Search Results
Results 101 - 150 of 3014
1 2 3 4 5 6 7 8 9 10 >
Lu Jinghua J Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, - - 2012
Pentraxins are innate pattern recognition molecules whose major function is to bind microbial pathogens or cellular debris during infection and inflammation and, by doing so, contribute to the clearance of necrotic cells as well as pathogens through complement activations. Fc receptors are the cellular mediators of antibody functions. Although conceptually ...
Brown Chad C CC Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695-7566, - - 2012
Recently, lymphoblastoid cell lines (LCLs) have emerged as an innovative model system for mapping gene variants that predict the dose response to chemotherapy drugs. In the current study, this strategy was expanded to the in-vitro genome-wide association approach, using 516 LCLs derived from a White cohort to assess the cytotoxic ...
Epperson Megan L ML Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, - - 2012
During the course of evolution, viruses have captured or created a diverse array of open reading frames, which encode for proteins that serve to evade and sabotage the host innate and adaptive immune responses that would otherwise lead to their elimination. These viral genomes are some of the best textbooks ...
Reynolds A M AM Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK. - - 2012
ABSTRACT The turbulent dispersal of fungal spores within plant canopies is very different from that within atmospheric boundary-layers and closely analogous to dispersal within turbulent mixing-layers. The process is dominated by the presence of large coherent flow structures, high-velocity downdrafts (sweeps) and updrafts (ejections), that punctuate otherwise quiescent flow. Turbulent ...
Bachert Collin C Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, - - 2013
Protein O-glycosylation is important in numerous processes including the regulation of proteolytic processing sites by O-glycan masking in select newly synthesized proteins. To investigate O-glycan-mediated masking using an assay amenable to large-scale screens, we generated a fluorescent biosensor with an O-glycosylation site situated to mask a furin cleavage site. The ...
Belozerova Irina I Department of Chemical & Biomolecular Engineering, Polytechnic Institute of New York University, Brooklyn, 11201, United - - 2012
A variety of solution methods exist for analysis of interactions between small molecule ligands and nucleic acids; however, accomplishing this task economically at the scale of hundreds to thousands of sequences remains challenging. Surface assays offer a prospective solution through array-based multiplexing, capable of mapping out the full sequence context ...
Ali M Yusuf MY Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA. - - 2013
Myosin VI (myoVI) and myosin Va (myoVa) serve roles both as intracellular cargo transporters and tethers/anchors. In both capacities, these motors bind to and processively travel along the actin cytoskeleton, a network of intersecting actin filaments and bundles that present directional challenges to these motors. Are myoVI and myoVa inherently ...
Odejinmi Sina I - - 2012
2-C-methyl-D-erythritol-4-phosphate (MEP) is a key chemical intermediate of the non-mevalonate pathway for isoprenoid biosynthesis employed by many pathogenic microbes. MEP is also the precursor for the synthesis of 4-diphosphocytidyl-2-C-methyl D-erythritol (CDP-ME), another key intermediate of the non-mevalonate pathway. As this pathway is non-existent in higher animals, including humans, it represents ...
Vincent Catherine E CE Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United - - 2013
Isobaric tagging enables the acquisition of highly multiplexed proteome quantification, but it is hindered by the pervasive problem of precursor interference. The elimination of coisolated contaminants prior to reporter tag generation can be achieved through the use of gas-phase purification via proton transfer ion/ion reactions (QuantMode); however, the original QuantMode ...
Frampton James E - - 2012
Aclidinium, an inhaled, long-acting antimuscarinic agent, has been developed as a twice-daily maintenance treatment for chronic obstructive pulmonary disease (COPD). Treatment with the approved dosage of aclidinium (400 μg twice daily) statistically significantly improved bronchodilation, disease-specific health status, dyspnoea, night-time COPD symptoms and use of rescue medication compared with placebo in ...
Liu Jingyu J Department of Chemistry, Brown University, Providence, Rhode Island 02912, United - - 2012
The widespread use of silver nanoparticles (Ag-NPs) in consumer and medical products provides strong motivation for a careful assessment of their environmental and human health risks. Recent studies have shown that Ag-NPs released to the natural environment undergo profound chemical transformations that can affect silver bioavailability, toxicity, and risk. Less ...
