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Results 301 - 350 of 3015
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McDonald Thomas J TJ Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Sciences Center, San Antonio, TX 78229, USA. - - 2013
Mechanisms linking maternal nutrient restriction (MNR) to intra-uterine growth restriction (IUGR) and programming of adult disease remain to be established. The impact of controlled MNR on maternal and fetal amino acid metabolism has not been studied in non-human primates. We hypothesised that MNR in pregnant baboons decreases fetal amino acid ...
Grozinsky-Glasberg Simona - - 2012
Neuroendocrine tumors (NETs) are a rare and heterogeneous group of neoplasms of a relatively indolent nature whose incidence and prevalence are increasing. Despite the advances made in the field of NETs over the past years, these tumors eventually progress to metastatic disease in most of the patients, with a fatal ...
Gong Inna Y - - 2012
There has been remarkable progress during the past decade in understanding of how genetic variations in drug metabolizing enzymes and transporters contribute to observed variation in drug responsiveness. Among drug transporters, the organic anion transporting polypeptide (OATP) class of transporters have proven to be remarkably important to the cellular uptake ...
Garrido-Martín Eva M EM Centro de Investigaciones Biológica, Ramiro de Maeztu 9, 28040, Madrid, - - 2013
Activin receptor-like kinase-1 (ALK1) is an endothelial transforming growth factor β receptor involved in angiogenesis. ALK1 expression is high in the embryo vasculature, becoming less detectable in the quiescent endothelium of adult stages. However, ALK1 expression becomes rapidly increased after angiogenic stimuli such as vascular injury. To characterize the molecular ...
Yang Jinyan - - 2012
The present study was designed to analyse the usefulness of a modified Calgary score system during differential diagnosis between cardiac syncope and postural orthostatic tachycardia syndrome-associated syncope through a large sample sized clinical investigation. The study included 213 children, including 101 boys and 112 girls, with cardiac syncope or postural ...
Wang Feihu - - 2012
A novel micelle formulation of paclitaxel (PTX) has been prepared for the purpose of prolonging the blood circulation time as well as modifying the biodistribution of PTX in comparison to a current PTX formulation, Taxol injection. This work was designed to investigate the preparation, in vitro release, in vivo pharmacokinetics, ...
White Andrew A - - 2012
Aspirin-exacerbated respiratory disease (AERD) is a unique syndrome of airway inflammation that frequently occurs in patients with nasal polyposis, chronic sinusitis, and asthma. These patients tend to have progressive and recalcitrant sinus disease requiring frequent surgical intervention and in many cases systemic corticosteroids. Much about the pathogenesis of AERD remains ...
Buckstein Michael - - 2012
What's known on the subject? and What does the study add? While the frequencies and severity of late toxicities following prostate brachytherapy are well known, less has been published with regard to time to first onset. Several series with limited median follow-up have published time to onset. An extensive analysis ...
Quintero Rubén A - - 2012
Abstract Objectives: To assess whether the observed vs. expected lung-to-head ratio (o/e LHR) corrects for the dependence of the LHR on gestational age. Study Design: Published data on right lung area (LA) and LHR were used to plot the 50(th) percentile and different fixed values of the o/e LHR (e.g., ...
Pereda Noemí - - 2012
Criterion A2 according to the Diagnostic and Statistical Manual of Mental Disorders (4(th) ed.; DSM-IV; American Psychiatric Association [APA], 1994) for posttraumatic stress disorder (PTSD) aims to assess the individual's subjective appraisal of an event, but it has been claimed that it might not be sufficiently specific for diagnostic purposes. ...
Abd-Elmoniem Khaled Z KZ Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Dr, Bldg 10, Room 3-5340, Bethesda, MD 20892, USA. - - 2012
To develop a technique for time-resolved acquisition of phase-sensitive dual-inversion recovery (TRAPD) coronary vessel wall magnetic resonance (MR) images, to investigate the success rate in coronary wall imaging compared with that of single-frame imaging, and to assess vessel wall thickness in healthy subjects and subjects with risk factors for coronary ...
Min James K JK Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., S. Taper Building 1258, Los Angeles, CA 90048, USA. - - 2012
To date, the therapeutic benefit of revascularization vs. medical therapy for stable individuals undergoing invasive coronary angiography (ICA) based upon coronary computed tomographic angiography (CCTA) findings has not been examined. We examined 15 223 patients without known coronary artery disease (CAD) undergoing CCTA from eight sites and six countries who ...
