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Results 251 - 300 of 3014
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Rivera Norma - - 2012
The compound VAM2-6 (1-methyl-7-nitro-4-(5-(piperidin-1-yl)pentyl)-3,4-dihydroquinoxalin-2(1H)-one) has previously been shown to have an in vitro efficacy of 100% at a concentration of 100 µg ml(-1) against Trichomonas vaginalis, a protozoon parasite that causes the sexually transmitted disease trichomoniasis. Because VAM2-6 is a quinoxaline derivative and given the lack of studies on the genotoxic activity ...
Fahmueller Yvonne Nadine - - 2012
Radioembolisation Therapy (RE) is an efficient locoregional treatment for liver metastases from colorectal cancer. Serum biomarkers involved in immunogenic cell death are potentially valuable for early predicting therapy response and estimating prognosis. In a prospective oberservation study, blood samples were taken from 49 consecutive colorectal cancer patients with extensive hepatic ...
Weisshaar Elke - - 2012
Background. Occupational skin disease (OSD) is common, and imposes a considerable personal and public burden. To tackle OSD, the German stepwise procedure of handling OSD was set up. It contains an interdisciplinary, integrated inpatient rehabilitation measure [tertiary individual prevention (TIP)] [dermatological treatment and diagnostic procedures, and patient education (health and ...
Rhinn Muriel - - 2012
The trigeminal circuit relays somatosensory input from the face into the central nervous system. In central nuclei, the spatial arrangement of neurons reproduces the physical distribution of peripheral receptors thus generating a somatotopic facial map during development. In mice, the ophthalmic, maxillary and mandibular trigeminal nerve branches maintain a somatotopic ...
Haug Marion F - - 2012
Glutamate, the most abundant excitatory neurotransmitter of the central nervous system, modulates synaptic transmission and neuronal excitability via metabotropic glutamate receptors (mGluRs). These receptors are essential components for diverse cognitive functions and they represent potential drug targets for the treatment of a number of neurological and psychiatric disorders. Here, we ...
de Jong E - - 2012
To achieve optimal reproductive performance in pig herds, sows need to become pregnant as soon as possible after weaning. The aim of this study was to investigate herd and management factors associated with reproductive performance of sows after weaning. A questionnaire pertaining to sow management at weaning and herd reproductive ...
Mark Annabelle - - 2012
The purpose of this paper is to consider capacity development for healthcare in Fragile States and its roles, for example, in securing civil and political stability, as well as improved health, within the various contexts prevailing in fragile settings across the world. As a precursor to this, however, it is ...
Ba K - - 2012
OBJECTIVES: Notch signalling plays an important role in many cell activities, involving proliferation, migration, differentiation and cell death. The aim of this study was to investigate effects of such signalling on adipogenesis of mouse adipose-derived stem cells (mASCs). MATERIALS AND METHODS: Jagged1 (50 and 100 ng/ml) was added to mASCs to ...
Lonien Joachim - - 2012
Regardless of the industry, standards are ubiquitous in our everyday lives and essential to the interconnection of people, businesses, and countries. Joachim Lonien, DIN - German Institute for Standardization, introduces the idea behind the ISO/TC "Biotechnology".
Strappini A C - - 2012
In Chile, cow carcasses present the highest bruise prevalence compared with other cattle categories; however, the causes of the bruises are frequently unknown. In this study, 52 cull cows were transported to the slaughterhouse in three batches under identical transport conditions. A combination of direct observation and video analyses was ...
Lee Marietta Y W T - - 2012
The p12 subunit of polymerase delta (Pol δ) is degraded in response to DNA damage induced by UV, alkylating agents, oxidative, and replication stresses. This leads to the conversion of the Pol δ4 holoenzyme to the heterotrimer, Pol δ3. We review studies that establish that Pol δ3 formation is an ...
Haste Nina M - - 2012
The rapid rise in antimicrobial resistance in bacteria has generated an increased demand for the development of novel therapies to treat contemporary infections, especially those caused by methicillin-resistant Staphylococcus aureus (MRSA). However, antimicrobial development has been largely abandoned by the pharmaceutical industry. We recently isolated the previously described thiopeptide antibiotic ...
Shaaban Khaled A - - 2012
Four new benzamides, pyramidamycins A-D (2-5) along with the new natural 3-hydroxyquinoline-2-carboxamide (6) were isolated from the crude extract of Streptomyces sp. DGC1. Additionally, five other known compounds, namely 2-aminobenzamide (anthranilamide) (1), 4',7-dihydroxyisoflavanone (7), 2'-deoxy-thymidine, 2'-deoxy-uridine and adenosine were also isolated and identified. The structures of the new compounds 2-6 ...