Ando Genki G Aoyama-Gakuin University, Sagamihara Campus L617, 5-10-1 Fuchinobe, Chuo, Sagamihara, Kanagawa, 252-5258 - - 2012
We investigate the diffusion and the drift motion of λ DNA molecules near solid-state nanopores prior to their translocation through the nanopores using fluorescence microscopy. The radial dependence of the electric field near a nanopore generated by an applied voltage in ionic solution can be estimated quantitatively in 3D by ...
Li Ding - - 2012
The surveillance and analysis of candidemia risk factors are necessary to reduce treatment failures in cancer patients. By understanding the geographic distribution of Candida spp. and their in vitro minimal antifungal inhibitory concentrations in cancer patients, optimal treatment protocols may be developed. On reviewing the candidemia data of cancer patients ...
Ehara Akira - - 2012
BACKGROUND: According to the Japan Pediatric Society, the mean extra work hours of hospital pediatricians in 2010 was about 80 hours per month, which is the certification criteria for Karoshi (death from overwork), and there is not a precise picture of personnel management at hospitals because the labor authorities do ...
van Vught Anneke J A H - - 2012
The amino acid arginine is a well-known growth hormone (GH) stimulator and GH is an important modulator of linear growth. The aim of the present study was to investigate the effect of dietary arginine on growth velocity in children between 7 and 13 years of age. Data from the Copenhagen ...
Khaled Elmorsy - - 2012
Miniaturized potentiometric sensors based on β-cyclodextrins (β-CDs) are described for determination of metformin (Mf) in pharmaceutical preparations and biological fluids. Electrode matrix compositions are optimized on the basis of the nature and content of sensing ionophore, ionic sites and plasticizers. Coated wire electrodes (CWEs) modified with heptakis(2,3,6-tri-O-methyl)-β-CD, sodium tetrakis(4-fluorophenyl)borate (NaTFPB) ...
Fife Dustin A - - 2012
In 2004, Hunter and Schmidt proposed a correction (called Case IV) that seeks to estimate disattenuated correlations when selection is made on an unmeasured variable. Although Case IV is an important theoretical development in the range restriction literature, it makes an untestable assumption, namely that the partial correlation between the ...
Krska Janet - - 2012
Aims To determine Citizen's Advice Bureaux (CAB) and general practice staff perceptions on the impact of a CAB Health Outreach (CABHO) service on staff workload. To quantify the frequency of mental health issues among patients referred to the CABHO service. To measure any impact of the CABHO service on appointments, ...
Pitman Roger K - - 2012
Post-traumatic stress disorder (PTSD) is the only major mental disorder for which a cause is considered to be known: that is, an event that involves threat to the physical integrity of oneself or others and induces a response of intense fear, helplessness or horror. Although PTSD is still largely regarded ...
Lindau Robert H - - 2012
BACKGROUND: Immunoglobulin G4 (IgG4)-related sclerosing disease is a systemic disease characterized by extensive IgG4-positive plasma cells and T-lymphocyte infiltration of various organs. We present a case of a 69-year-old man with maxillary sinus IgG4 sclerosing disease, with orbital invasion treated with rituximab and dexamethasone pulse therapy. Surgery was used as ...
Ito S - - 2012
Multidrug and toxin extrusion 1 (MATE1) and MATE2-K are H(+)/organic cation exchangers mediating the efflux of cationic drugs into the urine. N-methylnicotinamide (NMN) was found to be an endogenous substrate of MATE1 (Michaelis constant (K(m)) 301 ± 18 µmol/l) and MATE2-K (K(m) 422 ± 63 µmol/l) as well as a basolateral influx ...
Ran Tingting - - 2012
Cg1458 was recently characterized as a novel soluble oxaloacetate decarboxylase. However, sequence alignment identified that Cg1458 has no similarity with other oxaloacetate decarboxylases and instead belongs to the fumarylacetoacetate hydrolase (FAH) family. Differences in the function of Cg1458 and other FAH proteins may suggest a different catalytic mechanism. To help ...
Fridman Karen - - 2012
Visualizing the dynamic molecular architecture of cells is instrumental for answering fundamental questions in cellular and structural biology. Although modern microscopy techniques, including fluorescence and conventional electron microscopy, have allowed us to gain insights into the molecular organization of cells, they are limited in their ability to visualize multicomponent complexes ...
Zhang Yi - - 2012
The mechanism(s) by which hydrogen peroxide (H2O2) is photo-produced by humic substances (HS) and chromophoric dissolved organic matter (CDOM) was probed by examining the dependence of the initial H2O2 photo-production rate (RH2O2) and apparent H2O2 quantum yields on dioxygen concentration for both untreated and borohydride-reduced samples. Although borohydride reduction substantially ...