Visinescu Diana - - 2012
The reaction of [Cu(valen)] with Tb(NO(3))(3) and (Bu(3)NH)(3)[W(CN)(8)] affords two types of crystals: [{W(CN)(8)}Cu(valen)Tb(OH(2))(5)]·2H(2)O (, a discrete trinuclear complex) and [{W(CN)(8)}Cu(valen)Tb(OH(2))(4)]·CH(3)CN·H(2)O (, an infinite zig-zag chain), both compounds showing slow relaxation of the magnetization (H(2)valen is the Schiff base resulting from the reaction of o-vanillin with 1,2-ethanediamine).
Viet A-F - - 2012
Beef cow-calf farming systems are assumed to be resilient to biological disturbances that induce variations in herd demography; however, this hypothesis has not been fully investigated to date. Modeling is an interesting approach to study farming system resilience and evaluate the impact of biological disturbances while taking into account interactions ...
Bagai Akshay - - 2012
BACKGROUND: DESPITE VALUABLE SUPPLEMENTAL TRAINING RESOURCES FOR SURGICAL SKILL ACQUISITION, UTILITY OF VIRTUAL REALITY SIMULATORS TO IMPROVE SKILLS RELEVANT TO PERFORMING CARDIAC CATHETERIZATION HAS NOT BEEN EVALUATED.METHODS AND RESULTS: POST BASELINE CARDIAC CATHETERIZATION PERFORMANCE ASSESSMENT, 27 CARDIOLOGY TRAINEES WERE RANDOMIZED TO EITHER MENTORED TRAINING ON A VIRTUAL REALITY SIMULATOR (N=12) ...
Ronconi Luca - - 2012
The focus of spatial attention can be not only oriented to a particular location, but also adjusted in its size to select visual information from a narrow (zoom-in) or broad (zoom-out) region of the visual field. Attentional orienting, saccades programming, and visual search have been linked to the frontal eye ...
Shahnazari Mohammad M Division of Endocrinology, Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, CA 94121, - - 2012
Loss of skeletal weight bearing or skeletal unloading as occurs during spaceflight inhibits bone formation and stimulates bone resorption. These are associated with a decline in the osteoblast (Ob.S/BS) and an increase in the osteoclast (Oc.S/BS) bone surfaces. To determine the temporal relationship between changes in the bone cells and ...
Huang Yu Cheng - - 2012
The introduction of a second metal, gold, into a nickel matrix can effectively improve the catalytic performance and thermal stability of the catalysts toward steam reforming of methane. To investigate the effect of Au on the adsorption properties and electronic structure of the Ni(111) surface, we chose CO as a ...
de Golian Emily - - 2012
Linear atrophoderma of Moulin (LAM) is a rare dermatologic disorder characterized by a hyperpigmented atrophoderma that consistently follows the lines of Blaschko. There are many clinical and histologic similarities between LAM, atrophoderma of Pasini and Pierini (APP), and morphea, and whether LAM represents part of a disease spectrum or its ...
Paredes Sur Herrera SH Curriculum in Bioinformatics and Computational Biology, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, - - 2013
It has been known for more than 2 decades that after RNA polymerase II (RNAPII) initiates transcription, it can enter into a paused or stalled state immediately downstream of the transcription start site before productive elongation. Recent advances in high-throughput genomic technologies facilitated the discovery that RNAPII pausing at promoters ...
Belogurov Alexey A AA - - 2013
Multiple sclerosis (MS) is a severe inflammatory and neurodegenerative disease with an autoimmune background. Despite the variety of therapeutics available against MS, the development of novel approaches to its treatment is of high importance in modern pharmaceutics. In this study, experimental autoimmune encephalomyelitis (EAE) in Dark Agouti rats has been ...
Burns Jonathan R - - 2012
A programmable switch based on a DNA hairpin loop is functionalised with a rigid or flexible porphyrin or FAM and TAMRA FRET pair, which provides insight into the restructuring of the hairpin as well as porphyrin-porphyrin coupling. The switch contains five discrete states which can be accessed independently and followed ...
Sultana Nighat - - 2012
The plant-derived terpenoids are considered to be the most potent anticancer, anti-inflammatory and anticarcinogenic compounds known. Enzymatic biotransformation is a very useful approach to expand the chemical diversity of natural products. Recent enzymatic biotransformation studies on terpenoids have resulted in the isolation of novel compounds. 14-hydroxy methyl caryophyllene oxide produced ...
