPSD). Dementia is a challenging illness, and BPSD can be very difficult for carers to manage, with evidence that this contributes to carer strain and ...
Siladke Nathan A - - 2012
The synthesis of mixed tethered alkyl uranium metallocenes has been investigated by examining the reactivity of the bis(tethered alkyl) metallocene [(η(5) -C(5) Me(4) SiMe(2) CH(2) -κC)(2) U] (1) with substrates that react with only one of the UC linkages. The effect of these mixed tether coordination environments on the reactivity ...
Bernhard B C - - 2012
Crossbred steers (n = 20; 235 ± 4 kg) were fed for 53 d during a receiving period to determine if supplementing chromium (Cr; KemTRACE®(brand)ChromiumPropionate 0.04%, Kemin Industries) would alter glucose or lipid metabolism of newly received cattle. Chromium premixes were supplemented to add 0 (Con) or 0.2 mg/kg of ...
Mårtensson J - - 2012
Acute kidney injury (AKI) has a number of triggers, including ischaemia, nephrotoxins, radiocontrast, and bacterial endotoxins. It occurs in around one-third of patients treated in intensive care unit (ICU) and is even more prevalent in cardiac surgery patients. There is a higher mortality in patients with AKI compared with non-AKI ...
Narvaez-Rosales Veronica - - 2012
Background  Transient myeloproliferative disorder (TMD) affects up to 10% of patients with Down syndrome (DS). A small proportion of newborns are asymptomatic and only manifest circulating blast cells, with or without leukocytosis, while others present with hepatomegaly, splenomegaly, serous effusions, and liver fibrosis. Few cases in the literature also have ...
Gravel Dominique - - 2012
There is consensus that biodiversity losses will result in declining ecosystem functioning if species have different functional traits. Phylogenetic diversity has recently been suggested as a predictor of ecosystem functioning because it could approximate the functional complementarity among species. Here we describe an experiment that takes advantage of the rapid ...
Tan Feng - - 2012
Proteomic analysis allows detection of changes of proteins expression in organisms exposed to environmental pollutants, leading to the discovery of biomarkers of exposure and understanding of the action mechanism of toxicity. In the present study, we applied iTRAQ labeling quantitative proteomic technology for global characterization of the liver proteome in ...
Thompson Sanna J - - 2012
This study examined the direct effects of physical and sexual abuse, neglect, poor family communication and worries concerning family relationships, depression, anxiety, and dissociation on posttraumatic stress symptoms. Runaway youth were recruited from emergency youth shelters in New York and Texas. Interviews were completed with 350 youth who averaged 15 ...
Pfister C - - 2012
Vascular endothelial growth factor (VEGF)-mediated angiogenesis mediates tumour growth and metastasis. Meningiomas are primarily benign, slow-growing, highly vascularised tumours. Aside from VEGF, there is little data on the function of major angiogenic proteins in meningiomas. The VEGFA, platelet-derived growth factor B (PDGFB), and their respective receptors - VEGF receptor 2 ...
Yadav Prasad - - 2012
Thumbs up for porous graphene! Single-layer-graphene-assembled 3D hexaporous carbon is prepared by catalyst-free pyrolysis of poly(4-styrenesulfonic acid-co-maleic acid) sodium salt. The material has a hierarchical structure of mesoporous as well as microporous graphene with hexagonal nanopores of uniform size and shape. The results show that the sample is highly conducting ...
Bashir Mohamad M Department of Cardiac Surgery, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, Birmingham, UK. - - 2013
We report a 49-year old female who presented with ST elevation myocardial infarction, in whom thrombolysis and coronary angioplasty failed to perfuse the myocardium. She was unsuitable for emergency coronary artery bypass grafting surgery due to the interval elapsed between the myocardial infarction, thrombolysis and large infracted myocardium. Ventricular-assisted device ...
Carson Robert P RP Department of Neurology, Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, TN 37232-8552, - - 2013
Tuberous sclerosis complex (TSC) is a multisystem genetic disorder with severe neurologic manifestations, including epilepsy, autism, anxiety and attention deficit hyperactivity disorder. TSC is caused by the loss of either the TSC1 or TSC2 genes that normally regulate the mammalian target of rapamycin (mTOR) kinase. mTOR exists within two distinct ...
Warren-Gash Charlotte C Centre for Infectious Disease Epidemiology, Research Department of Infection & Population Health, University College London, Royal Free Hospital, Rowland Hill St, London NW3 2PF, United Kingdom. - - 2012
An association between infections and vascular events has been observed, but the specific effect of influenza and influenza-like illnesses on triggering acute myocardial infarction (AMI) is unclear. Episodes of first AMI from 1 January 2003 through 31 July 2009 were identified using linked anonymized electronic medical records from the Myocardial ...
Selvaraj M - - 2012
We demonstrate a much green synthesis method for highly selective synthesis of 6,8-di-t-butylated flavan (6,8-DTBF) by liquid phase alkylation of 2,4-di-t-butylphenol (2,4-DTBP) with cinnamyl alcohol (Cin-OH) over mesoporous Zn-Al-MCM-41 catalysts synthesized under direct basic hydrothermal method. The main alkylated product, 6,8-DTBF is importantly used as an intermediate in the manufacture ...
van Walraven Carl - - 2012
Hospital readmissions are important patient outcomes that can be accurately captured with routinely collected administrative data. Hospital-specific readmission rates have been reported as a quality-of-care indicator. However, the extent to which these measures vary with different calculation methods is uncertain. We identified all discharges from Ontario hospitals from 2005 to ...
Usichenko T I - - 2013
An organizational approach is proposed as an immediate solution for improving postoperative pain (POP) management. The aim was to evaluate the clinical effectiveness of a quality management system (QMS), based on procedure-specific, multimodal analgesic protocols, modified to meet the individual patients' requirements. Patients from the orthopaedic, gynaecological, visceral, and trauma ...
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