Allemani Claudia - - 2012
Few studies have addressed longer-term survival for breast cancer in European women. We have made predictions of ten-year survival for European women diagnosed with breast cancer in 2000-2002. Data for 114,312 adult women (15-99 years) diagnosed with a first primary malignant cancer of the breast during 2000-2002 were collected in ...
Skovgaard Alf - - 2012
The myxozoan Tetracapsuloides bryosalmonae is the causative agent of proliferative kidney disease (PKD), a widespread and serious condition in salmonid fishes in Europe and North America. In Europe, PKD is primarily reported affecting farmed rainbow trout Oncorhynchus mykiss, but limited information exists on the occurrence and effects of T. bryosalmonae ...
Stewart Merry - - 2012
AIM: To explore the influence of the haemodialysis regimen on African Americans' perceptions of sexuality. BACKGROUND: Sexuality is defined as the quality of humans as males or females. Sexuality concerns are commonly reported for individuals receiving haemodialysis; yet, sexuality-related research for this population has been limited to a focus on ...
Jang Seong Soon - - 2012
Abstract Purpose: The modification of radiation-induced lung injuries by melatonin was studied by measuring changes in oxidative stress, cytokine expression and histopathology in the lung tissue of mice following irradiation. Materials and methods: The thoraces of C57BL/6 mice were exposed to a single X-ray radiation dose of 12 Gy with ...
Applebaum Allison J - - 2012
Objective: Informal caregivers (ICs) are relatives, friends, and partners who have a significant relationship with and provide assistance (i.e., physical, emotional) to a patient with a life- threatening, incurable illness. The multidimensional burden that results from providing care to a patient with cancer is well documented, and as a result, ...
Buresi A - - 2012
Among the Lophotrochozoa, centralization of the nervous system reaches an exceptional level of complexity in cephalopods, where the typical molluscan ganglia become highly developed and fuse into hierarchized lobes. It is known that ganglionic primordia initially emerge early and simultaneously during cephalopod embryogenesis but no data exist on the process ...
Aguilar-Marcelino L - - 2012
Predation by the mite Lasioseius penicilliger was studied on three nematode species, i.e. infective larval stages (L3) of Haemonchus contortus and adults of Panagrellus redivivus and Rhabditis sp. Experiments were carried out in 5.5-cm diameter Petri dishes containing 2% water-agar over a period of 5 days. Batches of up to ...
Al-Sharqi Omar Zayan - - 2012
This paper outlines the health context of the Kingdom of Saudi Arabia (KSA). It reviews health systems development in the KSA from 1925 through to contemporary New Health Insurance System (NHIS). It also examines the consistency of NHIS in view of the emerging challenges. This paper identifies the determinants and ...
Li J Y - - 2012
The present study examined sequence variation in three mitochondrial DNA (mtDNA) genes, namely cytochrome c oxidase subunit 3 (cox3) and NADH dehydrogenase subunits 1 and 4 (nad1 and nad4), among Ascaridia galli isolates from different geographical localities in China. A portion of cox3 (pcox3), nad1 (pnad1) and nad4 (pnad4) genes ...
Schuttelaar Marie Louise A - - 2012
Background. It is unclear whether the respiratory tract is involved in eliciting or aggravating eczematous lesions in patients with vesicular hand eczema. Objectives. To investigate the effect of inhalation of house dust mite (HDM) on vesicular hand eczema. Methods. Eighteen patients with vesicular hand eczema and HDM allergy received inhalation ...
Larssen Lene - - 2012
Abstract Background. Self-expanding metal stents (SEMS) are commonly used in the palliative treatment of malignant gastrointestinal (GI) obstructions with favorable short-term outcome. Data on long-term outcome are scarce, however. Aim. To evaluate long-term outcome after palliative stent treatment of malignant GI obstruction. Method. Between October 2006 and April 2008, nine ...
Mazza Danielle - - 2012
BACKGROUND: While initial Human Papillomavirus (HPV) vaccine uptake estimates are encouraging, especially in the school-aged population, it is unclear to what extent general practitioners (GPs) have been recommending and administering the vaccine to adult women and what the uptake has been. METHODS: A mixed methods study of Australian GPs consisting ...