Harris Tyler L TL Department of Chemistry, North Carolina State University, Raleigh, 27695, - - 2012
Shields down! Adjuvant molecules that have the ability to restore the susceptibility of multi-drug-resistant bacteria, such as MRSA, to clinically available antibiotics are a promising alternative to the development of novel antimicrobials. Pictured is a potent small molecule (1) that, at sub-minimum inhibitory concentration (sub-MIC) levels, lowers the MIC of ...
Liu Yin - - 2012
AimsHypoplastic coronary artery disease is a rare congenital abnormality that is associated with sudden cardiac death. However, molecular mechanisms responsible for this disease are not clear. The aim of the present study was to assess the role of nitric oxide synthase-3 (NOS3) in the pathogenesis of hypoplastic coronary arteries.Methods and ...
Haynes F E M - - 2012
Lambs with the myostatin g+6723G>A mutation have a greater muscle mass, which is believed to be associated with reduced myostatin protein abundance. This experiment was designed to determine if differences in allelic frequency of the myostatin g+6723G>A mutation affected abundance of myostatin protein from birth to 24 wk of age. ...
Liang Zhao - - 2012
ABSTRACT: BACKGROUND: Cotton is the world's most important natural textile fiber and a significant oilseed crop. Decoding cotton genomes will provide the ultimate reference and resource for research and utilization of the species. Integration of high-density genetic maps with genomic sequence information will largely accelerate the process of whole-genome assembly ...
de Vetten L - - 2012
Objective With this case report, we aim to improve recognition of the systemic effects of hypothermia due to hypothalamic dysfunctioning. We present a patient who developed temperature dysregulation after surgery for craniopharyngioma. He suffered from several episodes of hypothermia associated with a decreased level of consciousness, hypoventilation, bradycardia, pancreatitis, and pancytopenia. ...
Trabelsi O - - 2012
Swallowing depends on physiological variables that have a decisive influence on the swallowing capacity and on the tracheal stress distribution. Prosthetic implantation modifies these values and the overall performance of the trachea. The objective of this work was to develop a decision support system based on experimental, numerical and statistical ...
Panyasing Y - - 2012
In commercial swine populations, influenza is an important component of the porcine respiratory disease complex (PRDC) and a pathogen with major economic impact. Previously, a commercial blocking ELISA (FlockChek(™) Avian Influenza Virus MultiS-Screen(®) Antibody Test Kit, IDEXX Laboratories, Inc., Westbrook, ME, USA) designed to detect influenza A nucleoprotein (NP) antibodies ...
Radat Françoise - - 2013
This study aims to describe the cognitive representations of migraine through the migraineurs' discourse. A sample of subjects taken at random from a representative sample of the French general population is interviewed about their representations of migraine. A content analysis is performed using the ALCESTE software. The population is composed ...
Jonassen Helene - - 2012
The physical stability of chitosan nanoparticles cross-linked with sodium tripolyphosphate (TPP) was investigated over a period of 1 month. Special emphasis was placed on changes in the particle size and the particle compactness, which are two important physicochemical parameters of nanoparticulate drug delivery systems. The chitosan-TPP particles were prepared at ...
Flassig R J - - 2012
MOTIVATION: Biochemical reaction networks in the form of coupled ordinary differential equations (ODEs) provide a powerful modeling tool for understanding the dynamics of biochemical processes. During the early phase of modeling, scientists have to deal with a large pool of competing nonlinear models. At this point, discrimination experiments can be ...
Sainiemi Lauri - - 2012
This paper presents parallel microfabrication of three-dimensionally sharp electrospray ionization emitters out of glass. For the first time, the fabrication of glass emitters relies only on standard microfabrication techniques (i.e., deposition, photolithography and wet etching), and all manual machining steps are omitted. We also demonstrate a straightforward integration of the ...
Mitchell Christopher R - - 2012
Abstract Pelvic organ prolapse is a common problem faced by many women, resulting in significant morbidity and negatively impacting quality of life. Sacrocolpopexy can treat women with vaginal vault prolapse, multicompartment prolapse, and/or a history of failed prolapse procedures. The transabdominal sacrocolpopexy has been shown, on multiple studies, to have ...
Larsson Anne - - 2012
In dopamine brain SPECT, semiquantitative techniques are in use, mostly for research purposes, to calculate activity uptake in the striatum relative to the background. The measured uptake ratios depend on both acquisition and reconstruction, and one important parameter is the rotation radius of the γ-camera detectors, which affects spatial resolution. ...