Joynt Karen E - - 2012
Public reporting of patient outcomes is an important tool to improve quality of care, but some observers worry that such efforts will lead clinicians to avoid high-risk patients. To determine whether public reporting for percutaneous coronary intervention (PCI) is associated with lower rates of PCI for patients with acute myocardial ...
Berthiller Franz - - 2013
The aim of this review is to give a comprehensive overview of the current knowledge on plant metabolites of mycotoxins, also called masked mycotoxins. Mycotoxins are secondary fungal metabolites, toxic to human and animals. Toxigenic fungi often grow on edible plants, thus contaminating food and feed. Plants, as living organisms, ...
Glatstein Miguel - - 2012
Sulfonylureas are used extensively for treating type-2 diabetes mellitus. Sulfonylurea poisoning can produce sustained and profound hypoglycemia refractory to IV dextrose, particularly in children and the elderly. To review the use of octreotide, a long-acting somatostatin analog, in the treatment of sulfonylurea-induced hypoglycemia. A computerized search of U.S. National Academy ...
Cheng Bastian - - 2013
In acute stroke magnetic resonance imaging, a 'mismatch' between visibility of an ischemic lesion on diffusion-weighted imaging (DWI) and missing corresponding parenchymal hyperintensities on fluid-attenuated inversion recovery (FLAIR) data sets was shown to identify patients with time from symptom onset ≤4.5 hours with high specificity. However, moderate sensitivity and suboptimal ...
Takaguchi Koichi - - 2013
To test if the treatment adherence to branched-chain amino acid (BCAA) granules influences the serum albumin level and prognosis in prospective 2984 patients with decompensated liver cirrhosis who were prescribed BCAA granules containing 952 mg of L-isoleucine, 1904 mg of L-leucine and 1144 mg of L-valine at 4.15 g/sachet three times a day after ...
Daland Robert - - 2012
ABSTRACT What are the sources of variation in the input, and how much do they matter for language acquisition? This study examines frequency variation in manner-of-articulation classes in child and adult input. The null hypothesis is that segmental frequency distributions of language varieties are unigram (modelable by stationary, ergodic processes), ...
Dani Krishna A KA Institute of Neurosciences and Psychology, School of Medicine, University of Glasgow, Glasgow, - - 2012
Hyperoxia during T2*-weighted magnetic resonance imaging (oxygen challenge imaging (OCI)) causes T2*-weighted signal change that is dependent on cerebral blood volume (CBV) and oxygen extraction fraction (OEF). Crossed cerebellar diaschisis (CCD), where CBV is reduced but OEF is maintained, may be used to understand the relative contributions of OEF and ...
Dalkara Turgay T Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey. - - 2012
Substantial experimental data and recent clinical evidence suggesting that tissue reperfusion is a better predictor of outcome after thrombolysis than recanalization necessitate that patency of microcirculation after recanalization should be reevaluated. If indeed microcirculatory blood flow cannot be sufficiently reinstituted despite complete recanalization as commonly observed in coronary circulation, it ...
Leger Pierre-Louis PL Sorbonne Paris Cité, INSERM U676, Univ Paris Diderot, Paris, - - 2013
The aim of the study was to better understand blood-flow changes in large arteries and microvessels during the first 15 minutes of reflow in a P7 rat model of arterial occlusion. Blood-flow changes were monitored by using ultrasound imaging with sequential Doppler recordings in internal carotid arteries (ICAs) and basilar ...
Liu W W Crop Genetics and Breeding Department, China Agricultural University, Beijing, - - 2013
Family mapping is based on multiple segregating families and is becoming increasingly popular because of its advantages over population mapping. Athough much progress has been made recently, the optimum design and allocation of resources for family mapping remains unclear. Here, we addressed these issues using a simulation study, resample model ...
Taylor S J SJ Department of Biology, Texas State University-San Marcos, San Marcos, TX 78666, USA. - - 2013
Hybrid speciation represents a relatively rapid form of diversification. Early models of homoploid hybrid speciation suggested that reproductive isolation between the hybrid species and progenitors primarily resulted from karyotypic differences between the species. However, genic incompatibilities and ecological divergence may also be responsible for isolation. Iris nelsonii is an example ...
Huang Sheng-You SY Department of Physics and Astronomy, University of Missouri, Columbia, Missouri 65211, - - 2013
Protein-RNA interactions play an important role in many biological processes. The ability to predict the molecular structures of protein-RNA complexes from docking would be valuable for understanding the underlying chemical mechanisms. We have developed a novel nonredundant benchmark dataset for protein-RNA docking and scoring. The diverse dataset of 72 targets ...