Quenouille Julie - - 2012
Genetic resistance provides efficient control of crop diseases, but is limited by pathogen evolution capacities which often result in resistance breakdown. It has been demonstrated recently, in three different pathosystems, that polygenic resistances combining a major-effect gene and quantitative resistance controlled by the genetic background are more durable than monogenic ...
Martínez-Salazar E A - - 2012
Species distribution modelling has been a powerful tool to explore the potential distribution of parasites in wildlife, being the basis of studies on biogeography. Vexillata spp. are intestinal nematodes found in several species of mammalian hosts, such as rodents (Geomyoidea) and hares (Leporidae) in the Nearctic and northern Neotropical regions. ...
Law James - - 2012
It is commonly assumed that boys have poorer language skills than girls, but this assumption is largely based on studies with small, clinical samples or focusing on expressive language skills. This study examines the relationship between gender and receptive vocabulary, literacy, and non-verbal performance at 5 years through to adulthood. ...
Hermans H - - 2012
BACKGROUND: In the Netherlands, no self-report screening questionnaire for anxiety in people with intellectual disabilities (ID) was available yet. Therefore, we have translated the Glasgow Anxiety Scale for people with an Intellectual Disability (GAS-ID) into Dutch and studied its reliability and validity in adults with borderline, mild or moderate ID. ...
Wang Jian - - 2012
It is a challenge to detect molecules lacking a chromophore, such as polyamines, by optical methods since they are insensitive to light. In order to detect the optical signals, it is compulsory to derive these molecules with optical labels, which, however, is complicated, time-consuming and may be expensive. In this ...
Malinauskiene Laura - - 2012
Several disperse dyes (DDs) are still considered to be the most important allergens in textile dermatitis, but there are sparse data about their current use in textiles. The aim of this review was to evaluate published studies and reports on contact allergy to DDs published in PubMed during the last ...
Dubuisson C - - 2012
Background/Objective:Our objective was to investigate whether school lunch attendance was associated with overall eating habits and sedentary behaviour in a French sample of children and adolescents.Subjects/Methods:Data for the study were taken from the second French cross-sectional dietary survey (INCA2-2006-07). In total, 1413 school children aged 3-17 years old were classified ...
Holmes Clive - - 2012
There is a great deal of evidence suggesting an important role for systemic inflammation in the pathogenesis of Alzheimer's Disease. The role of systemic inflammation, and indeed inflammation in general, is still largely considered to be as a contributor to the disease process rather than of aetiological importance although there ...
Sahin Ferat - - 2012
Core-shell magnetic nanoparticles (MNPs) offer tremendous opportunities in a large range of applications in biomedicine due to their superior magnetic properties, biocompatibility and suitability for modification. In most cases, these characteristic features are determined by their shell chemistry and morphology. Herein, we demonstrate a comparative study of silica and polydopamine ...
Vitaglione Paola - - 2012
Human bioavailability of cocoa flavanols and phenolic acids from a cocoa-nut cream (CC) and from CC enriched with a 1·5 % (w/w) cocoa polyphenol extract in free form (FPC) or encapsulated with a gastric-resistant high-amylose maize starch (EPC), was studied. In a randomised cross-over protocol, with 1-week wash-out in between, twelve ...
Sánchez-Meca Julio - - 2012
Precursors of the reliability generalization (RG) meta-analytic approach have not established a single preferred analytic method. By means of five real RG examples, we examine how using different statistical methods to integrate coefficients alpha can influence results in RG studies. Specifically, we compare thirteen different statistical models for averaging reliability ...
Shinohara Michi M - - 2012
Tattooing for ornamental purposes is an ancient practice that remains popular in modern times. Tattoos are encountered by the dermatopathologist either as incidental findings on skin biopsies or because of complications specific to the tattoo. A range of neoplasms and inflammatory conditions are seen in association with tattoos, many of ...
Pelaia G - - 2012
OBJECTIVE: 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can affect post-translational processes, thus being responsible for decreased farnesylation and geranylgeranylation of intracellular small G proteins such as Ras, Rho and Rac, essential for cell survival and proliferation. In this regard, recent in vitro and in vivo studies suggest a possible role ...
Dobratz Marjorie C - - 2012
Objective: With spirituality being one of the most important components of end-of-life (EOL) care, this study explored the oral responses of 44 dying persons who expressed spirituality. Method: Four identified spiritual themes: religious systems of beliefs and values, life meaning, purpose and connections with others, nonreligious systems of beliefs and ...
1 2 3 4 5 6 7 8 9 10 >