Xu Zejun - - 2012
A fragment-assembling strategy is used to form oxazoles from aryl acetaldehydes, amines, and molecular oxygen under mild conditions. The transformation is highly efficient with the removal of six hydrogen atoms, including the cleavage of four C(sp(3) )H bonds.
Akman Tolga - - 2012
Study Type - Prognosis (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? The presence of metabolic syndrome is associated with development of kidney stones and an increase in the stone-recurrence rate. However, studies reporting long-term results of percutaneous nephrolithotomy (PCNL) in metabolic syndrome ...
Fernandes M H M R - - 2012
During the last decade, advances in the mineral nutrition of goats have been made, especially in our understanding of the requirements for Ca and P. However, few studies have focused on the mineral requirements of crossbred Boer goats in their growth phase. The objective of this study was to determine ...
Dessuy Morgana B - - 2012
A simple method has been developed to determine antimony and lead in pewter alloy cups produced in Brazil, using fast sequential determination by high-resolution continuum source flame atomic absorption spectrometry. The samples were dissolved in HCl and H(2)O(2), employing a cold finger system in order to avoid analyte losses. The ...
Soós Vilmos - - 2012
Smoke-derived compounds provide a strong chemical signal to seeds in the soil seed bank, allowing them to take advantage of the germination niche created by the occurrence of fire. The germination stimulatory activity of smoke can largely be attributed to karrikinolide (KAR(1) ), while a related compound, trimethylbutenolide (TMB), has ...
Souza M A M De MA Unimontes Medical School, Montes Claros, Minas Gerais, - - 2013
To evaluate the effect of a synthetic progestin on the vascular resistance of the ophthalmic and central retinal arteries in climacteric women, compared to placebo, using transorbital ultrasound with Doppler velocimetry. We performed a prospective, randomized, double-blinded, placebo-controlled study with 216 climacteric women. Subjects were randomly allocated to one of ...
Ravi K - - 2012
In mixed systems of trapped ions and cold atoms, the ions and atoms can coexist at different temperatures. This is primarily due to their different trapping and cooling mechanisms. The key questions of how ions can cool collisionally with cold atoms and whether the combined system allows stable coexistence, need ...
Gebuis Titia - - 2012
Nonsymbolic number and its continuous visual properties are confounded in everyday life: When number changes, its continuous visual properties also change. It could therefore be efficient to rely on the visual properties to judge number. The current consensus, however, holds that number is processed independent of its visual properties. In ...
Rossner Pavel - - 2012
The health of human populations living in industrial regions is negatively affected by exposure to environmental air pollutants. In this study, we investigated the impact of air pollution on a cohort of subjects living in Ostrava, a heavily polluted industrial region and compared it with a cohort of individuals from ...
Rochelle Tristan - - 2012
We previously demonstrated that the Bcr-Abl oncogene, p210(bcr-abl), through its unique GEF domain, specifically activates RhoA and induces spontaneous amoeboid motility. We intend to study the pathways downstream RhoA controlling amoeboid motility. Mouse prolymphoblastic cells (Ba/F3 cell line) expressing different forms of Bcr-Abl were embedded in 3-dimensional (3D) Matrigel to ...
Yamaguchi Tomoko - - 2012
Mast cells play important roles in the pathogenesis of allergic diseases. They are generally classified into two phenotypically distinct populations: connective tissue-type mast cells (CTMCs) and mucosal-type mast cells (MMCs). The number of mast cells that can be obtained from tissues is limited, making it difficult to study the function ...
Eby Charles - - 2012
After a decade of clinical investigation, pharmacogenetic-guided initial dosing of warfarin is at a crossroads. Genotypes for two single nucleotide polymorphisms (SNPs) in the cytochrome P 450 2C9 gene, affecting warfarin metabolism, and one SNP in vitamin K reductase complex 1 gene, affecting warfarin sensitivity, account for approximately 30% of ...
Elsaid Naba - - 2012
Purpose: To explore the potential of an amphiphilic chitosan derivative to facilitate the transscleral delivery of rapamycin, a potential multi-therapeutic agent with poor water solubility. Methods: The amphiphilic chitosan derivative, O-octanoyl-chitosan-polyethylene glycol (OChiPEG) graft copolymer, was analysed using Fourier-transform infrared spectroscopy (FT-IR). OChiPEG micelles were prepared via the thin film ...
Ittermann Till - - 2012
Background: Hypothyroidism may be a risk factor for obesity, because metabolic rates tend to be decreased in this disorder. Currently it is under debate whether smoking may modify the association between hypothyroidism and obesity. Against this background the aims of our study were to investigate whether there is an association ...
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