Pullenayegum Eleanor M EM Biostatistics Unit, St Joseph's Healthcare, 50 Charlton Ave E, Canada. - - 2013
Longitudinal data arising from routine follow-up of patients will often have irregular measurement times. Existing methods for analysis include joint modelling of the outcome and measurement processes, and inverse-intensity weighting (IIW). This work extends previously proposed analysis of increments to the case of irregular follow-up, yielding a model for the ...
Yu Q Q Australian Herbicide Resistance Initiative, School of Plant Biology, Faculty of Natural and Agriculture Sciences, University of Western Australia, Crawley, Western Australia, - - 2013
Many herbicide-resistant weed species are polyploids, but far too little about the evolution of resistance mutations in polyploids is understood. Hexaploid wild oat (Avena fatua) is a global crop weed and many populations have evolved herbicide resistance. We studied plastidic acetyl-coenzyme A carboxylase (ACCase)-inhibiting herbicide resistance in hexaploid wild oat ...
Sefi Mediha - - 2012
This study aimed to investigate the protective effect of selenium (Se) on methimazole (MMI; an antithyroid drug)-induced hepatotoxicity in adult rats and their progeny. Female Wistar rats were randomly divided into four groups of six rats in each group: group I served as controls that received standard diet; group II ...
Watts Lora Talley - - 2012
Traumatic brain injury (TBI) is the leading cause of death and disability in children and young adults. Neuroprotective agents that may promote repair or counteract damage following injury do not currently exist. We recently reported that stimulation of the purinergic receptor subtype P2Y1R using 2-methylthioladenosine 5' diphosphate (2MeSADP) significantly reduced ...
Dang Song - - 2012
A family of new luminescent lanthanide MOFs have been synthesized and display a strong second-harmonic generation response, which is 6.0 times that of KDP and phase matchable. The LnMOFs also exhibit typical luminescence emissions with high quantum yields (up to 70.0% for Tb).
Nabi Robin L - - 2012
Grounded in social cognitive theory, this research examines the effects of reality entertainment programming and embedded commercials on viewers' perceived motivations and efficacy to exercise and consume a healthy diet as well as on food preference. In a 3 (program type) × 2 (advertisement type) study design, 253 female undergraduates were randomly ...
Murakawa Tomohiro - - 2012
OBJECTIVES: The radiological ground glass opacity (GGO) component of an adenocarcinoma pathologically reflects a non-invasive adenocarcinoma in situ (AIS). Measuring the tumour diameter to include the GGO component may overestimate the T factor. In this retrospective study, we evaluated the effect of the GGO component on the recurrence of an ...
Bushart Thomas J - - 2012
• Premise of the study: Gravity regulates the magnitude and direction of a trans-cell calcium current in germinating spores of Ceratopteris richardii. Blocking this current with nifedipine blocks the spore's downward polarity alignment, a polarization that is fixed by gravity ∼10 h after light induces the spores to germinate. RNA-seq ...
Salehi Iraj - - 2012
Investigations indicate a potential link between exposure to extremely low-frequency electromagnetic field (ELF-EMF) and some cancers. Carcinogenesis of ELF-EMF may be mediated by effect on the immune system. During an immune response, naïve T cells differentiate to effector type 1 helper T cells (T(H)1), T(H)2, or T(H)17 subsets according to ...
Nijkamp Jurgen F - - 2012
MOTIVATION: Comparing genomes of individual organisms using next generation sequencing data is, until now, mostly performed using a reference genome. This is challenging when the reference is distant and introduces bias towards the exact sequence present in the reference. Recent improvements in both sequencing read length and efficiency of assembly ...
Watanabe Kaori - - 2012
Treating infections with exogenous NO, which shows broad-spectrum antimicrobial activity, appears to be effective. Similar to NO biosynthesis, biosynthesis of α-1-acid glycoprotein variant A (AGPa), with a reduced cysteine (Cys149), increases markedly during inflammation and infection. We hypothesized that AGPa is an S-nitrosation target in acute-phase proteins. This study aimed ...
Balasanthiran Vagulejan - - 2012
Over the counter oral relief aids or dietary supplements, namely calcium carbonate, calcium hydroxyapatite, magnesium oxide, zinc oxide, Tums® and Pepto-Bismol® have been investigated in the melt ring-opening polymerization of lactide and a direct comparison with that involving tin(ii) octanoate has been made. Of these, Pepto-Bismol® is shown to be ...
Ogawa Masahiro - - 2012
Muscle atrophy increases the production of reactive oxygen species and the expression of atrophy-related genes, which are involved in the ubiquitin-proteasome system. In the present study, we investigated the effects of β-carotene on oxidative stress (100 μm-H2O2)-induced muscle atrophy in murine C2C12 myotubes. β-Carotene (10 μm) restored the H2O2-induced decreased levels of ...
Amouyal Yaron - - 2012
Recent developments in the technology of laser-pulsed local-electrode atom-probe (LEAP) tomography include a picosecond ultraviolet (UV) laser system having a 355 nm wavelength and both external and in-vacuum optics. This approach ensures focusing of the laser beam to a smaller spot diameter than has heretofore been obtained using a green ...
Maroto-Molina F - - 2012
Feed databases often have missing data. Despite their potentially major effect on data analysis (e.g. as a source of biased results and loss of statistical power), database managers and nutrition researchers have paid little attention to missing data. This study evaluated various methods of handling missing data using mining outputs ...
Dilalla Lisabeth Fisher - - 2012
This update on the Southern Illinois Twins and Siblings Study (SITSS) documents some of the follow-up studies that have been conducted and results that have been obtained from this sample. At the current time, 283 twin pairs, 8 triplet families, 98 non-twin sibling pairs, and 287 singletons have been enrolled ...
Ahn Jung-Min - - 2012
BACKGROUND: PROCEDURAL AND CLINICAL OUTCOMES STILL REMAIN UNFAVORABLE FOR PATIENTS WITH LONG CORONARY LESIONS WHO UNDERGO STENT-BASED CORONARY INTERVENTIONS. THEREFORE, WE COMPARED THE RELATIVE EFFICACY AND SAFETY OF RESOLUTE ZOTAROLIMUS-ELUTING STENTS (R-ZES) AND SIROLIMUS-ELUTING STENTS (SES) FOR PATIENTS WITH DE NOVO LONG CORONARY LESIONS.METHODS AND RESULTS: THIS RANDOMIZED, MULTICENTER, PROSPECTIVE ...
Zhang Zengyan - - 2012
In this study, we report new insights into the function of a wheat (Triticum aestivum) MYB gene TaPIMP1 through overexpression and underexpression, and its underlying mechanism in wheat. Electrophoretic mobility shift and yeast-one-hybrid assays indicated that TaPIMP1 can bind to five MYB-binding sites including ACI, and activate the expression of ...
Kurita Rei - - 2012
Often experimentalists study particulate samples that are nominally monodisperse. In reality, many samples have a polydispersity of 4-10%. At the level of an individual particle, the consequences of this polydispersity are unknown as it is difficult to measure an individual particle size from images of a dense sample. Here we ...
Jastrzebski Marek - - 2012
AIMS: To investigate the effect of implantation-related characteristics, especially lead position and left ventricular (LV)-paced QRS morphology, on long-term mortality and morbidity in cardiac resynchronization therapy (CRT) patients.METHODS AND RESULTS: The study retrospectively analysed 362 consecutive patients who underwent CRT device implantation over a 6 year period. Pre-implantation, LV-only paced, ...
Zhao Yuefang - - 2012
Acetohydroxyacid synthase (AHAS), which catalyzes the first step in the biosynthesis of branched-chain amino acids, is composed of catalytic and regulatory subunits. The enzyme exhibits full activity only when the regulatory subunit (RSU) binds to the catalytic subunit (CSU). However, the crystal structure of the holoenzyme has not been reported ...
Kubo Tomohiro - - 2012
The tpg1 mutant of Chlamydomonas lacks the tubulin polyglutamylase TTLL9 and is deficient in flagellar tubulin polyglutamylation. It exhibits slow swimming, whereas the double mutant with oda2 (a slow-swimming mutant that lacks outer-arm dynein) is completely nonmotile. Thus, tubulin polyglutamylation must be important for the functioning of inner-arm dynein(s). In ...
He Huiying - - 2012
Study Type - Diagnosis (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? High grade prostatic intraepithelial neoplasia is a pre-malignant lesion to prostate cancer and is associated with 20%-25% risk of prostate cancer in subsequent repeat biopsies. ERG is a highly prostate-cancer-specific marker. ...
Luo Yanfei - - 2012
The objective of the present study was to develop stable pellets-layered Simvastatin (SIM) nanosuspensions with improved dissolution and bioavailability. The nanosuspensions were prepared with 7% HPMC, antioxidant 0.03% butylated hydroxyanisole and 0.2% citric acid (m/v) by low temperature grinding. After that, SDS with SIM was in a ratio of 1:5 ...
Wang Hong - - 2012
Opportunistic pathogens represent a unique challenge because they establish and grow within drinking water systems, yet the factors stimulating their proliferation are largely unknown. The purpose of this study was to examine the influence of pipe materials, disinfectant type and water age on occurrence and persistence of three opportunistic pathogens ...
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